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Kristian W. Kaufmann · SciRah

Researcher profile · Semantic Scholar

Kristian W. Kaufmann

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Kristian W. Kaufmann — researcher profile on SciRah

h-index: 15
Works: 31
Citations: 1,012

Most-cited papers

Practically Useful: What the Rosetta Protein Modeling Suite Can Do for You
Kristian W. Kaufmann, G. Lemmon, Samuel L. DeLuca, Jonathan H. Sheehan +1 more
2010Biochemistry409 citations Open access
Semantic Scholar
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Kristian W. Kaufmann, Ian M. Romaine, Emily L. Days, C. Pascual +13 more
2013ACS Chemical Neuroscience148 citations Open access
Semantic Scholar
Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies
Kristian W. Kaufmann, Eric S. Dawson, L. Henry, Julie R. Field +2 more
2009Proteins: Structure, Function, and Bioinformatics58 citations Open access
Semantic Scholar
Using RosettaLigand for Small Molecule Docking into Comparative Models
Kristian W. Kaufmann, J. Meiler
2012PLoS ONE55 citations Open access
Semantic Scholar
RosettaEPR: Rotamer Library for Spin Label Structure and Dynamics
Nathan Alexander, R. Stein, H. A. Koteiche, Kristian W. Kaufmann +2 more
2013PLoS ONE44 citations Open access
Semantic Scholar
A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport*
L. Henry, H. Iwamoto, Julie R. Field, Kristian W. Kaufmann +13 more
2011Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y4 Receptor Binding Pocket*
Xavier Pedragosa-Badia, Gregory Sliwoski, Elizabeth Dong Nguyen, D. Lindner +4 more
2013Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Design and directed evolution of a dideoxy purine nucleoside phosphorylase.
D. Nannemann, Kristian W. Kaufmann, J. Meiler, B. Bachmann
2010Protein engineering, design & selection : PEDS28 citations Open access
Semantic Scholar
Octarellin VI: Using Rosetta to Design a Putative Artificial (β/α)8 Protein
Maximiliano Figueroa, N. Oliveira, Annabelle Lejeune, Kristian W. Kaufmann +5 more
2013PLoS ONE27 citations Open access
Semantic Scholar
Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors
W. Wen, Wen-Jun Wu, Ian M. Romaine, Kristian W. Kaufmann +4 more
2013Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
A physical model for PDZ-domain/peptide interactions
Kristian W. Kaufmann, N. Shen, L. Mizoue, J. Meiler
2010Journal of Molecular Modeling25 citations Open access
Semantic Scholar
Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators
Susan J. Ramos-Hunter, Darren W. Engers, Kristian W. Kaufmann, Yu Du +3 more
2013Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling.
Yu Du, Emily L. Days, Ian M. Romaine, Kristopher K. Abney +5 more
2015ACS Chemical Neuroscience20 citations
Semantic Scholar
Computational design of an endo-1,4-b -xylanase ligand binding site
Andrew Morin, Kristian W. Kaufmann, C. Fortenberry, J. Harp +2 more
201118 citations
Semantic Scholar
Prediction of HIV-1 Protease/Inhibitor Affinity using RosettaLigand
G. Lemmon, Kristian W. Kaufmann, J. Meiler
2012Chemical Biology and Drug Design17 citations Open access
Semantic Scholar
Y95 and E444 interaction required for high-affinity S-citalopram binding in the human serotonin transporter.
Steven A. Combs, Kristian W. Kaufmann, Julie R. Field, R. Blakely +1 more
2011ACS Chemical Neuroscience15 citations Open access
Semantic Scholar
Ligand-mimicking Receptor Variant Discloses Binding and Activation Mode of Prolactin-releasing Peptide*
D. Rathmann, D. Lindner, Stephanie H. DeLuca, Kristian W. Kaufmann +2 more
2012Journal of Biological Chemistry11 citations Open access
Semantic Scholar
Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel
Emily L. Days, Kristian W. Kaufmann, Ian M. Romaine, C. Niswender +12 more
20139 citations
Semantic Scholar
Small Molecule Rotamers Enable Simultaneous Optimization of Small Molecule and Protein Degrees of Freedom in R OSETTA L IGAND Docking
Kristian W. Kaufmann, Kristin L. Glab, Ralf Mueller, J. Meiler
20089 citations
Semantic Scholar
Simultaneous prediction of binding free energy and specificity for PDZ domain-peptide interactions
J. Crivelli, G. Lemmon, Kristian W. Kaufmann, J. Meiler
2013Journal of Computer-Aided Molecular Design2 citations Open access
Semantic Scholar
A CONSERVED ASPARAGINE RESIDUE IN TM 1 OF THE SEROTONIN TRANSPORTER DICTATES CHLORIDE-COUPLED NEUROTRANSMITTER TRANSPORT
L. Henry, H. Iwamoto, Julie R. Field, Kristian W. Kaufmann +13 more
20112 citations
Semantic Scholar
Rosettaepr: Developing Protein Structure Prediction Methods using Sparse SDSL-EPR Data
Stephanie Hirst, Nathan Alexander, Kristian W. Kaufmann, H. Mchaourab +1 more
20101 citations Open access
Semantic Scholar
Receptor Binding Pocket 4 Y Two Hydrophobic Domains of the Human Pancreatic Polypeptide Is Recognized by Signal Transduction :
Xavier Pedragosa-Badia, Gregory Sliwoski, E. Nguyen, D. Lindner +4 more
20140 citations
Semantic Scholar
Table 3, In vitro DMPK Profile of ML298
Emily Days, Kristian W. Kaufmann, Ian M. Romaine, C. Niswender +12 more
20130 citations
Semantic Scholar
Figure 2, Compound Preparation of Probe ML297
Emily L. Days, Kristian W. Kaufmann, Ian M. Romaine, C. Niswender +12 more
20130 citations
Semantic Scholar
Table 1, Stability of ML297
Emily L. Days, Kristian W. Kaufmann, Ian M. Romaine, C. Niswender +12 more
20130 citations
Semantic Scholar
Figure 3, Shown are fits to data obtained by performing thallium flux and voltage-clamp assays on Probe ML297 at varying concentrations with cells expressing GIRK1/GIRK2
Emily L. Days, Kristian W. Kaufmann, Ian M. Romaine, C. Niswender +12 more
20130 citations
Semantic Scholar
Computational prediction of protein small molecule interfaces using ROSETTA
Kristian W. Kaufmann
20110 citations
Semantic Scholar
Conformational Changes of CaMKII: A Model of Activation
Laurel Hoffman, Kristian W. Kaufmann, R. Colbran, J. Meiler +1 more
20100 citations Open access
Semantic Scholar
Serotonin and Supermodels: Model‐guided exploration of hSERT TM6
Julie R. Field, Kristian W. Kaufmann, L. Henry, Eric S. Dawson +2 more
20080 citations
Semantic Scholar
Small Molecules as Rotamers: Generation and Docking in RosettaLigand
Kristian W. Kaufmann, J. Meiler
2008German Conference on Bioinformatics0 citations
Semantic Scholar

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