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D. Nomura · SciRah

Researcher profile · Semantic Scholar

D. Nomura

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D. Nomura — researcher profile on SciRah

h-index: 76
Works: 198
Citations: 24K

Most-cited papers

The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis
K. Bersuker, Joseph M. Hendricks, Zhipeng Li, Leslie Magtanong +10 more
2019Nature3,387 citations Open access
Semantic Scholar
Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State
Leslie Magtanong, Pin-Joe Ko, Milton To, J. Cao +8 more
2019Cell Chemical Biology1,071 citations Open access
Semantic Scholar
Advances in covalent drug discovery
L. Boike, Nathaniel J. Henning, D. Nomura
2022Nature reviews. Drug discovery655 citations Open access
Semantic Scholar
DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy
Truc B Nguyen, Sharon M. Louie, J. Daniele, Quan Tran +4 more
2017Developmental Cell564 citations Open access
Semantic Scholar
Lysosomal Cholesterol Activates mTORC1 via an SLC38A9-Niemann Pick C1 Signaling Complex
Brian M. Castellano, Ashley M. Thelen, Ofer Moldavski, McKenna Feltes +11 more
2017Science506 citations Open access
Semantic Scholar
Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
Jessica N. Spradlin, Xirui Hu, Carl C. Ward, S. Brittain +14 more
2018bioRxiv359 citations Open access
Semantic Scholar
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism
Jiyoung Lee, A. Yesilkanal, Joseph P. Wynne, Casey Frankenberger +15 more
2019Nature319 citations Open access
Semantic Scholar
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
M. Watt, A. Clark, L. Selth, Vanessa R. Haynes +20 more
2019Science Translational Medicine294 citations
Semantic Scholar
Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization
Nathaniel J. Henning, L. Boike, Jessica N. Spradlin, Carl C. Ward +20 more
2022Nature Chemical Biology284 citations Open access
Semantic Scholar
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C
Chun-Yan Lim, Oliver B. Davis, Hijai R. Shin, Justin Zhang +6 more
2019Nature Cell Biology280 citations Open access
Semantic Scholar
Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
Carl C. Ward, Jordan I. Kleinman, S. Brittain, Patrick S. Lee +8 more
2018bioRxiv275 citations Open access
Semantic Scholar
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues
M. Wallace, Courtney R. Green, L. Roberts, Y. Lee +13 more
2018Nature Chemical Biology200 citations Open access
Semantic Scholar
A Cellular Mechanism to Detect and Alleviate Reductive Stress.
A. Manford, Fernando Rodríguez-Pérez, Karen Y. Shih, Z. Shi +5 more
2020Cell182 citations Open access
Semantic Scholar
Cancer Metabolism: Current Understanding and Therapies.
Jessica L. Counihan, Elizabeth A. Grossman, D. Nomura
2018Chemical Reviews181 citations
Semantic Scholar
Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
K. Patra, Y. Kato, Yusuke Mizukami, Sebastian A. Widholz +14 more
2018Nature Cell Biology174 citations Open access
Semantic Scholar
Covalent Targeting of the Vacuolar H+-ATPase Activates Autophagy Via mTORC1 Inhibition
C. Chung, Hijai R. Shin, Charles A. Berdan, Breanna Ford +4 more
2019Nature Chemical Biology172 citations Open access
Semantic Scholar
Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications
Nathaniel J. Henning, A. Manford, Jessica N. Spradlin, S. Brittain +6 more
2021bioRxiv170 citations Open access
Semantic Scholar
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
A. Tam, L. Roberts, Vivek Chandra, Io-Guané Rivera +3 more
2018Developmental Cell164 citations Open access
Semantic Scholar
Rational Chemical Design of Molecular Glue Degraders
Ethan S. Toriki, James W. Papatzimas, Kaila Nishikawa, Dustin Dovala +14 more
2022bioRxiv158 citations Open access
Semantic Scholar
Chemoproteomics-Enabled Discovery of Covalent RNF114-Based Degraders that Mimic Natural Product Function
Mai Luo, Jessica N. Spradlin, L. Boike, Bingqi Tong +6 more
2021Cell Chemical Biology151 citations Open access
Semantic Scholar
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine Within MYC
L. Boike, Alexander G. Cioffi, Felix C Majewski, Jennifer Co +7 more
2020Cell Chemical Biology146 citations Open access
Semantic Scholar
Reimagining Druggability Using Chemoproteomic Platforms.
Jessica N. Spradlin, Erika Zhang, D. Nomura
2021Accounts of Chemical Research139 citations
Semantic Scholar
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
Maxwell A. Ruby, J. Massart, Devon M. Hunerdosse, Milena Schönke +6 more
2017Cell Reports129 citations Open access
Semantic Scholar
Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light
C. Prasse, Breanna Ford, D. Nomura, D. Sedlak
2018Proceedings of the National Academy of Sciences of the United States of America127 citations Open access
Semantic Scholar
Lysosomal GPCR-like Protein LYCHOS Signals Cholesterol Sufficiency to mTORC1
Hijai R. Shin, Y. R. Citron, Lei Wang, Laura Tribouillard +16 more
2022Science125 citations Open access
Semantic Scholar
Bardoxolone conjugation enables targeted protein degradation of BRD4
Bingqi Tong, Mai Luo, Yi Xie, Jessica N. Spradlin +5 more
2020Scientific Reports116 citations Open access
Semantic Scholar
Ligandability of E3 Ligases for Targeted Protein Degradation Applications
Bridget P. Belcher, Carl C. Ward, D. Nomura
2021Biochemistry112 citations Open access
Semantic Scholar
Covalent Ligand Discovery Against Druggable Hotspots Targeted by Anti-Cancer Natural Products
Elizabeth A. Grossman, Carl C. Ward, Jessica N. Spradlin, L. Bateman +4 more
2017Cell Chemical Biology110 citations Open access
Semantic Scholar
Adhesion-mediated mechanosignaling forces mitohormesis
Kevin M. Tharp, Ryo Higuchi-Sanabria, G. Timblin, Breanna Ford +23 more
2021Cell Metabolism108 citations Open access
Semantic Scholar
Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53
Y. Isobe, M. Okumura, L. McGregor, Scott M. Brittain +9 more
2020Nature Chemical Biology107 citations Open access
Semantic Scholar
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis
Norbert Volkmar, M. Thézénas, Sharon M. Louie, S. Juszkiewicz +4 more
2019Journal of Cell Science101 citations Open access
Semantic Scholar
A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL
Bingqi Tong, Jessica N. Spradlin, L. Novaes, Erika Zhang +9 more
2020bioRxiv96 citations Open access
Semantic Scholar
Mapping Proteome-wide Targets of Glyphosate in Mice.
Breanna Ford, L. Bateman, Leilani Gutierrez-Palominos, Robin Park +1 more
2017Cell Chemical Biology93 citations Open access
Semantic Scholar
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
Candice B. Herber, William C. Krause, Li-Ping Wang, J. Bayrer +10 more
2019Nature Communications88 citations Open access
Semantic Scholar
Mitohormesis reprograms macrophage metabolism to enforce tolerance
G. Timblin, Kevin M. Tharp, Breanna Ford, J. Winchester +9 more
2020Nature Metabolism85 citations Open access
Semantic Scholar
Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells
Charles A. Berdan, R. Ho, H. Lehtola, Milton To +8 more
2019bioRxiv84 citations Open access
Semantic Scholar
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism
Vanha N. Pham, Kevin J. Bruemmer, J. D. Toh, Eva J. Ge +12 more
2023Science82 citations Open access
Semantic Scholar
Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB
E. King, Yoojin Cho, Nathan Hsu, Dustin Dovala +4 more
2022bioRxiv82 citations Open access
Semantic Scholar
Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain
R. F. Fernandez, Sora Q. Kim, Yingwei Zhao, R. Foguth +6 more
2018Proceedings of the National Academy of Sciences of the United States of America77 citations Open access
Semantic Scholar
Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging
D. I. Benjamin, Jamie O. Brett, Pieter Both, J. Benjamin +13 more
2023Cell Metabolism70 citations Open access
Semantic Scholar
UNBIASED PROTEOMIC PROFILING UNCOVERS A TARGETABLE GNAS/PKA/PP2A AXIS IN SMALL CELL LUNG CANCER STEM CELLS
Garry L. Coles, Sandra Cristea, James T. Webber, Rebecca S. Levin +24 more
2020Cancer Cell68 citations Open access
Semantic Scholar
Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus
Romain Gibeaux, R. Acker, Maiko Kitaoka, Georgios Georgiou +7 more
2018Nature67 citations Open access
Semantic Scholar
MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer
Brittany N. Anderton, R. Camarda, Sanjeev Balakrishnan, A. Balakrishnan +9 more
2017EMBO Reports66 citations Open access
Semantic Scholar
Fasting Induces a Highly Resilient Deep Quiescent State in Muscle Stem Cells via Ketone Body Signaling
D. I. Benjamin, Pieter Both, J. Benjamin, Christopher Nutter +12 more
2022bioRxiv62 citations Open access
Semantic Scholar
Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange
C. Nnadi, M. Jenkins, D. Gentile, L. Bateman +6 more
2018Journal of Chemical Information and Modeling59 citations Open access
Semantic Scholar
Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception
Jonathan Z. Long, Alexander M. Roche, Charles A. Berdan, Sharon M. Louie +14 more
2018Proceedings of the National Academy of Sciences of the United States of America57 citations Open access
Semantic Scholar
Oncogene Regulated Release of Extracellular Vesicles
Seda Kılınç, Rebekka Paisner, R. Camarda, Suprit Gupta +7 more
2021Developmental Cell52 citations Open access
Semantic Scholar
Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target
Jessica L. Counihan, Amanda L. Wiggenhorn, K. Anderson, D. Nomura
2018ACS Chemical Biology50 citations Open access
Semantic Scholar
The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ
Tzu-Chieh Chen, D. I. Benjamin, Taiyi Kuo, Rebecca A. Lee +5 more
2017Science Signaling50 citations Open access
Semantic Scholar
Toward abiotic sugar synthesis from CO2 electrolysis
Stefano Cestellos-Blanco, Sheena Louisia, Michael B. Ross, Yifan Li +5 more
2022Joule48 citations Open access
Semantic Scholar

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