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Hitoshi Takizawa · SciRah

Researcher profile · Semantic Scholar

Hitoshi Takizawa

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Hitoshi Takizawa — researcher profile on SciRah

h-index: 34
Works: 105
Citations: 5,195

Most-cited papers

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups
M. Berres, K. P. Lim, T. Peters, J. Price +21 more
2014Journal of Experimental Medicine456 citations Open access
Semantic Scholar
Demand-adapted regulation of early hematopoiesis in infection and inflammation.
Hitoshi Takizawa, Steffen Boettcher, M. Manz
2012Blood408 citations Open access
Semantic Scholar
Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine
A. Rongvaux, Hitoshi Takizawa, T. Strowig, T. Willinger +3 more
2013Annual Review of Immunology365 citations Open access
Semantic Scholar
Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment
Larisa V. Kovtonyuk, K. Fritsch, Xiaomin Feng, M. Manz +1 more
2016Frontiers in Immunology339 citations Open access
Semantic Scholar
Engineering of a functional bone organ through endochondral ossification
C. Scotti, E. Piccinini, Hitoshi Takizawa, A. Todorov +5 more
2013Proceedings of the National Academy of Sciences of the United States of America315 citations Open access
Semantic Scholar
Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness.
Hitoshi Takizawa, K. Fritsch, Larisa V. Kovtonyuk, Yasuyuki Saito +9 more
2017Cell Stem Cell257 citations Open access
Semantic Scholar
Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook
N. Legrand, A. Ploss, R. Balling, P. Becker +28 more
2009Cell Host and Microbe240 citations Open access
Semantic Scholar
Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice
T. Strowig, A. Rongvaux, C. Rathinam, Hitoshi Takizawa +5 more
2011Proceedings of the National Academy of Sciences of the United States of America239 citations Open access
Semantic Scholar
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
T. Willinger, A. Rongvaux, Hitoshi Takizawa, G. Yancopouloš +7 more
2011Proceedings of the National Academy of Sciences of the United States of America238 citations Open access
Semantic Scholar
The analysis, roles and regulation of quiescence in hematopoietic stem cells
A. Nakamura-Ishizu, Hitoshi Takizawa, T. Suda
2014Development211 citations Open access
Semantic Scholar
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
A. Rongvaux, T. Willinger, Hitoshi Takizawa, C. Rathinam +8 more
2010Proceedings of the National Academy of Sciences of the United States of America201 citations Open access
Semantic Scholar
Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells
Steffen Boettcher, Patrick Ziegler, M. A. Schmid, Hitoshi Takizawa +4 more
2012Journal of Immunology152 citations Open access
Semantic Scholar
IL-1 Mediates Microbiome-Induced Inflamm-Ageing of Hematopoietic Stem Cells in Mice.
Larisa V. Kovtonyuk, Francisco Caiado, Santiago García-Martín, E. Manz +7 more
2021Blood143 citations Open access
Semantic Scholar
Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F
P. Lundberg, Hitoshi Takizawa, L. Kubovcakova, G. Guo +5 more
2014Journal of Experimental Medicine101 citations Open access
Semantic Scholar
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.
Hitoshi Takizawa, S. Nishimura, N. Takayama, A. Oda +13 more
2010Journal of Clinical Investigation95 citations Open access
Semantic Scholar
Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.
A. Nakamura-Ishizu, T. Matsumura, P. Stumpf, Terumasa Umemoto +6 more
2018Cell Reports81 citations Open access
Semantic Scholar
Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes.
M. A. Schmid, Hitoshi Takizawa, Dior Baumjohann, Yasuyuki Saito +1 more
2011Blood80 citations Open access
Semantic Scholar
iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity
D. Suzuki, C. Flahou, Norihide Yoshikawa, Ieva Stirblytė +13 more
2019Stem Cell Reports75 citations Open access
Semantic Scholar
Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors
T. Yokomizo, Naoki Watanabe, Terumasa Umemoto, J. Matsuo +15 more
2019Journal of Experimental Medicine74 citations Open access
Semantic Scholar
Remote control of neural function by X-ray-induced scintillation
Takanori Matsubara, T. Yanagida, N. Kawaguchi, Takashi Nakano +10 more
2019Nature Communications62 citations Open access
Semantic Scholar
Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans
N. Mende, Hugo P. Bastos, A. Santoro, K. Mahbubani +20 more
2022Blood60 citations Open access
Semantic Scholar
Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo.
Larisa V. Kovtonyuk, M. Manz, Hitoshi Takizawa
2016Blood48 citations Open access
Semantic Scholar
Macrophage tolerance: CD47–SIRP-α–mediated signals matter
Hitoshi Takizawa, M. Manz
2007Nature Immunology48 citations
Semantic Scholar
Inflammation Regulates Haematopoietic Stem Cells and Their Niche
N. P. Ho, Hitoshi Takizawa
2022International Journal of Molecular Sciences46 citations Open access
Semantic Scholar
Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals.
Hitoshi Takizawa, K. Eto, A. Yoshikawa, H. Nakauchi +2 more
2008Experimental Hematology46 citations Open access
Semantic Scholar
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia
Y. Hayashi, S. Goyama, Xiaoxiao Liu, Moe Tamura +14 more
2019Nature Communications45 citations Open access
Semantic Scholar
MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia.
Philipp J Rauch, J. Ellegast, C. Widmer, K. Fritsch +5 more
2016Blood45 citations Open access
Semantic Scholar
Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity
C. Flahou, T. Morishima, Hitoshi Takizawa, N. Sugimoto
2021Frontiers in Immunology44 citations Open access
Semantic Scholar
Impact of inflammation on early hematopoiesis and the microenvironment
Hitoshi Takizawa, M. Manz
2017International journal of hematology42 citations Open access
Semantic Scholar
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
T. Fukushima, Yosuke Tanaka, F. Hamey, Chih-Hsiang Chang +16 more
2019Cell Reports40 citations Open access
Semantic Scholar
LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance
Patrick Ziegler, Steffen Boettcher, Hitoshi Takizawa, M. Manz +1 more
2015Annals of Hematology40 citations Open access
Semantic Scholar
Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation
M. Sezaki, Yoshikazu Hayashi, Yu-Xin Wang, Alban Johansson +2 more
2020Frontiers in Immunology34 citations Open access
Semantic Scholar
Macrophage tolerance: CD47-SIRP-alpha-mediated signals matter.
Hitoshi Takizawa, M. Manz
2007Nature Immunology34 citations
Semantic Scholar
Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance
S. Wueest, Rouven Mueller, M. Blüher, Flurin Item +8 more
2013EMBO Molecular Medicine33 citations Open access
Semantic Scholar
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia
Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jing-Mei Li +27 more
2022EMBO Molecular Medicine31 citations Open access
Semantic Scholar
A comprehensive surface proteome analysis of myeloid leukemia cell lines for therapeutic antibody development.
Verena Strassberger, Katrin L. Gutbrodt, N. Krall, C. Roesli +4 more
2014Journal of Proteomics30 citations Open access
Semantic Scholar
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors
Yosuke Tanaka, R. Takeda, T. Fukushima, K. Mikami +19 more
2022Nature Communications28 citations Open access
Semantic Scholar
IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer
Tsunenori Yamamoto, Ryouichi Tsunedomi, M. Nakajima, Nobuaki Suzuki +19 more
2023Annals of Surgical Oncology27 citations
Semantic Scholar
Ex vivo expansion of hematopoietic stem cells: mission accomplished?
Hitoshi Takizawa, U. Schanz, M. Manz
2011Swiss medical weekly27 citations Open access
Semantic Scholar
Engineered humanized bone organs maintain human hematopoiesis in vivo.
K. Fritsch, Sébastien Pigeot, Xiaomin Feng, P. Bourgine +4 more
2018Experimental Hematology25 citations Open access
Semantic Scholar
Quantitative analysis of sympathetic and nociceptive innervation across bone marrow regions in mice.
S. Fujita, T. Morikawa, Shinpei Tamaki, M. Sezaki +4 more
2022Experimental Hematology21 citations Open access
Semantic Scholar
Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages
H. Nasser, P. Adhikary, Amira Abdel-Daim, O. Noyori +9 more
2020Cell Death Discovery20 citations Open access
Semantic Scholar
GPRC5C drives branched-chain amino acid metabolism in leukemogenesis
Yu-Wei Zhang, T. Velasco-Hernández, Julian Mess, M. Lalioti +22 more
2023Blood Advances19 citations Open access
Semantic Scholar
Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness.
Hitoshi Takizawa, K. Fritsch, Larisa V. Kovtonyuk, Yasuyuki Saito +9 more
2020Cell Stem Cell16 citations Open access
Semantic Scholar
Hematopoietic stem and progenitor cells integrate microbial signals to promote post‐inflammation gut tissue repair
M. Sezaki, Yoshikazu Hayashi, G. Nakato, Yu-Xin Wang +11 more
2022EMBO Journal15 citations Open access
Semantic Scholar
Autophagy is dispensable for the maintenance of hematopoietic stem cells in neonates.
M. Hashimoto, Terumasa Umemoto, A. Nakamura-Ishizu, T. Matsumura +4 more
2021Blood Advances15 citations Open access
Semantic Scholar
Fate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs
P. Bourgine, K. Fritsch, Sébastien Pigeot, Hitoshi Takizawa +6 more
2019iScience14 citations Open access
Semantic Scholar
Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes
N. Mende, Hugo P. Bastos, A. Santoro, K. Sham +7 more
2020bioRxiv13 citations Open access
Semantic Scholar
Development of the hematopoietic system: Role of inflammatory factors
Yoshikazu Hayashi, M. Sezaki, Hitoshi Takizawa
2019Wiley Interdisciplinary Reviews: Developmental Biology13 citations
Semantic Scholar
Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs
Takako Yokomizo-Nakano, Ai Hamashima, Sho Kubota, Jie Bai +12 more
2023Journal of Experimental Medicine10 citations Open access
Semantic Scholar

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