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A. Saunders · SciRah

Researcher profile · Semantic Scholar

A. Saunders

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A. Saunders — researcher profile on SciRah

h-index: 25
Works: 70
Citations: 3,792

Most-cited papers

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
Xu-Dong Huang, M. Cuajungco, C. S. Atwood, M. Hartshorn +16 more
1999Journal of Biological Chemistry743 citations Open access
Semantic Scholar
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.
L. Bertram, D. Blacker, K. Mullin, D. Keeney +9 more
2000Science525 citations
Semantic Scholar
Results of a high-resolution genome screen of 437 Alzheimer's disease families.
D. Blacker, L. Bertram, A. Saunders, T. Moscarillo +17 more
2003Human Molecular Genetics363 citations
Semantic Scholar
Presenilin-mediated modulation of capacitative calcium entry.
Andrew S. Yoo, Isaac Cheng, Sungkwon Chung, Tallessyn Z. Grenfell +11 more
2000Neuron325 citations Open access
Semantic Scholar
MicroRNAs can regulate human APP levels
Neha Patel, David Hoang, Nathan H. Miller, S. Ansaloni +4 more
2008Molecular Neurodegeneration198 citations Open access
Semantic Scholar
Characterization of a Drosophila Alzheimer's Disease Model: Pharmacological Rescue of Cognitive Defects
Ranjita Chakraborty, Vidya Vepuri, Siddhita D. Mhatre, B. Paddock +15 more
2011PLoS ONE150 citations Open access
Semantic Scholar
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis.
L. Puglielli, Blake C. Ellis, A. Saunders, D. Kovacs
2003Journal of Biological Chemistry148 citations
Semantic Scholar
Withdrawal: Ceramide stabilizes β-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid β-peptide biogenesis
L. Puglielli, Blake C. Ellis, A. Saunders, D. Kovacs
2022Journal of Biological Chemistry133 citations Open access
Semantic Scholar
BACE Maps to Chromosome 11 and a BACE Homolog, BACE2, Reside in the Obligate Down Syndrome Region of Chromosome 21
A. Saunders, Tae-Wan Kim, R. Tanzi
1999121 citations
Semantic Scholar
Role of common and rare APP DNA sequence variants in Alzheimer disease
B. Hooli, G. Mohapatra, M. Mattheisen, A. Parrado +8 more
2012Neurology88 citations Open access
Semantic Scholar
In vivo selection for metastasis promoting genes in the mouse
K. Gumireddy, Fangxian Sun, Andres J Klein-Szanto, J. Gibbins +4 more
2007Proceedings of the National Academy of Sciences of the United States of America81 citations Open access
Semantic Scholar
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity
Xu-Dong Huang, M. Cuajungco, C. Atwood, M. Hartshorn +16 more
1999Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.
A. Saunders, L. Bertram, K. Mullin, A. J. Sampson +18 more
2003Human Molecular Genetics79 citations
Semantic Scholar
Synaptic abnormalities in a Drosophila model of Alzheimer’s disease
Siddhita D. Mhatre, Vivek Satyasi, Mark Killen, B. Paddock +3 more
2014Disease Models & Mechanisms71 citations Open access
Semantic Scholar
Invertebrate Models of Alzheimer's Disease
Siddhita D. Mhatre, B. Paddock, A. Saunders, D. Marenda
2012Journal of Alzheimer's Disease65 citations
Semantic Scholar
Ceramide Stabilizes β-Site Amyloid Precursor Protein-cleaving Enzyme 1 and Promotes Amyloid β-Peptide Biogenesis*
Luigi Puglielli, Blake C. Ellis, A. Saunders, D. Kovacs
2003Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
Anna G. Vorobyeva, A. Saunders
2018Cilia59 citations Open access
Semantic Scholar
An AICD-based functional screen to identify APP metabolism regulators
Can Zhang, P. Khandelwal, Ranjita Chakraborty, Trinna L. Cuellar +7 more
2007Molecular Neurodegeneration55 citations Open access
Semantic Scholar
Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex
Ezekiel Crenshaw, Brian P. Leung, Chun-Kit Kwok, Michal Sharoni +7 more
2015PLoS ONE50 citations Open access
Semantic Scholar
Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments
Haizhi Wang, N. Sang, C. Zhang, R. Raghupathi +2 more
2015Biochemistry47 citations Open access
Semantic Scholar
Characterization of human lysophospholipid acyltransferase 3[S]
Shilpa Jain, Xiaoling Zhang, P. Khandelwal, A. Saunders +2 more
2009Journal of Lipid Research46 citations Open access
Semantic Scholar
An Emerging Role for Ubiquilin 1 in Regulating Protein Quality Control System and in Disease Pathogenesis
C. Zhang, A. Saunders
2009Discover medicine40 citations
Semantic Scholar
Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster.
Siddhita D. Mhatre, Sarah J. Michelson, J. Gomes, L. Tabb +2 more
2014Experimental Neurology36 citations
Semantic Scholar
Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain.
L. Chylack, Ling Fu, R. Mancini, Matthew D Martin-Rehrmann +6 more
2004Experimental Eye Research34 citations
Semantic Scholar
The role of ubiquitin-proteasome in the metabolism of amyloid precursor protein (APP): implications for novel therapeutic strategies for Alzheimer's disease.
Haizhi Wang, A. Saunders
2014Discover medicine30 citations
Semantic Scholar
Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease.
Can Zhang, A. Saunders
2007Discover medicine23 citations
Semantic Scholar
Cyclopamine Modulates γ-Secretase-mediated Cleavage of Amyloid Precursor Protein by Altering Its Subcellular Trafficking and Lysosomal Degradation*
Anna G. Vorobyeva, Randall A. Lee, Sean J. Miller, Charles G Longen +5 more
2014Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Real‐time monitoring of the membrane‐binding and insertion properties of the cholesterol‐dependent cytolysin anthrolysin O from Bacillus anthracis
S. Cocklin, M. Jost, Noreen M. Robertson, S. Weeks +9 more
2006Journal of Molecular Recognition18 citations
Semantic Scholar
Potential therapeutic targets for Alzheimer’s disease
C. McKeon-O’Malley, A. Saunders, A. Bush, R. Tanzi
199818 citations
Semantic Scholar
Mechanisms that Synergistically Regulate η-Secretase Processing of APP and Aη-α Protein Levels: Relevance to Pathogenesis and Treatment of Alzheimer’s Disease
Joseph F. Ward, Haizhi Wang, A. Saunders, R. Tanzi +1 more
2017Discover medicine14 citations
Semantic Scholar
Automated analysis of courtship suppression learning and memory in Drosophila melanogaster
Mortuza Reza, Siddhita D. Mhatre, J. Morrison, S. Utreja +3 more
2013Fly12 citations Open access
Semantic Scholar
Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease.
A. Saunders, R. Tanzi
2003Experimental Neurology12 citations Open access
Semantic Scholar
Development and Cardiac Contractility: Cardiac Troponin T Isoforms and Cytosolic Calcium in Rabbit
S. McCall, R. Nassar, N. Malouf, A. Saunders +6 more
2006Pediatric Research10 citations Open access
Semantic Scholar
Drosophila lilliputian is required for proneural gene expression in retinal development
Ginnene M. DiStefano, A. Gangemi, P. Khandelwal, A. Saunders +1 more
2012Developmental Dynamics9 citations Open access
Semantic Scholar
TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains
S. Ansaloni, Brian P. Leung, Neeraj P. Sebastian, Rohini Samudralwar +2 more
2011International Journal of Alzheimer's Disease9 citations Open access
Semantic Scholar
A streamlined sub-cloning procedure to transfer shRNA from a pSM2 vector to a pGIPZ lentiviral vector
S. Ansaloni, Nadav Lelkes, Jonathan E. Snyder, Charles Epstein +2 more
2010Journal of RNAi and Gene Silencing7 citations
Semantic Scholar
Calcineurin overexpression regulates APP metabolism
S. Utreja, Sean J. Miller, A. Saunders
20134 citations Open access
Semantic Scholar
Association of the Protein-Quality-Control Protein Ubiquilin-1 With Alzheimer’s Disease Both in vitro and in vivo
Can Zhang, Shivangi M. Inamdar, S. Swaminathan, D. Marenda +1 more
2022Frontiers in Neuroscience2 citations Open access
Semantic Scholar
Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNF
S. Ansaloni, Brian P. Leung, Aditi Dubey, A. Saunders
20122 citations Open access
Semantic Scholar
No association between marker D10S1423 and Alzheimer's disease
Lars Bertram, A. Saunders, K. Mullin, A. J. Sampson +5 more
2003Molecular Psychiatry2 citations Open access
Semantic Scholar
Correction to Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.
Haizhi Wang, N. Sang, C. Zhang, R. Raghupathi +2 more
2015Biochemistry1 citations
Semantic Scholar
S3‐02‐05: Allele‐specific miRNA mediated regulation of APP expression
A. Saunders, Neha Patel, Basavaraja Hooli, Trisha Kadakia +4 more
20121 citations
Semantic Scholar
Video Analysis Algorithms for Automated Categorization of Fly Behaviors
Md. Alimoor Reza, Jeffrey Marker, Siddhita D. Mhatre, A. Saunders +2 more
2012International Symposium on Visual Computing1 citations
Semantic Scholar
Genetic Risk Factors: Their Function and Comorbidities in Alzheimer's Disease
M. Hiltunen, L. Bertram, A. Saunders
2011International Journal of Alzheimer's Disease1 citations Open access
Semantic Scholar
Candidate genes showing no evidence of association with Alzheimer disease — Results of the Nimh-Alzheimer disease genetics initiative
L. Bertram, D. Blacker, Jennifer L. Jones, D. Keeney +4 more
20001 citations
Semantic Scholar
Degradation Subcellular Trafficking and Lysosomal Precursor Protein by Altering Its-Secretase-mediated Cleavage of Amyloid γ Cyclopamine Modulates Molecular Bases of Disease :
Anna G. Vorobyeva, Randall A. Lee, Sean J. Miller, Charles G Longen +5 more
20140 citations
Semantic Scholar
P1‐299: Calcineurin inhibition alters APP metabolism in vitro and in vivo
A. Saunders, S. Utreja, B. Paddock, Sean J. Miller +1 more
20120 citations
Semantic Scholar
P4‐006: The tyrosine kinase receptor B alters APP and BACE1 expression levels
S. Ansaloni, Brian P. Leung, A. Saunders
20120 citations Open access
Semantic Scholar
Alzheimer disease DNA sequence variants in APP Role of common and rare
B. Hooli, G. Mohapatra, M. Mattheisen, A. Parrado +8 more
20120 citations
Semantic Scholar
P3‐197: TrkB isoforms differentially regulate amyloid precursor protein Swedish mutant glycosylation and processing
S. Ansaloni, Brian P. Leung, Mariana C. Gadaleta, A. Saunders
20110 citations
Semantic Scholar

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R. Tanzi×18
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D. Marenda×11
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L. Bertram×8
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S. Ansaloni×8
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Siddhita D. Mhatre

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