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S. Hille · SciRah

Researcher profile · Semantic Scholar

S. Hille

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S. Hille — researcher profile on SciRah

h-index: 20
Works: 52
Citations: 1,696

Most-cited papers

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy
Alexander Grabner, Ansel P. Amaral, K. Schramm, S. Singh +27 more
2015Cell Metabolism513 citations Open access
Semantic Scholar
Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants
J. Weinmann, S. Weis, Josefine Sippel, W. Tulalamba +14 more
2020Nature Communications224 citations Open access
Semantic Scholar
Aging impairs the neurovascular interface in the heart
J. Wagner, L. Tombor, P. Malacarne, Lisa-Maria Kettenhausen +38 more
2023Science117 citations
Semantic Scholar
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes
J. Okun, Patricia M. Rusu, Andrea Y. Chan, Yuqin Wu +17 more
2021Nature Metabolism95 citations Open access
Semantic Scholar
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders
J. El Andari, Edith Renaud-Gabardos, W. Tulalamba, J. Weinmann +23 more
2022Science Advances69 citations Open access
Semantic Scholar
Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response
Pablo Binder, Shunyao Wang, M. Radu, Zi Min +17 more
2019Circulation Research66 citations Open access
Semantic Scholar
Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling.
S. Hille, Franziska Dierck, C. Kühl, J. Sosna +5 more
2016Cardiovascular Research66 citations
Semantic Scholar
Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signaling.
I. Alesutan, Trang T. D. Luong, Nadeshda Schelski, Jaber Masyout +18 more
2020Cardiovascular Research64 citations Open access
Semantic Scholar
A human cell atlas of the pressure-induced hypertrophic heart
Luka Nicin, S. M. Schroeter, S. Glaser, Ralf Schulze-Brüning +18 more
2022Nature Cardiovascular Research55 citations Open access
Semantic Scholar
Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs
K. Kokot, J. Kneuer, D. John, S. Rebs +16 more
2022Basic Research in Cardiology43 citations Open access
Semantic Scholar
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
C. Carlson, J. M. Aronsen, A. Bergan-Dahl, M. Moutty +18 more
2021Circulation Research38 citations Open access
Semantic Scholar
Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure.
O. Müller, M. Heckmann, L. Ding, K. Rapti +19 more
2018Cardiovascular Research37 citations
Semantic Scholar
Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue
A. Remes, D. I. Basha, T. Puehler, Christopher Borowski +11 more
2021Molecular Therapy: Methods & Clinical Development30 citations Open access
Semantic Scholar
Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart
Pablo Binder, B. Nguyen, Lucy Collins, M. Zi +10 more
2022Frontiers in Cardiovascular Medicine27 citations Open access
Semantic Scholar
Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy
N. Kaur, A. Ruiz-Velasco, R. Raja, G. Howell +17 more
2022iScience26 citations Open access
Semantic Scholar
Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence
Jiong Hu, M. Leisegang, M. Looso, M. Drekolia +24 more
2023Circulation Research25 citations
Semantic Scholar
SPSB1‐mediated inhibition of TGF‐β receptor‐II impairs myogenesis in inflammation
Yi Li, Niklas Dörmann, B. Brinschwitz, Melanie Kny +15 more
2023Journal of Cachexia, Sarcopenia and Muscle22 citations Open access
Semantic Scholar
Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure
A. Ruiz-Velasco, M. Zi, S. Hille, Tayyiba Azam +14 more
2020eLife21 citations Open access
Semantic Scholar
FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo
C. Kuhn, M. Menke, F. Senger, C. Mack +14 more
2021JACC: Basic to Translational Science20 citations Open access
Semantic Scholar
Cardiac Fibroblast Growth Factor 23 Excess Does Not Induce Left Ventricular Hypertrophy in Healthy Mice
M. Leifheit-Nestler, Miriam A. Wagner, Beatrice Richter, Corinna Piepert +10 more
2021Frontiers in Cell and Developmental Biology20 citations Open access
Semantic Scholar
Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes
Ping Lai, S. Hille, H. Subramanian, Robert Weigman +4 more
2023Cardiovascular Research18 citations Open access
Semantic Scholar
The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling
Franziska Dierck, C. Kuhn, Claudia M. Rohr, S. Hille +6 more
2017Journal of Biological Chemistry18 citations Open access
Semantic Scholar
PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
Xin-Yi Chen, A. Ruiz-Velasco, Zhi-Yong Zou, S. Hille +19 more
2024Diabetes17 citations Open access
Semantic Scholar
AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model
A. Kliesow Remes, T. Ruf, Tinatin Zurashvili, L. Ding +18 more
2025Basic Research in Cardiology12 citations Open access
Semantic Scholar
AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9DY atherosclerosis mouse model
Leonie Achner, Tobias Klersy, B. Fels, Tobias Reinberger +7 more
2022Pflügers Archiv: European Journal of Physiology12 citations Open access
Semantic Scholar
C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation
Ricarda Haustein, F. Trogisch, Merve Keles, S. Hille +13 more
2023Cells8 citations Open access
Semantic Scholar
Regnase-1 overexpression as a therapeutic approach of Marfan syndrome
M. Noormalal, Nesrin Schmiedel, T. Bozoglu, Andrea Matzen +14 more
2023Molecular Therapy: Methods & Clinical Development7 citations Open access
Semantic Scholar
Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon
Yuqin Wu, Ashish Foollee, Andrea Y. Chan, S. Hille +20 more
2024Nature Communications6 citations Open access
Semantic Scholar
AAV library screening identifies novel vector for efficient transduction of human aorta
L. Schröder, Leonard Hüttermann, A. Kliesow Remes, J. Voran +7 more
2024Gene Therapy6 citations Open access
Semantic Scholar
Restored autophagy is protective against PAK3-induced cardiac dysfunction
A. Ruiz-Velasco, R. Raja, Xinyi Chen, Haresh Ganenthiran +15 more
2023iScience6 citations Open access
Semantic Scholar
Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II
B. Nguyen, Fangchao Zhou, Pablo Binder, Wei Liu +12 more
2023Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease6 citations Open access
Semantic Scholar
Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo
M. Christine H. Petersen, Nesrin Schmiedel, Franziska Dierck, S. Hille +9 more
2023Frontiers in Molecular Biosciences3 citations Open access
Semantic Scholar
Targeting P21‐Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction
Hong-Yuan Zhang, Honglin Xu, Fangchao Zhou, Tayyiba Azam +11 more
2025Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease2 citations Open access
Semantic Scholar
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Honglin Xu, Hong-Yuan Zhang, Tayyiba Azam, S. Hille +14 more
2026Advancement of science1 citations Open access
Semantic Scholar
Directed Evolution of AAV9 for Efficient Gene Expression in Cardiomyocytes In Vitro and In Vivo
Leonard Hüttermann, L. Schröder, P. M. V. Shetty, T. Jonker +10 more
2025Human Gene Therapy1 citations Open access
Semantic Scholar
Mkk7 Protects Against Cardiac Dysfunction in Heart Failure with Preserved Ejection Fraction
Tayyiba Azam, Hong-Yuan Zhang, S. Hille, E. J. Cartwright +2 more
2024International Journal of Drug Discovery and Pharmacology1 citations Open access
Semantic Scholar
Targeted overexpression of regnase-1 in the aorta prevents aneurysm growth in a murine model of Marfan syndrome
M. Noormalal, A. Remes, N. Schmiedel, A. Matzen +9 more
2022European Heart Journal1 citations Open access
Semantic Scholar
Decrease of RNA editing in the failing heart leads to induction of circRNAs
K. Kokot, J. Kneuer, D. John, S. Rebs +11 more
2022European Heart Journal1 citations Open access
Semantic Scholar
A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprograming
Jiong Hu, M. Leisegang, M. Looso, G. Dumbović +18 more
2022bioRxiv1 citations Open access
Semantic Scholar
O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy.
Nesrin Schmiedel, A. Remes, M. Valadan, S. Hille +5 more
2022Journal of Visualized Experiments1 citations
Semantic Scholar
FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling
F. Senger, S. Hille, A. Kliesow Remes, T. Baral +9 more
2026bioRxiv0 citations Open access
Semantic Scholar
Pharmacological MALT1 inhibition ameliorates cardiac inflammation and dysfunction in experimental autoimmune myocarditis
A. Remes, R. M. Ignaz, V. A. Zirkenbach, M. Noormalal +9 more
2026European Journal of Heart Failure0 citations
Semantic Scholar
Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis
J. Freundt, Paulina Hartmann, C. Loescher, A. Unger +12 more
2025bioRxiv0 citations
Semantic Scholar
Graded cleavage of elastic titin in living mouse hearts reveals the role of titin stiffness for cardiac contractility
J. Freundt, A. Unger, C. Loescher, Richard Holtmeier +3 more
2024Biophysical Journal0 citations Open access
Semantic Scholar
Overexpressing Mitogen-activated Protein Kinase Kinase 7 (MKK7) Alleviates Endoplasmic Reticulum Stress-induced Cardiac Dysfunction during Pressure Overload induced Heart Failure
Tayyiba Azam, M. Zi, S. Hille, Hong-Yuan Zhang +3 more
2023International Journal of Drug Discovery and Pharmacology0 citations Open access
Semantic Scholar
Regnase-1 overexpression as a novel gene therapy approach for pulmonary hypertension
A. Remes, P. Kasap, N. Schmiedel, S. Hille +8 more
2022European Heart Journal0 citations Open access
Semantic Scholar
An endocrine-hepato-muscular metabolic cycle links skeletal muscle atrophy and hyperglycemia in type 2 diabetes
J. Okun, Patricia M. Rusu, Andrea Y. Chan, Y. Yap +13 more
2020bioRxiv0 citations Open access
Semantic Scholar
Author response: Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure
A. Ruiz-Velasco, M. Zi, S. Hille, Tayyiba Azam +14 more
20200 citations Open access
Semantic Scholar
P1616L-2-hydroxyglutarate dehydrogenase (L2HGDH) is a novel target for heart failure due to pressure overload
A. Remes, L. Ding, B. Kamlage, U. Rennefahrt +9 more
2019European Heart Journal0 citations
Semantic Scholar
The cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling
Franziska Dierck, C. Kuhn, Claudia M. Rohr, S. Hille +7 more
20170 citations
Semantic Scholar

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