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S. Flavell · SciRah

Researcher profile · Semantic Scholar

S. Flavell

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S. Flavell — researcher profile on SciRah

h-index: 18
Works: 46
Citations: 878

Most-cited papers

Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells
R. Vago, C. Marsden, J. Lord, R. Ippoliti +4 more
2005The FEBS Journal98 citations
Semantic Scholar
Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen.
W. Stross, R. Warnke, D. Flavell, S. Flavell +3 more
1989Journal of Clinical Pathology60 citations Open access
Semantic Scholar
Preclinical studies with the anti-CD19-saporin immunotoxin BU12-SAPORIN for the treatment of human-B-cell tumours.
D. Flavell, S. Flavell, DA Boehm, L. Emery +5 more
1995British Journal of Cancer55 citations Open access
Semantic Scholar
Systemic therapy with 3BIT, a triple combination cocktail of anti-CD19, -CD22, and -CD38-saporin immunotoxins, is curative of human B-cell lymphoma in severe combined immunodeficient mice.
D. Flavell, A. Noss, K. Pulford, N. Ling +1 more
1997Cancer Research51 citations
Semantic Scholar
Opisthorchis viverrini: pathogenesis of infection in immunodeprived hamsters
D. Flavell, S. Flavell
1986Parasite immunology (Print)43 citations
Semantic Scholar
Pichia pastoris as a host for secretion of toxic saporin chimeras
A. Lombardi, S. Bursomanno, T. Lopardo, Roberta Traini +6 more
2010The FASEB Journal40 citations
Semantic Scholar
Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual immunotoxin
D. Flavell, DA Boehm, A. Noss, Sarah L. Warnes +1 more
2001British Journal of Cancer39 citations Open access
Semantic Scholar
The anti‐CD20 antibody rituximab augments the immunospecific therapeutic effectiveness of an anti‐CD19 immunotoxin directed against human B‐cell lymphoma
D. Flavell, Sarah L. Warnes, Christine J. Bryson, Sarah A. Field +3 more
2006British Journal of Haematology36 citations Open access
Semantic Scholar
Therapy of human B‐cell lymphoma bearing scid mice is more effective with anti‐CD19‐and anti‐CD38‐saporin immunotoxins used in combination than with either immunotoxin used alone
D. Flavell, Deborah A. Boehm, L. Emery, A. Moss +2 more
1995International Journal of Cancer35 citations
Semantic Scholar
Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems
Pietro Della Cristina, M. Castagna, A. Lombardi, E. Barison +11 more
2015Microbial Cell Factories28 citations Open access
Semantic Scholar
Localisation of granulocyte macrophage colony-stimulating factor in human long-term bone marrow cultures. Biological and immunocytochemical characterisation.
E. D. de Wynter, T. Allen, L. Coutinho, D. Flavell +2 more
1993Journal of Cell Science26 citations
Semantic Scholar
Host-mediated antibody-dependent cellular cytotoxicity contributes to the in vivo therapeutic efficacy of an anti-CD7-saporin immunotoxin in a severe combined immunodeficient mouse model of human T-cell acute lymphoblastic leukemia.
D. Flavell, Sarah Warnes, A. Noss, S. Flavell
1998Cancer Research25 citations
Semantic Scholar
Opisthorchis viverrini: Partial success in adoptively transferring immunity with spleen cells and serum in the hamster
D. Flavell, K. Pattanapanyasat, S. Flavell
1980Journal of Helminthology25 citations
Semantic Scholar
Effectiveness of HB2 (anti-CD7)--saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice.
B. Morland, J. Barley, DA Boehm, S. Flavell +5 more
1994British Journal of Cancer24 citations Open access
Semantic Scholar
Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent
Suzanne E. Holmes, C. Bachran, H. Fuchs, Alexander Weng +3 more
2015Immunopharmacology and immunotoxicology23 citations
Semantic Scholar
Characteristics and performance of a bispecific F (ab'gamma)2 antibody for delivering saporin to a CD7+ human acute T-cell leukaemia cell line.
D. Flavell, S. Cooper, B. Morland, S. Flavell
1991British Journal of Cancer21 citations Open access
Semantic Scholar
Therapy of human T‐cell acute lymphoblastic leukaemia in severe combined immunodeficient mice with two different anti‐CD7‐saporin immunotoxins containing hindered or non‐hindered disulphide cross‐linkers
D. Flavell, Deborah A. Boehm, K. Okayama, J. Kohler +1 more
1994International Journal of Cancer20 citations
Semantic Scholar
Opisthorchis viverrini: the relationship between egg production, worm size and intensity of infection in the hamster.
D. Flavell, S. Flavell, G. Field
1983Transactions of the Royal Society of Tropical Medicine and Hygiene19 citations
Semantic Scholar
Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera
Alfredo Errico Provenzano, Riccardo Posteri, F. Giansanti, F. Angelucci +8 more
2016Microbial Cell Factories18 citations Open access
Semantic Scholar
Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells.
Wendy S. Smith, Ella J. Baker, Suzanne E. Holmes, G. Koster +4 more
2017Biochimica et Biophysica Acta - Biomembranes16 citations Open access
Semantic Scholar
Comparison of the potency and therapeutic efficacy of the anti-CD7 immunotoxin HB2-saporin constructed with one or two saporin moieties per immunotoxin molecule.
D. Flavell, DA Boehm, A. Noss, S. Flavell
1997British Journal of Cancer16 citations Open access
Semantic Scholar
Effectiveness of combinations of bispecific antibodies for delivering saporin to human acute T-cell lymphoblastic leukaemia cell lines via CD7 and CD38 as cellular target molecules.
D. Flavell, S. Cooper, B. Morland, R. French +1 more
1992British Journal of Cancer16 citations Open access
Semantic Scholar
Plant-Derived Type I Ribosome Inactivating Protein-Based Targeted Toxins: A Review of the Clinical Experience
D. Flavell, S. Flavell
2022Toxins15 citations Open access
Semantic Scholar
A Flow Cytometric Method to Quantify the Endosomal Escape of a Protein Toxin to the Cytosol of Target Cells
Harrison J. Wensley, D. A. Johnston, Wendy S. Smith, Suzanne E. Holmes +2 more
2019Pharmaceutical Research15 citations Open access
Semantic Scholar
Examining College Choice among NCAA Student-Athletes: An Exploration of Gender Differences
D. Andrew, J. M. Martinez, S. Flavell
201614 citations
Semantic Scholar
Development of a sensitive monoclonal antibody-based enzyme-linked immunosorbent assay (ELISA) for mitozantrone.
S. Flavell, D. Flavell
1988JIM - Journal of Immunological Methods14 citations
Semantic Scholar
Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants.
F. Giansanti, L. Di Leandro, I. Koutris, G. Pitari +6 more
2010Protein engineering, design & selection : PEDS13 citations
Semantic Scholar
European Clinical Trials Directive: responses made to MHRA consultation letter MLX 287.
D. Flavell, S. Flavell, R. Sullivan
2003The Lancet13 citations
Semantic Scholar
Comparison of the performance of anti‐CD7 and anti‐CD38 bispecific antibodies and immunotoxins for the delivery of saporin to a human T‐cell acute lymphoblastic leukemia cell line
D. Flavell, S. Cooper, K. Okayama, L. Emery +1 more
1995Hematological Oncology11 citations
Semantic Scholar
The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin
Wendy S. Smith, D. A. Johnston, Harrison J. Wensley, Suzanne E. Holmes +2 more
2020International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Augmentation of Saporin-Based Immunotoxins for Human Leukaemia and Lymphoma Cells by Triterpenoid Saponins: The Modifying Effects of Small Molecule Pharmacological Agents
Wendy S. Smith, D. A. Johnston, Suzanne E. Holmes, Harrison J. Wensley +2 more
2019Toxins8 citations Open access
Semantic Scholar
The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-Cell Leukaemia
D. Flavell, Suzanne E. Holmes, S. Warnes, S. Flavell
2019Biomedicines6 citations Open access
Semantic Scholar
High‐dose mitoxantrone and etoposide conditioning in autologous bone marrow transplantation for relapsed Hodgkin's disease
S. H. Lim, T. Baglin, D. Flavell, S. Flavell +2 more
1992European Journal of Haematology6 citations
Semantic Scholar
The Effect of Small Molecule Pharmacological Agents on the Triterpenoid Saponin Induced Endolysosomal Escape of Saporin and a Saporin-Based Immunotoxin in Target Human Lymphoma Cells
Harrison J. Wensley, Wendy S. Smith, Suzanne E. Holmes, S. Flavell +1 more
2021Biomedicines5 citations Open access
Semantic Scholar
Immunotoxin studies in a model of human T-cell acute lymphoblastic leukemia developed in severe combined immune-deficient mice
B. Morland, DA Boehm, S. Flavell, J. Kohler +1 more
2007Cell Biophysics4 citations
Semantic Scholar
Comparison of immunotoxins bearing a single saporin molecule with multiple toxin conjugates.
D. Flavell, S. Flavell
2001Methods in molecular biology3 citations
Semantic Scholar
The anti‐mitozantrone monoclonal antibody NO‐1, protects acute leukaemia cell lines from the cytotoxic effects of mitozantrone
S. Flavell, D. Flavell
1991British Journal of Haematology2 citations
Semantic Scholar
World Health Organization Public Health Approaches to Expand Antiretroviral Treatment Public Health Approaches to Expand Antiretroviral Treatment
I. de Zoysa, C. Dolea, M. Darder, M. Dybul +25 more
2 citations
Semantic Scholar
Dissecting the Entry Route of Saporin-based a-CD7 Immunotoxins in Human T-Cell Acute Lymphoblastic Leukaemia Cells
F. Giansanti, V. Giordani, R. Vago, D. Flavell +5 more
20131 citations Open access
Semantic Scholar
Abstract 5624: Saponins fromGypsophila paniculata Lsignificantly potentiate the immunospecific cytotoxic activity of anti-CD19 and CD38 saporin-based immunotoxins for a human lymphoma cell line
D. Flavell, Suzanne E. Holmes, Emily L. Gibbs, H. Fuchs +4 more
20101 citations
Semantic Scholar
Stimulation of antibody dependent cellular cytotoxicity (ADCC) in SCID mice significantly improves the therapeutic efficacy of an anti-CD7 antibody and immunotoxin directed against human T-cell leukaemia xenografts
D. Flavell, J. Keeley, S. Warnes, A. Noss +1 more
20051 citations
Semantic Scholar
Comparison of the therapeutic efficacy of anti-CD7-saporin immunotoxins constructed with one or two saporin moieties per immunotoxin molecule in SCID mice with human T-cell acute leukaemia
D. Flavell, DA Boehm, L. Emery, A. Noss +1 more
19951 citations
Semantic Scholar
Abstract 767:Gypsophilasaponins significantly augment the cytotoxicity of saporin-based anti-CD19, -CD22, -CD38 and -CD71 immunotoxins in human leukemia and lymphoma
D. Flavell, Suzanne E. Holmes, Emily L. Gibbs, Jennifer Adcott +6 more
20110 citations
Semantic Scholar
Co-Operativity between Antibody-Dependent Cellular Cytotoxicity (ADCC) and Immunotoxin-Mediated Killing of Human T-ALL Cells in a SCID Mouse Model: Simultaneous Delivery of Saporin Via CD7 and ADCC Via CD38 Is No Better Than the Simultaneous Delivery of Each Against Only CD7.
D. Flavell, S. Flavell
20060 citations Open access
Semantic Scholar
Antibody Dependent Cellular Cytotoxicity (ADCC) Augmentation of Immunotoxin Activity in SCID-HSB-2 Mice Is Adoptively Transferable to NOD/SCID-HSB-2 Mice.
D. Flavell, S. Flavell
20060 citations
Semantic Scholar
The effect of tumour burden in human leukaemia bearing SCID mice on immunotoxin therapy outcome
J. Turner, D. Flavell, J. Kohler, A. Noss +1 more
19960 citations
Semantic Scholar

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