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K. Reynolds · SciRah

Researcher profile · Semantic Scholar

K. Reynolds

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K. Reynolds — researcher profile on SciRah

h-index: 17
Works: 48
Citations: 1,313

Most-cited papers

Hotspots for allosteric regulation on protein surfaces
K. Reynolds, Richard N. McLaughlin, R. Ranganathan
2011Cell353 citations Open access
Semantic Scholar
Evolution-Based Functional Decomposition of Proteins
O. Rivoire, K. Reynolds, R. Ranganathan
2015bioRxiv137 citations Open access
Semantic Scholar
Analysis of Full and Partial Agonists Binding to β2-Adrenergic Receptor Suggests a Role of Transmembrane Helix V in Agonist-Specific Conformational Changes
V. Katritch, K. Reynolds, V. Cherezov, M. Hanson +3 more
2009Journal of Molecular Recognition128 citations Open access
Semantic Scholar
An evolutionary hotspot defines functional differences between CRYPTOCHROMES
Clark Rosensweig, K. Reynolds, Peng Gao, Isara Laothamatas +4 more
2018Nature Communications88 citations Open access
Semantic Scholar
High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection
Y. T. Tamer, I. Gaszek, Haleh Abdizadeh, Tugce Batur +4 more
2018bioRxiv72 citations Open access
Semantic Scholar
Identifying conformational changes of the β2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators
K. Reynolds, V. Katritch, R. Abagyan
2009J. Comput. Aided Mol. Des.66 citations Open access
Semantic Scholar
Structural and Computational Characterization of the SHV-1 β-Lactamase-β-Lactamase Inhibitor Protein Interface*
K. Reynolds, J. M. Thomson, K. Corbett, C. Bethel +4 more
2006Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Evolution-based design of proteins.
K. Reynolds, William P. Russ, M. Socolich, R. Ranganathan
2013Methods in Enzymology40 citations
Semantic Scholar
Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface.
K. Reynolds, M. Hanes, J. M. Thomson, A. Antczak +4 more
2008Journal of Molecular Biology39 citations Open access
Semantic Scholar
An object‐oriented library for computational protein design
A. Chowdry, K. Reynolds, M. Hanes, M. Voorhies +2 more
2007Journal of Computational Chemistry37 citations
Semantic Scholar
Structurally distributed surface sites tune allosteric regulation
J. McCormick, M. Russo, Samuel Thompson, Aubrie Blevins +1 more
2021bioRxiv35 citations Open access
Semantic Scholar
A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism
A. Schober, Andrew D. Mathis, C. Ingle, Junyoung O. Park +5 more
2019Cell Reports34 citations Open access
Semantic Scholar
Evolution and Engineering of Allosteric Regulation in Protein Kinases
David Pincus, J. Pandey, Zoë A. Feder, Pau Creixell +2 more
2018Science Signaling32 citations Open access
Semantic Scholar
A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth
Andrew D. Mathis, Ryan M. Otto, K. Reynolds
2020Nucleic Acids Research28 citations Open access
Semantic Scholar
Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily
C. Narayanan, D. Gagné, K. Reynolds, N. Doucet
2017Scientific Reports27 citations Open access
Semantic Scholar
Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface.
K. Reynolds, J. M. Thomson, K. Corbett, C. Bethel +4 more
2006Journal of Biological Chemistry18 citations
Semantic Scholar
Melting of duplex DNA in the absence of ATP by NS3 helicase domain through specific interaction with a single-strand/double-strand junction
K. Reynolds, C. Cameron, K. Raney
2015Biochemistry17 citations Open access
Semantic Scholar
Strategies for Engineering and Rewiring Kinase Regulation.
J. McCormick, David Pincus, O. Resnekov, K. Reynolds
2019TIBS -Trends in Biochemical Sciences. Regular ed16 citations
Semantic Scholar
Specificity and Cooperativity at β-lactamase Position 104 in TEM-1/BLIP and SHV-1/BLIP interactions
M. Hanes, K. Reynolds, C. McNamara, P. Ghosh +3 more
2011Proteins: Structure, Function, and Bioinformatics16 citations Open access
Semantic Scholar
A continuous epistasis model for predicting growth rate given combinatorial variation in gene expression and environment
Ryan M. Otto, Agata Turska-Nowak, P. M. Brown, K. Reynolds
2023bioRxiv15 citations Open access
Semantic Scholar
An evolution-based strategy for engineering allosteric regulation
David Pincus, O. Resnekov, K. Reynolds
2017Physical Biology14 citations Open access
Semantic Scholar
A two-enzyme adaptive unit within bacterial folate metabolism
A. Schober, Andrew D. Mathis, C. Ingle, Junyoung O. Park +5 more
2017bioRxiv11 citations Open access
Semantic Scholar
Structure and Modeling of GPCRs: Implications for Drug Discovery
K. Reynolds, V. Katritch, R. Abagyan
20108 citations
Semantic Scholar
The Genetic Landscape of a Metabolic Interaction
T. N. Nguyen, C. Ingle, Samuel Thompson, K. Reynolds
2023bioRxiv7 citations Open access
Semantic Scholar
Accelerating biological insight for understudied genes.
K. Reynolds, E. Rosa-Molinar, Robert E. Ward, Hong-Bin Zhang +2 more
2021Integrative and Comparative Biology7 citations Open access
Semantic Scholar
Binding by the Hepatitis C Virus NS3 Helicase Partially Melts Duplex DNA
V. M. Raney, K. Reynolds, M. Harrison, D. Harrison +2 more
2012Biochemistry7 citations Open access
Semantic Scholar
Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information.
Jerry C. Dinan, James W. McCormick, K. Reynolds
2023Cold Spring Harbor Perspectives in Biology5 citations Open access
Semantic Scholar
Evolution and Engineering of Allosteric Regulation in Protein Kinases
David Pincus, J. Pandey, Pau Creixell, O. Resnekov +1 more
2017bioRxiv2 citations Open access
Semantic Scholar
Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily
C. Narayanan, D. Gagné, K. Reynolds, N. Doucet
2017Scientific Reports2 citations Open access
Semantic Scholar
Modulating the cellular context broadly reshapes the mutational landscape of a model enzyme
Samuel Thompson, Yang Zhang, C. Ingle, K. Reynolds +1 more
2019bioRxiv1 citations Open access
Semantic Scholar
A new test of computational protein design: predicting posttranslational modification specificity for the enzyme SMYD2.
K. Reynolds
2015Structure1 citations Open access
Semantic Scholar
Finding a common path: predicting gene function using inferred evolutionary trees.
K. Reynolds
2014Developmental Cell1 citations Open access
Semantic Scholar
TEN Evolution-Based Design of Proteins
K. Reynolds, William P. Russ, M. Socolich, R. Ranganathan
20141 citations
Semantic Scholar
Quantifying the evolvability of allostery at different protein surfaces.
Jerry C. Dinan, K. Reynolds
2023Biophysical Journal0 citations Open access
Semantic Scholar
Determining the mechanisms of the allosteric architecture of DHFR.
J. McCormick, Jerry C. Dinan, M. Russo, K. Reynolds
2023Biophysical Journal0 citations
Semantic Scholar
Resonant fluctuations of selection pressure exponentially accelerate fitness valley crossing
M. D. Di Salvo, K. Reynolds, Milo M. Lin
2022bioRxiv0 citations Open access
Semantic Scholar
The Internal Allosteric Architecture of Dihydrofolate Reductase
J. McCormick, Samuel Thompson, K. Reynolds
20200 citations Open access
Semantic Scholar
Determining the Internal Allosteric Architecture of DHFR with Total Saturation Mutagenesis
J. McCormick, Samuel Thompson, K. Reynolds
2019Biophysical Journal0 citations Open access
Semantic Scholar
Optimal Drift Time for Crossing Fitness Valleys
M. D. Di Salvo, K. Reynolds, Milo M. Lin
2019Biophysical Journal0 citations Open access
Semantic Scholar
Engineering and Evolution of Allosteric Communication
K. Reynolds
2019Biophysical Journal0 citations Open access
Semantic Scholar
Minimizing the Number of Measurements Required to Predict a Phenotypic Landscape in Bacterial Folate Metabolism
Andrew D. Mathis, J. Boldt, K. Reynolds
2019Biophysical Journal0 citations Open access
Semantic Scholar
Evolution of Regulatory Diversity in the Kinase Superfamily
J. Pandey, O. Resnekov, David Pincus, K. Reynolds
20170 citations Open access
Semantic Scholar
Probing RNA translocases with DNA.
K. Reynolds, V. M. Raney, K. Raney
2015Methods in molecular biology0 citations
Semantic Scholar
A mechanism for the evolution of allosteric control in proteins
K. Reynolds, R. Ranganathan
20110 citations
Semantic Scholar
Crystal structure of the SHV-1 D104E beta-lactamase/beta-lactamase inhibitor protein (BLIP) complex
M. Hanes, K. Reynolds, C. McNamara, P. Ghosh +3 more
20110 citations
Semantic Scholar
Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M complex
K. Reynolds, M. Hanes, J. M. Thomson, A. Antczak +4 more
20080 citations
Semantic Scholar
Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M/S130K/S146M complex
K. Reynolds, M. Hanes, J. M. Thomson, A. Antczak +4 more
20080 citations
Semantic Scholar
Crystal Structure of the SHV D104K Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex
K. Reynolds, J. M. Thomson, K. Corbett, C. Bethel +4 more
20060 citations
Semantic Scholar

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