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L. Watkins · SciRah

Researcher profile · Semantic Scholar

L. Watkins

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L. Watkins — researcher profile on SciRah

h-index: 127
Works: 446
Citations: 57K

Most-cited papers

Pathological pain and the neuroimmune interface
P. Grace, M. Hutchinson, S. Maier, L. Watkins
2014Nature reviews. Immunology899 citations Open access
Semantic Scholar
Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation
P. Grace, K. Strand, E. Galer, D. Urban +15 more
2016Proceedings of the National Academy of Sciences of the United States of America354 citations Open access
Semantic Scholar
NEUROINFLAMMATION IN THE NORMAL AGING HIPPOCAMPUS
R. Barrientos, M. M. Kitt, L. Watkins, S. Maier
2015Neuroscience325 citations Open access
Semantic Scholar
Microglia inflammatory responses are controlled by an intrinsic circadian clock
L. Fonken, M. Frank, M. M. Kitt, R. Barrientos +2 more
2014Brain, behavior, and immunity269 citations Open access
Semantic Scholar
MicroRNAs: Roles in Regulating Neuroinflammation
Andrew D. Gaudet, L. Fonken, L. Watkins, R. Nelson +1 more
2018The Neuroscientist252 citations Open access
Semantic Scholar
The therapeutic potential of interleukin-10 in neuroimmune diseases
A. Kwilasz, P. Grace, P. Šerbedžija, S. Maier +1 more
2014Neuropharmacology224 citations Open access
Semantic Scholar
Stress sounds the alarmin: the role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming
M. Frank, Michael D. Weber, L. Watkins, S. Maier
2015Brain, behavior, and immunity222 citations Open access
Semantic Scholar
Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome
Michael D. Weber, M. Frank, K. Tracey, L. Watkins +1 more
2015Journal of Neuroscience208 citations Open access
Semantic Scholar
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory
S. Spencer, H. D'Angelo, A. Soch, L. Watkins +2 more
2017Neurobiology of Aging193 citations Open access
Semantic Scholar
Toll-like receptors and their role in persistent pain
M. Lacagnina, L. Watkins, P. Grace
2017Pharmacology and Therapeutics179 citations Open access
Semantic Scholar
High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism
Julia L. Sobesky, R. Barrientos, Henning S. De May, Brittany M. Thompson +3 more
2014Brain, behavior, and immunity156 citations Open access
Semantic Scholar
HMGB1 activates proinflammatory signaling via TLR5 leading to allodynia
Nabanita Das, Varun Dewan, P. Grace, R. J. Gunn +5 more
2016Cell Reports137 citations Open access
Semantic Scholar
Microglia: neuroimmune-sensors of stress
M. Frank, L. Fonken, L. Watkins, S. Maier
2019Seminars in Cell and Developmental Biology134 citations Open access
Semantic Scholar
Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders
M. Frank, Michael D. Weber, L. Watkins, S. Maier
2015Neurobiology of Stress133 citations Open access
Semantic Scholar
The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: a role for the NLRP3 inflammasome
M. Frank, Michael D. Weber, L. Fonken, Sarah A. Hershman +2 more
2015Brain, behavior, and immunity132 citations Open access
Semantic Scholar
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming
L. Fonken, M. Frank, M. M. Kitt, H. D'Angelo +6 more
2016Journal of Neuroscience130 citations Open access
Semantic Scholar
Prior voluntary wheel running attenuates neuropathic pain
P. Grace, T. Fabisiak, Suzanne M. Green-Fulgham, Nathan D. Anderson +8 more
2016Pain124 citations Open access
Semantic Scholar
Nitroxidative signaling mechanisms in pathological pain
P. Grace, Andrew D. Gaudet, V. Staikopoulos, S. Maier +3 more
2016Trends in Neurosciences121 citations Open access
Semantic Scholar
Neuroinflammatory priming to stress is differentially regulated in male and female rats
L. Fonken, M. Frank, Andrew D. Gaudet, H. D'Angelo +5 more
2018Brain, behavior, and immunity100 citations Open access
Semantic Scholar
DREADDed microglia in pain: implications for spinal inflammatory signaling in male rats
P. Grace, Xiao-Hui Wang, K. Strand, M. Baratta +5 more
2018Experimental Neurology96 citations Open access
Semantic Scholar
Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4
R. Bachtell, M. Hutchinson, Xiao-Hui Wang, K. Rice +2 more
2015CNS and Neurological Disorders - Drug Targets92 citations Open access
Semantic Scholar
Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior
M. Frank, L. Fonken, Samuel D. Dolzani, Jessica L Annis +5 more
2018Brain, behavior, and immunity85 citations Open access
Semantic Scholar
Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-Like Receptor 4 (TLR4) Antagonists
Brandon R. Selfridge, Xiao-Hui Wang, Ying-Ning Zhang, H. Yin +4 more
2015Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell
Xiao-Hui Wang, A. Northcutt, T. A. Cochran, Xiaozheng Zhang +9 more
2019ACS Chemical Neuroscience81 citations Open access
Semantic Scholar
Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking
Kyle T. Brown, Sophia C. Levis, C. E. O'Neill, A. Northcutt +3 more
2017Brain, behavior, and immunity79 citations Open access
Semantic Scholar
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns in male rats
P. Grace, K. Strand, E. Galer, K. Rice +2 more
2017Brain, behavior, and immunity78 citations Open access
Semantic Scholar
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury
A. Ellis, P. Grace, J. Wieseler, Jacob Favret +8 more
2016Brain, behavior, and immunity76 citations Open access
Semantic Scholar
Pioglitazone rapidly reduces neuropathic pain through astrocyte and non-genomic PPARγ mechanisms
R. Griggs, R. Donahue, J. Morgenweck, P. Grace +3 more
2015Pain72 citations Open access
Semantic Scholar
Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress
J. Amat, Samuel D. Dolzani, S. Tilden, J. P. Christianson +6 more
2016Journal of Neuroscience71 citations Open access
Semantic Scholar
Stress disinhibits microglia via down-regulation of CD200R: a mechanism of neuroinflammatory priming
M. Frank, L. Fonken, Jessica L Annis, L. Watkins +1 more
2017Brain, behavior, and immunity70 citations Open access
Semantic Scholar
Stress-induced neuroinflammatory priming is time of day dependent
L. Fonken, Michael D. Weber, R. Daut, M. M. Kitt +3 more
2016Psychoneuroendocrinology70 citations Open access
Semantic Scholar
Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization
L. Fonken, M. M. Kitt, Andrew D. Gaudet, R. Barrientos +2 more
2016Neurobiology of Aging70 citations Open access
Semantic Scholar
The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine
M. Frank, Sweta Adhikary, Julia L. Sobesky, Michael D. Weber +2 more
2015Brain, behavior, and immunity70 citations Open access
Semantic Scholar
Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction.
J. Jacobsen, L. Watkins, M. Hutchinson
2014International review of neurobiology67 citations
Semantic Scholar
Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: toxicology and pain efficacy assessments.
L. Watkins, R. Chavez, R. Landry, Megan E. Fry +6 more
2020Brain, behavior, and immunity66 citations
Semantic Scholar
Greater Glucocorticoid Receptor Activation in Hippocampus of Aged Rats Sensitizes Microglia
R. Barrientos, Vanessa M. Thompson, M. M. Kitt, J. Amat +9 more
2014Neurobiology of Aging65 citations Open access
Semantic Scholar
Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1
Julia L. Sobesky, H. D'Angelo, Michael D. Weber, Nathan D. Anderson +4 more
2016eNeuro64 citations Open access
Semantic Scholar
Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy
P. Grace, L. Loram, J. P. Christianson, K. Strand +8 more
2016Brain, behavior, and immunity60 citations Open access
Semantic Scholar
Activation of a Habenulo–Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat
Samuel D. Dolzani, M. Baratta, J. Amat, Kara L. Agster +3 more
2016eNeuro59 citations Open access
Semantic Scholar
Acute Stress Induces Chronic Neuroinflammatory, Microglial and Behavioral Priming: A Role for Potentiated NLRP3 Inflammasome Activation
M. Frank, L. Fonken, L. Watkins, S. Maier
2020Brain, behavior, and immunity58 citations Open access
Semantic Scholar
Systemic Administration of Propentofylline, Ibudilast, and (+)-Naltrexone Each Reverses Mechanical Allodynia in a Novel Rat Model of Central Neuropathic Pain
A. Ellis, J. Wieseler, Jacob Favret, K. Johnson +4 more
2014Journal of Pain57 citations Open access
Semantic Scholar
Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction
L. Fonken, M. Frank, H. D'Angelo, Jared D. Heinze +3 more
2018Neurobiology of Aging50 citations Open access
Semantic Scholar
Exploring acute‐to‐chronic neuropathic pain in rats after contusion spinal cord injury
Andrew D. Gaudet, Monica T. Ayala, W. Schleicher, E. Smith +3 more
2017Experimental Neurology50 citations Open access
Semantic Scholar
Mechanisms of Microglia-Mediated Synapse Turnover and Synaptogenesis.
Jayson Ball, Suzanne M. Green-Fulgham, L. Watkins
2022Progress in neurobiology49 citations Open access
Semantic Scholar
TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes
T. LaRocca, A. Mariani, L. Watkins, C. Link
2019Neurobiology of Disease49 citations Open access
Semantic Scholar
Behavioral and neural sequelae of stressor exposure are not modulated by controllability in females
M. Baratta, Nathan R. Leslie, Isabella P. Fallon, Samuel D. Dolzani +4 more
2018European Journal of Neuroscience49 citations Open access
Semantic Scholar
Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
Yinghua Peng, Xiaozheng Zhang, Tian-Shu Zhang, P. Grace +8 more
2019Brain, behavior, and immunity48 citations
Semantic Scholar
The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights
M. Frank, L. Watkins, S. Maier
2015Current Opinion in Endocrinology, Diabetes & Obesity46 citations Open access
Semantic Scholar
Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists
Xiaozheng Zhang, Fengchao Cui, Hongqian Chen, Tian-Shu Zhang +9 more
2018Journal of Chemical Information and Modeling44 citations Open access
Semantic Scholar
Repeated Morphine Prolongs Postoperative Pain in Male Rats
P. Grace, E. Galer, K. Strand, Kaci Corrigan +3 more
2019Anesthesia and Analgesia42 citations Open access
Semantic Scholar

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S. Maier×38
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P. Grace×15
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L. Fonken×12
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Michael D. Weber

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M. Hutchinson×8

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K. Strand — researcher profile on SciRah

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M. M. Kitt — researcher profile on SciRah

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