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H. Hara · SciRah

Researcher profile · Semantic Scholar

H. Hara

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H. Hara — researcher profile on SciRah

h-index: 32
Works: 70
Citations: 5,857

Most-cited papers

Mechanism and regulation of NLRP3 inflammasome activation
Yuan He, H. Hara, G. Núñez
2016TIBS -Trends in Biochemical Sciences. Regular ed2,529 citations Open access
Semantic Scholar
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
Stephanie A Conos, Kai-Wen W. Chen, D. De Nardo, H. Hara +9 more
2017Proceedings of the National Academy of Sciences of the United States of America461 citations Open access
Semantic Scholar
The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection
H. Hara, S. Seregin, Dahai Yang, K. Fukase +5 more
2018Cell264 citations Open access
Semantic Scholar
Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity
H. Hara, K. Tsuchiya, I. Kawamura, Rendong Fang +6 more
2013Nature Immunology240 citations Open access
Semantic Scholar
Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome
Eduardo Hernández-Cuellar, K. Tsuchiya, H. Hara, Rendong Fang +4 more
2012Journal of Immunology187 citations
Semantic Scholar
Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
Rendong Fang, K. Tsuchiya, I. Kawamura, Yanna Shen +11 more
2011Journal of Immunology176 citations Open access
Semantic Scholar
Title Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
H. Hara, K. Tsuchiya, I. Kawamura, Rendong Fang +8 more
2016127 citations
Semantic Scholar
Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes
K. Tsuchiya, H. Hara, I. Kawamura, T. Nomura +6 more
2010Journal of Immunology126 citations
Semantic Scholar
Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.
K. Tsuchiya, S. Hosojima, H. Hara, Hiroko Kushiyama +3 more
2021Cell Reports119 citations Open access
Semantic Scholar
Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified Tac-positive T cells.
S. Negoro, H. Hara, S. Miyata, O. Saiki +4 more
1986Mechanisms of Ageing and Development108 citations
Semantic Scholar
IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections
Kei Sakamoto, Yun-Gi Kim, H. Hara, N. Kamada +6 more
2017Science immunology101 citations Open access
Semantic Scholar
Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-1-Dependent Cytokines in Infection with Streptococcus pneumoniae In Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation
S. Shoma, K. Tsuchiya, I. Kawamura, T. Nomura +4 more
2008Infection and Immunity91 citations Open access
Semantic Scholar
Toll-Like Receptor 2- and MyD88-Dependent Phosphatidylinositol 3-Kinase and Rac1 Activation Facilitates the Phagocytosis of Listeria monocytogenes by Murine Macrophages
Yanna Shen, I. Kawamura, T. Nomura, K. Tsuchiya +7 more
2010Infection and Immunity85 citations Open access
Semantic Scholar
HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines.
Kenji Sugata, Yorifumi Satou, Jun-ichirou Yasunaga, H. Hara +4 more
2012Blood73 citations Open access
Semantic Scholar
Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection
Rendong Fang, H. Hara, Shunsuke Sakai, Eduardo Hernández-Cuellar +3 more
2014Infection and Immunity65 citations Open access
Semantic Scholar
Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.
Takayuki Tanaka, Kazutoshi Takahashi, Mayu Yamane, Shota Tomida +18 more
2012Blood65 citations
Semantic Scholar
Dependency of Caspase-1 Activation Induced in Macrophages by Listeria monocytogenes on Cytolysin, Listeriolysin O, after Evasion from Phagosome into the Cytoplasm1
H. Hara, K. Tsuchiya, T. Nomura, I. Kawamura +2 more
2008Journal of Immunology58 citations
Semantic Scholar
The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages
Takeshi Kurenuma, I. Kawamura, H. Hara, R. Uchiyama +6 more
2009Infection and Immunity57 citations Open access
Semantic Scholar
Oligomerization of Clostridium perfringens epsilon-toxin is dependent upon membrane fluidity in liposomes.
M. Nagahama, H. Hara, M. Fernández-Miyakawa, Yukari Itohayashi +1 more
2006Biochemistry55 citations
Semantic Scholar
The inflammasome and its regulation.
K. Tsuchiya, H. Hara
2014Critical Reviews in Immunology50 citations
Semantic Scholar
Combined therapy of mice bearing a lymphokine-activated killer-resistant tumor with recombinant interleukin 2 and an antitumor monoclonal antibody capable of inducing antibody-dependent cellular cytotoxicity.
I. Kawase, K. Komuta, H. Hara, T. Inoue +6 more
1988Cancer Research49 citations
Semantic Scholar
Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.
H. Hara, B. Seon
1987Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Development of selective IgM deficiency in systemic lupus erythematosus patients with disease of long duration.
Osamu Saiki, Y. Saeki, Toshio Tanaka, S. Doi +4 more
1987Arthritis & Rheumatism47 citations
Semantic Scholar
Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages.
S. Daim, I. Kawamura, K. Tsuchiya, H. Hara +7 more
2011Journal of Medical Microbiology46 citations Open access
Semantic Scholar
Listeria monocytogenes Strain-Specific Impairment of the TetR Regulator Underlies the Drastic Increase in Cyclic di-AMP Secretion and Beta Interferon-Inducing Ability
Takeshi Yamamoto, H. Hara, K. Tsuchiya, Shunsuke Sakai +6 more
2012Infection and Immunity45 citations Open access
Semantic Scholar
Cytolysin-Dependent Escape of the Bacterium from the Phagosome Is Required but Not Sufficient for Induction of the Th1 Immune Response against Listeria monocytogenes Infection: Distinct Role of Listeriolysin O Determined by Cytolysin Gene Replacement
H. Hara, I. Kawamura, T. Nomura, T. Tominaga +2 more
2007Infection and Immunity43 citations Open access
Semantic Scholar
Age-associated changes in proliferative and differentiative response of human B cells and production of T cell-derived factors regulating B cell functions.
H. Hara, S. Negoro, S. Miyata, O. Saiki +4 more
1987Mechanisms of Ageing and Development42 citations
Semantic Scholar
Cellular vacuolation induced by Clostridium perfringens epsilon‐toxin
M. Nagahama, Yukari Itohayashi, H. Hara, M. Higashihara +6 more
2011The FEBS Journal38 citations Open access
Semantic Scholar
mdm2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line.
Seiji Kondo, Y. Kondo, H. Hara, R. Kaakaji +4 more
1996British Journal of Cancer36 citations Open access
Semantic Scholar
Age-related changes of the function of T cell subsets: predominant defect of the proliferative response in CD8 positive T cell subset in aged persons.
S. Negoro, H. Hara, S. Miyata, O. Saiki +4 more
1987Mechanisms of Ageing and Development36 citations
Semantic Scholar
ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism
Rendong Fang, R. Uchiyama, Shunsuke Sakai, H. Hara +5 more
2019Mucosal Immunology33 citations Open access
Semantic Scholar
Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation.
H. Hara, Toshio Tanaka, S. Negoro, Y. Deguchi +3 more
1988Mechanisms of Ageing and Development33 citations
Semantic Scholar
Efficient transplantation of human non-T-leukemia cells into nude mice and induction of complete regression of the transplanted distinct tumors by ricin A-chain conjugates of monoclonal antibodies SN5 and SN6.
H. Hara, Yi Luo, Y. Haruta, B. Seon
1988Cancer Research32 citations
Semantic Scholar
Effect of Weakly-Virulent Bacteriocin-Producing Strain of Pseudomonas solanacearum on the Protection of Tobacco Plant from Bacterial Wilt
H. Hara, Kuniaki Ono
199130 citations Open access
Semantic Scholar
Synergistic potentiation of in vivo antitumor activity of anti-human T-leukemia immunotoxins by recombinant alpha-interferon and daunorubicin.
S. Yokota, H. Hara, Yi Luo, B. Seon
1990Cancer Research30 citations
Semantic Scholar
Listeriolysin O-Dependent Bacterial Entry into the Cytoplasm Is Required for Calpain Activation and Interleukin-1α Secretion in Macrophages Infected with Listeria monocytogenes
Sita R. Dewamitta, T. Nomura, I. Kawamura, H. Hara +9 more
2010Infection and Immunity28 citations Open access
Semantic Scholar
The effect of taurine on age-related immune decline in mice: the effect of taurine on T cell and B cell proliferative response under costimulation with ionomycin and phorbol myristate acetate.
S. Nishio, S. Negoro, T. Hosokawa, H. Hara +8 more
1990Mechanisms of Ageing and Development24 citations
Semantic Scholar
Ecological studies on the bacterial wilt of tobacco, caused by Pseudomonas solanacearum E.F. Smith. V. The movement of the pathogen in tobacco plants.
K. Ono, H. Hara, J. Akazawa
198423 citations
Semantic Scholar
The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL‐18 production in an inflammasome‐dependent and ‐independent manner
K. Tsuchiya, H. Hara, Rendong Fang, Eduardo Hernández-Cuellar +7 more
2014European Journal of Immunology21 citations
Semantic Scholar
Human pulmonary infection with Corynebacterium equi.
T. Egawa, H. Hara, I. Kawase, T. Masuno +3 more
1990European Respiratory Journal20 citations Open access
Semantic Scholar
Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
Yuko Tanishita, Hisateru Sekiya, N. Inohara, K. Tsuchiya +3 more
2021Cell Reports16 citations Open access
Semantic Scholar
The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation.
Rui-Li Yang, Chen Xi, D. R. Sita, Shunsuke Sakai +7 more
2014Pathogens and Disease16 citations Open access
Semantic Scholar
Inactivation of the MAPK signaling pathway by Listeria monocytogenes infection promotes trophoblast giant cell death
M. Hashino, Masato Tachibana, T. Nishida, H. Hara +5 more
2015Frontiers in Microbiology14 citations Open access
Semantic Scholar
Age-related changes of proliferative response, kinetics of expression of protooncogenes after the mitogenic stimulation and methylation level of the protooncogene in purified human lymphocyte subsets.
Y. Deguchi, S. Negoro, H. Hara, S. Nishio +1 more
1988Mechanisms of Ageing and Development13 citations
Semantic Scholar
Chemo‐radioresistance of Small Cell Lung Cancer Cell Lines Derived from Untreated Primary Tumors Obtained by Diagnostic Bronchofiberscopy
Y. Tanio, Masatoshi Watanabe, Tamotsu Inoue, I. Kawase +14 more
1990Japanese journal of cancer research : Gann12 citations Open access
Semantic Scholar
Suppressive Soils to Bacterial Wilt of Tobacco in Japan and Population Dynamics of Pseudomonas solanacearum in These Soils
K. Koga, H. Hara, Hiroshi Tanaka
199710 citations Open access
Semantic Scholar
Establishment of ascitic tumor of human pre-B acute lymphoblastic leukemia in nonconditioned nude mice.
Yi Luo, H. Hara, Y. Haruta, B. Seon
1989Cancer Research10 citations
Semantic Scholar
Activation of inflammasomes and mechanisms for intracellular recognition of Listeria monocytogenes
Yasuyuki Matsuda, Hajime Yamauchi, H. Hara
2023Microbiology and immunology8 citations Open access
Semantic Scholar
New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells.
Takashi Fukukawa, H. Matsuzaki, Y. Haruta, H. Hara +1 more
1986Experimental Hematology8 citations
Semantic Scholar
Effector mechanism in concomitant immunity potentiated by intratumoral injection of Nocardia rubra cell wall skeleton.
Takeshi Ogura, H. Hara, S. Yokota, S. Hosoe +3 more
1985Cancer Research7 citations
Semantic Scholar

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K. Tsuchiya×21
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K. Tsuchiya — researcher profile on SciRah
M. Mitsuyama×21
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M. Mitsuyama — researcher profile on SciRah
I. Kawamura×17
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I. Kawamura — researcher profile on SciRah
Shunsuke Sakai×11
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Shunsuke Sakai — researcher profile on SciRah

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Rendong Fang — researcher profile on SciRah

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T. Nomura — researcher profile on SciRah

S. Kishimoto×9

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S. Kishimoto — researcher profile on SciRah

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Yanna Shen — researcher profile on SciRah

Sita R. Dewamitta×7

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Sita R. Dewamitta — researcher profile on SciRah

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S. Daim — researcher profile on SciRah

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Huixin Qu — researcher profile on SciRah

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S. Negoro — researcher profile on SciRah