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M. Desbois · SciRah

Researcher profile · Semantic Scholar

M. Desbois

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M. Desbois — researcher profile on SciRah

h-index: 14
Works: 37
Citations: 2,295

Most-cited papers

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
C. Coutzac, J. Jouniaux, A. Paci, J. Schmidt +21 more
2020Nature Communications463 citations Open access
Semantic Scholar
IL-18 induces PD-1-dependent immunosuppression in cancer.
M. Terme, E. Ullrich, L. Aymeric, K. Meinhardt +13 more
2011Cancer Research343 citations
Semantic Scholar
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer.
Milena Hornburg, M. Desbois, Sha Lu, Y. Guan +13 more
2021Cancer Cell342 citations Open access
Semantic Scholar
Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors.
S. Rusakiewicz, M. Semeraro, M. Sarabi, M. Desbois +28 more
2013Cancer Research290 citations
Semantic Scholar
Cancer‐associated fibroblasts: Key players in shaping the tumor immune microenvironment
M. Desbois, Yulei Wang
2021Immunological Reviews175 citations Open access
Semantic Scholar
Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
M. Desbois, Akshata R. Udyavar, L. Ryner, Cleopatra Kozlowski +15 more
2020Nature Communications130 citations Open access
Semantic Scholar
Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells.
M. Terme, E. Ullrich, L. Aymeric, K. Meinhardt +17 more
2012Cancer Research117 citations Open access
Semantic Scholar
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25
D. Hannani, M. Vetizou, D. Enot, S. Rusakiewicz +27 more
2015Cell Research102 citations Open access
Semantic Scholar
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25
D. Hannani, M. Vetizou, D. Enot, S. Rusakiewicz +27 more
2015Cell Research94 citations Open access
Semantic Scholar
Abstract 463: Integrated digital pathology and transcriptome analysis identifies molecular mediators of T cell exclusion in ovarian cancer
M. Desbois, Akshata R. Udyavar, L. Ryner, Cleopatra Kozlowski +16 more
2019Clinical research61 citations
Semantic Scholar
IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists
M. Desbois, P. LeVu, C. Coutzac, E. Marcheteau +11 more
2016Journal of Immunology61 citations
Semantic Scholar
IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment
M. Desbois, Coralie Béal, M. Charrier, B. Besse +6 more
2020Journal for ImmunoTherapy of Cancer43 citations Open access
Semantic Scholar
Natural killer cells in non-hematopoietic malignancies
M. Desbois, S. Rusakiewicz, C. Locher, L. Zitvogel +1 more
2012Front. Immun.28 citations Open access
Semantic Scholar
Phase I clinical trial combining imatinib mesylate and IL-2
N. Chaput, C. Flament, C. Locher, M. Desbois +12 more
2013Oncoimmunology25 citations Open access
Semantic Scholar
IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8+ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells
M. Desbois, T. Giffon, P. Yakkundi, Carolyn R Denson +12 more
2025Cancer immunology research5 citations Open access
Semantic Scholar
Oxazaphosphorines combined with immune checkpoint blockers: dose-dependent tuning between immune and cytotoxic effects
J. Delahousse, C. Skarbek, M. Desbois, J. Perfettini +2 more
2020Journal for ImmunoTherapy of Cancer5 citations Open access
Semantic Scholar
Abstract 1068: Anti-DR5 agonist IgM antibody IGM-8444 combined with SMAC mimetic birinapant induces strong synergistic tumor cytotoxicity
Beatrice T. Wang, M. Desbois, Susan E Calhoun, T. Matthew +12 more
2022Cancer Research3 citations
Semantic Scholar
Abstract 1899: Novel combinations of aplitabart, a DR5 agonist IgM antibody, with ADCs or chemotherapeutic agents lead to robust anti-tumor responses in solid tumor models
M. Desbois, Susan E Calhoun, K. Hart, Carolyn R Denson +11 more
2024Cancer Research2 citations
Semantic Scholar
Abstract 5660: IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell mediated cytotoxicity of PD-L1-positive tumor cells
T. Giffon, M. Desbois, P. Yakkundi, Susan E Calhoun +18 more
2023Cancer Research2 citations
Semantic Scholar
711 IGM-7354 is an anti-PD-L1 IgM antibody and IL-15 cytokine fusion that enhances NK and CD8+ T cell proliferation and tumor cytotoxicity plus potently reverses T cell exhaustion
T. Giffon, M. Desbois, Dean Ng, P. Yakkundi +11 more
2021Journal for ImmunoTherapy of Cancer2 citations Open access
Semantic Scholar
[Breaking immune tolerance in cancer].
M. Desbois, S. Champiat, N. Chaput
2015Bulletin du Cancer2 citations
Semantic Scholar
959 Tebentafusp controls disease and prolongs survival by increasing the T cell: tumor cell ratio, activating T cells and inhibiting tumor proliferation in metastatic uveal melanoma patients
Adel Benlahrech, James Clubley, Anna Broomfield, E. Leach +5 more
2025Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity
Beatrice T. Wang, Tasnim Kothambawala, Kevin C. Hart, Xingjie Chen +15 more
2021Experimental and Molecular Therapeutics1 citations
Semantic Scholar
981PReactive stroma mediates CD8+ T cell spatial distribution and function in ovarian cancer
Yulei Wang, L. Ryner, Akshata R. Udyavar, M. Desbois +8 more
20171 citations Open access
Semantic Scholar
Full field investigation of salt deformation at room temperature: Cooperation of crystal plasticity and grain sliding : M. Bourcier, A. Dimanov, E. Héripré & J.L. Raphanel M. Bornert
M. Bourcier, A. Dimanov, E. Héripré, J. Raphanel +1 more
20121 citations
Semantic Scholar
Effect of IL7 on ImmTAC-mediated killing by T cells in vitro and T-cell fitness in patients.
Joseph J. Sacco, Anna Broomfield, M. Desbois, Des C Jones +5 more
2026Journal of Clinical Oncology0 citations
Semantic Scholar
Abstract A137: Pharmacokinetics and pharmacodynamics of IGM-8444, a first-in-class engineered pentameric DR5-targeting agonist IgM monoclonal antibody, in patients with R/R and newly diagnosed cancers
G. Hernandez, Sanela Bilic, Yinghui Guan, John So +22 more
2023Molecular Cancer Therapeutics0 citations
Semantic Scholar
Abstract 6123: Characterization of the synergistic tumor cytotoxicity of agonistic DR5 IgM antibody IGM-8444 with chemotherapeutic agents
Beatrice T. Wang, T. Matthew, P. Yakkundi, M. Oyasu +10 more
2023Cancer Research0 citations
Semantic Scholar
Abstract 3438: Enhanced NK and CD8+ T cell proliferation, tumor cytotoxicity and reversal of T cell exhaustion with IGM-7354, an anti-PD-L1 IgM antibody and IL-15 cytokine fusion
T. Giffon, M. Desbois, P. Yakkundi, K. Sekar +13 more
2022Cancer Research0 citations
Semantic Scholar
1215 IGM-7354, an anti-PD-L1/IL-15 IgM immunocytokine, activates and expands NK cells and effector memory CD8+ T cells in vivo
M. Desbois, T. Giffon, P. Yakkundi, Sivani Pandey +26 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
Targeting molecular mediators of T cell exclusion for effective immunotherapy in ovarian cancer
Yulei Wang, M. Desbois, Akshata R. Udyavar, L. Ryner +15 more
2019Annals of Oncology0 citations Open access
Semantic Scholar
Abstract 2195: Combined strategy based on pre-activated analogs of oxazaphosphorines for increased therapeutic index and immune modulation
J. Delahousse, C. Skarbek, Valentine Gauthier, M. Desbois +10 more
20170 citations
Semantic Scholar
This information is current as Activity of PD-1 Antagonists Cell Responses and Enhances Antitumor T + RLI Promotes Effector / Memory CD 8 IL-15 Trans-Signaling with the Superagonist Cassard and
M. Desbois, P. LeVu, C. Coutzac, E. Marcheteau +11 more
20160 citations
Semantic Scholar
New oxazaphosphorine prodrug’s for immunotherapy and n anomedicine against cancer
C. Skarbek, H. Gondé, M. Desbois, J. Delahousse +4 more
20160 citations
Semantic Scholar
Abstract 2194: New oxazaphosphorine prodrugs for immunotherapy and nanomedicine against cancer
C. Skarbek, H. Gondé, M. Desbois, J. Delahousse +4 more
20160 citations
Semantic Scholar
Abstract 2577: RLI, a sushi-IL-15Rα/IL-15 fusion protein, is a potent immunomodulatory agent on NK and CD8+ T cells and synergizes with anti-PD1 treatment in preclinical mouse tumor models
M. Desbois, Coralie Béal, C. Coutzac, M. Terme +5 more
20140 citations
Semantic Scholar
Natural nanoparticules against cancer: mature dendritic cell-derived exosomes
S. Viaud, M. Desbois, Stéphanie Ploix, L. Zitvogel +1 more
20110 citations Open access
Semantic Scholar

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