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S. Khom · SciRah

Researcher profile · Semantic Scholar

S. Khom

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S. Khom — researcher profile on SciRah

h-index: 25
Works: 71
Citations: 1,872

Most-cited papers

The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission
Vicky Chuong, M. Farokhnia, S. Khom, Claire L. Pince +7 more
2023JCI Insight181 citations Open access
Semantic Scholar
Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity.
S. Khom, I. Baburin, E. Timin, A. Hohaus +3 more
2007Neuropharmacology177 citations
Semantic Scholar
Microglia control escalation of drinking in alcohol dependent mice: Genomic and synaptic drivers
A. Warden, Sarah A. Wolfe, S. Khom, F. Varodayan +11 more
2020Biological Psychiatry122 citations Open access
Semantic Scholar
The role of the central amygdala in alcohol dependence
M. Roberto, Dean Kirson, S. Khom
2020Cold Spring Harbor Perspectives in Medicine107 citations Open access
Semantic Scholar
Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala
B. Tunstall, Dean Kirson, L. Zallar, S. McConnell +10 more
2019PLoS Biology98 citations Open access
Semantic Scholar
Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid.
Gabriele Trauner, S. Khom, I. Baburin, B. Benedek +2 more
2008Planta Medica97 citations
Semantic Scholar
Pharmacological Properties of GABAA Receptors Containing γ1 Subunits
S. Khom, I. Baburin, E. Timin, A. Hohaus +2 more
2006Molecular Pharmacology90 citations Open access
Semantic Scholar
IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala
Reesha R. Patel, S. Khom, M. Steinman, F. Varodayan +8 more
2018Brain, behavior, and immunity70 citations Open access
Semantic Scholar
Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal
A. Roberts, S. Khom, M. Bajo, R. Vlkolinský +4 more
2019Brain, behavior, and immunity61 citations Open access
Semantic Scholar
Valerenic acid derivatives as novel subunit‐selective GABAA receptor ligands –in vitro and in vivo characterization
S. Khom, B. Strommer, J. Ramharter, Thomas Schwarz +5 more
2010British Journal of Pharmacology56 citations Open access
Semantic Scholar
GABAA receptor modulation by piperine and a non-TRPV1 activating derivative
S. Khom, B. Strommer, Angela Schöffmann, Juliane Hintersteiner +7 more
2013Biochemical Pharmacology55 citations Open access
Semantic Scholar
Efficient Modulation of γ-Aminobutyric Acid Type A Receptors by Piperine Derivatives
Angela Schöffmann, Laurin Wimmer, Daria Goldmann, S. Khom +11 more
2014Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Pharmacological properties of GABAA receptors containing gamma1 subunits.
S. Khom, I. Baburin, E. Timin, A. Hohaus +2 more
2006Molecular Pharmacology47 citations
Semantic Scholar
The amygdala noradrenergic system is compromised with alcohol use disorder
F. Varodayan, Reesha R. Patel, A. Matzeu, Sarah A. Wolfe +14 more
2022Biological Psychiatry41 citations Open access
Semantic Scholar
Synthetic, Mechanistic and Biological Interrogation of Ginkgo biloba Chemical Space en route to (−)-Bilobalide
R. Demoret, Meghan A. Baker, M. Ohtawa, Shuming Chen +6 more
2020Journal of the American Chemical Society39 citations Open access
Semantic Scholar
Sex Differences in Acute Alcohol Sensitivity of Naïve and Alcohol Dependent Central Amygdala GABA Synapses.
Dean Kirson, S. Khom, Larry Rodriguez, Sarah A. Wolfe +6 more
2021Alcohol and Alcoholism38 citations Open access
Semantic Scholar
Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala
S. Khom, Sarah A. Wolfe, Reesha R. Patel, Dean Kirson +4 more
2020Journal of Neuroscience36 citations Open access
Semantic Scholar
Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders
M. Steinman, Dean Kirson, Sarah A. Wolfe, S. Khom +11 more
2020Molecular Psychiatry36 citations Open access
Semantic Scholar
CRF modulates glutamate transmission in the central amygdala of naïve and ethanol-dependent rats
F. Varodayan, D. Correia, Dean Kirson, S. Khom +4 more
2017Neuropharmacology34 citations Open access
Semantic Scholar
HPLC-Based Activity Profiling Approach for the Discovery of GABAA Receptor Ligands using an Automated Two Microelectrode Voltage Clamp Assay on Xenopus Oocytes
H. Kim, I. Baburin, S. Khom, S. Hering +1 more
2008Planta Medica34 citations Open access
Semantic Scholar
Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site‐directed mutagenesis
D. Luger, G. Poli, M. Wieder, M. Stadler +8 more
2015British Journal of Pharmacology33 citations Open access
Semantic Scholar
Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa.
S. Çiçek, S. Khom, B. Taferner, S. Hering +1 more
2010Journal of Natural Products33 citations
Semantic Scholar
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice.
J. Zaugg, S. Khom, D. Eigenmann, I. Baburin +2 more
2011Journal of Natural Products30 citations
Semantic Scholar
Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala
S. Khom, Thomas Steinkellner, T. Hnasko, Marisa Roberto
2020Science Advances27 citations Open access
Semantic Scholar
GABAA Receptor Modulators from the Chinese Herbal Drug Junci Medulla – The Pith of Juncus effusus
Judith Singhuber, Igor Baburin, S. Khom, M. Zehl +3 more
2012Planta Medica26 citations
Semantic Scholar
Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress
F. Varodayan, S. Khom, Reesha R. Patel, M. Steinman +5 more
2018Alcohol and Alcoholism24 citations Open access
Semantic Scholar
Estimating the efficiency of benzodiazepines on GABAA receptors comprising γ1 or γ2 subunits
I. Baburin, S. Khom, Evgeny Timin, Annette Hohaus +2 more
2008British Journal of Pharmacology23 citations Open access
Semantic Scholar
Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses
Larry Rodriguez, Dean Kirson, Sarah A. Wolfe, Reesha R. Patel +7 more
2022International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats
S. Khom, Larry Rodriguez, Pauravi J. Gandhi, Dean Kirson +5 more
2022Neurobiology of Disease20 citations Open access
Semantic Scholar
Esters of valerenic acid as potential prodrugs
Juliane Hintersteiner, M. Haider, D. Luger, C. Schwarzer +5 more
2014European Journal of Pharmacology19 citations Open access
Semantic Scholar
IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder
V. Borgonetti, Bryan Cruz, Valentina Vozella, S. Khom +9 more
2023Cells15 citations Open access
Semantic Scholar
Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABAA) Receptor Modulators.
M. Stadler, Serena Monticelli, T. Seidel, D. Luger +9 more
2018Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats
R. Vlkolinský, S. Khom, Valentina Vozella, M. Bajo +1 more
2024Neurobiology of Disease14 citations Open access
Semantic Scholar
Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala
J. Suárez, S. Khom, F. Alén, Luis A. Natividad +10 more
2019Addiction Biology14 citations Open access
Semantic Scholar
Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives
S. Khom, Juliane Hintersteiner, D. Luger, M. Haider +4 more
2016Journal of Pharmacology and Experimental Therapeutics14 citations Open access
Semantic Scholar
Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes.
Laurin Wimmer, David Schönbauer, Peter Pakfeifer, Angela Schöffmann +3 more
2015Organic and biomolecular chemistry13 citations
Semantic Scholar
A Cycloartane Glycoside Derived from Actaea racemosa L. Modulates GABAA Receptors and Induces Pronounced Sedation in Mice
B. Strommer, S. Khom, Iris Kastenberger, S. Çiçek +3 more
2014Journal of Pharmacology and Experimental Therapeutics9 citations
Semantic Scholar
Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats
S. Khom, V. Borgonetti, Valentina Vozella, Dean Kirson +9 more
2023Neurobiology of Stress8 citations Open access
Semantic Scholar
Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats
S. Khom, Jacques D. Nguyen, Sophia A. Vandewater, Yanabel Grant +2 more
2021Frontiers in Behavioral Neuroscience8 citations Open access
Semantic Scholar
Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function
Jacques D. Nguyen, Dean Kirson, M. Steinman, Reesha R. Patel +7 more
2017bioRxiv7 citations Open access
Semantic Scholar
Pharmacological Properties of GABA A Receptors Containing 1 Subunits □ S
S. Khom, I. Baburin, E. Timin, A. Hohaus +2 more
20066 citations
Semantic Scholar
Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits.
I. Baburin, S. Khom, E. Timin, A. Hohaus +2 more
20085 citations
Semantic Scholar
Total Synthesis of (15R)- and (15S)-Prostaglandin A2.
Justus Lackner, Christoph Alberti, T. Bock, Katharina Neßmerak +3 more
2024Chemistry4 citations Open access
Semantic Scholar
Modulation of GABAA Receptors by Valerian Extracts is Related to the Content of Valerenic Acid
Gabriele Trauner, S. Khom, Igor Baburin, B. Benedek +2 more
20074 citations
Semantic Scholar
HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using a functional assay with Xenopus oocytes
H. Kim, S. Baburin, S. Khom, S. Hering +1 more
20083 citations
Semantic Scholar
Self-Administration of entactogen psychostimulants dysregulates GABA and Kappa Opioid Receptor signaling in the central nucleus of the amygdala of female Wistar rats
S. Khom, Jacques D. Nguyen, Sophia A. Vandewater, Yanabel Grant +2 more
2021bioRxiv2 citations Open access
Semantic Scholar
Identification of GABAA-modulators obtained from Valeriana officinalis L
Gabriele Trauner, S. Khom, B. Benedek, S. Hering +1 more
20062 citations
Semantic Scholar
Kappa Opioid Receptor Signaling Contributes to Re‐escalation of Oxycodone Self‐administration Under Extended Access Conditions
Jacques D. Nguyen, Dean Kirson, Yanabel Grant, F. Varodayan +5 more
2017The FASEB Journal1 citations Open access
Semantic Scholar
HPLC-based activity profiling of plant and fungal extracts for GABAA receptor ligands using a functional assay with Xenopus oocytes
H. J. Kim, S. Khom, I. Baburin, S. Hering +1 more
20071 citations
Semantic Scholar
Valerian extract modulates the GABAA-action on its receptors
A. Brattström, I. Baburin, S. Khom, S. Hering +1 more
20061 citations
Semantic Scholar

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