M. A. Schiffler

Most-cited papers

1. Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.

   P. Jadhav, M. A. Schiffler, K. Gavardinas, Euibong J. Kim +13 more

   2014ACS Medicinal Chemistry Letters66 citations Open access

   Semantic Scholar

   Save

2. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

   M. A. Schiffler, S. Antonysamy, Shobha Bhattachar, K. Campanale +20 more

   2016Journal of Medicinal Chemistry56 citations Open access

   Semantic Scholar

   Save

3. An Enantioselective Total Synthesis of (+)-Peloruside A

   Meredeth A. McGowan, Christian P. Stevenson, M. A. Schiffler, E. Jacobsen

   2010Angewandte Chemie42 citations Open access

   Semantic Scholar

   Save

4. Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

   S. L. Kuklish, S. Antonysamy, Shobha Bhattachar, S. Chandrasekhar +17 more

   2016Bioorganic & Medicinal Chemistry Letters25 citations Open access

   Semantic Scholar

   Save

5. Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia

   S. Chandrasekhar, A. Harvey, Xiao-peng Yu, M. Chambers +8 more

   2016Journal of Pharmacology and Experimental Therapeutics25 citations Open access

   Semantic Scholar

   Save

6. Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.

   B. Norman, M. J. Fisher, M. A. Schiffler, S. L. Kuklish +6 more

   2018Journal of Medicinal Chemistry23 citations

   Semantic Scholar

   Save

7. Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

   K. Partridge, S. Antonysamy, Shobha Bhattachar, S. Chandrasekhar +19 more

   2017Bioorganic & Medicinal Chemistry Letters22 citations Open access

   Semantic Scholar

   Save

8. Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.

   L. Winneroski, M. A. Schiffler, J. Erickson, P. May +15 more

   2015Bioorganic & Medicinal Chemistry18 citations Open access

   Semantic Scholar

   Save

9. Analgesic and anti‐inflammatory properties of novel, selective, and potent EP4 receptor antagonists

   S. Chandrasekhar, Xiao-peng Yu, A. Harvey, J. Oskins +11 more

   2017Pharmacology Research & Perspectives15 citations Open access

   Semantic Scholar

   Save

10. Stereoselective Aldehyde Addition to Rhenium-Coordinated Furans

    M. A. Schiffler, L. Friedman, Benjamin C. Brooks, M. Sabat +1 more

    20036 citations

    Semantic Scholar

    Save

11. Discovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonists.

    M. Blanco, T. Vetman, S. Chandrasekhar, M. J. Fisher +6 more

    2016Bioorganic & Medicinal Chemistry Letters4 citations Open access

    Semantic Scholar

    Save

12. Discovery and characterization of a potent and selective EP4 receptor antagonist.

    M. A. Schiffler, S. Chandrasekhar, M. J. Fisher, A. Harvey +5 more

    2015Bioorganic & Medicinal Chemistry Letters3 citations Open access

    Semantic Scholar

    Save

13. Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain

    M. J. Fisher, M. A. Schiffler, S. L. Kuklish, S. Antonysamy +1 more

    20161 citations

    Semantic Scholar

    Save

14. Synthesis of (+)-Peloruside A

    Meredeth A. McGowan, Christian P. Stevenson, M. A. Schiffler, E. Jacobsen

    20100 citations

    Semantic Scholar

    Save

15. Total synthesis of membrenones A-C, dynamic kinetic hetero-Diels-Alder cycloaddition, and progress toward a total synthesis of peloruside A

    M. A. Schiffler

    20080 citations

    Semantic Scholar

    Save