Researcher profile · Semantic Scholar

G. Harris

h-index: 18
Works: 34
Citations: 980

Most-cited papers

Activity of the type 1 5 alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin.
D. Thiboutot, G. Harris, Vicki Iles, G. Cimis +2 more
1995Journal of Investigative Dermatology221 citations Open access
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Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta).
S. Prahalada, A. Tarantal, G. Harris, K. Ellsworth +9 more
1997Teratology77 citations
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Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.
A. Ogawa, C. A. Willoughby, R. Bergeron, K. Ellsworth +5 more
2003Bioorganic & Medicinal Chemistry Letters60 citations Open access
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Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Amjad Ali, Christopher F. Thompson, J. Balkovec, D. Graham +19 more
2004Journal of Medicinal Chemistry59 citations Open access
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Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: design, synthesis, and biological evaluation.
Amjad Ali, Gayle E. Taylor, K. Ellsworth, G. Harris +3 more
2003Journal of Medicinal Chemistry57 citations
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Allosteric Effects of Dexamethasone and RU486 on Glucocorticoid Receptor-DNA Interactions*
Shilpa Pandit, W. Geissler, G. Harris, A. Sitlani
2002Journal of Biological Chemistry48 citations Open access
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Comparison of the effects of new specific azasteroid inhibitors of steroid 5α‐reductase on canine hyperplastic prostate: Suppression of prostatic DHT correlated with prostate regression
Sheila M. Cohen, J. G. Werrmann, G. H. Rasmusson, W. Tanaka +5 more
1995The Prostate48 citations
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Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation.
E. Carballo-Jane, Shilpa Pandit, Joseph C. Santoro, C. Freund +4 more
2004Journal of Steroid Biochemistry and Molecular Biology39 citations
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Colorimetric detection of glutamine synthetase-catalyzed transferase activity in glucocorticoid-treated skeletal muscle cells.
Joseph C. Santoro, G. Harris, Ayesha Sitlani
2001Analytical Biochemistry39 citations
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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Christopher F. Thompson, Nazia Q. Quraishi, Amjad Ali, J. Tata +20 more
2005Bioorganic & Medicinal Chemistry Letters35 citations Open access
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Steroid 5α-reductase inhibitors in androgen-dependent disorders
G. Harris, J. Kozarich
199735 citations
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A new class of glycogen phosphorylase inhibitors.
Zhijian Lu, Joann Bohn, R. Bergeron, Q. Deng +10 more
2003Bioorganic & Medicinal Chemistry Letters34 citations Open access
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Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.
K. Rosauer, A. Ogawa, C. A. Willoughby, K. Ellsworth +6 more
2003Bioorganic & Medicinal Chemistry Letters33 citations Open access
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4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.
R. K. Bakshi, Gary H. Rasmusson, Gool F. Patel, R. Mosley +4 more
1995Journal of Medicinal Chemistry32 citations Open access
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MK386: a potent, selective inhibitor of the human type 1 5α-reductase
K. Ellsworth, B. Azzolina, W. Baginsky, Herbert G. Bull +8 more
199627 citations
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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.
Cameron J. Smith, Amjad Ali, J. Balkovec, D. Graham +23 more
2005Bioorganic & Medicinal Chemistry Letters23 citations Open access
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Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism.
M. Einstein, M. L. Greenlee, G. Rouen, A. Sitlani +16 more
2004Journal of Steroid Biochemistry and Molecular Biology22 citations
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Expression of the Type 1 and Type 2 Steroid 5α-Reductases in Human Fetal Tissues
K. Ellsworth, G. Harris
199520 citations
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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.
Christopher F. Thompson, Nazia Q. Quraishi, Amjad Ali, R. Mosley +21 more
2007Bioorganic & Medicinal Chemistry Letters14 citations Open access
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Modeling aided design of potent glycogen phosphorylase inhibitors.
Q. Deng, Zhijian Lu, Joann Bohn, K. Ellsworth +7 more
2005Journal of Molecular Graphics and Modelling12 citations
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Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.
Amjad Ali, J. Balkovec, M. L. Greenlee, M. Hammond +17 more
2008Bioorganic & Medicinal Chemistry9 citations Open access
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Expression of the type 1 and 2 steroid 5 alpha-reductases in human fetal tissues.
K. Ellsworth, G. Harris
1995Biochemical and Biophysical Research Communications - BBRC9 citations
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Enzymatic preparation of high-specific-activity beta-D-[6,6'-3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase.
R. W. Myers, W. Baginsky, D. J. Gattermeir, W. Geissler +1 more
2010Analytical Biochemistry6 citations
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Steroid 5alpha-reductase inhibitors in androgen-dependent disorders.
G. Harris, J. Kozarich
1997Current Opinion in Chemical Biology5 citations
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Steroid 5α-Reductase: Comparative Study of Mechanism of Inhibition by Nonsteroids ONO-3805 and LY191704
G. Harris, K. Ellsworth, B. Witzel, R. L. Tolman
19964 citations
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MK386: a potent, selective inhibitor of the human type 1 5alpha-reductase.
K. Ellsworth, B. Azzolina, W. Baginsky, H. Bull +8 more
1996Journal of Steroid Biochemistry and Molecular Biology4 citations
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Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque.
E. Bayne, J. Flanagan, B. Azzolina, M. Einstein +6 more
19973 citations
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Novel 3,4‐Dihydroquinolin‐2(1H)‐one Inhibitors of Human Glycogen Phosphorylase a.
K. Rosauer, A. Ogawa, C. A. Willoughby, K. Ellsworth +6 more
20042 citations
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4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro].
R. L. Tolman, S. Sahoo, R. Bakshi, D. Gratale +5 more
1997Journal of Steroid Biochemistry and Molecular Biology2 citations
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4-AZASTEROIDS AS 5α-REDUCTASE INHIBITORS: IDENTIFICATION OF 4,7β-DIMETHYL-4-AZA-5α-CHOLESTAN-3-ONE (MK-386) AS A SCALP ISOZYME SELECTIVE INHIBITOR
R. L. Tolman, S. Aster, R. Bakshi, Jeffrey P. Bergman +19 more
1995European Journal of Medicinal Chemistry1 citations
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Design, synthesis, and biological evaluation of 16beta-aryl/heteroaryl ethers of 7beta-methyl-4-aza-5alpha-androstan-1-ene-3-one as selective steroidal type-1 5alpha-reductase inhibitors
S. Sahoo, R. K. Bakshi, P. Durette, D. F. Gratale +9 more
20010 citations
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Intermediate for synthesizing new 7beta-substituted-4-aza-5alpha-cholestanone being 5alpha-reductase inhibitor
R. Bakshi, G. Harris, G. Patel, G. H. Rasmusson +6 more
19950 citations
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New 7beta-substituted-4-aza-5alpha-kolestanonit 5alpha-reductase inhibitors
R. Bakshi, G. H. Rasmusson, R. L. Tolman, G. Patel +1 more
19940 citations
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NOUVELLES 4-AZA-5α-CHOLESTAN-ONES SUBSTITUEES EN POSITION 7β ET UTILISEES COMME INHIBITEURS DE 5α-REDUCTASE
R. Bakshi, G. H. Rasmusson, R. L. Tolman, G. Patel +1 more
19930 citations
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A. Sitlani

×8

Amjad Ali×7

M. Einstein×7

R. Bakshi×7

R. L. Tolman×7

G. Patel×7

R. W. Myers×6

J. Balkovec×6