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A. Higginbottom · SciRah

Researcher profile · Semantic Scholar

A. Higginbottom

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A. Higginbottom — researcher profile on SciRah

h-index: 38
Works: 81
Citations: 5,319

Most-cited papers

Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81
M. Flint, C. Maidens, Lawrence D. Loomis-Price, C. Shotton +5 more
1999Journal of Virology530 citations Open access
Semantic Scholar
CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection
Jie Zhang, G. Randall, A. Higginbottom, P. Monk +2 more
2004Journal of Virology414 citations Open access
Semantic Scholar
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions
J. Cooper-Knock, Matthew J. Walsh, A. Higginbottom, J. R. Highley +8 more
2014Brain : a journal of neurology307 citations Open access
Semantic Scholar
Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)
L. E. Cox, L. Ferraiuolo, E. Goodall, P. Heath +12 more
2010PLoS ONE275 citations Open access
Semantic Scholar
Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2
A. Higginbottom, E. Quinn, C. Kuo, M. Flint +6 more
2000Journal of Virology255 citations Open access
Semantic Scholar
Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation.
O. Barreiro, M. Yáñez-Mó, Mónica Sala-Valdés, M. Gutiérrez-López +5 more
2005Blood235 citations Open access
Semantic Scholar
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis
Hagai Marmor-Kollet, Aviad Siany, N. Kedersha, Naama Knafo +23 more
2020bioRxiv222 citations Open access
Semantic Scholar
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
Christopher P. Webster, Emma F. Smith, C. Bauer, Annekathrin Moller +11 more
2016EMBO Journal216 citations Open access
Semantic Scholar
Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.
L. Ferraiuolo, A. Higginbottom, P. Heath, S. Barber +3 more
2011Brain : a journal of neurology198 citations Open access
Semantic Scholar
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
J. Cooper-Knock, A. Higginbottom, Matthew J. Stopford, J. R. Highley +6 more
2015Acta Neuropathologica163 citations Open access
Semantic Scholar
C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair
C. Walker, Saúl Herranz-Martín, Evangelia Karyka, C. Liao +18 more
2017Nature Neuroscience156 citations Open access
Semantic Scholar
Loss of nuclear TDP‐43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones
J. R. Highley, J. Kirby, Joeri A. Jansweijer, Philip S. Webb +10 more
2014Neuropathology and Applied Neurobiology140 citations
Semantic Scholar
PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons.
K. Ning, C. Drepper, C. F. Valori, M. Ahsan +6 more
2010Human Molecular Genetics132 citations
Semantic Scholar
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
G. Hautbergue, L. Castelli, L. Ferraiuolo, Alvaro Sanchez‐Martinez +22 more
2017Nature Communications129 citations Open access
Semantic Scholar
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
Scott P. Allen, Benjamin J. Hall, L. Castelli, Laura Francis +19 more
2019Brain : a journal of neurology98 citations Open access
Semantic Scholar
C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis
J. Cooper-Knock, Joanna J. Bury, P. Heath, Matthew D. Wyles +7 more
2015PLoS ONE98 citations Open access
Semantic Scholar
An in vitro screening cascade to identify neuroprotective antioxidants in ALS
S. Barber, A. Higginbottom, R. Mead, S. Barber +1 more
2009Free Radical Biology & Medicine96 citations Open access
Semantic Scholar
Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis.
Scott P. Allen, S. Rajan, L. Duffy, H. Mortiboys +3 more
2014Neurobiology of Aging91 citations
Semantic Scholar
Recombinant Extracellular Domains of Tetraspanin Proteins Are Potent Inhibitors of the Infection of Macrophages by Human Immunodeficiency Virus Type 1
S. Ho, F. Martin, A. Higginbottom, L. Partridge +5 more
2006Journal of Virology91 citations
Semantic Scholar
A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening
Marc M. J. Da Costa, Claire E. Allen, A. Higginbottom, T. Ramesh +2 more
2013Disease Models & Mechanisms71 citations Open access
Semantic Scholar
Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells
V. Parthasarathy, F. Martin, A. Higginbottom, H. Murray +6 more
2009Immunology71 citations Open access
Semantic Scholar
Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis
J. Cooper-Knock, T. Moll, T. Ramesh, L. Castelli +25 more
2019Cell Reports70 citations Open access
Semantic Scholar
THE ROLE OF THE N-TERMINAL DOMAIN OF THE COMPLEMENT FRAGMENT RECEPTOR, C5L2, IN LIGAND BINDING
A. Scola, A. Higginbottom, L. Partridge, R. Reid +4 more
2006Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion.
A. Higginbottom, Yuji Takahashi, Laura C. Bolling, S. Coonrod +3 more
2003Biochemical and Biophysical Research Communications - BBRC67 citations
Semantic Scholar
Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.
C. Wood-Allum, S. Barber, J. Kirby, P. Heath +8 more
2006Brain : a journal of neurology66 citations Open access
Semantic Scholar
Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation
V. Buchman, J. Cooper-Knock, Natalie Connor-Robson, A. Higginbottom +4 more
2013Molecular Neurodegeneration64 citations Open access
Semantic Scholar
S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis
R. Mead, A. Higginbottom, Scott P. Allen, J. Kirby +9 more
2013Free Radical Biology & Medicine62 citations Open access
Semantic Scholar
Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features
M. Shaw, A. Higginbottom, A. McGown, L. Castelli +4 more
2018Acta Neuropathologica Communications61 citations Open access
Semantic Scholar
Comparative Agonist/Antagonist Responses in Mutant Human C5a Receptors Define the Ligand Binding Site*
A. Higginbottom, Stuart A. Cain, T. Woodruff, Lavinia M. Proctor +5 more
2005Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Zengjie Xia, Emily E. Prescott, Agnieszka Urbanek, H. Wareing +27 more
2021bioRxiv55 citations Open access
Semantic Scholar
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons
M. Vogt, Zahra Ehsaei, P. Knuckles, A. Higginbottom +9 more
2018Scientific Reports55 citations Open access
Semantic Scholar
A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort
J. Simpson, P. Ince, F. Matthews, Pamela J. Shaw +5 more
2015Neuropathology and Applied Neurobiology54 citations Open access
Semantic Scholar
Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis
Alejandro Lorente Pons, A. Higginbottom, J. Cooper-Knock, A. Alrafiah +5 more
2020Journal of Pathology51 citations Open access
Semantic Scholar
Viral Delivery of Antioxidant Genes as a Therapeutic Strategy in Experimental Models of Amyotrophic Lateral Sclerosis
Aikaterini Nanou, A. Higginbottom, C. F. Valori, Matthew D. Wyles +3 more
2013Molecular Therapy49 citations Open access
Semantic Scholar
Mutations in CHMP 2 B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis ( ALS )
L. E. Cox, L. Ferraiuolo, E. Goodall, P. Heath +12 more
201049 citations
Semantic Scholar
Oligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP‐43‐negative inclusions of C9ORF72‐ALS
Joanna J. Bury, J. R. Highley, J. Cooper-Knock, E. Goodall +5 more
2016Neuropathology (Kyoto. 1993)47 citations
Semantic Scholar
Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response
A. J. Wright, A. Higginbottom, D. Philippe, A. Upadhyay +4 more
2007Molecular Immunology44 citations Open access
Semantic Scholar
Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS
T. Iannitti, Joseph M. Scarrott, S. Likhite, Ian Coldicott +11 more
2018Molecular Therapy: Nucleic Acids43 citations Open access
Semantic Scholar
Identification of the High Affinity Receptor Binding Region in Human Immunoglobulin E (*)
B. Helm, I. Sayers, A. Higginbottom, D. Machado +4 more
1996Journal of Biological Chemistry37 citations Open access
Semantic Scholar
S19 ribosomal protein dimer augments metal‐induced apoptosis in a mouse fibroblastic cell line by ligation of the C5a receptor
H. Nishiura, S. Tanase, Y. Shibuya, Noriko Futa +5 more
2005Journal of Cellular Biochemistry33 citations
Semantic Scholar
Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits
Saúl Herranz-Martín, Jayanth S. Chandran, Katherine E. A. Lewis, P. Mulcahy +11 more
2017Disease Models & Mechanisms32 citations Open access
Semantic Scholar
Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype
J. Cooper-Knock, H. Robins, Isabell Niedermoser, Matthew D. Wyles +9 more
2017Frontiers in Molecular Neuroscience32 citations Open access
Semantic Scholar
C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles
J. Cooper-Knock, A. Higginbottom, Natalie Connor-Robson, N. Bayatti +5 more
2013Neurology31 citations Open access
Semantic Scholar
PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons
D.-J. Yang, X.-L. Wang, A. Ismail, Cj Ashman +9 more
2014Cell Death and Disease28 citations Open access
Semantic Scholar
C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten
Matthew J. Stopford, A. Higginbottom, G. Hautbergue, J. Cooper-Knock +11 more
2017Human Molecular Genetics27 citations Open access
Semantic Scholar
Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation
Rachel S. Hulme, A. Higginbottom, J. Palmer, L. Partridge +1 more
2014PLoS ONE21 citations Open access
Semantic Scholar
Antibody cross‐linking of human CD9 and the high‐affinity immunoglobulin E receptor stimulates secretion from transfected rat basophilic leukaemia cells
A. Higginbottom, I. Wilkinson, B. McCullough, F. Lanza +3 more
2000Immunology19 citations Open access
Semantic Scholar
Prospects for gene replacement therapies in amyotrophic lateral sclerosis
I. Giovannelli, A. Higginbottom, J. Kirby, M. Azzouz +1 more
2022Nature Reviews Neurology18 citations
Semantic Scholar
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins
L. Castelli, Ya-Hui Lin, Alvaro Sanchez‐Martinez, Aytaç Gül +18 more
2023Science Translational Medicine14 citations Open access
Semantic Scholar
Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology
Alexander M. Beer, J. Cooper-Knock, A. Higginbottom, J. R. Highley +7 more
2015Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration13 citations
Semantic Scholar

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J. Cooper-Knock×13
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