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D. Kovacs · SciRah

Researcher profile · Semantic Scholar

D. Kovacs

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D. Kovacs — researcher profile on SciRah

h-index: 41
Works: 92
Citations: 8,623

Most-cited papers

A three-dimensional human neural cell culture model of Alzheimer’s disease
Se-Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski +15 more
2014Nature1,110 citations Open access
Semantic Scholar
Alzheimer's disease: the cholesterol connection
L. Puglielli, R. Tanzi, D. Kovacs
2003Nature Neuroscience870 citations
Semantic Scholar
Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells
D. Kovacs, Hillary J. Fausett, K. Page, Tae-Wan Kim +9 more
1996Nature Medicine581 citations
Semantic Scholar
The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential
R. Vassar, D. Kovacs, Riqiang Yan, P. Wong
2009Journal of Neuroscience519 citations Open access
Semantic Scholar
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide
L. Puglielli, G. Konopka, E. Pack-Chung, L. MacKenzie-Ingano +5 more
2001Nature Cell Biology470 citations
Semantic Scholar
The Many Substrates of Presenilin/γ-Secretase
A. Haapasalo, D. Kovacs
2011Journal of Alzheimer's Disease397 citations Open access
Semantic Scholar
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
Tae-Wan Kim, W. Pettingell, Y. Jung, D. Kovacs +1 more
1997Science358 citations
Semantic Scholar
BACE1 regulates voltage-gated sodium channels and neuronal activity
D. Y. Kim, Bryce W. Carey, Haibin Wang, L. MacKenzie-Ingano +7 more
2007Nature Cell Biology320 citations Open access
Semantic Scholar
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.
B. Hutter-Paier, H. Huttunen, L. Puglielli, C. Eckman +7 more
2004Neuron276 citations Open access
Semantic Scholar
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.
M. Palmert, T. E. Golde, M. Cohen, D. Kovacs +5 more
1988Science243 citations
Semantic Scholar
REVIEWThe Gene Defects Responsible for Familial Alzheimer's Disease
R. Tanzi, D. Kovacs, Tae-Wan Kim, R. Moir +2 more
1996237 citations
Semantic Scholar
Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts
R. Bhattacharyya, C. Barren, D. Kovacs
2013Journal of Neuroscience173 citations Open access
Semantic Scholar
Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage*
D. Y. Kim, L. MacKenzie-Ingano, D. Kovacs
2002Journal of Biological Chemistry154 citations Open access
Semantic Scholar
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
M. Seeger, C. Nordstedt, S. Petanceska, D. Kovacs +11 more
1997Proceedings of the National Academy of Sciences of the United States of America153 citations Open access
Semantic Scholar
The gene defects responsible for familial Alzheimer's disease.
R. Tanzi, D. Kovacs, T. Kim, R. Moir +2 more
1996Neurobiology of Disease151 citations
Semantic Scholar
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis.
L. Puglielli, Blake C. Ellis, A. Saunders, D. Kovacs
2003Journal of Biological Chemistry148 citations
Semantic Scholar
Presenilin/γ-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel β2-Subunit Regulates Cell Adhesion and Migration*
D. Y. Kim, L. MacKenzie-Ingano, Bryce W. Carey, W. Pettingell +1 more
2005Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Withdrawal: Ceramide stabilizes β-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid β-peptide biogenesis
L. Puglielli, Blake C. Ellis, A. Saunders, D. Kovacs
2022Journal of Biological Chemistry133 citations Open access
Semantic Scholar
Alzheimer disease β-amyloid activity mimics cholesterol oxidase
L. Puglielli, A. Friedlich, K. Setchell, S. Nagano +7 more
2005126 citations Open access
Semantic Scholar
Familial Alzheimer's chromosome 14 mutations
W. Wasco, W. Pettingell, P. Jondro, Stephen D. Schmidt +8 more
1995Nature Medicine114 citations
Semantic Scholar
Role of amyloid precursor protein (APP): Study with antisense transfection of human neuroblastoma cells
A. LeBlanc, D. Kovacs, H.-Y. Chen, F. Villare +3 more
1992Journal of Neuroscience Research97 citations
Semantic Scholar
α2-Macroglobulin in late-onset Alzheimer's disease
D. Kovacs
200087 citations
Semantic Scholar
Reduced Sodium Channel Nav1.1 Levels in BACE1-null Mice*
D. Y. Kim, Manuel T. Gersbacher, Perrine Inquimbert, D. Kovacs
2010Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.
D. Y. Kim, L. MacKenzie-Ingano, Bryce W. Carey, W. Pettingell +1 more
2005Journal of Biological Chemistry80 citations
Semantic Scholar
HtrA2 Regulates β-Amyloid Precursor Protein (APP) Metabolism through Endoplasmic Reticulum-associated Degradation*
H. Huttunen, S. Guénette, Camilla Peach, C. Greco +5 more
2007Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
L. Puglielli, G. Konopka, E. Pack-Chung, L. A. Ingano +5 more
2001Nature Cell Biology69 citations
Semantic Scholar
Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
R. Bhattacharyya, Sophia E. Black, M. Lotlikar, Rebecca H. Fenn +3 more
2021Cell Reports68 citations Open access
Semantic Scholar
ACAT INHIBITION AND AMYLOID BETA REDUCTION
R. Bhattacharyya, D. Kovacs
2010Biochimica et Biophysica Acta68 citations Open access
Semantic Scholar
Presenilin/γ‐secretase activity regulates protein clearance from the endocytic recycling compartment
Mei-kui Zhang, A. Haapasalo, D. Y. Kim, Laura A. Mackenzie Ingano +2 more
2006The FASEB Journal65 citations
Semantic Scholar
Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage.
D. Y. Kim, L. MacKenzie-Ingano, D. Kovacs
2002Journal of Biological Chemistry64 citations
Semantic Scholar
Ceramide Stabilizes β-Site Amyloid Precursor Protein-cleaving Enzyme 1 and Promotes Amyloid β-Peptide Biogenesis*
Luigi Puglielli, Blake C. Ellis, A. Saunders, D. Kovacs
2003Journal of Biological Chemistry63 citations Open access
Semantic Scholar
The Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice
H. Huttunen, D. Havas, Camilla Peach, C. Barren +6 more
2010Journal of Neuropathology and Experimental Neurology58 citations Open access
Semantic Scholar
Knockdown of ACAT‐1 reduces amyloidogenic processing of APP
H. Huttunen, C. Greco, D. Kovacs
2007FEBS Letters58 citations Open access
Semantic Scholar
Staurosporine‐Induced Activation of Caspase‐3 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells
D. Kovacs, R. Mancini, J. Henderson, Sang J. Na +3 more
1999Journal of Neurochemistry58 citations
Semantic Scholar
Inhibition of acyl‐coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway
H. Huttunen, Camilla Peach, R. Bhattacharyya, C. Barren +5 more
2009The FASEB Journal55 citations Open access
Semantic Scholar
Presenilin/γ-Secretase-mediated Cleavage Regulates Association of Leukocyte-Common Antigen-related (LAR) Receptor Tyrosine Phosphatase with β-Catenin*
A. Haapasalo, D. Y. Kim, Bryce W. Carey, Mari K. Turunen +2 more
2007Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
L. Puglielli, A. Friedlich, K. Setchell, S. Nagano +7 more
2005Journal of Clinical Investigation55 citations
Semantic Scholar
BACE1 activity regulates cell surface contactin-2 levels
V. Gautam, C. D'Avanzo, Matthias Hebisch, D. Kovacs +1 more
2014Molecular Neurodegeneration51 citations Open access
Semantic Scholar
ACAT as a Drug Target for Alzheimer’s Disease
H. Huttunen, D. Kovacs
2008Neurodegenerative Diseases49 citations Open access
Semantic Scholar
BACE1 and presenilin/γ‐secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage‐gated potassium channels
Carolyn C. Sachse, Young Hye Kim, Marianne Agsten, T. Huth +3 more
2013The FASEB Journal48 citations Open access
Semantic Scholar
Synaptotagmins interact with APP and promote Aβ generation
V. Gautam, C. D'Avanzo, O. Berezovska, R. Tanzi +1 more
2015Molecular Neurodegeneration41 citations Open access
Semantic Scholar
Presenilin/γ-secretase and α-secretase-like peptidases cleave human MHC Class I proteins
Bryce W. Carey, D. Y. Kim, D. Kovacs
200741 citations Open access
Semantic Scholar
The amyloid precursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types
L. Autilio‐Gambetti, A. Morandi, M. Tabaton, B. Schaetzle +4 more
198841 citations Open access
Semantic Scholar
alpha2-macroglobulin in late-onset Alzheimer's disease.
D. Kovacs
2000Experimental Gerontology38 citations
Semantic Scholar
Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
Manuel T. Gersbacher, D. Y. Kim, R. Bhattacharyya, D. Kovacs
2010Molecular Neurodegeneration37 citations Open access
Semantic Scholar
The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene.
D. Kovacs, W. Wasco, Johanna Witherby, K. Felsenstein +3 more
1995Human Molecular Genetics37 citations
Semantic Scholar
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
A. Kuzuya, K. Zoltowska, Kathryn L. Post, M. Arimon +8 more
2016BMC Biology36 citations Open access
Semantic Scholar
Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site
G. Abbenante, D. Kovacs, D. Leung, D. Craik +2 more
200036 citations
Semantic Scholar
Hypocapnia Induces Caspase-3 Activation and Increases Aβ Production
Zhong-Cong Xie, R. Moir, D. Romano, G. Tesco +2 more
2004Neurodegenerative Diseases32 citations
Semantic Scholar
Palmitoylated APP Forms Dimers, Cleaved by BACE1
R. Bhattacharyya, Rebecca H. Fenn, C. Barren, R. Tanzi +1 more
2016PLoS ONE30 citations Open access
Semantic Scholar

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