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R. Coffman · SciRah

Researcher profile · Semantic Scholar

R. Coffman

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R. Coffman — researcher profile on SciRah

h-index: 95
Works: 267
Citations: 56K

Most-cited papers

Vaccine Adjuvants: Putting Innate Immunity to Work
R. Coffman, A. Sher, R. Seder
2010Immunity1,886 citations Open access
Semantic Scholar
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus
G. García-Romo, S. Caielli, B. Vega, J. Connolly +9 more
2011Science Translational Medicine1,395 citations Open access
Semantic Scholar
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
F. Barrat, T. Meeker, Josh D. Gregorio, Jean H. Chan +5 more
2005Journal of Experimental Medicine1,006 citations Open access
Semantic Scholar
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
H. Kanzler, F. Barrat, E. Hessel, R. Coffman
2007Nature Medicine939 citations
Semantic Scholar
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells
L. Fahlén, S. Read, L. Gorelik, S. Hurst +3 more
2005Journal of Experimental Medicine598 citations Open access
Semantic Scholar
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9.
Irma Garcia-Martinez, N. Santoro, Yonglin Chen, Rafaz Hoque +6 more
2016Journal of Clinical Investigation445 citations Open access
Semantic Scholar
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
Cristiana Guiducci, G. Ott, Jean H. Chan, E. Damon +5 more
2006Journal of Experimental Medicine419 citations Open access
Semantic Scholar
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
J. Mandl, Ashley P. Barry, T. Vanderford, Natalia Kozyr +6 more
2008Nature Medicine409 citations
Semantic Scholar
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
Cristiana Guiducci, Mei Gong, Zhao-Hui Xu, M. Gill +11 more
2010Nature386 citations Open access
Semantic Scholar
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity
Prabhu S. Arunachalam, A. Walls, Nadia A. Golden, C. Atyeo +57 more
2021Nature313 citations
Semantic Scholar
Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses
Kun Yang, A. Puel, Shen-Ying Zhang, Celine Eidenschenk +24 more
2005Immunity278 citations Open access
Semantic Scholar
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.
Fumi Sato-Kaneko, Shiyin Yao, Alast Ahmadi, Shannon S. Zhang +13 more
2017JCI Insight264 citations Open access
Semantic Scholar
SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study
A. Ribas, T. Medina, S. Kummar, A. Amin +10 more
2018Cancer Discovery262 citations Open access
Semantic Scholar
Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the anti-viral germinal center response
B. Hou, P. Saudan, G. Ott, Matthew L. Wheeler +6 more
2011Immunity259 citations Open access
Semantic Scholar
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
Cristiana Guiducci, C. Ghirelli, Marie-Annick Marloie-Provost, T. Matray +4 more
2008Journal of Experimental Medicine241 citations Open access
Semantic Scholar
Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells
Shu Wang, J. Campos, Marilena Gallotta, Mei Gong +4 more
2016Proceedings of the National Academy of Sciences of the United States of America236 citations Open access
Semantic Scholar
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T follicular Helper Response
C. Jacquemin, N. Schmitt, C. Contin-Bordes, Yang Liu +26 more
2015Immunity216 citations Open access
Semantic Scholar
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
Cristiana Guiducci, C. Tripodo, Mei Gong, S. Sangaletti +3 more
2010Journal of Experimental Medicine213 citations Open access
Semantic Scholar
RNA recognition by human TLR8 can lead to autoimmune inflammation
Cristiana Guiducci, Mei Gong, A. Cepika, Zhao-Hui Xu +8 more
2013Journal of Experimental Medicine196 citations Open access
Semantic Scholar
Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19
Tsun-Yung Kuo, M. Lin, R. Coffman, John D. M. Campbell +11 more
2020Scientific Reports167 citations Open access
Semantic Scholar
In situ vaccination with a TLR 9 agonist and local low dose radiation induces systemic responses in untreated indolent lymphoma
M. Frank, P. Reagan, N. Bartlett, L. Gordon +8 more
2018Cancer Discovery154 citations Open access
Semantic Scholar
Pillars Article: Two Types of Murine Helper T Cell Clone. I. Definition According to Profiles of Lymphokine Activities and Secreted Proteins. J. Immunol., 1986, 136: 2348–2357.
T. Mosmann, H. Cherwinski, M. Bond, M. Giedlin +1 more
2005Journal of Immunology142 citations
Semantic Scholar
Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response.
Felix Yarovinsky, H. Kanzler, S. Hieny, R. Coffman +1 more
2006Immunity140 citations Open access
Semantic Scholar
Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses.
G. Gauvreau, E. Hessel, L. Boulet, R. Coffman +1 more
2006American Journal of Respiratory and Critical Care Medicine139 citations
Semantic Scholar
Origins of the TH1-TH2 model: a personal perspective
R. Coffman
2006Nature Immunology136 citations
Semantic Scholar
Inhibitors of TLR-9 Act on Multiple Cell Subsets in Mouse and Man In Vitro and Prevent Death In Vivo from Systemic Inflammation
Omar Duramad, K. Fearon, B. Chang, Jean H. Chan +3 more
2005Journal of Immunology134 citations Open access
Semantic Scholar
CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
C. Mionnet, V. Buatois, Akira Kanda, Valerie Milcent +10 more
2010Nature Medicine129 citations Open access
Semantic Scholar
Signalling pathways leading to IFN‐α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications
Cristiana Guiducci, R. Coffman, F. Barrat
2009Journal of Internal Medicine104 citations
Semantic Scholar
Origins of the T(H)1-T(H)2 model: a personal perspective.
R. Coffman
2006Nature Immunology99 citations
Semantic Scholar
Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma
Jonathan W. Friedberg, J. Kelly, D. Neuberg, Derick R. Peterson +15 more
2009British Journal of Haematology91 citations Open access
Semantic Scholar
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. 1986.
T. Mosmann, H. Cherwinski, M. Bond, M. Giedlin +1 more
2005Journal of Immunology89 citations
Semantic Scholar
CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
W. Haining, J. Davies, H. Kanzler, Linda Drury +15 more
2008Clinical Cancer Research77 citations Open access
Semantic Scholar
CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans.
John D. M. Campbell, Cho Yan, M. Foster, H. Kanzler +9 more
2009Journal of Clinical Investigation71 citations Open access
Semantic Scholar
Superior Activity of the Type C Class of ISS In Vitro and In Vivo Across Multiple Species
J. Marshall, K. Fearon, D. Higgins, E. Hessel +12 more
2005DNA and Cell Biology70 citations
Semantic Scholar
Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay.
Marilena Gallotta, H. Assi, Émilie Degagné, S. Kannan +2 more
2018Cancer Research69 citations
Semantic Scholar
Assessing the Safety of Adjuvanted Vaccines
S. S. Ahmed, S. Plotkin, S. Black, R. Coffman
2011Science Translational Medicine53 citations
Semantic Scholar
Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice
Lilit Grigoryan, Audrey Lee, A. Walls, Lilin Lai +26 more
2022npj Vaccines52 citations Open access
Semantic Scholar
A Novel TLR-9 Agonist C792 Inhibits Plasmacytoid Dendritic Cell-induced Myeloma Cell Growth and Enhance Cytotoxicity of Bortezomib
A. Ray, Z. Tian, D. Das, R. Coffman +3 more
2014Leukemia46 citations Open access
Semantic Scholar
Airway generation‐specific differences in the spatial distribution of immune cells and cytokines in allergen‐challenged rhesus monkeys
L. Miller, S. Hurst, R. Coffman, N. Tyler +7 more
2005Clinical and Experimental Allergy45 citations Open access
Semantic Scholar
A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice
John D. M. Campbell, Sariah Kell, Heather M. Kozy, Jeremy A Lum +7 more
2014Thorax35 citations Open access
Semantic Scholar
The Origin of TH2 Responses
R. Coffman
2010Science32 citations
Semantic Scholar
A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-immunization Protection against Inhaled Anthrax in Monkeys
M. Kachura, Colin Hickle, Sariah Kell, A. Sathe +8 more
2015Journal of Immunology27 citations Open access
Semantic Scholar
Allergen‐specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression
J. Campbell, P. Buchmann, S. Kesting, Cameron R. Cunningham +2 more
2010Clinical and Experimental Allergy26 citations
Semantic Scholar
A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice
S. Strohmeier, Fatima Amanat, John D. M. Campbell, P. Traquina +2 more
2022npj Vaccines24 citations Open access
Semantic Scholar
Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non‐human primates, and human primary cells
Sariah Kell, M. Kachura, A. Renn, P. Traquina +2 more
2019International Immunopharmacology23 citations
Semantic Scholar
First‐in‐Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well‐Tolerated
S. Jackson, A. Candia, S. Delaney, Simone Floettmann +12 more
2018Clinical pharmacology and therapy21 citations
Semantic Scholar
Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates
Prabhu S. Arunachalam, A. Walls, Nadia A. Golden, C. Atyeo +56 more
2021bioRxiv20 citations Open access
Semantic Scholar
Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses
Weng-In Leong, Rachel Y. Ames, Jessica M. Haverkamp, Laura Torres +7 more
2019OncoTarget19 citations Open access
Semantic Scholar
Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 1989. 170: 1039-1044.
R. Coffman, D. Lebman, B. Shrader
2009Journal of Immunology19 citations
Semantic Scholar
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
C. Ager, M. Reilley, C. Nicholas, Todd Bartkowiak +496 more
2016Journal for ImmunoTherapy of Cancer18 citations Open access
Semantic Scholar

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