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M. Blaskovich · SciRah

Researcher profile · Semantic Scholar

M. Blaskovich

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M. Blaskovich — researcher profile on SciRah

h-index: 30
Works: 66
Citations: 4,343

Most-cited papers

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
K. Siddiquee, Shumin Zhang, W. Guida, M. Blaskovich +8 more
2007Proceedings of the National Academy of Sciences of the United States of America755 citations Open access
Semantic Scholar
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
M. Blaskovich, Jia-Zhi Sun, A. Cantor, J. Turkson +2 more
2003Cancer Research621 citations
Semantic Scholar
Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes (*)
Edwina C. Lerner, Y. Qian, M. Blaskovich, R. Fossum +6 more
1995Journal of Biological Chemistry380 citations Open access
Semantic Scholar
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Jia-Zhi Sun, M. Blaskovich, David B. Knowles, Yi-Min Qian +4 more
1999Cancer Research230 citations
Semantic Scholar
Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling1
Y. Nefedova, P. Cheng, Daniele M. Gilkes, M. Blaskovich +3 more
2005Journal of Immunology227 citations Open access
Semantic Scholar
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
Jia-Zhi Sun, M. Blaskovich, R. Jove, S. Livingston +2 more
2005Oncogene143 citations Open access
Semantic Scholar
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
Jia-Zhi Sun, M. Blaskovich, Richard Jove, S. Livingston +2 more
2008Oncogene140 citations Open access
Semantic Scholar
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice
M. Blaskovich, Qing Lin, F. Delarue, Jia-Zhi Sun +4 more
2000Nature Biotechnology127 citations
Semantic Scholar
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors
Jia-Zhi Sun, De-an Wang, R. Jain, Adam Carie +7 more
2004Oncogene108 citations
Semantic Scholar
A Non-peptide Mimetic of Ras-CAAX: Selective Inhibition of Farnesyltransferase and Ras Processing (*)
A. Vogt, Y. Qian, M. Blaskovich, R. Fossum +2 more
1995Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.
Yi-Min Qian, M. Blaskovich, M. Saleem, C. Seong +3 more
1994Journal of Biological Chemistry99 citations Open access
Semantic Scholar
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
W. W. Stark, M. Blaskovich, Bruce A. Johnson, Y. Qian +5 more
1998American Journal of Physiology - Lung cellular and Molecular Physiology86 citations
Semantic Scholar
Phase I Trial of a Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Advanced Malignancies
D. Hong, S. Sebti, R. Newman, M. Blaskovich +13 more
2009Clinical Cancer Research85 citations Open access
Semantic Scholar
Inhibition of Protein Geranylgeranylation Causes a Superinduction of Nitric-oxide Synthase-2 by Interleukin-1β in Vascular Smooth Muscle Cells*
J. Finder, J. Litz, M. Blaskovich, T. Mcguire +4 more
1997Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)
T. Gajewski, A. Salama, D. Niedzwiecki, Jeffrey L. Johnson +5 more
2012Journal of Translational Medicine83 citations Open access
Semantic Scholar
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
A. Vasudevan, Y. Qian, A. Vogt, M. Blaskovich +3 more
1999Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Inhibitors of protein farnesyltransferase as novel anticancer agents.
Junko Ohkanda, David B. Knowles, M. Blaskovich, S. Sebti +1 more
2002Current Topics in Medicinal Chemistry70 citations
Semantic Scholar
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Junko Ohkanda, Jeffrey W. Lockman, K. Yokoyama, M. Gelb +7 more
2001Bioorganic & Medicinal Chemistry Letters67 citations Open access
Semantic Scholar
Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy
Aslamuzzaman Kazi, Adam Carie, M. Blaskovich, Cynthia J. Bucher +9 more
2009Molecular and Cellular Biology66 citations Open access
Semantic Scholar
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
F. Delarue, J. Adnane, B. Joshi, M. Blaskovich +8 more
2007Oncogene66 citations Open access
Semantic Scholar
Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor
Jia-Zhi Sun, M. Blaskovich, R. Jain, F. Delarue +9 more
2004Cancer Research65 citations
Semantic Scholar
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling.
P. Epling-Burnette, L. Sokol, Xian-Hong Chen, Fan-Qi Bai +11 more
2008Blood52 citations Open access
Semantic Scholar
Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts.
Xiao-qin Xu, T. Mcguire, M. Blaskovich, S. Sebti +1 more
1996Archives of Biochemistry and Biophysics46 citations
Semantic Scholar
Structure-Based Design and Synthesis of Potent, Ethylenediamine-Based, Mammalian Farnesyltransferase Inhibitors as Anticancer Agents
S. Fletcher, Erin P. Keaney, C. Cummings, M. Blaskovich +11 more
2010Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Dora Carrico, Junko Ohkanda, H. Kendrick, K. Yokoyama +9 more
2004Bioorganic & Medicinal Chemistry45 citations
Semantic Scholar
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
Hai-Ruo Peng, Dora Carrico, Van Thai, M. Blaskovich +4 more
2006Organic and biomolecular chemistry44 citations
Semantic Scholar
Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening.
M. Gasparetto, T. Gentry, S. Sebti, E. O'Bryan +7 more
2004JIM - Journal of Immunological Methods42 citations Open access
Semantic Scholar
Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase
M. Hast, S. Fletcher, C. Cummings, Erin E. Pusateri +7 more
2009Chemistry and Biology37 citations Open access
Semantic Scholar
A Phase I Clinical-Pharmacodynamic Study of the Farnesyltransferase Inhibitor Tipifarnib in Combination with the Proteasome Inhibitor Bortezomib in Advanced Acute Leukemias
J. Lancet, V. Duong, E. Winton, R. Stuart +7 more
2011Clinical Cancer Research34 citations Open access
Semantic Scholar
Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
Xiao-Lei Zhang, M. Blaskovich, K. Forinash, Saïd M. Sebti
2014British Journal of Cancer32 citations Open access
Semantic Scholar
Lysophosphatidic Acid Acyltransferase Beta Regulates mTOR Signaling
M. Blaskovich, Vimala Yendluri, H. Lawrence, N. Lawrence +2 more
2013PLoS ONE29 citations Open access
Semantic Scholar
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Junko Ohkanda, Jeffrey W. Lockman, M. Kothare, Y. Qian +3 more
2002Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
U. Kucich, J. Rosenbloom, Gloria Shen, W. Abrams +5 more
1998Biochemical and Biophysical Research Communications - BBRC28 citations Open access
Semantic Scholar
Peptidomimetic inhibitors of p21ras farnesyltransferase: Hydrophobic functionalization leads to disruption of p21ras membrane association in whole cells
Y. Qian, M. Blaskovich, C. Seong, A. Vogt +2 more
199428 citations
Semantic Scholar
Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
F. Epifano, M. Curini, S. Genovese, M. Blaskovich +2 more
2007Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104.
T. Gajewski, D. Niedzwiecki, Jeffrey Johnson, G. Linette +4 more
2006Journal of Clinical Oncology17 citations
Semantic Scholar
CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.
Terence F. McGuire, Yi-Min Qian, M. Blaskovich, R. Fossum +7 more
1995Biochemical and Biophysical Research Communications - BBRC17 citations
Semantic Scholar
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.
A. Boota, BruceE. Johnson, KEE-L Lee, M. Blaskovich +6 more
2000American Journal of Physiology - Lung cellular and Molecular Physiology16 citations
Semantic Scholar
Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase
M. Kothare, Junko Ohkanda, Jeffrey W. Lockman, Y. Qian +3 more
200012 citations
Semantic Scholar
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
Dora Carrico, M. Blaskovich, Cynthia J. Bucher, S. Sebti +1 more
2005Bioorganic & Medicinal Chemistry11 citations
Semantic Scholar
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Junko Ohkanda, C. Strickland, M. Blaskovich, Dora Carrico +9 more
2006Organic and biomolecular chemistry10 citations
Semantic Scholar
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
Andreas Lundqvist, V. van Hoef, Xiao-Nan Zhang, E. Wennerberg +496 more
2016Journal for ImmunoTherapy of Cancer9 citations Open access
Semantic Scholar
Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces.
S. Machida, K. Usuba, M. Blaskovich, A. Yano +4 more
2008Chemistry8 citations
Semantic Scholar
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
W. W. Stark, M. Blaskovich, B. Johnson, Y. Qian +5 more
1998American Journal of Physiology8 citations
Semantic Scholar
873P In vivo persistence of Iovance tumour-infiltrating lymphocytes LN-145 in cervical cancer patients
A. Jazaeri, V. Gontcharova, M. Blaskovich, K. Kunkalla +3 more
20206 citations Open access
Semantic Scholar
Tipifarnib-mediated suppression of T-bet-dependent signaling pathways
Fan-Qi Bai, A. Villagra, J. Zou, J. Painter +9 more
2011Cancer Immunology and Immunotherapy5 citations Open access
Semantic Scholar
Corrigendum to “Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I” [Bioorg. Med. Chem. Lett. 17 (2007) 2639–2642]
F. Epifano, M. Curini, S. Genovese, M. Blaskovich +2 more
20074 citations Open access
Semantic Scholar
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.
Junko Ohkanda, M. Blaskovich, S. Sebti, A. Hamilton
2003Progress in cell cycle research4 citations
Semantic Scholar
Dynamics of circulating cytokines and chemokines during and after tumor-infiltrating lymphocyte cell therapy with lifileucel in advanced melanoma patients.
Rong-Su Qi, A. Sarnaik, J. M. Kirkwood, J. Larkin +7 more
2024Journal of Clinical Oncology2 citations
Semantic Scholar
Abstract LB-069: Persistence of cryopreserved tumor-infiltrating lymphocyte product lifileucel (LN-144) in C-144-01 study of advanced metastatic melanoma
V. Gontcharova, Samuel Suzuki, M. Simpson-Abelson, M. Blaskovich +1 more
2019Immunology2 citations
Semantic Scholar

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