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P. Leroy · SciRah

Researcher profile · Semantic Scholar

P. Leroy

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P. Leroy — researcher profile on SciRah

h-index: 28
Works: 76
Citations: 1,818

Most-cited papers

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.
B. Phillips, B. Titz, U. Kogel, D. Sharma +18 more
2017Food and Chemical Toxicology113 citations Open access
Semantic Scholar
An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes
B. Phillips, E. Veljkovic, S. Boué, W. Schlage +16 more
2015Toxicological Sciences103 citations Open access
Semantic Scholar
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.
E. Wong, U. Kogel, E. Veljkovic, F. Martin +10 more
2016Regulatory toxicology and pharmacology : RTP98 citations Open access
Semantic Scholar
A framework for in vitro systems toxicology assessment of e-liquids
A. Iskandar, I. Gonzalez-Suarez, Shoaib Majeed, D. Marescotti +12 more
2016Toxicology Mechanisms and Methods81 citations Open access
Semantic Scholar
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.
A. Oviedo, S. Lebrun, U. Kogel, J. Ho +13 more
2016Regulatory toxicology and pharmacology : RTP73 citations Open access
Semantic Scholar
Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke
Shoaib Majeed, S. Frentzel, Sandra Wagner, Diana Kuehn +5 more
2014Chemistry Central Journal73 citations Open access
Semantic Scholar
A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.
U. Kogel, W. Schlage, F. Martin, Y. Xiang +9 more
2014Food and Chemical Toxicology71 citations Open access
Semantic Scholar
A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures.
A. Iskandar, C. Mathis, W. Schlage, S. Frentzel +15 more
2017Toxicology in Vitro64 citations Open access
Semantic Scholar
3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product.
A. Iskandar, C. Mathis, F. Martin, P. Leroy +12 more
2016ALTEX60 citations Open access
Semantic Scholar
Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice—An Integrative Systems Toxicology Analysis
B. Titz, S. Boué, B. Phillips, M. Talikka +18 more
2015Toxicological Sciences60 citations Open access
Semantic Scholar
Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.
Filippo Zanetti, B. Titz, A. Sewer, Giuseppe Lo Sasso +15 more
2017Food and Chemical Toxicology56 citations Open access
Semantic Scholar
Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts
A. Iskandar, Y. Xiang, S. Frentzel, M. Talikka +8 more
2015Toxicological Sciences56 citations Open access
Semantic Scholar
Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.
Filippo Zanetti, A. Sewer, C. Mathis, A. Iskandar +13 more
2016Chemical Research in Toxicology55 citations Open access
Semantic Scholar
A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.
B. Phillips, J. Szostak, B. Titz, W. Schlage +18 more
2019Food and Chemical Toxicology51 citations Open access
Semantic Scholar
A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke.
J. Szostak, E. Wong, B. Titz, Tom Lee +19 more
2020American Journal of Physiology. Heart and Circulatory Physiology46 citations Open access
Semantic Scholar
Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties.
Sandra Schorderet Weber, K. Kaminski, J. Perret, P. Leroy +4 more
2019Food and Chemical Toxicology46 citations Open access
Semantic Scholar
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology.
B. Phillips, W. Schlage, B. Titz, U. Kogel +13 more
2018Food and Chemical Toxicology44 citations Open access
Semantic Scholar
Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
B. Titz, J. Szostak, A. Sewer, B. Phillips +19 more
2020Computational and Structural Biotechnology Journal42 citations Open access
Semantic Scholar
Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)
B. Titz, K. Luettich, P. Leroy, S. Boué +6 more
2016International Journal of Molecular Sciences42 citations Open access
Semantic Scholar
Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology
B. Phillips, M. Esposito, J. Verbeeck, S. Boué +12 more
2015Inhalation Toxicology41 citations Open access
Semantic Scholar
The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product.
M. van der Toorn, A. Sewer, D. Marescotti, Stéphanie Johne +14 more
2018Toxicology in Vitro33 citations Open access
Semantic Scholar
An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes
B. Phillips, E. Veljkovic, S. Boué, W. Schlage +16 more
2016Toxicological Sciences33 citations Open access
Semantic Scholar
A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
A. Iskandar, Filippo Zanetti, A. Kondylis, F. Martin +15 more
2019Internal and Emergency Medicine32 citations Open access
Semantic Scholar
Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.
Filippo Zanetti, A. Sewer, E. Scotti, B. Titz +14 more
2018Food and Chemical Toxicology31 citations Open access
Semantic Scholar
Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis
Giuseppe Lo Sasso, B. Titz, Catherine Nury, S. Boué +19 more
2016Inhalation Toxicology29 citations
Semantic Scholar
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice
Sam Ansari, Karin Baumer, S. Boué, Sophie Dijon +23 more
2016Scientific Data29 citations Open access
Semantic Scholar
E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model
Marie K. Reumann, J. Schaefer, B. Titz, Romina H. Aspera-Werz +17 more
2020Archives of Toxicology28 citations Open access
Semantic Scholar
Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract
A. Iskandar, B. Titz, A. Sewer, P. Leroy +10 more
2017Toxicological Research28 citations Open access
Semantic Scholar
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
A. Iskandar, Filippo Zanetti, D. Marescotti, B. Titz +17 more
2019Archives of Toxicology27 citations Open access
Semantic Scholar
Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.
A. Iskandar, F. Martin, P. Leroy, W. Schlage +13 more
2018Food and Chemical Toxicology27 citations Open access
Semantic Scholar
Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke
E. Wong, K. Luettich, Subash Krishnan, S. Wong +9 more
2020Toxicological Sciences26 citations Open access
Semantic Scholar
Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
A. Iskandar, Y. Martinez, F. Martin, W. Schlage +12 more
2017Toxicological Research25 citations Open access
Semantic Scholar
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.
B. Titz, U. Kogel, F. Martin, W. Schlage +18 more
2018Food and Chemical Toxicology23 citations Open access
Semantic Scholar
Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells
D. Marescotti, C. Mathis, V. Belcastro, P. Leroy +16 more
2019Toxicology Reports22 citations Open access
Semantic Scholar
Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model
U. Kogel, E. Wong, J. Szostak, Wei Teck Tan +13 more
2021Journal of Applied Toxicology21 citations Open access
Semantic Scholar
Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.
J. Szostak, B. Titz, W. Schlage, E. Guedj +11 more
2019Chemico-Biological Interactions16 citations
Semantic Scholar
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
J. Ho, Davide Sciuscio, U. Kogel, B. Titz +17 more
2020Archives of Toxicology15 citations Open access
Semantic Scholar
Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice
B. Titz, A. Sewer, K. Luettich, E. Wong +13 more
2020Toxicological Sciences15 citations Open access
Semantic Scholar
Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures.
Filippo Zanetti, A. Sewer, B. Titz, W. Schlage +11 more
2019Food and Chemical Toxicology14 citations Open access
Semantic Scholar
Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures.
A. Giralt, A. Iskandar, F. Martin, E. Moschini +14 more
2020Toxicology Letters13 citations Open access
Semantic Scholar
A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract
E. Wong, J. Szostak, B. Titz, Tom Lee +28 more
2021Archives of Toxicology10 citations Open access
Semantic Scholar
Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice
E. Wong, K. Luettich, Lydia Cammack, Suan-Chua Chin +17 more
2022Journal of Applied Toxicology9 citations Open access
Semantic Scholar
Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case
W. Schlage, B. Titz, A. Iskandar, C. Poussin +13 more
2020Toxicology Reports9 citations Open access
Semantic Scholar
Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium
M. Talikka, F. Martin, A. Sewer, G. Vuillaume +6 more
2017Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine9 citations Open access
Semantic Scholar
Differences in biomarkers of potential harm after 2+ years of tobacco heating system use compared to cigarette smoking: a cross-sectional study
S. Ansari, P. Leroy, G. de La Bourdonnaye, Sandrine Pouly +2 more
2025Biomarkers6 citations Open access
Semantic Scholar
Optimization of a Novel In Situ Hybridization Technology on 3D Organotypic Cell Cultures
L. Neau, C. Lorin, S. Frentzel, J. Hoeng +3 more
2019Applied In Vitro Toxicology5 citations Open access
Semantic Scholar
An application of 3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product
A. Iskandar, C. Mathis, F. Martin, P. Leroy +12 more
20164 citations
Semantic Scholar
Data of physiological measurements and quality of life in subjects with mild to moderate COPD compared to asymptomatic current smokers, former smokers and never-smokers
N. Chaudhary, K. Luettich, M. Peck, E. Pierri +5 more
2017F1000Research3 citations Open access
Semantic Scholar
P13-08 Toxicological assessment of nicotine salt in Sprague Dawley rats following subchronic inhalation exposure
J. Ho, B. Phillips, A. Oviedo, P. Leroy +5 more
2022Toxicology Letters0 citations
Semantic Scholar
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
J. Ho, Davide Sciuscio, U. Kogel, B. Titz +17 more
2020Archives of Toxicology0 citations Open access
Semantic Scholar

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