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William E. Hughes · SciRah

Researcher profile · Semantic Scholar

William E. Hughes

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William E. Hughes — researcher profile on SciRah

h-index: 29
Works: 55
Citations: 4,066

Most-cited papers

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.
M. Whitham, B. Parker, M. Friedrichsen, J. Hingst +16 more
2018Cell Metabolism621 citations Open access
Semantic Scholar
I-motif DNA structures are formed in the nuclei of human cells
Mahdi Zeraati, D. Langley, P. Schofield, Aaron L. Moye +5 more
2018Nature Chemistry472 citations
Semantic Scholar
Ezrin is a downstream effector of trafficking PKC–integrin complexes involved in the control of cell motility
T. Ng, M. Parsons, William E. Hughes, J. Monypenny +7 more
2001EMBO Journal324 citations Open access
Semantic Scholar
A Cortactin-CD2-associated Protein (CD2AP) Complex Provides a Novel Link between Epidermal Growth Factor Receptor Endocytosis and the Actin Cytoskeleton*
Danielle K. Lynch, Stephanie C Winata, R. Lyons, William E. Hughes +5 more
2003Journal of Biological Chemistry234 citations Open access
Semantic Scholar
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.
A. K. Busch, Ebru Gurisik, D. Cordery, M. Sudlow +4 more
2005Diabetes188 citations Open access
Semantic Scholar
The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling*
M. Falasca, William E. Hughes, Verónica Domínguez, G. Sala +6 more
2007Journal of Biological Chemistry141 citations Open access
Semantic Scholar
Site-Directed Perturbation of Protein Kinase C- Integrin Interaction Blocks Carcinoma Cell Chemotaxis
M. Parsons, M. Keppler, A. Kline, A. Messent +7 more
2002Molecular and Cellular Biology127 citations Open access
Semantic Scholar
Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment.
D. Herrmann, James R. W. Conway, C. Vennin, Astrid Magenau +3 more
2014Carcinogenesis126 citations
Semantic Scholar
SAC1 Encodes a Regulated Lipid Phosphoinositide Phosphatase, Defects in Which Can Be Suppressed by the Homologous Inp52p and Inp53p Phosphatases*
William E. Hughes, R. Woscholski, F. Cooke, R. Patrick +3 more
2000Journal of Biological Chemistry126 citations Open access
Semantic Scholar
A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.
H. McGuire, A. Vogelzang, Cindy S. Ma, William E. Hughes +6 more
2011Immunity117 citations
Semantic Scholar
Phospholipid signalling through phospholipase D and phosphatidic acid
R. Cazzolli, Anne N. Shemon, Michelle Q. Fang, William E. Hughes
2006IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology115 citations Open access
Semantic Scholar
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
C. Jandl, S. Liu, Pablo F. Cañete, J. Warren +11 more
2017Nature Communications110 citations Open access
Semantic Scholar
Phospholipase D1 Regulates Secretagogue-stimulated Insulin Release in Pancreatic β-Cells*
William E. Hughes, Z. Elgundi, Ping Huang, M. Frohman +1 more
2004Journal of Biological Chemistry99 citations Open access
Semantic Scholar
Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish
A. Lagendijk, Guillermo A. Gomez, Sungmin Baek, D. Hesselson +9 more
2017Nature Communications95 citations Open access
Semantic Scholar
Identification of a distal GLUT4 trafficking event controlled by actin polymerization.
Jamie Lopez, J. Burchfield, Duncan H. Blair, K. Mele +4 more
2009Molecular Biology of the Cell94 citations Open access
Semantic Scholar
Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity
Thomas Grewal, R. Evans, C. Rentero, F. Tebar +10 more
2005Oncogene94 citations Open access
Semantic Scholar
Akt Mediates Insulin-stimulated Phosphorylation of Ndrg2
J. Burchfield, A. Lennard, S. Narasimhan, William E. Hughes +6 more
2004Journal of Biological Chemistry80 citations Open access
Semantic Scholar
The role of phosphoinositide 3-kinase C2alpha in insulin signaling.
M. Falasca, William E. Hughes, Verónica Domínguez, G. Sala +6 more
2007Journal of Biological Chemistry76 citations
Semantic Scholar
An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
A. Kee, Ling-Yan Yang, C. Lucas, Michael J. Greenberg +9 more
2015Traffic : the International Journal of Intracellular Transport71 citations Open access
Semantic Scholar
Exocytotic Vesicle Behaviour Assessed by Total Internal Reflection Fluorescence Microscopy
J. Burchfield, Jamie Lopez, K. Mele, P. Vallotton +1 more
2010Traffic : the International Journal of Intracellular Transport66 citations
Semantic Scholar
Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.
T. Biden, Darren Robinson, D. Cordery, William E. Hughes +1 more
2004Diabetes55 citations
Semantic Scholar
XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice
Kai-Lun Lee, J. Chan, Cassandra Liang, Chi-Kin Ip +8 more
2022Diabetologia54 citations Open access
Semantic Scholar
Phosphorylation of Nonmuscle Myosin Heavy Chain IIA on Ser1917 Is Mediated by Protein Kinase CβII and Coincides with the Onset of Stimulated Degranulation of RBL-2H3 Mast Cells1
R. Ludowyke, Z. Elgundi, T. Kranenburg, J. Stehn +3 more
2006Journal of Immunology54 citations
Semantic Scholar
The myotubularin phosphatase MTMR4 regulates sorting from early endosomes
Monica Naughtin, D. A. Sheffield, P. Rahman, William E. Hughes +5 more
2010Journal of Cell Science50 citations
Semantic Scholar
A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization*
Brie Sorrenson, Emmanuelle Cognard, Kathryn Lee, Waruni Dissanayake +4 more
2016Journal of Biological Chemistry47 citations Open access
Semantic Scholar
Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells.
C. Rentero, R. Evans, Peta Wood, F. Tebar +9 more
2006Cellular Signalling40 citations
Semantic Scholar
Endosomal localization of phospholipase D 1a and 1b is defined by the C-termini of the proteins, and is independent of activity.
William E. Hughes, P. Parker
2001Biochemical Journal38 citations Open access
Semantic Scholar
Novel Systems for Dynamically Assessing Insulin Action in Live Cells Reveals Heterogeneity in the Insulin Response
J. Burchfield, Jinling Lu, D. Fazakerley, Shi-Xiong Tan +6 more
2013Traffic : the International Journal of Intracellular Transport31 citations Open access
Semantic Scholar
A new approach for spot detection in total internal reflection fluorescence microscopy
S. H. Rezatofighi, R. Hartley, William E. Hughes
2012IEEE International Symposium on Biomedical Imaging31 citations
Semantic Scholar
Adipocyte specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice.
M. Whitham, Martin Pal, Tim Petzold, M. Hjorth +10 more
2019American Journal of Physiology. Endocrinology and Metabolism26 citations Open access
Semantic Scholar
Mutations in the Saccharomyces cerevisiae gene SAC1 cause multiple drug sensitivity
William E. Hughes, M. Pocklington, E. Orr, C. Paddon
1999Yeast25 citations
Semantic Scholar
Detecting Protein-Phospholipid Interactions
William E. Hughes, B. Larijani, P. Parker
2002Journal of Biological Chemistry23 citations Open access
Semantic Scholar
A Multiple Model Probability Hypothesis Density Tracker for Time-Lapse Cell Microscopy Sequences
S. H. Rezatofighi, S. Gould, B. Vo, K. Mele +2 more
2013Information Processing in Medical Imaging19 citations
Semantic Scholar
The Diacylglycerol-dependent Translocation of Ras Guanine Nucleotide-releasing Protein 4 inside a Human Mast Cell Line Results in Substantial Phenotypic Changes, Including Expression of Interleukin 13 Receptor α2*
G. Katsoulotos, M. Qi, Jian C. Qi, Kumiko E. Tanaka +5 more
2008Journal of Biological Chemistry19 citations Open access
Semantic Scholar
PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes.
J. Robinson, Iryna Leshchyns’ka, H. Farghaian, William E. Hughes +3 more
2014Biochemical Journal18 citations
Semantic Scholar
Application of the IMM-JPDA Filter to Multiple Target Tracking in Total Internal Reflection Fluorescence Microscopy Images
S. H. Rezatofighi, S. Gould, R. Hartley, K. Mele +1 more
2012International Conference on Medical Image Computing and Computer-Assisted Intervention18 citations Open access
Semantic Scholar
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
Alvaro Gonzalez Rajal, K. Marzec, R. Mccloy, Max Nobis +11 more
2021eLife17 citations Open access
Semantic Scholar
A framework for generating realistic synthetic sequences of total internal reflection fluorescence microscopy images
S. H. Rezatofighi, W. Pitkeathly, S. Gould, R. Hartley +3 more
2013IEEE International Symposium on Biomedical Imaging17 citations
Semantic Scholar
Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin
Alexander F. Rowland, Mark Larance, William E. Hughes, D. E. James
2011Molecular and Cellular Biology16 citations Open access
Semantic Scholar
Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response
Noha Gwili, Stacey Jones, W. A. Alamri, I. Carr +14 more
2021British Journal of Cancer15 citations Open access
Semantic Scholar
&bgr;‐catenin is important for the development of an insulin responsive pool of GLUT4 glucose transporters in 3T3‐L1 adipocytes
Waruni Dissanayake, Brie Sorrenson, Emmanuelle Cognard, William E. Hughes +1 more
2018Experimental Cell Research15 citations
Semantic Scholar
Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes.
Bing M. Liao, Sophie A. McManus, William E. Hughes, C. Schmitz‐Peiffer
2016Molecular Endocrinology14 citations Open access
Semantic Scholar
Automatic identification of fusion events in TIRF microscopy image sequences
K. Mele, A. Coster, J. Burchfield, Jamie Lopez +3 more
20092009 IEEE 12th International Conference on Computer Vision Workshops, ICCV Workshops14 citations
Semantic Scholar
Towards fully automated identification of vesicle-membrane fusion events in TIRF microscopy
K. Mele, P. Vallotton, J. Burchfield, D. E. James +1 more
2007International Journal of Computer Aided Engineering and Technology11 citations
Semantic Scholar
Detecting Protein-Phospholipid Interactions EPIDERMAL GROWTH FACTOR-INDUCED ACTIVATION OF PHOSPHOLIPASE D1b IN SITU *
William E. Hughes, B. Larijani, P. Parker
20027 citations
Semantic Scholar
Resistance to platinum chemotherapy in lung adenocarcinoma is driven by a non-genetic, cell-cycle dependent mechanism
Álvaro González-Rajal, R. Mccloy, Max Nobis, K. Marzec +11 more
2020bioRxiv6 citations Open access
Semantic Scholar
An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
A. Kee, Ling-Yan Yang, C. Lucas, M. J. Greenberg +9 more
2016Traffic : the International Journal of Intracellular Transport5 citations Open access
Semantic Scholar
Using Total Internal Reflection Fluorescence Microscopy (TIRFM) to Visualise Insulin Action
J. Burchfield, Jamie Lopez, William E. Hughes
20125 citations
Semantic Scholar
Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and adipocytes.
R. Cazzolli, Ping Huang, Shu-Zhi Teng, William E. Hughes
2009Methods in molecular biology4 citations
Semantic Scholar
Automating the quantification of membrane proteins under confocal microscopy
P. Vallotton, Matthew Payne, T. Bednarz, L. Domanski +3 more
2012IEEE International Symposium on Biomedical Imaging1 citations
Semantic Scholar

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