E. Doyle

Most-cited papers

1. Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.

   C. Arico-Muendel, Dennis R. Benjamin, T. Caiazzo, Paolo A. Centrella +17 more

   2009Journal of Medicinal Chemistry32 citations

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2. Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis.

   H. Deng, S. Bernier, E. Doyle, J. Lorusso +3 more

   2013ACS Medicinal Chemistry Letters19 citations Open access

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3. Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis.

   Philip N. Collier, H. Twin, Ronald M. A. Knegtel, Dean Boyall +13 more

   2019ACS Medicinal Chemistry Letters15 citations Open access

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4. An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis

   D. Lazarus, E. Doyle, S. Bernier, A. Rogers +9 more

   2008Inflammation Research14 citations

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5. Selective protein kinase Cθ (PKCθ) inhibitors for the treatment of autoimmune diseases.

   A. Curnock, Clare M. Bolton, Peter Chiu, E. Doyle +5 more

   2014Biochemical Society Transactions13 citations

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6. Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.

   G. Evindar, S. Bernier, Malcolm J. Kavarana, E. Doyle +9 more

   2009Bioorganic & Medicinal Chemistry Letters13 citations Open access

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7. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity

   C. Arico-Muendel, B. Belanger, Dennis R. Benjamin, Heather S. Blanchette +17 more

   2013Drug Metabolism And Disposition12 citations Open access

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8. Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.

   G. Evindar, S. Bernier, E. Doyle, Malcolm J. Kavarana +7 more

   2010Bioorganic & Medicinal Chemistry Letters8 citations Open access

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9. Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.

   G. Evindar, A. Satz, S. Bernier, Malcolm J. Kavarana +11 more

   2009Bioorganic & Medicinal Chemistry Letters8 citations Open access

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10. Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.

    C. Arico-Muendel, Heather S. Blanchette, Dennis R. Benjamin, T. Caiazzo +13 more

    2013ACS Medicinal Chemistry Letters7 citations Open access

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11. Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1.

    G. Evindar, H. Deng, S. Bernier, E. Doyle +3 more

    2013Bioorganic & Medicinal Chemistry Letters3 citations Open access

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12. Adaptive Focused Acoustics™ for Nanosuspensions to Enable Pharmacology Assessment of Poorly Soluble Molecules in Lead Optimization.

    K. Stavropoulos, J. Bernhard, K. Nti-Addae, E. Doyle +3 more

    2021Journal of Pharmacy and Science1 citations

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13. DMD048355 814..826

    C. Arico-Muendel, B. Belanger, Dennis R. Benjamin, Heather S. Blanchette +18 more

    20130 citations

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14. Microsoft Word-23905833-file00

    Christopher C. Arico-Muendel, B. Belanger, D. Benjamin, Heather S. Blanchette +15 more

    20130 citations

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