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Talat H. Malik · SciRah

Researcher profile · Semantic Scholar

Talat H. Malik

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Talat H. Malik — researcher profile on SciRah

h-index: 25
Works: 59
Citations: 2,576

Most-cited papers

Dimerization of complement factor H-related proteins modulates complement activation in vivo
Elena Goicoechea de Jorge, J. Caesar, Talat H. Malik, Mitali M. Patel +7 more
2013Proceedings of the National Academy of Sciences of the United States of America297 citations Open access
Semantic Scholar
Immunoglobulin M is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
M. Lewis, Talat H. Malik, M. Ehrenstein, J. Boyle +2 more
2009Circulation268 citations Open access
Semantic Scholar
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.
A. Tortajada, Hugo Yébenes, C. Abarrategui-Garrido, J. Anter +12 more
2013Journal of Clinical Investigation195 citations Open access
Semantic Scholar
IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut
S. Sattler, G. Ling, Da-Mo Xu, L. Hussaarts +10 more
2014Journal of Autoimmunity172 citations Open access
Semantic Scholar
Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1
Talat H. Malik, S. Shoichet, Peter Latham, T. Kroll +2 more
2001EMBO Journal139 citations Open access
Semantic Scholar
Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.
K. L. Rose, D. Paixão-Cavalcante, J. Fish, Anthony P. Manderson +8 more
2008Journal of Clinical Investigation135 citations Open access
Semantic Scholar
A hybrid CFHR3-1 gene causes familial C3 glomerulopathy.
Talat H. Malik, P. Lavin, Elena Goicoechea de Jorge, K. Vernon +7 more
2012Journal of the American Society of Nephrology129 citations Open access
Semantic Scholar
Deletion of the GATA Domain of TRPS1 Causes an Absence of Facial Hair and Provides New Insights into the Bone Disorder in Inherited Tricho-Rhino-Phalangeal Syndromes
Talat H. Malik, D. von Stechow, R. Bronson, R. Shivdasani
2002Molecular and Cellular Biology110 citations Open access
Semantic Scholar
ADAP–SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell–APC Conjugation
Hong-Yan Wang, F. McCann, J. Gordan, Xiang Wu +4 more
2004Journal of Experimental Medicine99 citations Open access
Semantic Scholar
Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration.
Jaimie Hoh Kam, E. Lenassi, Talat H. Malik, M. Pickering +1 more
2013American Journal of Pathology88 citations Open access
Semantic Scholar
Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells
L. Fossati-Jimack, G. Ling, A. Cortini, Marta Szajna +6 more
2013PLoS ONE76 citations Open access
Semantic Scholar
A novel CFHR5 fusion protein causes C3 glomerulopathy in a family without Cypriot ancestry
Nicholas R. Medjeral-Thomas, Talat H. Malik, Mitali P. Patel, T. Tóth +3 more
2013Kidney International72 citations Open access
Semantic Scholar
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death
J. Gisby, C. Clarke, Nicholas R. Medjeral-Thomas, Talat H. Malik +21 more
2021eLife71 citations Open access
Semantic Scholar
C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells.
P. Baruah, I. Dumitriu, Talat H. Malik, H. T. Cook +4 more
2009Blood68 citations Open access
Semantic Scholar
Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4
H. Manku, C. Langefeld, Sandra G. Guerra, Talat H. Malik +34 more
2013PLoS Genetics63 citations Open access
Semantic Scholar
Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility
J. Caesar, Hayley Lavender, P. N. Ward, R. Exley +7 more
2014eLife59 citations Open access
Semantic Scholar
B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis
A. Cortini, U. Ellinghaus, Talat H. Malik, D. Cunninghame Graham +2 more
2017Annals of the Rheumatic Diseases50 citations Open access
Semantic Scholar
Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice.
V. Leung, S. Yun, M. Botto, J. Mason +6 more
2009American Journal of Pathology47 citations Open access
Semantic Scholar
Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis
R. Khamis, K. Woollard, G. Hyde, J. Boyle +11 more
2016Scientific Reports46 citations Open access
Semantic Scholar
Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes
Maha F. Saja, L. Baudino, W. Jackson, H. Cook +6 more
2015Cell Reports40 citations Open access
Semantic Scholar
Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence
J. Gisby, N. Buang, A. Papadaki, C. Clarke +13 more
2022Nature Communications32 citations Open access
Semantic Scholar
Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.
K. Vernon, Marieta M. Ruseva, H. T. Cook, M. Botto +2 more
2016Journal of the American Society of Nephrology32 citations Open access
Semantic Scholar
Factor H–Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy
Bárbara Márquez-Tirado, Josué Gutiérrez-Tenorio, A. Tortajada, Laura Lucientes Continente +11 more
2022Journal of the American Society of Nephrology30 citations Open access
Semantic Scholar
Requirement of JNK1 for endothelial cell injury in atherogenesis
Narges Amini, J. Boyle, B. Moers, C. Warboys +6 more
2014Atherosclerosis30 citations Open access
Semantic Scholar
Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia
M. Lewis, Talat H. Malik, L. Fossati-Jimack, D. Carassiti +3 more
2012Arthritis & Rheumatism27 citations Open access
Semantic Scholar
Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage
Talat H. Malik, D. Gitterman, Deborah P. Lavin, H. Lomax-Browne +12 more
2021Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar
Nonfunctional Variant 3 Factor H Binding Proteins as Meningococcal Vaccine Candidates
S. van der Veen, S. Johnson, I. Jongerius, Talat H. Malik +7 more
2013Infection and Immunity25 citations Open access
Semantic Scholar
Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model
J. Østergaard, M. Ruseva, Talat H. Malik, I. T. Hoffmann-Petersen +3 more
2016Journal of Diabetes Research24 citations Open access
Semantic Scholar
Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice
K. L. Rose, D. Paixão-Cavalcante, J. Fish, Anthony P. Manderson +8 more
200716 citations
Semantic Scholar
A novel mutation in EROS (CYBC1) causes Chronic Granulomatous Disease
P. Mortimer, Esme Nichols, Joe Thomas, Rachna Shanbhag +8 more
2023medRxiv14 citations Open access
Semantic Scholar
Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice
Ola Kamala, Talat H. Malik, T. Hallam, T. Cox +12 more
2021Frontiers in Immunology14 citations Open access
Semantic Scholar
A Hybrid CFHR 3-1 Gene Causes Familial C 3 Glomerulopathy
Talat H. Malik, P. Lavin, E. G. de Jorge, K. Vernon +7 more
201213 citations
Semantic Scholar
C1q enhances IFN-γ production by antigen specific T cells via the CD40 co-stimulatory pathway on dendritic cells
P. Baruah, I. Dumitriu, Talat H. Malik, H. T. Cook +4 more
200813 citations
Semantic Scholar
Defining the glycosaminoglycan interactions of complement factor H-related protein 5
Frederick Gyapon Quast, Elena Goicoechea de Jorge, Talat H. Malik, Nian Wu +5 more
2021Journal of Immunology12 citations Open access
Semantic Scholar
Severe COVID‐19 is associated with endothelial activation and abnormal glycosylation of von Willebrand factor in patients undergoing hemodialysis
G. Mobayen, Amrita Dhutia, C. Clarke, M. Prendecki +6 more
2021Research and Practice in Thrombosis and Haemostasis12 citations Open access
Semantic Scholar
Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice
H. Kerr, A. Herbert, Elisavet Makou, Dariusz Abramczyk +9 more
2021Frontiers in Immunology12 citations Open access
Semantic Scholar
Adeno-Associated Virus Vector Gene Delivery Elevates Factor I Levels and Downregulates the Complement Alternative Pathway In Vivo
Amina Ahmad, M. Mandwie, Anna K Dreismann, C. Smyth +6 more
2021Human Gene Therapy9 citations
Semantic Scholar
Multi-omics identify LRRC15 as a COVID-19 severity predictor and persistent pro-thrombotic signals in convalescence
Jack Gisby, N. Buang, A. Papadaki, Candice L. Clarke +13 more
2022medRxiv5 citations Open access
Semantic Scholar
Temporal multi-omics analysis of COVID-19 in end-stage kidney disease
Emily Stephenson, E. Macdonald-Dunlop, L. Dratva, R. Lindeboom +26 more
2025Cell Genomics3 citations Open access
Semantic Scholar
Structural findings in complement factor H-related proteins unravel the pathogenesis of C3 glomerulopathy
E. G. de Jorge, Joe Caeser, Talat H. Malik, Mitali M. Patel +5 more
20123 citations
Semantic Scholar
Longitudinal proteomic profiling of high-risk patients with COVID-19 reveals markers of severity and predictors of fatal disease
J. Gisby, C. Clarke, Nicholas R. Medjeral-Thomas, Talat H. Malik +20 more
2020medRxiv2 citations Open access
Semantic Scholar
A novel fusion protein reduces kidney complement in experimental C3 glomerulopathy
Talat H. Malik, K. Kwiatkowska, H. Lomax-Browne, C. Bottomley +6 more
2026Clinical and Experimental Immunology1 citations Open access
Semantic Scholar
Temporal multi-omic analysis of COVID-19 in end-stage kidney disease
Emily Stephenson, E. Macdonald-Dunlop, Lisa M. Dratva, R. Lindeboom +25 more
2024medRxiv1 citations Open access
Semantic Scholar
Author response: Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death
J. Gisby, C. Clarke, Nicholas R. Medjeral-Thomas, Talat H. Malik +21 more
20211 citations Open access
Semantic Scholar
Insights into the role of FHR5 in C3 glomerulopathy
Marieta M. Ruseva, Talat H. Malik, M. Pickering
20161 citations
Semantic Scholar
Generation of mice with deficiency of complement factor H and the complement factor H-related proteins
D. Gitterman, Talat H. Malik, A. Bradley, M. Pickering
20161 citations
Semantic Scholar
Mouse FHRB interacts with renal-bound C3 in vivo: Implications for C3 glomerulopathy
Talat H. Malik, D. Gitterman, Deborah P. Lavin, H. Lomax-Browne +3 more
20170 citations
Semantic Scholar
SaO019EVALUATION OF RECOMBINANT COMPLEMENT FACTOR H IN A MODEL OF DENSE DEPOSIT DISEASE
H. Kerr, Andrew H Herbert, Talat H. Malik, A. Richards +2 more
20150 citations
Semantic Scholar
Author response: Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility
J. Caesar, Hayley Lavender, P. N. Ward, R. Exley +7 more
20140 citations Open access
Semantic Scholar
Further insights into modulation of complement activation by the factor H-related family of proteins
J. Caesar, E. G. de Jorge, E. Chittock, Talat H. Malik +3 more
20130 citations
Semantic Scholar

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