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L. R. Penke · SciRah

Researcher profile · Semantic Scholar

L. R. Penke

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L. R. Penke — researcher profile on SciRah

h-index: 16
Works: 40
Citations: 950

Most-cited papers

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling
Emilie Bourdonnay, Z. Zaslona, L. R. Penke, J. Speth +7 more
2015Journal of Experimental Medicine195 citations Open access
Semantic Scholar
FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis
L. R. Penke, J. Speth, Vijaya L. Dommeti, E. White +2 more
2018Journal of Clinical Investigation104 citations Open access
Semantic Scholar
Prostaglandin E2 Inhibits α-Smooth Muscle Actin Transcription during Myofibroblast Differentiation via Distinct Mechanisms of Modulation of Serum Response Factor and Myocardin-related Transcription Factor-A*
L. R. Penke, Steven K. Huang, E. White, M. Peters-Golden
2014Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions
S. Fortier, L. R. Penke, D. King, T. Pham +2 more
2021JCI Insight75 citations Open access
Semantic Scholar
Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication
D. J. Schneider, J. Speth, L. R. Penke, S. Wettlaufer +2 more
2017Journal of Biological Chemistry73 citations Open access
Semantic Scholar
Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations
C. Draijer, L. R. Penke, M. Peters-Golden
2019Journal of Immunology53 citations Open access
Semantic Scholar
Resident Alveolar Macrophage-Derived Vesicular SOCS3 Dampens Allergic Airway Inflammation
C. Draijer, J. Speth, L. R. Penke, Z. Zaslona +5 more
2020The FASEB Journal41 citations Open access
Semantic Scholar
Molecular Determinants of Mesenchymal Cell Activation in Fibroproliferative Diseases
L. R. Penke, M. Peters-Golden
2019Cellular and Molecular Life Sciences39 citations Open access
Semantic Scholar
Alveolar epithelial cell-derived prostaglandin E2 serves as a request signal for macrophage secretion of suppressor of cytokine signaling 3 during innate inflammation
J. Speth, Emilie Bourdonnay, L. R. Penke, P. Mancuso +3 more
2016Journal of Immunology37 citations Open access
Semantic Scholar
KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis
L. R. Penke, J. Speth, Steven K. Huang, S. Fortier +2 more
2022JCI Insight34 citations Open access
Semantic Scholar
The anti-fibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis
Maya Malaab, L. Renaud, N. Takamura, Kip D. Zimmerman +10 more
2021Annals of the Rheumatic Diseases33 citations Open access
Semantic Scholar
Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics.
J. Speth, L. R. Penke, J. Bazzill, Kyung Soo Park +9 more
2019JCI Insight32 citations Open access
Semantic Scholar
Megakaryocytes compensate for Kit insufficiency in murine arthritis
P. Cunin, L. R. Penke, Jonathan N. Thon, P. Monach +11 more
2017Journal of Clinical Investigation32 citations Open access
Semantic Scholar
MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution
S. Fortier, N. Walker, L. R. Penke, J. Baas +6 more
2024Journal of Clinical Investigation31 citations Open access
Semantic Scholar
Bortezomib inhibits lung fibrosis and fibroblast activation without proteasome inhibition
L. R. Penke, J. Speth, S. Wettlaufer, C. Draijer +1 more
2021bioRxiv19 citations Open access
Semantic Scholar
Distinct PKA regulatory subunits mediate PGE2 inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation.
S. Wettlaufer, L. R. Penke, Katsuhide Okunishi, M. Peters-Golden
2017American Journal of Physiology - Lung cellular and Molecular Physiology17 citations Open access
Semantic Scholar
Alveolar macrophage‐derived extracellular vesicles inhibit endosomal fusion of influenza virus
D. J. Schneider, Katherine A. Smith, Catrina E Latuszek, C. Wilke +8 more
2020EMBO Journal14 citations Open access
Semantic Scholar
PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
L. R. Penke, J. Speth, C. Draijer, Z. Zaslona +6 more
2020Life Science Alliance13 citations Open access
Semantic Scholar
Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts
L. R. Penke, Hideyasu Ouchi, J. Speth, N. Lugogo +3 more
2020Scientific Reports9 citations Open access
Semantic Scholar
Prostaglandin E2 receptors have differential effects on Leishmania major infection
L. R. Penke, R. Sudan, S. Sathishkumar, Biswarup Saha
2013Parasite immunology (Print)9 citations
Semantic Scholar
Illuminating the lung regenerative potential of prostanoids
S. Fortier, L. R. Penke, M. Peters-Golden
2022Science Advances3 citations Open access
Semantic Scholar
Special Delivery: A New Package for an Old Antifibrotic Mediator.
L. R. Penke, M. Peters-Golden
2019American Journal of Respiratory Cell and Molecular Biology2 citations Open access
Semantic Scholar
ATP citrate lyase links increases in glycolysis to diminished release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages
M. D. Haggadone, J. Speth, H. Hong, L. R. Penke +3 more
2022Biochimica et Biophysica Acta - Molecular Basis of Disease1 citations Open access
Semantic Scholar
Mechanisms of Alveolar Macrophage Derived Extracellular Vesicle Defense Against Influenza Infection of Alveolar Epithelial Cells
D. J. Schneider, Katherine A. Smith, J. Speth, C. Wilke +5 more
20201 citations
Semantic Scholar
2165 Vesicular secretion of suppressor of cytokine signaling 3 by alveolar macrophages is dysregulated in NSCLC patients and its provision inhibits epithelial cell transformation and tumor cell function
J. Speth, L. R. Penke, J. Bazzill, D. Arenberg +4 more
2018Journal of Clinical and Translational Science1 citations Open access
Semantic Scholar
Mitogen Activated Protein Kinase Phosphatase 1 Induction Leads to P38 Inhibition and Myofibroblast De-differentiation
N. M. Walker, S. Fortier, J. Speth, L. R. Penke +1 more
2023A66. DISSECTING THE MATRIX AND MESENCHYMAL CELLS IN FIBROSIS0 citations
Semantic Scholar
Inhibition of p38 Promotes Lung Myofibroblast De-Differentiation
S. Fortier, L. R. Penke, M. Peters-Golden
2022A60. PULMONARY FIBROSIS: ANIMAL AND CELL CULTURE MODELS0 citations
Semantic Scholar
Pumping the Brakes on Pulmonary Fibrosis: A New Role for Regulator of Cell Cycle
L. R. Penke, Gina Torres Matias, M. Ballinger
2021American Journal of Respiratory Cell and Molecular Biology0 citations Open access
Semantic Scholar
FGF2 and PGE2 Utilize Distinct Signaling Pathways to Accelerate the Degradation of αSma mRNA in Human Lung Myofibroblasts
S. Fortier, L. R. Penke, M. Peters-Golden
20200 citations
Semantic Scholar
Synthetic Liposomes Containing Suppressor of Cytokine Signaling 3 Protein Dampen Acute Allergic Inflammatory Responses in the Lung
J. Speth, C. Draijer, L. R. Penke, Z. Zaslona +3 more
20200 citations
Semantic Scholar
Novel Proteasome-Independent Anti-Fibrotic Mechanisms of Bortezomib
L. R. Penke, Hideyasu Ouchi, S. Wettlaufer, C. Draijer +1 more
20200 citations
Semantic Scholar
Prostaglandin E2 Inhibits AM Proliferation and Its Levels in the Lung Inversely Correlate with AM Numbers in Models of Cigarette Smoking and Aging
J. Speth, L. R. Penke, C. Draijer, Z. Zaslona +6 more
20200 citations
Semantic Scholar
Synthetic Liposome Mimics of Alveolar Macrophage-Derived Vesicles Containing Suppressor of Cytokine Signaling 3: Inhibitors of Lung Tumor Cell Expansion and Potential Therapeutic for Lung Cancer
J. Speth, L. R. Penke, J. Bazzill, J. Moon +1 more
2019C63. MECHANISTIC STUDIES IN COPD0 citations
Semantic Scholar
Alveolar Macrophage-Derived Extracellular Vesicles Protect Alveolar Epithelial Cells from Influenza Infection
D. J. Schneider, Daniel M. Lyons, C. Wilke, L. R. Penke +3 more
2019C107. GOING VIRAL TO REPAIR0 citations
Semantic Scholar
De-Differentiation of Human Lung Myofibroblasts by FGF2 and PGE2 Involves Accelerated Degradation of αSMA mRNA
S. Fortier, L. R. Penke, M. Peters-Golden
2019C62. FIBROBLAST BIOLOGY0 citations
Semantic Scholar
Kruppel-Like Factor 4 (KLF4): A Brake on Fibroblast Activation and A Target for Pharmacologic Induction in Pulmonary Fibrosis
L. R. Penke, Hideyasu Ouchi, C. Draijer, B. Hu +3 more
2019D17. TOWARDS THE NEXT IPF THERAPIES0 citations
Semantic Scholar
Abstract A35: Vesicular secretion of suppressor of cytokine signaling 3 by alveolar macrophages is dysregulated in NSCLC and its provision inhibits tumor cell function
J. Speth, L. R. Penke, J. Bazzill, D. J. Schneider +4 more
2018Other Topics0 citations
Semantic Scholar
Extracellular Secretion of Suppressor of Cytokine Signaling (SOCS) Proteins by Alveolar Macrophages (AMs)
Emilie Bourdonnay, L. R. Penke, M. Peters-Golden
20130 citations
Semantic Scholar
Modulation of chemokines and chemokine receptors expression in leishmaniasis
L. R. Penke
20100 citations
Semantic Scholar
Colony Stimulating Factor-Induced Metabolic Changes Contribute to AM Proliferation via Akt/mTOR Pathway
J. Speth, L. R. Penke, M. D. Haggadone, C. Draijer +1 more
TP4. TP004 ARDS, SEPSIS, AND TRANSPLANTATION MECHANISTIC STUDIES0 citations Open access
Semantic Scholar

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