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T. Whitehead · SciRah

Researcher profile · Semantic Scholar

T. Whitehead

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T. Whitehead — researcher profile on SciRah

h-index: 28
Works: 88
Citations: 3,408

Most-cited papers

Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
S. Fleishman, T. Whitehead, D. Ekiert, C. Dreyfus +4 more
2011Science610 citations Open access
Semantic Scholar
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
T. Whitehead, Aaron Chevalier, Yifan Song, C. Dreyfus +7 more
2012Nature Biotechnology391 citations Open access
Semantic Scholar
Plasmid-based one-pot saturation mutagenesis
Emily E. Wrenbeck, Justin R. Klesmith, J. Stapleton, Adebola V. Adeniran +2 more
2016Nature Methods158 citations Open access
Semantic Scholar
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
Justin R. Klesmith, J. Bacik, Emily E. Wrenbeck, R. Michalczyk +1 more
2017Proceedings of the National Academy of Sciences of the United States of America147 citations Open access
Semantic Scholar
Community-wide assessment of protein-interface modeling suggests improvements to design methodology
S. Fleishman, T. Whitehead, Eva-Maria Strauch, J. Corn +92 more
2011Journal of Molecular Biology144 citations Open access
Semantic Scholar
Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
Emily E. Wrenbeck, Laura R. Azouz, T. Whitehead
2017Nature Communications142 citations Open access
Semantic Scholar
Lignin triggers irreversible cellulase loss during pretreated lignocellulosic biomass saccharification
Da-Hai Gao, C. Haarmeyer, V. Balan, T. Whitehead +2 more
2014Biotechnology for Biofuels119 citations Open access
Semantic Scholar
Mechanical nanosensor based on FRET within a thermosome: damage-reporting polymeric materials.
N. Bruns, Katarzyna Pustelny, L. Bergeron, T. Whitehead +1 more
2009Angewandte Chemie93 citations
Semantic Scholar
The Interrelationship between Promoter Strength, Gene Expression, and Growth Rate
Matthew Bienick, Katherine W. Young, Justin R. Klesmith, Emily E. Detwiler +2 more
2014PLoS ONE88 citations Open access
Semantic Scholar
Deep Sequencing Methods for Protein Engineering and Design
Emily E. Wrenbeck, M. Faber, T. Whitehead
2016Current Opinion in Structural Biology84 citations Open access
Semantic Scholar
Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds
J. Beltrán, Paul J. Steiner, Matthew A. Bedewitz, Shuang Wei +15 more
2022Nature Biotechnology79 citations Open access
Semantic Scholar
Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing*
Caitlin A. Kowalsky, M. Faber, A. Nath, Hailey E. Dann +7 more
2015Journal of Biological Chemistry79 citations Open access
Semantic Scholar
Minimal protein-folding systems in hyperthermophilic archaea
P. Laksanalamai, T. Whitehead, F. Robb
2004Nature Reviews Microbiology75 citations
Semantic Scholar
Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non-lethal cold shock.
Boonchai B. Boonyaratanakornkit, A. J. Simpson, T. Whitehead, C. Fraser +2 more
2005Environmental Microbiology69 citations
Semantic Scholar
High-Resolution Sequence-Function Mapping of Full-Length Proteins
Caitlin A. Kowalsky, Justin R. Klesmith, J. Stapleton, Vince W. Kelly +2 more
2015PLoS ONE68 citations Open access
Semantic Scholar
Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli.
Justin R. Klesmith, J. Bacik, R. Michalczyk, T. Whitehead
2015ACS Synthetic Biology60 citations
Semantic Scholar
Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses
B. B. Banach, G. Cerutti, A. Fahad, Chen-Hsiang Shen +30 more
2021Cell Reports56 citations Open access
Semantic Scholar
Hotspot-Centric De Novo Design of Protein Binders
S. Fleishman, J. Corn, Eva-Maria Strauch, T. Whitehead +2 more
2011Journal of Molecular Biology49 citations Open access
Semantic Scholar
Self‐renaturing enzymes: Design of an enzyme‐chaperone chimera as a new approach to enzyme stabilization
L. Bergeron, Lizabeth Gomez, T. Whitehead, D. Clark
2009Biotechnology and Bioengineering46 citations Open access
Semantic Scholar
Negatively Supercharging Cellulases Render Them Lignin-Resistant
T. Whitehead, C. Bandi, M. Berger, Jihyun Park +1 more
201742 citations Open access
Semantic Scholar
One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening
Irene M. Francino Urdániz, Paul J. Steiner, Monica B Kirby, Fang-Zhu Zhao +7 more
2021bioRxiv41 citations Open access
Semantic Scholar
A filamentous molecular chaperone of the prefoldin family from the deep‐sea hyperthermophile Methanocaldococcus jannaschii
T. Whitehead, Boonchai B. Boonyaratanakornkit, Volker Höllrigl, D. Clark
2007Protein Science41 citations Open access
Semantic Scholar
Computational design of novel protein binders and experimental affinity maturation.
T. Whitehead, D. Baker, S. Fleishman
2013Methods in Enzymology39 citations
Semantic Scholar
Haplotype-Phased Synthetic Long Reads from Short-Read Sequencing
J. Stapleton, Jeongwoon Kim, J. Hamilton, Ming Wu +9 more
2015bioRxiv35 citations Open access
Semantic Scholar
Tying up the loose ends: circular permutation decreases the proteolytic susceptibility of recombinant proteins.
T. Whitehead, L. Bergeron, D. Clark
2009Protein engineering, design & selection : PEDS34 citations
Semantic Scholar
Biotemplated metal nanowires using hyperthermophilic protein filaments.
J. Slocik, S. Kim, T. Whitehead, D. Clark +1 more
2009Small34 citations
Semantic Scholar
One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening
I. Francino-Urdaniz, Paul J. Steiner, Monica B Kirby, Fang-Zhu Zhao +8 more
2021Cell Reports31 citations Open access
Semantic Scholar
Computational redesign of the lipid-facing surface of the outer membrane protein OmpA
J. Stapleton, T. Whitehead, Vikas Nanda
2015Proceedings of the National Academy of Sciences of the United States of America31 citations Open access
Semantic Scholar
An automated data-driven pipeline for improving heterologous enzyme expression
Emily E. Wrenbeck, Matthew A. Bedewitz, Justin R. Klesmith, S. Noshin +2 more
2019ACS Synthetic Biology27 citations Open access
Semantic Scholar
Rosetta in CAPRI rounds 13–19
S. Fleishman, J. Corn, Eva-Maria Strauch, T. Whitehead +6 more
2010Proteins: Structure, Function, and Bioinformatics27 citations Open access
Semantic Scholar
Characterizing Protein-Protein Interactions Using Deep Sequencing Coupled to Yeast Surface Display
Angélica V. Medina-Cucurella, T. Whitehead
2018Methods in molecular biology26 citations Open access
Semantic Scholar
Insights into cellulase‐lignin non‐specific binding revealed by computational redesign of the surface of green fluorescent protein
C. Haarmeyer, Matthew Smith, Shishir P. S. Chundawat, D. Sammond +1 more
2017Biotechnology and Bioengineering24 citations Open access
Semantic Scholar
Data-driven engineering of protein therapeutics.
M. Faber, T. Whitehead
2019Current Opinion in Biotechnology23 citations Open access
Semantic Scholar
Design and engineering of genetically encoded protein biosensors for small molecules
Alison C. Leonard, T. Whitehead
2022Current Opinion in Biotechnology22 citations Open access
Semantic Scholar
Saturation Mutagenesis Genome Engineering of Infective ΦX174 Bacteriophage via Unamplified Oligo Pools and Golden Gate Assembly
M. Faber, J. T. Van Leuven, M. Ederer, Yesol Sapozhnikov +4 more
2019bioRxiv22 citations Open access
Semantic Scholar
Determination of binding affinity upon mutation for type I dockerin–cohesin complexes from Clostridium thermocellum and Clostridium cellulolyticum using deep sequencing
Caitlin A. Kowalsky, T. Whitehead
2016Proteins: Structure, Function, and Bioinformatics22 citations
Semantic Scholar
User-defined single pot mutagenesis using unamplified oligo pools.
Angélica V. Medina-Cucurella, Paul J. Steiner, M. Faber, J. Beltrán +4 more
2019Protein engineering, design & selection : PEDS21 citations Open access
Semantic Scholar
An overview of methods for the structural and functional mapping of epitopes recognized by anti-SARS-CoV-2 antibodies
I. Francino-Urdaniz, T. Whitehead
2021RSC Chemical Biology19 citations Open access
Semantic Scholar
Removal and upgrading of lignocellulosic fermentation inhibitors by in situ biocatalysis and liquid-liquid extraction.
Kyle J. Tomek, Carlos Rafael Castillo Saldarriaga, F. Velasquez, Tongjun Liu +2 more
2015Biotechnology and Bioengineering19 citations
Semantic Scholar
Fine epitope mapping of two antibodies neutralizing the Bordetella adenylate cyclase toxin
Xianzhe Wang, J. Stapleton, Justin R. Klesmith, E. Hewlett +2 more
2017Biochemistry18 citations Open access
Semantic Scholar
Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires
Brian M. Petersen, Sophia A. Ulmer, Emily R. Rhodes, Matías Gutiérrez-González +3 more
2021bioRxiv17 citations Open access
Semantic Scholar
Producing Glucose 6-Phosphate from Cellulosic Biomass
J. Bacik, Justin R. Klesmith, T. Whitehead, L. Jarboe +3 more
2015Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Rational shape engineering of the filamentous protein γ prefoldin through incremental gene truncation
T. Whitehead, Elizabeth Je, D. Clark
2009Biopolymers17 citations
Semantic Scholar
A Closed Form Model for Molecular Ratchet-Type Chemically Induced Dimerization Modules.
Paul J. Steiner, Samuel D Swift, Matthew A. Bedewitz, I. Wheeldon +3 more
2022Biochemistry16 citations
Semantic Scholar
The Importance and Future of Biochemical Engineering
T. Whitehead, S. Banta, W. Bentley, M. Betenbaugh +15 more
2020Biotechnology and Bioengineering15 citations Open access
Semantic Scholar
Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti-NGF monoclonal antibodies
Angélica V. Medina-Cucurella, Yaqi Zhu, Scott J. Bowen, L. Bergeron +1 more
2018Biotechnology and Bioengineering15 citations Open access
Semantic Scholar
Controlling the self-assembly of a filamentous hyperthermophilic chaperone by an engineered capping protein.
T. Whitehead, Adam L. Meadows, D. Clark
2008Small15 citations
Semantic Scholar
Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways
Fang-Zhu Zhao, Celina Keating, G. Ozorowski, N. Shaabani +19 more
2022bioRxiv14 citations Open access
Semantic Scholar
Impact of in vivo protein folding probability on local fitness landscapes.
M. Faber, Emily E. Wrenbeck, Laura R. Azouz, Paul J. Steiner +1 more
2019Molecular biology and evolution14 citations
Semantic Scholar
Characterization of Individual Human Antibodies That Bind Pertussis Toxin Stimulated by Acellular Immunization
Edith Acquaye-Seedah, Elizabeth E. Reczek, H. Russell, Andrea M. DiVenere +5 more
2018Infection and Immunity13 citations Open access
Semantic Scholar

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