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H. Ichijo · SciRah

Researcher profile · Semantic Scholar

H. Ichijo

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H. Ichijo — researcher profile on SciRah

h-index: 99
Works: 406
Citations: 46K

Most-cited papers

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L. Galluzzi, I. Vitale, S. Aaronson, J. Abrams +165 more
2018Cell Death and Differentiation6,079 citations Open access
Semantic Scholar
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases.
Toshitaka Nakamura, Isao Naguro, H. Ichijo
2019Biochimica et Biophysica Acta - General Subjects474 citations
Semantic Scholar
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I. Vitale, F. Pietrocola, E. Guilbaud, S. Aaronson +224 more
2023Cell Death and Differentiation346 citations Open access
Semantic Scholar
A guideline on the molecular ecosystem regulating ferroptosis
En-Yong Dai, Xin Chen, A. Linkermann, Xue-Jun Jiang +44 more
2024Nature Cell Biology284 citations
Semantic Scholar
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
K. Imamura, Y. Izumi, Akira Watanabe, Kayoko Tsukita +32 more
2017Science Translational Medicine234 citations Open access
Semantic Scholar
The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction
Shun Koizumi, Taro Irie, Shoshiro Hirayama, Yasuyuki Sakurai +5 more
2016eLife164 citations Open access
Semantic Scholar
Cryo-EM structures of the human volume-regulated anion channel LRRC8
G. Kasuya, T. Nakane, T. Yokoyama, Yanyan Jia +15 more
2018Nature Structural & Molecular Biology119 citations Open access
Semantic Scholar
Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway
K. Hattori, Hiroyuki O. Ishikawa, Chihiro Sakauchi, Saki Takayanagi +2 more
2017EMBO Reports115 citations Open access
Semantic Scholar
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki +4 more
2020Nature Communications110 citations Open access
Semantic Scholar
The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis
Toshitaka Nakamura, Motoyuki Ogawa, Kazuki Kojima, Saki Takayanagi +4 more
2021EMBO Reports77 citations Open access
Semantic Scholar
Mitogen-activated protein kinases as key players in osmotic stress signaling.
Xiangyu Zhou, Isao Naguro, H. Ichijo, Kengo Watanabe
2016Biochimica et Biophysica Acta73 citations
Semantic Scholar
Mitochondrial fatty acid oxidation drives senescence
S. Yamauchi, Yuki Sugiura, Junji Yamaguchi, Xiang-Yu Zhou +8 more
2024Science Advances68 citations Open access
Semantic Scholar
Cell volume regulation in cancer cell migration driven by osmotic water flow
Kazuhiro Morishita, Kengo Watanabe, H. Ichijo
2019Cancer Science66 citations Open access
Semantic Scholar
Pleiotropic properties of ASK1.
Chihiro Sakauchi, Hiroaki Wakatsuki, H. Ichijo, K. Hattori
2017Biochimica et Biophysica Acta - General Subjects63 citations
Semantic Scholar
TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.
Y. Hirata, K. Katagiri, Keita Nagaoka, Tohru Morishita +11 more
2017Cell Reports61 citations Open access
Semantic Scholar
Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation.
M. Naik, Pravin Patel, Randall J. Derstine, Ramya Turaga +5 more
2017Blood59 citations Open access
Semantic Scholar
Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
R. Nakamura, T. Numata, G. Kasuya, T. Yokoyama +14 more
2020Communications Biology53 citations Open access
Semantic Scholar
A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.
Kengo Watanabe, Tsuyoshi Umeda, Kuniyoshi Niwa, Isao Naguro +1 more
2018Cell Reports48 citations Open access
Semantic Scholar
Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly
A. Chaikuad, P. Filippakopoulos, S. Marcsisin, S. Picaud +6 more
2017Structure47 citations Open access
Semantic Scholar
The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.
T. Fujisawa, Motoo Takahashi, Yuka Tsukamoto, Namiko Yamaguchi +8 more
2016Human Molecular Genetics42 citations
Semantic Scholar
ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets
Miki Kamiyama, Toshiaki Shirai, S. Tamura, K. Suzuki-Inoue +8 more
2017Cell Death and Differentiation40 citations Open access
Semantic Scholar
ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue
H. Kato, K. Okabe, M. Miyake, K. Hattori +16 more
2020Life Science Alliance34 citations Open access
Semantic Scholar
ASK family kinases mediate cellular stress and redox signaling to circadian clock
Kiyomichi Imamura, H. Yoshitane, K. Hattori, M. Yamaguchi +5 more
2018Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging
T. Odawara, S. Yamauchi, H. Ichijo
2024Communications Biology29 citations Open access
Semantic Scholar
Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response.
Kazuhiro Morishita, Kengo Watanabe, Isao Naguro, H. Ichijo
2023Cell Reports28 citations Open access
Semantic Scholar
TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins
Yuki Hayashi, Sho Takatori, Waleed Y Warsame, T. Tomita +2 more
2023EMBO Journal26 citations Open access
Semantic Scholar
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
Naomi Tsuburaya, Kengo Homma, T. Higuchi, Andrii G. Balia +18 more
2018Nature Communications26 citations Open access
Semantic Scholar
NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress
T. Nishida, Isao Naguro, H. Ichijo
2022Cell Death Discovery25 citations Open access
Semantic Scholar
Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation
Takeshi Ikizawa, Kazutaka Ikeda, M. Arita, S. Kitajima +3 more
2022Journal of Biological Chemistry22 citations Open access
Semantic Scholar
ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function
Takashi Sugiyama, Naoya Murao, H. Kadowaki, K. Takao +14 more
2021iScience22 citations Open access
Semantic Scholar
Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer’s Disease and Brain Aging
Yu Hasegawa, Kensuke Toyama, Ken Uekawa, H. Ichijo +1 more
2017Journal of Alzheimer's Disease22 citations
Semantic Scholar
Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells
S. Ito, Keisuke Kuromiya, Miho Sekai, Hiroaki Sako +15 more
2023Proceedings of the National Academy of Sciences of the United States of America19 citations Open access
Semantic Scholar
FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells.
Motoyuki Ogawa, Yosuke Kawarazaki, Yasuyuki Fujita, Isao Naguro +1 more
2020Current Biology19 citations Open access
Semantic Scholar
Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.
Haruka Matsui, Takayuki Iriyama, S. Sayama, Naoko Inaoka +11 more
2021Placenta18 citations Open access
Semantic Scholar
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression
Taku Ito-Kureha, Takahisa Miyao, Saori Nishijima, Toru Suzuki +10 more
2020Nature Communications18 citations Open access
Semantic Scholar
ASK1 signaling regulates phase-specific glial interactions during neuroinflammation
Xiaoli Guo, A. Kimura, K. Namekata, C. Harada +4 more
2022Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Apoptosis signal-regulating kinase 1 (ASK1) as a therapeutic target for neurological diseases
Satoshi Takenaka, T. Fujisawa, H. Ichijo
2020Expert opinion on therapeutic targets15 citations Open access
Semantic Scholar
mTOR-AKT Signaling in Cellular Clock Resetting Triggered by Osmotic Stress
H. Yoshitane, Kiyomichi Imamura, Takenori Okubo, Y. Otobe +7 more
2022Antioxidants and Redox Signaling14 citations
Semantic Scholar
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1
S. Sugawara, Yusuke Kanamaru, Shiori Sekine, Lila Maekawa +6 more
2020Journal of Biological Chemistry13 citations Open access
Semantic Scholar
ASK1 promotes uterine inflammation leading to pathological preterm birth
Midori Yoshikawa, Takayuki Iriyama, Kensuke Suzuki, S. Sayama +8 more
2020Scientific Reports13 citations Open access
Semantic Scholar
β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.
Ran Cheng, K. Takeda, Isao Naguro, T. Hatta +4 more
2018Biochimica et Biophysica Acta - General Subjects13 citations
Semantic Scholar
Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation
M. Sawamura, K. Imamura, Rie Hikawa, Takako Enami +12 more
2022Scientific Reports11 citations Open access
Semantic Scholar
Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes
C. De Blasio, Nagendra Verma, M. Moretti, Samantha Cialfi +8 more
2021Cell Death Discovery10 citations Open access
Semantic Scholar
A Novel Lens for Cell Volume Regulation: Liquid-Liquid Phase Separation.
Shunya Ishihara, H. Ichijo, Kengo Watanabe
2021Cellular Physiology and Biochemistry7 citations Open access
Semantic Scholar
ASK1 suppresses NK cell‐mediated intravascular tumor cell clearance in lung metastasis
M. Fujimoto, Miki Kamiyama, K. Fuse, Hiroki Ryuno +12 more
2021Cancer Science7 citations Open access
Semantic Scholar
Protein Misfolding Disorders: A Trip into the ER
C. Hetz, R. Kaufman, Amy S. Lee, J. Atkin +32 more
20187 citations Open access
Semantic Scholar
β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes
K. Hattori, Hiroaki Wakatsuki, Chihiro Sakauchi, Shotaro Furutani +4 more
2020bioRxiv5 citations Open access
Semantic Scholar
Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis.
Kazuki Kojima, H. Ichijo, Isao Naguro
2020Journal of Biochemistry (Tokyo)5 citations
Semantic Scholar
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase
Kengo Homma, Hiromitsu Takahashi, Naomi Tsuburaya, Isao Naguro +2 more
2020Journal of Biological Chemistry5 citations Open access
Semantic Scholar
Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP
Yuki Hayashi, H. Ichijo
2024Autophagy4 citations
Semantic Scholar

Frequent co-authors

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Isao Naguro×27
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Isao Naguro — researcher profile on SciRah
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Kengo Watanabe — researcher profile on SciRah
K. Hattori×9
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K. Hattori — researcher profile on SciRah
K. Takeda×7
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T. Fujisawa — researcher profile on SciRah

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H. Nishitoh — researcher profile on SciRah

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Kengo Homma — researcher profile on SciRah

E. Baehrecke×3

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E. Baehrecke — researcher profile on SciRah

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A. Linkermann — researcher profile on SciRah