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G. Hannig · SciRah

Researcher profile · Semantic Scholar

G. Hannig

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G. Hannig — researcher profile on SciRah

h-index: 22
Works: 65
Citations: 2,301

Most-cited papers

Strategies for optimizing heterologous protein expression in Escherichia coli.
G. Hannig, S. Makrides
1998Trends in Biotechnology507 citations
Semantic Scholar
Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.
J. Castro, A. Harrington, P. Hughes, C. Martin +15 more
2013Gastroenterology276 citations Open access
Semantic Scholar
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.
R. Busby, A. Bryant, W. Bartolini, Etchell A Cordero +9 more
2010European Journal of Pharmacology218 citations
Semantic Scholar
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.
A. Bryant, R. Busby, W. Bartolini, Etchell A Cordero +9 more
2010Life Science190 citations
Semantic Scholar
Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
R. Busby, Marco M. Kessler, W. Bartolini, A. Bryant +7 more
2013Journal of Pharmacology and Experimental Therapeutics141 citations
Semantic Scholar
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
S. Bernier, D. Lazarus, E. Clark, B. Doyle +4 more
2004Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
Reversible tyrosine phosphorylation and cell cycle control.
Sue Atherton-Fessler, G. Hannig, H. Piwnica-Worms
1993Seminars in Cell Biology74 citations
Semantic Scholar
Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.
L. Grundy, A. Harrington, J. Castro, Sonia Garcia-Caraballo +12 more
2018JCI Insight66 citations Open access
Semantic Scholar
Methionine aminopeptidases type I and type II are essential to control cell proliferation
S. Bernier, Nazbeh Taghizadeh, C. D. Thompson, William F. Westlin +1 more
2005Journal of Cellular Biochemistry65 citations
Semantic Scholar
Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase‐C/cGMP activation
I. Silos-santiago, G. Hannig, H. Eutamène, E. Ustinova +16 more
2013Pain64 citations
Semantic Scholar
Recombinant Glycoproteins That Inhibit Complement Activation and Also Bind the Selectin Adhesion Molecules*
C. Rittershaus, L. Thomas, David P. Miller, M. Picard +14 more
1999Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine
M. Ahsan, B. Tchernychev, Marco M. Kessler, Robert M. Solinga +5 more
2017Physiological Reports46 citations Open access
Semantic Scholar
Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain
G. Hannig, B. Tchernychev, C. Kurtz, A. Bryant +2 more
2014Frontiers in Molecular Neuroscience43 citations Open access
Semantic Scholar
Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris.
Sabine Ottilie, F. Raulf, A. Barnekow, G. Hannig +1 more
1992Oncogene41 citations
Semantic Scholar
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
C. Arico-Muendel, Dennis R. Benjamin, T. Caiazzo, Paolo A. Centrella +17 more
2009Journal of Medicinal Chemistry32 citations
Semantic Scholar
Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscero-visceral cross-talk.
P. Ge, Jing-Mei Ren, A. Harrington, L. Grundy +3 more
2019Pain31 citations Open access
Semantic Scholar
Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458.
G. Hannig, S. Bernier, J. Hoyt, B. Doyle +4 more
2007Arthritis & Rheumatism29 citations
Semantic Scholar
The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
P. Ge, Iris D. Navarro, Marco M. Kessler, S. Bernier +5 more
2016Investigative Ophthalmology and Visual Science28 citations Open access
Semantic Scholar
A tightly regulated high level expression vector that utilizes a thermosensitive lac repressor: production of the human T cell receptor V beta 5.3 in Escherichia coli.
B. Andrews, H. Adari, G. Hannig, E. Lahue +6 more
1996Gene28 citations
Semantic Scholar
Guanylate Cyclase-C agonists as peripherally acting treatments of chronic visceral pain
S. Brierley, L. Grundy, J. Castro, A. Harrington +2 more
2021TIPS - Trends in Pharmacological Sciences24 citations Open access
Semantic Scholar
A Novel Methionine Aminopeptidase-2 Inhibitor, PPI-2458, Inhibits Non–Hodgkin's Lymphoma Cell Proliferation In vitro and In vivo
A. C. Cooper, R. Karp, E. J. Clark, Nazbeh Taghizadeh +6 more
2006Clinical Cancer Research23 citations
Semantic Scholar
MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux
B. Tchernychev, P. Ge, Marco M. Kessler, Robert M. Solinga +10 more
2015Journal of Pharmacology and Experimental Therapeutics22 citations Open access
Semantic Scholar
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
G. Hannig, D. Lazarus, S. Bernier, R. Karp +6 more
2006International Journal of Oncology22 citations Open access
Semantic Scholar
Linaclotide inhibits colonic and urinary bladder hypersensitivity in adult female rats following unpredictable neonatal stress
C. Ligon, E. Mohammadi, P. Ge, G. Hannig +2 more
2018Neurogastroenterology and Motility19 citations
Semantic Scholar
Guanylate cyclase 2C agonism corrects CFTR mutants.
K. Arora, Yun-Jie Huang, K. Mun, Sunitha Yarlagadda +10 more
2017JCI Insight19 citations Open access
Semantic Scholar
Experimentally Induced Bladder Permeability Evokes Bladder Afferent Hypersensitivity in the Absence of Inflammation
L. Grundy, Ashlee Caldwell, A. Lumsden, E. Mohammadi +3 more
2020Frontiers in Neuroscience16 citations Open access
Semantic Scholar
Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization
Ehsan N. Mohammadi, C. Ligon, A. Silos-Santiago, P. Ge +4 more
2018Journal of Pharmacology and Experimental Therapeutics14 citations Open access
Semantic Scholar
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
D. Lazarus, E. Doyle, S. Bernier, A. Rogers +9 more
2008Inflammation Research14 citations
Semantic Scholar
Fumagillin class inhibitors of methionine aminopeptidase-2
S. Bernier, W. Westlin, G. Hannig
200514 citations
Semantic Scholar
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.
G. Evindar, S. Bernier, Malcolm J. Kavarana, E. Doyle +9 more
2009Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
G. T. Milne, P. Sandner, Kathleen A. Lincoln, P. C. Harrison +444 more
2017BMC Pharmacology and Toxicology10 citations Open access
Semantic Scholar
Comparison of the biochemical and biological functions of tyrosine phosphatases from fission yeast, budding yeast and animal cells
G. Hannig, Sabine Ottilie, Andrea R. Schievella, R. L. Erikson
1993Yeast10 citations
Semantic Scholar
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.
G. Evindar, S. Bernier, E. Doyle, Malcolm J. Kavarana +7 more
2010Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
G. Evindar, A. Satz, S. Bernier, Malcolm J. Kavarana +11 more
2009Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Pharmacological Properties, Metabolism and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation #
R. Busby, Marco M. Kessler, W. Bartolini, A. Bryant +7 more
20127 citations
Semantic Scholar
Peripheral Guanylate Cyclase‐C modulation of corticolimbic activation and corticotropin‐releasing factor signaling in a rat model of stress‐induced colonic hypersensitivity
C. Ligon, G. Hannig, B. Greenwood-Van Meerveld
2020Neurogastroenterology and Motility6 citations
Semantic Scholar
561 Chronic Oral Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity
L. Grundy, Sonia Garcia-Carraballo, Jessica Maddern, G. Rychkov +4 more
20163 citations
Semantic Scholar
Su1578 – Chronic Intracolonic Administration of Linaclotide Inhibits Nociceptive Signaling in a Mouse Model of Chronic Visceral Hypersensitivity
J. Castro, A. Harrington, Jessica Maddern, Gudrun Schober +4 more
2019Gastroenterology2 citations
Semantic Scholar
366 Guanylate Cyclase-C Expression Is Down-Regulated in Colonic Biopsies From Female Irritable Bowel Syndrome Patients With Constipation
Sonia Garcia-Carraballo, A. Harrington, J. Castro, G. Hannig +4 more
20162 citations
Semantic Scholar
Mo1146 CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY
A. Harrington, Sonia Garcia-Caraballo, L. Grundy, J. Castro +2 more
20201 citations
Semantic Scholar
Sa1677 – Chronic Colonic Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity
L. Grundy, J. Castro, Jessica Maddern, A. Harrington +3 more
2019Gastroenterology1 citations
Semantic Scholar
Sa1681 – Gc-C Agonism with Linaclotide Attenuates Chronic Stressinduced Colonic Hypersensitivity Independently of Elevated Crf Expression in the Central Nucleus of the Amygdala
C. Ligon, G. Hannig, P. Ge, C. Higgins +1 more
2019Gastroenterology1 citations Open access
Semantic Scholar
Mo1515 - Bile Acid Sequestrant Shows Effects on the Contractile Activity of Ex Vivo Lower Esophageal Sphincter Muscle
Sarah M. Jacobson, G. Hannig, A. Silos-Santiago, M. Currie
20181 citations
Semantic Scholar
Chronic Oral Administration of Linaclotide Inhibits Nociceptive Signalling in Response to Noxious Colorectal Distension in a Model of Chronic Visceral Hypersensitivity
J. Castro, A. Deiteren, A. Harrington, Jessica Maddern +8 more
20171 citations
Semantic Scholar
Extracellular CGMP Reduces the Excitability of Sensory Dorsal Root Ganglion Neurons via an Extracellular Mechanism
L. Grundy, J. Castro, A. Harrington, Stefanie Peters +7 more
20171 citations
Semantic Scholar
Linaclotide-induced electrolyte secretion in human and rat colon: Ussing chamber studies
B. Tchernychev, G. Hannig, David Arthur, P. Ge +2 more
2015BMC Pharmacology and Toxicology1 citations Open access
Semantic Scholar
Mo1752 Linaclotide Induces Endocytosis of the Sodium/Hydrogen Exchanger 3 (NHE3) and Inhibits Sodium Absorption
Nadia A. Ameen, R. Jakab, G. Hannig, B. Tchernychev +2 more
20141 citations
Semantic Scholar
Determination of cGMP levels in rodent tissues following oral dosing of a soluble guanylate cyclase stimulator
Nisha Perez, Christopher Graul, Peter Germano, Erik O. Solberg +7 more
2013BMC Pharmacology and Toxicology1 citations Open access
Semantic Scholar
EP1238: COLORECTAL NOCICEPTIVE PROCESSING IN THE CAUDAL VENTROLATERAL MEDULLA AND THE LATERAL PARABRACHIAL NUCLEI IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT.
A. Harrington, Qing-Qing Wang, G. Hannig, S. Brierley
2022Gastroenterology0 citations
Semantic Scholar
EP1239: DESCENDING PAIN MODULATION OF COLORECTAL NOCICEPTIVE PROCESSING IN THE SPINAL CORD IS IMBALANCED IN A MOUSE MODEL OF POST-COLITIS CHRONIC VISCERAL HYPERSENSITIVITY AND IS REDUCED BY CHRONIC ORAL LINACLOTIDE TREATMENT.
A. Harrington, Gudrun Schober, Jessica Maddern, Qingqing Wang +2 more
2022Gastroenterology0 citations
Semantic Scholar

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C. Kurtz×15
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C. Kurtz — researcher profile on SciRah
S. Brierley×14
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S. Bernier×13
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A. Harrington×12
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P. Ge — researcher profile on SciRah

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I. Silos-santiago×10

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W. Westlin — researcher profile on SciRah

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Marco M. Kessler — researcher profile on SciRah

Robert M. Solinga×8

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A. Bryant — researcher profile on SciRah