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C. Freeman · SciRah

Researcher profile · Semantic Scholar

C. Freeman

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C. Freeman — researcher profile on SciRah

h-index: 36
Works: 126
Citations: 6,118

Most-cited papers

Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD
J. Erb-Downward, Deborah L. Thompson, Mei-Lan K. Han, C. Freeman +8 more
2011PLoS ONE950 citations Open access
Semantic Scholar
Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals
Christine M. Bassis, J. Erb-Downward, R. Dickson, C. Freeman +5 more
2015mBio712 citations Open access
Semantic Scholar
Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography.
R. Dickson, J. Erb-Downward, C. Freeman, Lisa McCloskey +3 more
2015Annals of the American Thoracic Society480 citations Open access
Semantic Scholar
Bacterial Topography of the Healthy Human Lower Respiratory Tract
R. Dickson, J. Erb-Downward, C. Freeman, Lisa McCloskey +3 more
2017mBio457 citations Open access
Semantic Scholar
At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease
F. Martinez, Mei-Lan K. Han, J. Allinson, G. Barr +22 more
2018American Journal of Respiratory and Critical Care Medicine229 citations Open access
Semantic Scholar
Sputum or blood eosinophil association with clinical measures of COPD severity in the SPIROMICS cohort
A. Hastie, Fernando J. Martinez, Jeffrey L. Curtis, C. Doerschuk +42 more
2017The Lancet Respiratory Medicine214 citations Open access
Semantic Scholar
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling
Emilie Bourdonnay, Z. Zaslona, L. R. Penke, J. Speth +7 more
2015Journal of Experimental Medicine195 citations Open access
Semantic Scholar
Changes in the Lung Microbiome following Lung Transplantation Include the Emergence of Two Distinct Pseudomonas Species with Distinct Clinical Associations
R. Dickson, J. Erb-Downward, C. Freeman, N. Walker +6 more
2014PLoS ONE179 citations Open access
Semantic Scholar
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
L. Raffield, H. Dang, K. Pratte, S. Jacobson +34 more
2020Proteomics154 citations Open access
Semantic Scholar
Cytotoxic potential of lung CD8+ T cells increases with COPD severity and with in vitro stimulation by IL-18 or IL-15
C. Freeman, Mei-Lan K. Han, F. Martinez, S. Murray +11 more
2010Journal of Immunology128 citations Open access
Semantic Scholar
Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD
Wei Sun, Katerina Kechris, S. Jacobson, M. B. Drummond +41 more
2016PLoS Genetics116 citations Open access
Semantic Scholar
Lung CD8+ T cells in COPD have increased expression of bacterial TLRs
C. Freeman, F. Martinez, Mei-Lan K. Han, G. Washko +6 more
2013Respiratory Research75 citations Open access
Semantic Scholar
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
K. Opron, L. Begley, J. Erb-Downward, C. Freeman +28 more
2021npj Biofilms and Microbiomes65 citations Open access
Semantic Scholar
Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood
C. Freeman, C. Martinez, J. Todt, F. Martinez +4 more
2015Respiratory Research63 citations Open access
Semantic Scholar
The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.
J. Sanders, R. Putman, J. Dupuis, Han-Fei Xu +13 more
2020American Journal of Respiratory and Critical Care Medicine60 citations Open access
Semantic Scholar
Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease
C. Freeman, V. Stolberg, S. Crudgington, F. Martinez +6 more
2014PLoS ONE55 citations Open access
Semantic Scholar
The Immunopathogenesis of Chronic Obstructive Pulmonary Disease
J. Curtis, C. Freeman, J. Hogg
201251 citations
Semantic Scholar
The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS.
V. Ortega, Xing-Nan Li, W. O'Neal, Lela Lackey +51 more
2020American Journal of Respiratory and Critical Care Medicine49 citations Open access
Semantic Scholar
Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report
R. Tighe, E. Redente, Yen-Rei Yu, S. Herold +12 more
2019American Journal of Respiratory Cell and Molecular Biology47 citations Open access
Semantic Scholar
Lung Dendritic Cells: Shaping Immune Responses throughout Chronic Obstructive Pulmonary Disease Progression
C. Freeman, J. Curtis
2016American Journal of Respiratory Cell and Molecular Biology46 citations Open access
Semantic Scholar
Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage COPD.
S. Madapoosi, C. Cruickshank-Quinn, K. Opron, J. Erb-Downward +23 more
2022American Journal of Respiratory and Critical Care Medicine44 citations Open access
Semantic Scholar
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
C. Freeman, S. Crudgington, V. Stolberg, Jeanette P. Brown +15 more
2015Journal of Translational Medicine44 citations Open access
Semantic Scholar
Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL‐15R&agr;
D. Finch, V. Stolberg, John Ferguson, Henrih Alikaj +7 more
2018American Journal of Respiratory and Critical Care Medicine41 citations Open access
Semantic Scholar
Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis
J. Erb-Downward, N. Falkowski, Jennifer D'Souza, Lisa McCloskey +10 more
2020mBio40 citations Open access
Semantic Scholar
Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function
V. Stolberg, A. McCubbrey, C. Freeman, Jeanette P. Brown +5 more
2015Journal of Immunology38 citations Open access
Semantic Scholar
miR-34a negatively regulates efferocytosis by tissue macrophages in part via SIRT1
A. McCubbrey, Joshua D. Nelson, V. Stolberg, Pennelope K. Blakely +4 more
2015Journal of Immunology36 citations Open access
Semantic Scholar
GDF-15 in Pulmonary and Critical Care Medicine.
F. Verhamme, C. Freeman, G. Brusselle, K. Bracke +1 more
2019American Journal of Respiratory Cell and Molecular Biology35 citations Open access
Semantic Scholar
Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function.
P. Mancuso, J. Curtis, C. Freeman, M. Peters-Golden +2 more
2018American Journal of Physiology - Lung cellular and Molecular Physiology35 citations Open access
Semantic Scholar
Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression
J. Todt, C. Freeman, Jeanette P. Brown, J. Sonstein +6 more
2013Respiratory Research34 citations Open access
Semantic Scholar
Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα
A. McCubbrey, J. Sonstein, Theresa M. Ames, C. Freeman +1 more
2012Journal of Immunology31 citations Open access
Semantic Scholar
GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease
C. Martinez, C. Freeman, Joshua D. Nelson, S. Murray +11 more
2017Respiratory Research29 citations Open access
Semantic Scholar
Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure.
V. Stolberg, Brian E. Martin, P. Mancuso, M. Olszewski +3 more
2014American Journal of Pathology25 citations Open access
Semantic Scholar
Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent
C. Freeman, A. McCubbrey, S. Crudgington, Joshua D. Nelson +8 more
2014PLoS ONE24 citations Open access
Semantic Scholar
Easier said than done: ABO compatibility and D matching in apheresis platelet transfusions
N. Dunbar, Matthew C. Katus, C. Freeman, Z. Szczepiorkowski
2015Transfusion23 citations
Semantic Scholar
Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort
C. Martinez, Sara X. Li, Andrew J. Hirzel, Valerie R. Stolberg +23 more
2017Journal of Allergy and Clinical Immunology21 citations Open access
Semantic Scholar
Presence of Tropheryma whipplei in Different Body Sites in a Cohort of Healthy Subjects.
S. Qin, E. Clausen, L. Lucht, H. Michael +4 more
2016American Journal of Respiratory and Critical Care Medicine21 citations Open access
Semantic Scholar
Diet-induced obesity in mice impairs host defense against Klebsiella pneumonia in vivo and glucose transport and bactericidal functions in neutrophils in vitro.
P. Mancuso, J. Curtis, A. M. Weitzel, C. Griffin +4 more
2021American Journal of Physiology - Lung cellular and Molecular Physiology18 citations Open access
Semantic Scholar
Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.
R. Domingo-Gonzalez, C. Wilke, Steven K. Huang, Y. Laouar +5 more
2015American Journal of Physiology - Lung cellular and Molecular Physiology18 citations Open access
Semantic Scholar
Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease
A.M. Pallazola, Jessica X. Rao, D. T. Mengistu, Maria Morcos +6 more
2021American Journal of Physiology - Lung cellular and Molecular Physiology15 citations Open access
Semantic Scholar
"B" for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease.
J. Curtis, C. Freeman, G. Huffnagle
2015American Journal of Respiratory and Critical Care Medicine14 citations Open access
Semantic Scholar
Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS
V. Tejwani, H. Woo, Chen Liu, Anna Tillery +23 more
2022Respiratory Research13 citations Open access
Semantic Scholar
PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
L. R. Penke, J. Speth, C. Draijer, Z. Zaslona +6 more
2020Life Science Alliance13 citations Open access
Semantic Scholar
Murine iNOS expression is essential for antifungal defenses in kidneys during disseminated Cryptococcus deneoformans infection
Kristie D. Goughenour, Jessica Zhao, Jintao Xu, Ziyin P. Zhao +3 more
2021Journal of Immunology12 citations Open access
Semantic Scholar
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
C. Freeman, S. Crudgington, V. Stolberg, Jeanette P. Brown +15 more
2015Journal of Translational Medicine12 citations Open access
Semantic Scholar
Neutrophil-to-Lymphocyte Ratio (NLR) as a Biomarker in Clinically Stable Chronic Obstructive Pulmonary Disease: SPIROMICS cohort.
D. Hoesterey, H. Dang, Daniela Markovic, R. Buhr +31 more
2025Annals of the American Thoracic Society11 citations
Semantic Scholar
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
K. DiLillo, Katy C. Norman, C. Freeman, S. Christenson +29 more
2023Scientific Reports10 citations Open access
Semantic Scholar
The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS
J. M. Wells, D. Xing, L. Viera, Robert M. Burkes +16 more
2019Respiratory Research10 citations Open access
Semantic Scholar
Lung dendritic cells : shaping immune responses throughout COPD progression
C. Freeman, J. Curtis
201610 citations Open access
Semantic Scholar
Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study.
J. Curtis, L. Bateman, Susan Murray, D. Couper +32 more
2024Chronic obstructive pulmonary diseases9 citations Open access
Semantic Scholar
A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in COPD
D. T. Mengistu, Jeffrey L. Curtis, C. Freeman
2024Trends in immunology7 citations Open access
Semantic Scholar

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J. Erb-Downward — researcher profile on SciRah

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S. Christenson — researcher profile on SciRah

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Jeffrey L. Curtis — researcher profile on SciRah