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M. Canals · SciRah

Researcher profile · Semantic Scholar

M. Canals

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M. Canals — researcher profile on SciRah

h-index: 49
Works: 132
Citations: 8,496

Most-cited papers

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
R. Dror, H. F. Green, C. Valant, D. Borhani +10 more
2013Nature402 citations
Semantic Scholar
The role of kinetic context in apparent biased agonism at GPCRs
Carmen Klein Herenbrink, D. Sykes, P. Donthamsetti, M. Canals +9 more
2016Nature Communications328 citations Open access
Semantic Scholar
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
A. Gillis, Arisbel B. Gondin, A. Kliewer, Julie Sanchez +18 more
2020Science Signaling315 citations Open access
Semantic Scholar
Pharmacological modulation of chemokine receptor function
D. Scholten, M. Canals, D. Maussang, L. Roumen +5 more
2012British Journal of Pharmacology266 citations Open access
Semantic Scholar
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
D. Jensen, T. Lieu, M. Halls, N. Veldhuis +22 more
2017Science Translational Medicine206 citations Open access
Semantic Scholar
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
R. E. Yarwood, Wendy L. Imlach, T. Lieu, N. Veldhuis +13 more
2017Proceedings of the National Academy of Sciences of the United States of America171 citations Open access
Semantic Scholar
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
N. Jiménez-Vargas, Luke A. Pattison, Pei-Shen Zhao, T. Lieu +23 more
2018Proceedings of the National Academy of Sciences of the United States of America156 citations Open access
Semantic Scholar
Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor.
A. Gillis, A. Kliewer, E. Kelly, G. Henderson +3 more
2020TIPS - Trends in Pharmacological Sciences136 citations Open access
Semantic Scholar
Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization
E. Miess, Arisbel B. Gondin, Arsalan Yousuf, Ralph Steinborn +10 more
2018Science Signaling116 citations Open access
Semantic Scholar
Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor
Georgina L. Thompson, J. R. Lane, Thomas Coudrat, P. M. Sexton +2 more
2015Molecular Pharmacology96 citations Open access
Semantic Scholar
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain
N. Jiménez-Vargas, J. Gong, Matthew Wisdom, D. Jensen +19 more
2020Proceedings of the National Academy of Sciences of the United States of America95 citations Open access
Semantic Scholar
Structure-Based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors
J. R. Lane, P. Chubukov, Wei Liu, M. Canals +4 more
2013Molecular Pharmacology91 citations Open access
Semantic Scholar
The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts*
D. Jensen, Cody B. Godfrey, Christian Niklas, M. Canals +9 more
2013Journal of Biological Chemistry91 citations Open access
Semantic Scholar
Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling
M. Halls, Holly R. Yeatman, C. Nowell, Georgina L. Thompson +6 more
2016Science Signaling82 citations Open access
Semantic Scholar
Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)*
Joshua H. Y. Tan, J. Ludeman, Jamie Wedderburn, M. Canals +7 more
2013Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1.
C. J. Millard, J. Ludeman, M. Canals, Jessica L. Bridgford +5 more
2014Structure76 citations Open access
Semantic Scholar
Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor
N. Burford, Kathryn E. Livingston, M. Canals, M. Ryan +14 more
2015Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.
M. Wijtmans, D. Maussang, F. Sirci, D. Scholten +10 more
2012European journal of medicinal chemistry64 citations Open access
Semantic Scholar
Novel GPCR paradigms at the μ‐opioid receptor
Georgina L. Thompson, E. Kelly, A. Christopoulos, M. Canals
2015British Journal of Pharmacology60 citations Open access
Semantic Scholar
Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor*
Alaa Abdul-Ridha, Laura Lopez, Peter Keov, D. Thal +5 more
2014Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors
Yi Shang, Holly R. Yeatman, D. Provasi, A. Alt +3 more
2016ACS Chemical Biology59 citations Open access
Semantic Scholar
Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer
S. Blasco-Benito, E. Moreno, M. Seijo-Vila, I. Tundidor +19 more
2019Proceedings of the National Academy of Sciences of the United States of America57 citations Open access
Semantic Scholar
Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors
Kathryn E. Livingston, M. Stańczyk, N. Burford, A. Alt +2 more
2018Molecular Pharmacology53 citations Open access
Semantic Scholar
Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.
Cheng Huang, C. Lewis, N. A. Borg, M. Canals +9 more
2018Journal of Proteome Research52 citations Open access
Semantic Scholar
Regulation of G protein-coupled receptors by allosteric ligands.
J. R. Lane, Alaa Abdul-Ridha, M. Canals
2013ACS Chemical Neuroscience52 citations Open access
Semantic Scholar
Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.
Georgina L. Thompson, J. R. Lane, Thomas Coudrat, P. Sexton +2 more
2016Biochemical Pharmacology51 citations Open access
Semantic Scholar
Ticks from diverse genera encode chemokine-inhibitory evasin proteins
Jenni A. Hayward, Julie Sanchez, A. Perry, Cheng Huang +4 more
2017Journal of Biological Chemistry50 citations Open access
Semantic Scholar
Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2
Z. Huma, Julie Sanchez, H. Lim, Jessica L. Bridgford +8 more
2017Science Signaling50 citations Open access
Semantic Scholar
Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor*
Alaa Abdul-Ridha, J. R. Lane, Shailesh N Mistry, Laura Lopez +4 more
2014Journal of Biological Chemistry47 citations Open access
Semantic Scholar
The Life Cycle of the Mu-Opioid Receptor.
J. Cuitavi, L. Hipólito, M. Canals
2020TIBS -Trends in Biochemical Sciences. Regular ed44 citations Open access
Semantic Scholar
Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons*
Pei-Shen Zhao, M. Canals, Jane E. Murphy, D. Klingler +5 more
2013Journal of Biological Chemistry36 citations Open access
Semantic Scholar
A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor
Zoltan Dekan, S. Sianati, Arsalan Yousuf, K. Sutcliffe +18 more
2019Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
Allosteric Modulation of M1 Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking*
Holly R. Yeatman, J. R. Lane, K. C. Choy, N. Lambert +3 more
2014Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Pre-assembled GPCR signaling complexes mediate unique cellular responses to ultra-low ligand concentrations
S. Civciristov, A. Ellisdon, Ryan Suderman, C. Pon +6 more
2018Science Signaling32 citations Open access
Semantic Scholar
Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity
Georgina L. Thompson, M. Canals, D. Poole
2014Frontiers in Pharmacology32 citations Open access
Semantic Scholar
Allosteric Modulation of a Chemogenetically Modified G Protein-Coupled Receptor
Alaa Abdul-Ridha, J. R. Lane, P. Sexton, M. Canals +1 more
2013Molecular Pharmacology31 citations
Semantic Scholar
The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine
R. Hill, Andrew C. Kruegel, J. Javitch, J. R. Lane +1 more
2022British Journal of Pharmacology29 citations Open access
Semantic Scholar
Atypical opioid receptors: unconventional biology and therapeutic opportunities.
Christie B. Palmer, M. Meyrath, M. Canals, E. Kostenis +2 more
2021Pharmacology and Therapeutics29 citations Open access
Semantic Scholar
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon
Jesse J. DiCello, S. E. Carbone, A. Saito, P. Rajasekhar +8 more
2019Cellular and Molecular Gastroenterology and Hepatology29 citations Open access
Semantic Scholar
Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1
Julie Sanchez, Z. Huma, J. R. Lane, Xuyu Liu +4 more
2018Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling.
M. Halls, M. Canals
2017TIPS - Trends in Pharmacological Sciences28 citations Open access
Semantic Scholar
Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.
M. Halls, D. Poole, A. Ellisdon, C. Nowell +1 more
2015Methods in molecular biology28 citations Open access
Semantic Scholar
Identification of Overlapping but Differential Binding Sites for the High-Affinity CXCR3 Antagonists NBI-74330 and VUF11211
D. Scholten, L. Roumen, M. Wijtmans, Marlies C. A. Verkade-Vreeker +8 more
2014Molecular Pharmacology28 citations
Semantic Scholar
Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10
H. Lim, J. R. Lane, M. Canals, M. J. Stone
2021International Journal of Molecular Sciences26 citations Open access
Semantic Scholar
G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases
M. Canals, D. Poole, N. Veldhuis, B. Schmidt +1 more
2019Gastroenterology26 citations Open access
Semantic Scholar
Novel Dual-Target Mu Opioid (MOR) and Dopamine D3 Receptors (D3R) Ligands as Potential Non-Addictive Pharmacotherapeutics for Pain Management
A. Bonifazi, Francisco O. Battiti, Julie Sanchez, Saheem A. Zaidi +10 more
2021Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks
S. Civciristov, Cheng Huang, Bo-Nan Liu, Elsa A. Marquez +5 more
2019Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.
Luke S. Schembri, Leigh A. Stoddart, S. Briddon, B. Kellam +3 more
2015Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization
Arisbel B. Gondin, M. Halls, M. Canals, S. Briddon
2019Frontiers in Molecular Neuroscience22 citations Open access
Semantic Scholar
Fluorescently Labeled Morphine Derivatives for Bioimaging Studies.
Raymond Lam, Arisbel B. Gondin, M. Canals, B. Kellam +3 more
2018Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar

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