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Hiroyuki Yamakawa · SciRah

Researcher profile · Semantic Scholar

Hiroyuki Yamakawa

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Hiroyuki Yamakawa — researcher profile on SciRah

h-index: 20
Works: 55
Citations: 3,578

Most-cited papers

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.
S. Tohyama, Fumiyuki Hattori, M. Sano, T. Hishiki +17 more
2013Cell Stem Cell658 citations Open access
Semantic Scholar
Nongenetic method for purifying stem cell–derived cardiomyocytes
Fumiyuki Hattori, Hao Chen, Hiromi Yamashita, S. Tohyama +19 more
2010Nature Methods429 citations
Semantic Scholar
Induction of human cardiomyocyte-like cells from fibroblasts by defined factors
Rie Wada, Naoto Muraoka, K. Inagawa, Hiroyuki Yamakawa +15 more
2013Proceedings of the National Academy of Sciences of the United States of America331 citations Open access
Semantic Scholar
MiR‐133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures
Naoto Muraoka, Hiroyuki Yamakawa, Kazutaka Miyamoto, Taketaro Sadahiro +18 more
2014EMBO Journal283 citations Open access
Semantic Scholar
Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5
K. Inagawa, Kazutaka Miyamoto, Hiroyuki Yamakawa, Naoto Muraoka +11 more
2012Circulation Research246 citations
Semantic Scholar
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function
G. Neely, K. Kuba, A. Cammarato, Kazuya Isobe +31 more
2010Cell241 citations Open access
Semantic Scholar
Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging.
K. Shinmura, K. Tamaki, M. Sano, M. Murata +3 more
2011Journal of Molecular and Cellular Cardiology173 citations
Semantic Scholar
Disease characterization using LQTS-specific induced pluripotent stem cells.
Toru Egashira, S. Yuasa, Tomoyuki Suzuki, Yoshiyasu Aizawa +25 more
2012Cardiovascular Research163 citations
Semantic Scholar
Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions
Hiroyuki Yamakawa, Naoto Muraoka, Kazutaka Miyamoto, Taketaro Sadahiro +10 more
2015Stem Cell Reports156 citations Open access
Semantic Scholar
Stem Cell Aging in Skeletal Muscle Regeneration and Disease
Hiroyuki Yamakawa, D. Kusumoto, H. Hashimoto, S. Yuasa
2020International Journal of Molecular Sciences155 citations Open access
Semantic Scholar
Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction.
Kazutaka Miyamoto, Mizuha Akiyama, Fumiya Tamura, Mari Isomi +18 more
2018Cell Stem Cell142 citations Open access
Semantic Scholar
Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside
Hiroyuki Yamakawa, Tomoko Kato, J. Noh, S. Yuasa +3 more
2021Frontiers in Physiology121 citations Open access
Semantic Scholar
Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction
Hidenori Tani, Taketaro Sadahiro, Yu Yamada, Mari Isomi +13 more
2022Circulation110 citations Open access
Semantic Scholar
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
Naoto Muraoka, K. Nara, Fumiya Tamura, Hidenori Kojima +14 more
2019Nature Communications85 citations Open access
Semantic Scholar
Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures
Shota Kurotsu, Taketaro Sadahiro, R. Fujita, Hidenori Tani +13 more
2020Stem Cell Reports76 citations Open access
Semantic Scholar
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure
Shogo Ito, H. Hashimoto, Hiroyuki Yamakawa, D. Kusumoto +31 more
2022Nature Communications37 citations Open access
Semantic Scholar
Cardiac regeneration by direct reprogramming in this decade and beyond
Hiroyuki Yamakawa, M. Ieda
2021Inflammation and Regeneration35 citations Open access
Semantic Scholar
Strategies for heart regeneration: approaches ranging from induced pluripotent stem cells to direct cardiac reprogramming.
Hiroyuki Yamakawa, M. Ieda
2015International Heart Journal28 citations Open access
Semantic Scholar
Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression
Tomohiko C Umei, Hiroyuki Yamakawa, Naoto Muraoka, Taketaro Sadahiro +11 more
2017International Journal of Molecular Sciences22 citations Open access
Semantic Scholar
MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes
Hidenori Kojima, Taketaro Sadahiro, Naoto Muraoka, Hiroyuki Yamakawa +15 more
2023Stem Cell Reports21 citations Open access
Semantic Scholar
Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart.
Mari Isomi, Taketaro Sadahiro, Hiroyuki Yamakawa, R. Fujita +8 more
2021Circulation20 citations Open access
Semantic Scholar
Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy
Takahide Arai, H. Kanazawa, Kensuke Kimura, Masahito Munakata +5 more
2022Frontiers in Neuroscience10 citations Open access
Semantic Scholar
Heart regeneration for clinical application update 2016: from induced pluripotent stem cells to direct cardiac reprogramming
Hiroyuki Yamakawa
2016Inflammation and Regeneration7 citations Open access
Semantic Scholar
Suppression of Rad leads to arrhythmogenesis via PKA-mediated phosphorylation of ryanodine receptor activity in the heart.
Hiroyuki Yamakawa, M. Murata, Tomoyuki Suzuki, Hirotaka Yada +5 more
2014Biochemical and Biophysical Research Communications - BBRC6 citations
Semantic Scholar
Inducible expression of long-chain acyl-CoA hydrolase gene in cell cultures
Mitsuhiro Takagi, Hiroyuki Yamakawa, Takafumi Watanabe, T. Suga +1 more
2003Molecular and Cellular Biochemistry6 citations
Semantic Scholar
Direct Reprogramming of Fibroblasts into Functional Cardiomyocyte-like Cells without Viral Integration
Kazutaka Miyamoto, Hiroyuki Yamakawa, Naoto Muraoka, Taketaro Sadahiro +6 more
20145 citations Open access
Semantic Scholar
Sipa1 Drives a Maladaptive Fibroblast-Myeloid Axis After Myocardial Infarction.
Seien Ko, Xueyuan Liu, Yurika Taniguchi, Genki Ichihara +11 more
2025Circulation Research4 citations
Semantic Scholar
Fabry disease associated with multiple myeloma: a case report
Keika Adachi, Hirobumi Tokuyama, Yoichi Oshima, T. Itoh +6 more
2021CEN Case Reports4 citations Open access
Semantic Scholar
Enhancement of the olfactory response by lipocalin Cp-Lip1 in newt olfactory receptor cells: An electrophysiological study.
Tadashi Nakamura, Yoshihiro Noumi, Hiroyuki Yamakawa, Atsushi Nakamura +5 more
2019Chemical Sensors4 citations
Semantic Scholar
A case of female Fabry disease revealed by renal biopsy
Sae Aratani, Hiroyuki Yamakawa, Shinya Suzuki, T. Otsuka +3 more
2019CEN Case Reports2 citations Open access
Semantic Scholar
A multi-country time and motion study to describe the experience and burden associated with the treatment of Fabry disease with enzyme replacement therapy with agalsidase alfa and agalsidase beta
Ian Keyzor, A. M. Martins, S. K. Uçar, Hiroyuki Yamakawa +7 more
2025Orphanet Journal of Rare Diseases1 citations Open access
Semantic Scholar
The need for home enzyme replacement therapy for patients with lysosomal disease in Japan
Hiroyuki Yamakawa, M. Kosuga, Y. Hoshino, I. Kaku +7 more
2022Molecular Genetics and Metabolism1 citations
Semantic Scholar
Comment on: Expandable cardiovascular progenitor cells reprogrammed from fibroblasts.
Hiroyuki Yamakawa, K. Fukuda
2016Stem Cell Investigation1 citations Open access
Semantic Scholar
Case report: Discovery of a family with a novel variant of Fabry disease following presentation of a female patient with peripheral limb pain
Hiroyuki Yamakawa, S. Nakamura, Nana Kushima, Toshiya Sato +5 more
2026Molecular Genetics and Metabolism0 citations
Semantic Scholar
A case of CD36 deficiency with multiple white matter lesions
Yuta Kizuka, Hiroyuki Yamakawa, Y. Iwabuchi, Jun Sakai +7 more
2026BMC Neurology0 citations Open access
Semantic Scholar
Standardization of home enzyme replacement therapy for lysosomal disease in Japan
Hiroyuki Yamakawa
2025Molecular Genetics and Metabolism0 citations
Semantic Scholar
Conductance at the Junction of a Pipe or an Orifice with a Pipe of Different Radius
Hiroyuki Yamakawa
2025Vacuum and Surface Science0 citations Open access
Semantic Scholar
Cardiac characteristics of Fabry disease from baseline enrolment data in a nationwide prospective Japanese registry.
Toru Kubo, Yuichiro Maekawa, K. Hongo, Saori Yamamoto +26 more
2025International Journal of Cardiology0 citations Open access
Semantic Scholar
Abstract P3061: Development Of Molecular Targeted Therapy Against Right Ventricular Failure: Involvement In Complement C3- Factor D- C3a Pathway
Shogo Ito, S. Yuasa, Hiroyuki Yamakawa, Jin Komuro +5 more
2023Circulation Research0 citations
Semantic Scholar
Cardiac regeneration by direct reprogramming in this decade and beyond
Hiroyuki Yamakawa, M. Ieda
2021Inflammation and Regeneration0 citations Open access
Semantic Scholar
A case of myeloma cast nephropathy complicated by Fabry disease after withdrawal from dialysis
Hiroyuki Yamakawa, Keika Adachi, Hirobumi Tokuyama, S. Wakino +5 more
20200 citations
Semantic Scholar
Fabry disease has been found by using of the tumor mutational burden analysis of 3000 Japanese cancer genomes using whole exome and targeted gene panel sequencing: Project Hightech Omics-based Patient Evaluation (Project HOPE)
Hiroyuki Yamakawa, Hiroyuki Matsubayash, S. Nishimura, Y. Horiuchi +9 more
2019Molecular Genetics and Metabolism0 citations
Semantic Scholar
For a patient of unidentified cardiomyopathy, NGS (nest gene sequense analysis) was useful for a diagnosis for Fabry disease
Hiroyuki Yamakawa, Yoshiyasu Aisawa, S. Yuasa, T. Tsukimura +4 more
20180 citations
Semantic Scholar
Abstract 20287: Tbx6 is Critical for Mesoderm Induction and Specification Into Cardiovascular and Somite Lineages
Taketaro Sadahiro, Mari Isomi, Naoto Muraoka, Hidenori Kojima +9 more
20170 citations
Semantic Scholar
Abstract 13806: Sendai Virus Vectors Achieve Efficient Integration-Free Cardiac Reprogramming in vitro and in vivo
Kazutaka Miyamoto, Mizuha Akiyama, Fumiya Tamura, Mari Isomi +8 more
20170 citations
Semantic Scholar
Tbx6 directly programs fibroblasts and pluripotent stem cells into cardiac mesodermal cells
Sadahiro Taketaro, Ieda Masaki, Fukuda Keiichi, Naoto Muraoka +4 more
20160 citations
Semantic Scholar
Abstract 13003: MicroRNA-133 Promotes Direct Cardiac Reprogramming by Snai1 Repression and Silencing Fibroblast Signatures
Naoto Muraoka, Hiroyuki Yamakawa, Kazutaka Miyamoto, Taketaro Sadahiro +12 more
2013Circulation0 citations
Semantic Scholar
Abstract 14297: Hypothalamic Activation Due to Ccl2 Causes Stress (takotsubo) Cardiomyopathy via Upregulation of Neuropeptide Y in the Cardiac Sympathetic Nerves
Takahide Arai, Kensuke Kimura, M. Ieda, Hiroyuki Yamakawa +2 more
20120 citations
Semantic Scholar
Abstract 11935: Disease Characterization Using Long QT Syndrome-Specific Induced Pluripotent Stem Cells
Toru Egashira, S. Yuasa, Tomoyuki Suzuki, K. Yae +6 more
20110 citations
Semantic Scholar
Abstract 15383: Direct Conversion of Cardiac Fibroblasts into Cardiomyocyte-Like Cells in vivo
K. Inagawa, Naoto Muraoka, Rie Wada, Hiroyuki Yamakawa +4 more
20110 citations
Semantic Scholar

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K. Fukuda×28
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M. Ieda×20
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Naoto Muraoka×16
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Naoto Muraoka — researcher profile on SciRah
Taketaro Sadahiro×15
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Kazutaka Miyamoto×12

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Kazutaka Miyamoto — researcher profile on SciRah

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Mari Isomi — researcher profile on SciRah

H. Hashimoto×9

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Hidenori Kojima×9

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Tomohiko C Umei×8

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S. Tohyama — researcher profile on SciRah

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M. Murata — researcher profile on SciRah