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A. Bertolotti · SciRah

Researcher profile · Semantic Scholar

A. Bertolotti

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A. Bertolotti — researcher profile on SciRah

h-index: 34
Works: 67
Citations: 16K

Most-cited papers

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
F. Urano, Xiaozhong Wang, A. Bertolotti, Yu-Hong Zhang +3 more
2000Science3,062 citations
Semantic Scholar
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
A. Bertolotti, Yu-Hong Zhang, L. Hendershot, H. Harding +1 more
2000Nature Cell Biology2,919 citations
Semantic Scholar
Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded
H. Harding, Yu-Hong Zhang, A. Bertolotti, Hui-Qing Zeng +1 more
20002,030 citations
Semantic Scholar
Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652
D. Klionsky, K. Abdelmohsen, A. Abe, M. Abedin +496 more
20161,544 citations Open access
Semantic Scholar
Sustained translational repression by eIF2α–P mediates prion neurodegeneration
Julie A. Moreno, H. Radford, Diego Peretti, J. Steinert +12 more
2012Nature638 citations Open access
Semantic Scholar
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
P. Tsaytler, H. Harding, D. Ron, A. Bertolotti
2011Science545 citations
Semantic Scholar
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
C. Münch, J. O'Brien, A. Bertolotti
2011Proceedings of the National Academy of Sciences of the United States of America496 citations Open access
Semantic Scholar
Regulation of proteasome assembly and activity in health and disease
A. Rousseau, A. Bertolotti
2018Nature reviews. Molecular cell biology448 citations Open access
Semantic Scholar
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice.
A. Bertolotti, Xiaozhong Wang, I. Novoa, Rivka Jungreis +4 more
2001Journal of Clinical Investigation434 citations Open access
Semantic Scholar
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
I. Das, Agnieszka Krzyzosiak, Kim Schneider, L. Wrabetz +4 more
2015Science423 citations Open access
Semantic Scholar
hTAF(II)68, a novel RNA/ssDNA‐binding protein with homology to the pro‐oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.
A. Bertolotti, Y. Lutz, David J. Heard, P. Chambon +1 more
1996EMBO Journal369 citations Open access
Semantic Scholar
Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition
A. Suraweera, C. Münch, Ariane Hanssum, A. Bertolotti
2012Molecules and Cells310 citations Open access
Semantic Scholar
EWS, but Not EWS-FLI-1, Is Associated with Both TFIID and RNA Polymerase II: Interactions between Two Members of the TET Family, EWS and hTAFII68, and Subunits of TFIID and RNA Polymerase II Complexes
A. Bertolotti, T. Melot, J. Acker, M. Vigneron +2 more
1998Molecular and Cellular Biology289 citations Open access
Semantic Scholar
IRE1 and efferent signaling from the endoplasmic reticulum.
F. Urano, A. Bertolotti, D. Ron
2000Journal of Cell Science287 citations
Semantic Scholar
Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1α
M. Marcu, M. Doyle, A. Bertolotti, D. Ron +2 more
2002Molecular and Cellular Biology211 citations Open access
Semantic Scholar
An evolutionarily conserved pathway controls proteasome homeostasis
A. Rousseau, A. Bertolotti
2016Nature168 citations Open access
Semantic Scholar
Critical Role of the Proline-rich Region in Huntingtin for Aggregation and Cytotoxicity in Yeast*
B. Dehay, A. Bertolotti
2006Journal of Biological Chemistry152 citations Open access
Semantic Scholar
Exposure of Hydrophobic Surfaces Initiates Aggregation of Diverse ALS-Causing Superoxide Dismutase-1 Mutants
C. Münch, A. Bertolotti
2010Journal of Molecular Biology142 citations Open access
Semantic Scholar
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
Agnieszka Krzyzosiak, A. Sigurdardottir, L. Luh, Marta Carrara +3 more
2018Cell125 citations Open access
Semantic Scholar
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
M. Marcu, M. Doyle, A. Bertolotti, D. Ron +2 more
2002Molecular and Cellular Biology112 citations
Semantic Scholar
Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors
Marta Carrara, A. Sigurdardottir, A. Bertolotti
2017Nature Structural &Molecular Biology85 citations Open access
Semantic Scholar
The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties
A. Bertolotti, B. Bell, L. Tora
1999Oncogene85 citations
Semantic Scholar
Activation of the integrated stress response by inhibitors of its kinases
Maria Szaruga, Dino A. Janssen, Claudia De Miguel, George Hodgson +4 more
2023Nature Communications80 citations Open access
Semantic Scholar
An Inducible Chaperone Adapts Proteasome Assembly to Stress
Ariane Hanssum, Zhen Zhong, A. Rousseau, Agnieszka Krzyzosiak +2 more
2014Molecules and Cells76 citations Open access
Semantic Scholar
Coping with Protein Quality Control Failure.
Esther Pilla, Kim Schneider, A. Bertolotti
2017Annual Review of Cell and Developmental Biology71 citations
Semantic Scholar
Surviving protein quality control catastrophes – from cells to organisms
Kim Schneider, A. Bertolotti
2015Journal of Cell Science58 citations Open access
Semantic Scholar
Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.
H. Harding, I. Novoa, A. Bertolotti, H. Zeng +4 more
2001Cold Spring Harbor Symposia on Quantitative Biology58 citations
Semantic Scholar
Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones
Erwann Rousseau, R. Kojima, G. Hoffner, P. Djian +1 more
2009Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation
Erwann Rousseau, B. Dehay, Léa Ben-Haı̈em, Y. Trottier +2 more
2004Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
D. Klionsky, K. Abdelmohsen, A. Abe, J. Abedin +496 more
201650 citations Open access
Semantic Scholar
Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention
P. Tsaytler, A. Bertolotti
2013The FEBS Journal50 citations
Semantic Scholar
The split protein phosphatase system
A. Bertolotti
2018Biochemical Journal45 citations Open access
Semantic Scholar
Prion-like protein aggregates exploit the RHO to cofilin-1 signaling pathway to enter cells
Zhen Zhong, L. Grasso, Caroline Sibilla, T. Stevens +2 more
2018EMBO Journal36 citations Open access
Semantic Scholar
Propagation of the prion phenomenon: beyond the seeding principle.
C. Münch, A. Bertolotti
2012Journal of Molecular Biology35 citations
Semantic Scholar
Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy.
Caroline Sibilla, A. Bertolotti
2017Cold Spring Harbor Perspectives in Biology32 citations Open access
Semantic Scholar
Self-propagation and transmission of misfolded mutant SOD1: Prion or prion-like phenomenon?
C. Münch, A. Bertolotti
2011Cell Cycle29 citations Open access
Semantic Scholar
Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation
Kim Schneider, G. M. Nelson, Joseph L. Watson, Jörg Morf +4 more
2020Cell Reports27 citations Open access
Semantic Scholar
Alterations in an IRE1-RNA complex in the mammalian unfolded protein response.
A. Bertolotti, David Ron
2001Journal of Cell Science27 citations
Semantic Scholar
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response
Aleksandra P. Pitera, Maria Szaruga, S. Peak-Chew, S. Wingett +1 more
2022EMBO Journal26 citations Open access
Semantic Scholar
Potential benefit of manipulating protein quality control systems in neurodegenerative diseases.
L. Luh, A. Bertolotti
2020Current Opinion in Neurobiology24 citations
Semantic Scholar
Importance of the subcellular location of protein deposits in neurodegenerative diseases.
A. Bertolotti
2018Current Opinion in Neurobiology19 citations
Semantic Scholar
qMotor, a set of rules for sensitive, robust and quantitative measurements of motor performances in mice
L. Luh, I. Das, A. Bertolotti
2016Nature Protocols19 citations Open access
Semantic Scholar
Lymphomatoid papulosis type D: an aggressive histology for an indolent disease
A. Bertolotti, A. Pham-Ledard, B. Vergier, M. Parrens +2 more
2013British Journal of Dermatology19 citations
Semantic Scholar
Integrated stress response activator halofuginone protects mice from diabetes-like phenotypes
Shashank Rai, Maria Szaruga, Aleksandra P. Pitera, A. Bertolotti
2024Journal of Cell Biology17 citations Open access
Semantic Scholar
Perk is essential for translational regulation and cell survival during the unfolded protein response.
Heather P. Harding, Yu-Hong Zhang, A. Bertolotti, Hui-Qing Zeng +1 more
2000Molecules and Cells17 citations Open access
Semantic Scholar
Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity.
B. Dehay, C. Weber, Y. Trottier, A. Bertolotti
2007Biotechnology Journal15 citations
Semantic Scholar
[Two cases of proliferation of monoclonal and monotypic lymphocytes and plasma cells corresponding to acrodermatitis chronica atrophicans].
A. Bertolotti, A. Pham-Ledard, D. Petrot, M. Coindre +4 more
2014Annales de dermatologie et de vénéréologie10 citations
Semantic Scholar
Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B
Agnieszka Fatalska, George Hodgson, Stefan M. V. Freund, Sarah L. Maslen +7 more
2023Molecules and Cells9 citations Open access
Semantic Scholar
An Overview of Methods for Detecting eIF2α Phosphorylation and the Integrated Stress Response.
Agnieszka Krzyzosiak, Aleksandra P. Pitera, A. Bertolotti
2022Methods in molecular biology8 citations
Semantic Scholar
Erdheim-Chester disease: a rare diagnosis with evocative imaging.
N. Alberti, N. Frulio, A. Bertolotti, F. Petitpierre +7 more
2013Diagnostic and Interventional Imaging7 citations Open access
Semantic Scholar

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B. Dehay×5
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L. Luh — researcher profile on SciRah

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Aleksandra P. Pitera — researcher profile on SciRah

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