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G. Cortopassi · SciRah

Researcher profile · Semantic Scholar

G. Cortopassi

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G. Cortopassi — researcher profile on SciRah

h-index: 57
Works: 176
Citations: 13K

Most-cited papers

A ketogenic diet extends longevity and healthspan in adult mice
M. Roberts, M. Wallace, A. Tomilov, Ze-Yu Zhou +16 more
2017Cell Metabolism472 citations Open access
Semantic Scholar
Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern
W. Arnold, A. Blum, Jennifer Branyan, T. Bruton +22 more
2023Environmental Science and Technology365 citations Open access
Semantic Scholar
Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression*
Winyoo Chowanadisai, Kathryn A. Bauerly, E. Tchaparian, A. Wong +2 more
2009Journal of Biological Chemistry241 citations Open access
Semantic Scholar
OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability
Le Chen, Tingting Liu, A. Tran, Xi-Yuan Lu +7 more
2012Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease211 citations Open access
Semantic Scholar
Frataxin Deficiency Leads to Defects in Expression of Antioxidants and Nrf2 Expression in Dorsal Root Ganglia of the Friedreich's Ataxia YG8R Mouse Model
Yuxi Shan, R. Schoenfeld, Genki Hayashi, Eleonora Napoli +5 more
2013Antioxidants and Redox Signaling163 citations Open access
Semantic Scholar
Oxidative Stress in Inherited Mitochondrial Diseases
Genki Hayashi, G. Cortopassi
2015Free Radical Biology & Medicine146 citations Open access
Semantic Scholar
Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
Genki Hayashi, Mittal J Jasoliya, Sunil Sahdeo, F. Saccà +7 more
2017Human Molecular Genetics131 citations Open access
Semantic Scholar
Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure
T. Hrubec, Ryan P. Seguin, Libin Xu, G. Cortopassi +8 more
2021Toxicology Reports119 citations Open access
Semantic Scholar
AI is a viable alternative to high throughput screening: a 318-target study
Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho +496 more
2024Scientific Reports112 citations Open access
Semantic Scholar
The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells
S. Datta, C. Baudouin, F. Brignole-Baudouin, A. Denoyer +1 more
2017Investigative Ophthalmology and Visual Science108 citations Open access
Semantic Scholar
Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production1
Christa R. Darr, D. Varner, S. Teague, G. Cortopassi +2 more
2016Biology of Reproduction106 citations
Semantic Scholar
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
D. Harrison, R. Strong, P. Reifsnyder, Navasuja Kumar +18 more
2021Aging Cell97 citations Open access
Semantic Scholar
The p66Shc knockout mice are short lived under natural condition
M. Giorgio, A. Berry, Ina Berniakovich, I. Poletaeva +11 more
2012Aging Cell85 citations Open access
Semantic Scholar
Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity
Lee-Way Jin, M. Horiuchi, H. Wulff, Xiao-bo Liu +3 more
2015Journal of Neuroscience81 citations Open access
Semantic Scholar
Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia
Sunil Sahdeo, B. D. Scott, Marissa Z. McMackin, Mittal J Jasoliya +5 more
2014Human Molecular Genetics77 citations Open access
Semantic Scholar
PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection
K. Crakes, Clarissa Santos Rocha, I. Grishina, L. Hirao +10 more
2019Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
Galectin‐3 regulates inflammasome activation in cholestatic liver injury
Ji-Jing Tian, Guo-Xiang-X. Yang, Huan-Yuan Chen, D. Hsu +10 more
2016The FASEB Journal74 citations Open access
Semantic Scholar
Mitochondrial oxygen consumption is a unique indicator of stallion spermatozoal health and varies with cryopreservation media.
Christa R. Darr, G. Cortopassi, S. Datta, D. Varner +1 more
2016Theriogenology69 citations
Semantic Scholar
Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse.
Alfred K. Yu, Lanying Song, Karl Murray, D. A. van der List +4 more
2015Human Molecular Genetics61 citations Open access
Semantic Scholar
Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes
J. di Lucente, G. Persico, Ze-Yu Zhou, Lee-Way Jin +8 more
2024Communications Biology57 citations Open access
Semantic Scholar
Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter
Agnese De Mario, Anna Tosatto, J. Hill, J. Kriston-Vizi +6 more
2021Cell Reports57 citations Open access
Semantic Scholar
HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis.
Yuxi Shan, G. Cortopassi
2012Human Molecular Genetics53 citations Open access
Semantic Scholar
Hepatic Src homology phosphatase 2 regulates energy balance in mice.
Naoto Matsuzawa Nagata, Kosuke Matsuo, A. Bettaieb, Jesse L. Bakke +13 more
2012Endocrinology50 citations Open access
Semantic Scholar
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
David E. Harrison, Randy Strong, Peter C. Reifsnyder, N. Rosenthal +25 more
2023GeroScience49 citations Open access
Semantic Scholar
Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans
Mittal J Jasoliya, Marissa Z. McMackin, Chelsea K. Henderson, S. Perlman +1 more
2017Human Molecular Genetics49 citations Open access
Semantic Scholar
Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34
Yan Shen, Marissa Z. McMackin, Yuxi Shan, Alan G. Raetz +2 more
2016PLoS ONE49 citations Open access
Semantic Scholar
Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich’s Ataxia
Mittal J Jasoliya, F. Saccà, Sunil Sahdeo, Frédéric Chédin +5 more
2019PLoS ONE44 citations Open access
Semantic Scholar
Correction
M. Roberts, M. Wallace, A. Tomilov, Ze-Yu Zhou +16 more
2018Cell Metabolism43 citations Open access
Semantic Scholar
In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride
S. Datta, Guochun He, A. Tomilov, Sunil Sahdeo +2 more
2017Environmental Health Perspectives43 citations Open access
Semantic Scholar
The influence of Shc proteins on life span in mice.
J. Ramsey, Dianna Tran, M. Giorgio, S. Griffey +11 more
2014The journals of gerontology. Series A, Biological sciences and medical sciences40 citations Open access
Semantic Scholar
Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.
Yuxi Shan, G. Cortopassi
2016Mitochondrion (Amsterdam. Print)38 citations
Semantic Scholar
Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression.
Lanying Song, Yuxi Shan, Kevin C. K. Lloyd, G. Cortopassi
2012Human Molecular Genetics38 citations Open access
Semantic Scholar
The ketone body β-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-β oligomer-induced inflammation in human microglia
Lee-Way Jin, J. di Lucente, U. R. Mendiola, Nopparat Suthprasertporn +5 more
2023The FASEB Journal37 citations Open access
Semantic Scholar
Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria
Damien Y. Duveau, Pablo Arce, R. Schoenfeld, N. Raghav +2 more
2010Bioorganic & Medicinal Chemistry36 citations Open access
Semantic Scholar
Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.
J. Teixeira, R. Amorim, Katia Santos, P. Soares +7 more
2018Toxicology34 citations
Semantic Scholar
“Repurposing FDA Approved Drugs Inhibiting Mitochondrial Function for Targeting Glioma-Stem Like Cells.”
S. Datta, Thomas K. Sears, G. Cortopassi, K. Woolard +1 more
2020Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie30 citations Open access
Semantic Scholar
Sperm Mitochondrial Function is Affected by Stallion Age and Predicts Post‐Thaw Motility
Christa R. Darr, Luis E. Moraes, Tawny N. Scanlan, J. Baumber-Skaife +3 more
201730 citations
Semantic Scholar
Development of an HTS assay for EPHX2 phosphatase activity and screening of non-targeted libraries
C. Morisseau, Sunil Sahdeo, G. Cortopassi, B. Hammock
2012Analytical Biochemistry30 citations Open access
Semantic Scholar
Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition
A. Tomilov, Sonia A Allen, ChunKiu Hui, A. Bettaieb +1 more
2018Pharmacological Research29 citations
Semantic Scholar
Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia
Genki Hayashi, Yan Shen, T. Pedersen, J. Newman +2 more
2014Human Molecular Genetics29 citations Open access
Semantic Scholar
Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model.
Lanying Song, Alfred K. Yu, Karl Murray, G. Cortopassi
2017Brain Research28 citations
Semantic Scholar
Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism.
Lanying Song, Marissa Z. McMackin, Andy Nguyen, G. Cortopassi
2017Neurobiology of Disease28 citations Open access
Semantic Scholar
High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects
Sunil Sahdeo, A. Tomilov, K. Komachi, Christine K. Iwahashi +4 more
2014Mitochondrion (Amsterdam. Print)28 citations Open access
Semantic Scholar
Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.
ChunKiu Hui, E. Dedkova, C. Montgomery, G. Cortopassi
2020Human Molecular Genetics27 citations Open access
Semantic Scholar
Neurobehavioral deficits in the KIKO mouse model of Friedreich’s ataxia
Marissa Z. McMackin, Chelsea K. Henderson, G. Cortopassi
2016Behavioural Brain Research25 citations Open access
Semantic Scholar
Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia
Genki Hayashi, G. Cortopassi
2016PLoS ONE22 citations Open access
Semantic Scholar
Mitochondrial complex I defects increase ubiquitin in substantia nigra.
Lanying Song, G. Cortopassi
2015Brain Research21 citations
Semantic Scholar
Non-phagocytic Activation of NOX2 is Implicated in Progressive Non-alcoholic Steatohepatitis During Aging
Joy X. Jiang, Sarah R. Fish, A. Tomilov, Yuan Li +9 more
2020Hepatology20 citations Open access
Semantic Scholar
An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice
C. J. Finno, Matthew H. Bordbari, Giuliana Gianino, Brittni Ming-Whitfield +15 more
2018Free Radical Biology & Medicine20 citations Open access
Semantic Scholar
Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection.
David M Fash, Omar M. Khdour, Sunil Sahdeo, Ruth Goldschmidt +6 more
2013Bioorganic & Medicinal Chemistry20 citations
Semantic Scholar

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