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T. Sampath · SciRah

Researcher profile · Semantic Scholar

T. Sampath

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T. Sampath — researcher profile on SciRah

h-index: 52
Works: 106
Citations: 13K

Most-cited papers

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
P. ten Dijke, H. Yamashita, T. Sampath, A. Reddi +5 more
1994Journal of Biological Chemistry754 citations
Semantic Scholar
Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.
T. Sampath, J. Maliakal, Peter V. Hauschka, W. Jones +6 more
1992Journal of Biological Chemistry681 citations
Semantic Scholar
OP‐1 cDNA encodes an osteogenic protein in the TGF‐beta family.
E. Ozkaynak, D. Rueger, E. Drier, C. Corbett +3 more
1990EMBO Journal545 citations Open access
Semantic Scholar
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
H. Yamashita, P. ten Dijke, Danny Huylebroeck, T. Sampath +4 more
1995Journal of Cell Biology542 citations Open access
Semantic Scholar
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.
M. Fujii, K. Takeda, T. Imamura, Hiromasa Aoki +6 more
1999Molecular Biology of the Cell430 citations Open access
Semantic Scholar
The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects.
S. Cook, G. C. Baffes, M. W. Wolfe, T. Sampath +2 more
1994Journal of Bone and Joint Surgery. American volume393 citations
Semantic Scholar
Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily.
T. Sampath, J. Coughlin, R. Whetstone, D. Banach +5 more
1990Journal of Biological Chemistry377 citations Open access
Semantic Scholar
Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model.
Stephen D. Cook, G. C. Baffes, M. W. Wolfe, T. Sampath +1 more
1994Clinical Orthopaedics and Related Research363 citations
Semantic Scholar
Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development.
D. Macías, Y. Gańan, T. Sampath, M. Piedra +2 more
1997Development360 citations
Semantic Scholar
Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography.
T. Sampath, N. Muthukumaran, A. Reddi
1987Proceedings of the National Academy of Sciences of the United States of America342 citations Open access
Semantic Scholar
Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.
S. Vukicevic, V. Bašić, D. Rogić, N. Bašić +13 more
1998Journal of Clinical Investigation337 citations Open access
Semantic Scholar
Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation.
Takanori Ebisawa, Keiichi Tada, I. Kitajima, K. Tojo +4 more
1999Journal of Cell Science332 citations
Semantic Scholar
Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm.
J. Dale, C. Vesque, Thierry J. Lints, T. Sampath +3 more
1997Cell305 citations Open access
Semantic Scholar
Smad6 Is a Smad1/5-induced Smad Inhibitor
W. Ishida, Toshiaki Hamamoto, Kiyoshi Kusanagi, K. Yagi +5 more
2000Journal of Biological Chemistry296 citations Open access
Semantic Scholar
Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
D. L. Griffith, P. Keck, T. Sampath, D. Rueger +1 more
1996Proceedings of the National Academy of Sciences of the United States of America296 citations Open access
Semantic Scholar
Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats.
Toshiyuki Onishi, Y. Ishidou, T. Nagamine, K. Yone +5 more
1998Bone262 citations
Semantic Scholar
Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells.
I. Asahina, T. Sampath, P. Hauschka
1996Experimental Cell Research253 citations
Semantic Scholar
Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction.
Keith A. Hruska, G. Guo, M. Wozniak, D. Martin +6 more
2000AJP - Renal Physiology250 citations
Semantic Scholar
Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes.
J. Flechtenmacher, Klaus Huch, E. Thonar, Juergen Mollenhauer +6 more
1996Arthritis & Rheumatism249 citations Open access
Semantic Scholar
Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria
I. Asahina, T. Sampath, Ichiro Nishimura, P. Hauschka
1993Journal of Cell Biology243 citations Open access
Semantic Scholar
Excessive TGFβ signaling is a common mechanism in Osteogenesis Imperfecta
I. Grafe, Tao Yang, Stefanie Alexander, Erica P. Homan +13 more
2014Nature Medicine225 citations Open access
Semantic Scholar
Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.
T. Sampath, K. Rashka, J. Doctor, R. F. Tucker +1 more
1993Proceedings of the National Academy of Sciences of the United States of America222 citations Open access
Semantic Scholar
Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: high affinity binding to basement membranes.
S. Vukicevic, V. Latin, Ping Chen, R. Batorsky +2 more
1994Biochemical and Biophysical Research Communications - BBRC214 citations Open access
Semantic Scholar
Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).
S. Vukicevic, J. Kopp, F. Luyten, T. Sampath
1996Proceedings of the National Academy of Sciences of the United States of America198 citations Open access
Semantic Scholar
Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7).
U. Ripamonti, B. van den Heever, T. Sampath, M. Tucker +2 more
1996Growth Factors190 citations
Semantic Scholar
Induction of Smad6 mRNA by bone morphogenetic proteins.
M. Takase, T. Imamura, T. Sampath, K. Takeda +3 more
1998Biochemical and Biophysical Research Communications - BBRC170 citations
Semantic Scholar
Localization of Smads, the TGF‐β Family Intracellular Signaling Components During Endochondral Ossification
T. Sakou, Toshiyuki Onishi, Takuya Yamamoto, T. Nagamine +2 more
1999Journal of Bone and Mineral Research163 citations Open access
Semantic Scholar
Bone morphogenetic protein‐7 (osteogenic protein‐1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro
H. Dorai, S. Vukicevic, T. Sampath
2000Journal of Cellular Physiology158 citations
Semantic Scholar
Thyroid‐Stimulating Hormone Restores Bone Volume, Microarchitecture, and Strength in Aged Ovariectomized Rats*
T. Sampath, P. Simic, Rebecca Sendak, N. Drača +5 more
2007Journal of Bone and Mineral Research145 citations
Semantic Scholar
Induction of cementogenesis by recombinant human osteogenic protein-1 (hop-1/bmp-7) in the baboon (Papio ursinus).
U. Ripamonti, M. Heliotis, D. Rueger, T. Sampath
1996Archives of Oral Biology143 citations
Semantic Scholar
Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum.
Kyouji Hayashi, Y. Ishidou, Kouji Yonemori, T. Nagamine +8 more
1997Bone104 citations
Semantic Scholar
Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7.
E. González, R. Lund, Kevin J. Martin, J. Mccartney +3 more
2002Kidney International98 citations Open access
Semantic Scholar
Advances in Brief Expression of Bone Morphogenetic Protein Receptors Type-IA ,-IB , and-II Correlates with Tumor Grade in Human Prostate Cancer Tissues 1
I. Kim, Dong-Hyeon Lee, H. Ahn, H. Tokunaga +5 more
200097 citations
Semantic Scholar
Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament.
Kouji Yonemori, Takeshi Imamura, Y. Ishidou, Toshihiro Okano +7 more
1997American Journal of Pathology96 citations
Semantic Scholar
Long‐Term Evaluation of Bone Formation by Osteogenic Protein 1 in the Baboon and Relative Efficacy of Bone‐Derived Bone Morphogenetic Proteins Delivered by Irradiated Xenogeneic Collagenous Matrices
U. Ripamonti, B. van den Heever, J. Crooks, M. Tucker +3 more
2000Journal of Bone and Mineral Research88 citations
Semantic Scholar
Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E2, and interleukin‐1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin‐1β
K. Huch, J. Flechtenmacher, B. Wilbrink, Holger E. Koepp +5 more
199787 citations
Semantic Scholar
Osteogenic protein-1 promotes growth and maturation of chick sternal chondrocytes in serum-free cultures.
Ping Chen, S. Vukicevic, T. Sampath, F. Luyten
1995Journal of Cell Science85 citations
Semantic Scholar
Osteogenic protein-1 stimulates proliferation and differentiation of human bone cells in vitro.
Raymond Knutsen, J. Wergedal, T. Sampath, D. Baylink +1 more
1993Biochemical and Biophysical Research Communications - BBRC83 citations
Semantic Scholar
Bovine articular chondrocytes do not undergo hypertrophy when cultured in the presence of serum and osteogenic protein-1.
Ping Chen, S. Vukicevic, T. Sampath, F. Luyten
1993Biochemical and Biophysical Research Communications - BBRC82 citations
Semantic Scholar
Osteogenic protein-1 (BMP-7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma (17/2.8) cells.
J. Maliakal, Izumi Asahina, Peter V. Hauschka, T. Sampath
1994Growth Factors81 citations
Semantic Scholar
Use of bovine osteogenic protein to promote rapid osseointegration of endosseous dental implants.
R. Rutherford, T. Sampath, D. Rueger, T. D. Taylor
1992The International Journal of Oral and Maxillofacial Implants81 citations
Semantic Scholar
Opposite effects of osteogenic protein and transforming growth factor β on chondrogenesis in cultured long bone rudiments
S. Dieudonné, C. Semeins, S. Goei, S. Vukicevic +4 more
1994Journal of Bone and Mineral Research75 citations
Semantic Scholar
Stimulation of Proteoglycan Synthesis in Explants of Porcine Articular Cartilage by Recombinant Osteogenic Protein-1 (Bone Morphogenetic Protein-7)*
S. Lietman, M. Yanagishita, T. Sampath, A. Reddi
1997Journal of Bone and Joint Surgery. American volume74 citations
Semantic Scholar
Discovery of Bone Morphogenetic Proteins - A Historical Perspective.
T. Sampath, A. Reddi
2020Bone72 citations
Semantic Scholar
Regulation of insulin-like growth factor system components by osteogenic protein-1 in human bone cells.
Raymond Knutsen, Y. Honda, D. Strong, T. Sampath +2 more
1995Endocrinology67 citations
Semantic Scholar
Identification of a Novel Bone Morphogenetic Protein-responsive Gene That May Function as a Noncoding RNA*
K. Takeda, H. Ichijo, M. Fujii, Y. Mochida +4 more
1998Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Osteogenic protein-1 is required for mammalian eye development.
M. Solursh, R. Langille, J. Wood, T. Sampath
1996Biochemical and Biophysical Research Communications - BBRC48 citations
Semantic Scholar
Effects of recombinant human osteogenic protein-1 on the differentiation of osteoclast-like cells and bone resorption.
T. Hentunen, P. Lakkakorpi, J. Tuukkanen, P. Lehenkari +2 more
1995Biochemical and Biophysical Research Communications - BBRC47 citations
Semantic Scholar
Bone Morphogenetic Protein-7 Modulates Genes that Maintain the Vascular Smooth Muscle Cell Phenotype in Culture
H. Dorai, T. Sampath
2001Journal of Bone and Joint Surgery. American volume44 citations
Semantic Scholar
Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4.
T. Yamashita, H. Ishii, K. Shimoda, T. Sampath +4 more
1996Bone42 citations
Semantic Scholar

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