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D. Simmons · SciRah

Researcher profile · Semantic Scholar

D. Simmons

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D. Simmons — researcher profile on SciRah

h-index: 41
Works: 67
Citations: 11K

Most-cited papers

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration
I. Martìn-padura, S. Lostaglio, M. Schneemann, L. Williams +8 more
1998Journal of Cell Biology1,461 citations Open access
Semantic Scholar
Identification of a novel aspartic protease (Asp 2) as beta-secretase.
I. Hussain, David Powell, D. Howlett, D. Tew +11 more
1999Molecular and cellular neurosciences1,121 citations
Semantic Scholar
Human CD14 mediates recognition and phagocytosis of apoptotic cells
A. Devitt, Odette D. Moffatt, C. Raykundalia, J. Capra +2 more
1998Nature741 citations
Semantic Scholar
Neurobiology: Inhibitor of neurite outgrowth in humans
R. Prinjha, S. E. Moore, M. Vinson, Sian Blake +5 more
2000Nature627 citations
Semantic Scholar
ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM
D. Simmons, M. Makgoba, B. Seed
1988Nature624 citations
Semantic Scholar
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells
A. Davies, D. Simmons, G. Hale, R. Harrison +3 more
1989Journal of Experimental Medicine615 citations Open access
Semantic Scholar
Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.
Claire L. L. Holness, D. Simmons
1993Blood542 citations Open access
Semantic Scholar
RGD peptides induce apoptosis by direct caspase-3 activation
C. Buckley, D. Pilling, N. Henriquez, Greg Parsonage +6 more
1999Nature453 citations
Semantic Scholar
Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes
J. Fawcett, Claire L. L. Holness, L. Needham, H. Turley +3 more
1992Nature392 citations
Semantic Scholar
Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.
Stephen B. Fox, J. Fawcett, D. Jackson, I. Collins +4 more
1994Cancer Research328 citations
Semantic Scholar
Signal-regulatory protein is selectively expressed by myeloid and neuronal cells.
S. Adams, L. V. D. van der Laan, Elizabeth Vernon-Wilson, Chantal Renardel de Lavalette +4 more
1998Journal of Immunology285 citations
Semantic Scholar
Molecular Cloning of CD68, a Human Macrophage Marker Related to Lysosomal Glycoproteins
Claire L. L. Holness, D. Simmons
1993273 citations Open access
Semantic Scholar
Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells.
D. Simmons, A. B. Satterthwaite, D. G. Tenen, B. Seed
1992Journal of Immunology258 citations
Semantic Scholar
The Myeloid-specific Sialic Acid-binding Receptor, CD33, Associates with the Protein-tyrosine Phosphatases, SHP-1 and SHP-2*
V. Taylor, C. Buckley, M. Douglas, A. Cody +2 more
1999Journal of Biological Chemistry196 citations Open access
Semantic Scholar
Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue.
P. Bradfield, N. Amft, Elizabeth Vernon-Wilson, Andrew Exley +7 more
2003Arthritis & Rheumatism192 citations
Semantic Scholar
Macrophage recognition of ICAM-3 on apoptotic leukocytes.
Odette D. Moffatt, A. Devitt, E. Bell, D. Simmons +1 more
1999Journal of Immunology186 citations
Semantic Scholar
The Fcγ receptor of natural killer cells is a phospholipid-linked membrane protein
D. Simmons, B. Seed
1988Nature183 citations
Semantic Scholar
Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1
C. Buckley, R. Doyonnas, J. Newton, S. Blystone +3 more
1996177 citations
Semantic Scholar
The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes.
S. Watt, J. Williamson, H. Genevier, J. Fawcett +4 more
1993Blood173 citations Open access
Semantic Scholar
Galectin 3 Induces a Distinctive Pattern of Cytokine and Chemokine Production in Rheumatoid Synovial Fibroblasts via Selective Signaling Pathways
A. Filer, Magdalena Bik, Greg Parsonage, J. Fitton +11 more
2009Arthritis & Rheumatism169 citations Open access
Semantic Scholar
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
I. Hussain, David J. Powell, D. Howlett, G. Chapman +15 more
2000Molecular and cellular neurosciences169 citations
Semantic Scholar
Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro
T. Jackson, A. Sharma, R. A. Ghazaleh, W. Blakemore +5 more
1997Journal of Virology160 citations Open access
Semantic Scholar
A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis.
A. J. Littler, C. Buckley, Paul Wordsworth, I. Collins +2 more
1997British Journal of Rheumatology142 citations Open access
Semantic Scholar
Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31*
J. Newton, Christopher D. Buckley, E. Jones, D. Simmons
1997Journal of Biological Chemistry139 citations Open access
Semantic Scholar
Cytosolic phospholipase A2α–deficient mice are resistant to experimental autoimmune encephalomyelitis
S. Marušić, M. Leach, Jeffrey W. Pelker, Mihai L. Azoitei +11 more
2005Journal of Experimental Medicine134 citations Open access
Semantic Scholar
Myelin-associated Glycoprotein Interacts with Ganglioside GT1b
M. Vinson, Paul J. L. M. Strijbos, A. Rowles, L. Facci +3 more
2001Journal of Biological Chemistry125 citations Open access
Semantic Scholar
Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3
R. Landis, A. Mcdowall, Claire L. L. Holness, A. J. Littler +2 more
1994Journal of Cell Biology118 citations Open access
Semantic Scholar
Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts
J. Fawcett, C. Buckley, Claire L. L. Holness, I. N. Bird +4 more
1995Journal of Cell Biology110 citations Open access
Semantic Scholar
Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration.
I. N. Bird, V. Taylor, J. Newton, J. Spragg +3 more
1999Journal of Cell Science89 citations
Semantic Scholar
Analysis of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated Antigen 1 (*)
Claire L. L. Holness, P. Bates, A. J. Littler, C. Buckley +4 more
1995Journal of Biological Chemistry86 citations Open access
Semantic Scholar
What makes a good anti-inflammatory drug target?
D. Simmons
2006Drug Discovery Today77 citations
Semantic Scholar
University of Birmingham Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1
D. Buckley, R. Doyonnas, J. Newton, S. Blystone +3 more
199668 citations
Semantic Scholar
In search of an enzyme: the β-secretase of Alzheimer's disease is an aspartic proteinase
D. Howlett, D. Simmons, C. Dingwall, G. Christie
200061 citations
Semantic Scholar
Extracellular matrix-mediated chemotaxis can impede cell migration
A. Perumpanani, D. Simmons, A. Gearing, K. Miller +4 more
1998Proceedings of the Royal Society of London. Series B: Biological Sciences61 citations Open access
Semantic Scholar
Anti-adhesion therapies.
D. Simmons
2005Current opinion in pharmacology (Print)60 citations
Semantic Scholar
Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen.
W. Stross, R. Warnke, D. Flavell, S. Flavell +3 more
1989Journal of Clinical Pathology60 citations Open access
Semantic Scholar
The FCγ receptor of natural killer cells is a phospholipid-linked membrane protein
D. Simmons, B. Seed
1989Nature53 citations Open access
Semantic Scholar
Neutrophils sense flow-generated stress and direct their migration through αVβ3-integrin.
G. Rainger, C. Buckley, D. Simmons, G. Nash
1999American Journal of Physiology. Heart and Circulatory Physiology52 citations
Semantic Scholar
TLiSA1 (PTA1) Activation Antigen Implicated in T Cell Differentiation and Platelet Activation Is a Member of the Immunoglobulin Superfamily Exhibiting Distinctive Regulation of Expression*
P. Sherrington, Judith L. Scott, B. Jin, D. Simmons +7 more
1997Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Targeting kinases: a new approach to treating inflammatory rheumatic diseases.
D. Simmons
2013Current opinion in pharmacology (Print)41 citations
Semantic Scholar
The deleted in colon cancer (DCC) gene is consistently expressed in colorectal cancers and metastases.
D. Gotley, J. Reeder, J. Fawcett, M. Walsh +3 more
1996Oncogene41 citations
Semantic Scholar
ICAM-3 expression on endothelium in lymphoid malignancy.
I. Doussis-Anagnostopoulou, Loukas Kaklamanis, J. Cordell, Margaret Jones +5 more
1993American Journal of Pathology36 citations
Semantic Scholar
Prognostic markers
D. Gotley, J. Fawcett, M. Walsht, J. Reeder +3 more
2004Clinical and Experimental Metastasis23 citations
Semantic Scholar
The role of the cysteine‐rich region of the β2 integrin subunit in the leukocyte function‐associated antigen‐1 (LFA‐1, αLβ2, CD11a/CD18) heterodimer formation and ligand binding
W. Douglass, R. Hyland, Christopher D. Buckley, A. Al-Shamkhani +4 more
199823 citations Open access
Semantic Scholar
Neutrophils Rolling on Immobilised Platelets Migrate into Homotypic Aggregates after Activation
G. Rainger, C. Buckley, D. Simmons, G. Nash
1998Thrombosis and Haemostasis23 citations
Semantic Scholar
The role of ICAM expression in immunity and disease.
D. Simmons
1995Cancer Surveys23 citations
Semantic Scholar
The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.
D. Simmons, B. Seed
1988Nature21 citations
Semantic Scholar
Cloning cell surface molecules using monoclonal antibodies
D. Simmons, L. Needham
199118 citations
Semantic Scholar
Neutrophils sense flow-generated stress and direct their migration using anchorage through αVβ3-integrin
C. Buckley, G. Rainger, D. Simmons, G. Nash
199915 citations
Semantic Scholar
Role of ligands in the activation of LFA‐1
Christopher D. Buckley, E. D. Ferguson, A. J. Littler, D. Bossy +1 more
1997European Journal of Immunology15 citations
Semantic Scholar

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J. Fawcett×5
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