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V. Colotta · SciRah

Researcher profile · Semantic Scholar

V. Colotta

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V. Colotta — researcher profile on SciRah

h-index: 28
Works: 138
Citations: 2,218

Most-cited papers

Competitive AMPA receptor antagonists
D. Catarzi, V. Colotta, F. Varano
2007Medicinal research reviews (Print)77 citations
Semantic Scholar
Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455
S. Gessi, S. Bencivenni, Enrica Battistello, F. Vincenzi +6 more
2017Frontiers in Pharmacology70 citations Open access
Semantic Scholar
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists.
F. Varano, D. Catarzi, V. Colotta, G. Filacchioni +3 more
2002Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.
V. Colotta, D. Catarzi, F. Varano, F. R. Calabri +6 more
2004Journal of Medicinal Chemistry59 citations Open access
Semantic Scholar
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.
Daniela Poli, D. Catarzi, V. Colotta, F. Varano +6 more
2011Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation, and molecular modeling study.
F. Varano, D. Catarzi, V. Colotta, F. R. Calabri +6 more
2005Bioorganic & Medicinal Chemistry55 citations
Semantic Scholar
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.
Alessandro Bonardi, M. Falsini, D. Catarzi, F. Varano +6 more
2018European journal of medicinal chemistry54 citations Open access
Semantic Scholar
Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A2A Adenosine Receptor Inverse Agonists with Antinociceptive Activity.
F. Varano, D. Catarzi, F. Vincenzi, M. Betti +5 more
2016Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
Ombretta Lenzi, V. Colotta, D. Catarzi, F. Varano +8 more
2009Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Ombretta Lenzi, V. Colotta, D. Catarzi, F. Varano +8 more
2006Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.
V. Colotta, D. Catarzi, F. Varano, L. Cecchi +4 more
2000Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
V. Colotta, D. Catarzi, F. Varano, F. Capelli +10 more
2007Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
V. Colotta, D. Catarzi, F. Varano, Ombretta Lenzi +9 more
2006Journal of Medicinal Chemistry43 citations
Semantic Scholar
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.
D. Catarzi, V. Colotta, F. Varano, F. R. Calabri +4 more
2004Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
1,2,4-Triazolo[1,5-a]quinoxaline as a Versatile Tool for the Design of Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Biological Evaluation, and Molecular Modeling Studies of 2-(Hetero)aryl- and 2-Carboxy-Substitued Derivatives
D. Catarzi, V. Colotta, F. Varano, Ombretta Lenzi +5 more
200541 citations Open access
Semantic Scholar
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
V. Colotta, D. Catarzi, F. Varano, Ombretta Lenzi +9 more
2008Bioorganic & Medicinal Chemistry38 citations Open access
Semantic Scholar
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
V. Colotta, Ombretta Lenzi, D. Catarzi, F. Varano +9 more
2009Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor.
M. Betti, D. Catarzi, F. Varano, M. Falsini +5 more
2018European journal of medicinal chemistry34 citations Open access
Semantic Scholar
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies.
V. Colotta, Ombretta Lenzi, D. Catarzi, F. Varano +11 more
2012European journal of medicinal chemistry34 citations
Semantic Scholar
Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173.
D. Catarzi, V. Colotta, F. Varano, G. Filacchioni +3 more
2001Journal of Medicinal Chemistry33 citations
Semantic Scholar
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
V. Colotta, D. Catarzi, F. Varano, F. R. Calabri +3 more
2004Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype.
M. Falsini, L. Squarcialupi, D. Catarzi, F. Varano +8 more
2017Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.
D. Catarzi, V. Colotta, F. Varano, Daniela Poli +8 more
2013Bioorganic & Medicinal Chemistry30 citations Open access
Semantic Scholar
Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine skeleton as a key study.
Erika Morizzo, F. Capelli, Ombretta Lenzi, D. Catarzi +7 more
2007Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists.
D. Catarzi, V. Colotta, F. Varano, L. Cecchi +4 more
2000Journal of Medicinal Chemistry29 citations
Semantic Scholar
Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: Synthesis and structure-activity relationships.
F. Varano, D. Catarzi, V. Colotta, Ombretta Lenzi +3 more
2008Bioorganic & Medicinal Chemistry28 citations
Semantic Scholar
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.
L. Squarcialupi, V. Colotta, D. Catarzi, F. Varano +9 more
2013Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.
M. Falsini, L. Squarcialupi, D. Catarzi, F. Varano +8 more
2017Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A₁ and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.
L. Squarcialupi, V. Colotta, D. Catarzi, F. Varano +7 more
2014European journal of medicinal chemistry25 citations Open access
Semantic Scholar
Synthesis and pharmacological studies at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring.
F. R. Calabri, V. Colotta, D. Catarzi, F. Varano +4 more
2005European journal of medicinal chemistry25 citations
Semantic Scholar
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation.
F. Varano, D. Catarzi, L. Squarcialupi, M. Betti +7 more
2015European journal of medicinal chemistry24 citations Open access
Semantic Scholar
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones: excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity.
D. Catarzi, V. Colotta, F. Varano, L. Cecchi +3 more
1999Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway.
E. Coppi, F. Cherchi, Irene Fusco, Ilaria Dettori +12 more
2020Biochemical Pharmacology22 citations
Semantic Scholar
Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus.
Irene Fusco, F. Cherchi, D. Catarzi, V. Colotta +4 more
2019Brain Research Bulletin22 citations
Semantic Scholar
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor.
L. Squarcialupi, D. Catarzi, F. Varano, M. Betti +7 more
2016European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Ombretta Lenzi, V. Colotta, D. Catarzi, F. Varano +8 more
2011Bioorganic & Medicinal Chemistry22 citations Open access
Semantic Scholar
Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and of their constrained analogue imidazo.
F. Varano, D. Catarzi, V. Colotta, L. Cecchi +3 more
2001European journal of medicinal chemistry22 citations
Semantic Scholar
Modifications on the amino-3,5-dicyanopyridine core to obtain multifaceted adenosine receptor ligands with antineuropathic activity.
M. Betti, D. Catarzi, F. Varano, M. Falsini +11 more
2019Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies.
V. Colotta, F. Capelli, Ombretta Lenzi, D. Catarzi +9 more
2009Bioorganic & Medicinal Chemistry21 citations Open access
Semantic Scholar
2-aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists.
D. Catarzi, V. Colotta, F. Varano, F. R. Calabri +7 more
2005Bioorganic & Medicinal Chemistry21 citations
Semantic Scholar
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents.
F. Varano, D. Catarzi, F. Vincenzi, Silvia Pasquini +8 more
2020Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
A2A Adenosine Receptor Antagonists and their Potential in Neurological Disorders.
C. Lambertucci, G. Marucci, D. Catarzi, V. Colotta +4 more
2022Current Medicinal Chemistry19 citations
Semantic Scholar
Antioxidant-conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain.
M. Falsini, D. Catarzi, F. Varano, Costanza Ceni +10 more
2019Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Competitive Gly/NMDA receptor antagonists.
D. Catarzi, V. Colotta, F. Varano
2006Current Topics in Medicinal Chemistry19 citations
Semantic Scholar
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes.
Daniela Poli, M. Falsini, F. Varano, M. Betti +10 more
2017European journal of medicinal chemistry18 citations Open access
Semantic Scholar
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.
L. Squarcialupi, M. Falsini, D. Catarzi, F. Varano +7 more
2016Bioorganic & Medicinal Chemistry18 citations Open access
Semantic Scholar
Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders.
D. Catarzi, F. Varano, Erica Vigiani, C. Lambertucci +3 more
2022Current Medicinal Chemistry17 citations
Semantic Scholar
Tandem 3D-QSARs approach as a valuable tool to predict binding affinity data: design of new Gly/NMDA receptor antagonists as a key study.
M. Bacilieri, F. Varano, Francesca Deflorian, M. Marini +7 more
2007Journal of Chemical Information and Modeling17 citations
Semantic Scholar
Piperazine- and Piperidine-Containing Thiazolo[5,4-d]pyrimidine Derivatives as New Potent and Selective Adenosine A2A Receptor Inverse Agonists
F. Varano, D. Catarzi, Erica Vigiani, F. Vincenzi +3 more
2020Pharmaceuticals16 citations Open access
Semantic Scholar
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1 and A2A adenosine receptor antagonists/inverse agonists.
F. Varano, D. Catarzi, M. Falsini, F. Vincenzi +3 more
2018Bioorganic & Medicinal Chemistry15 citations Open access
Semantic Scholar

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G. Filacchioni×27
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Ombretta Lenzi×16

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