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G. Manfroni · SciRah

Researcher profile · Semantic Scholar

G. Manfroni

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G. Manfroni — researcher profile on SciRah

h-index: 30
Works: 109
Citations: 2,338

Most-cited papers

Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.
S. Sabatini, Francesca Gosetto, G. Manfroni, O. Tabarrini +3 more
2011Journal of Medicinal Chemistry102 citations Open access
Semantic Scholar
Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.
S. Sabatini, Francesca Gosetto, S. Serritella, G. Manfroni +7 more
2012Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
S. Massari, Giulio Nannetti, J. Desantis, G. Muratore +9 more
2015Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.
Jean-Pierre Brincat, E. Carosati, S. Sabatini, G. Manfroni +5 more
2011Journal of Medicinal Chemistry71 citations
Semantic Scholar
Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.
D. Tarantino, Rolando Cannalire, E. Mastrangelo, R. Croci +6 more
2016Antiviral Research67 citations Open access
Semantic Scholar
Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.
Andrea Astolfi, Tommaso Felicetti, N. Iraci, G. Manfroni +7 more
2017Journal of Medicinal Chemistry60 citations Open access
Semantic Scholar
Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity.
P. Blasi, A. Schoubben, G. Traina, G. Manfroni +4 more
2013International journal of pharmaceutics58 citations
Semantic Scholar
Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.
J. Desantis, Giulio Nannetti, S. Massari, M. L. Barreca +6 more
2017European journal of medicinal chemistry54 citations Open access
Semantic Scholar
Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly.
S. Massari, Giulio Nannetti, Laura Goracci, L. Sancineto +10 more
2013Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.
S. Sabatini, Francesca Gosetto, N. Iraci, M. L. Barreca +7 more
2013Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.
Rolando Cannalire, M. L. Barreca, G. Manfroni, V. Cecchetti
2016Journal of Medicinal Chemistry51 citations
Semantic Scholar
2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.
Tommaso Felicetti, Rolando Cannalire, D. Pietrella, G. Latacz +10 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
G. Manfroni, Francesco Meschini, M. L. Barreca, P. Leyssen +7 more
2012Bioorganic & Medicinal Chemistry46 citations
Semantic Scholar
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication
M. L. Barreca, G. Manfroni, P. Leyssen, J. Winquist +10 more
2013Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development.
M. L. Barreca, N. Iraci, G. Manfroni, V. Cecchetti
2011Future Medicinal Chemistry43 citations
Semantic Scholar
Investigation on the effect of known potent S. aureus NorA efflux pump inhibitors on the staphylococcal biofilm formation
S. Sabatini, Miranda Piccioni, Tommaso Felicetti, Stefania De Marco +5 more
201742 citations Open access
Semantic Scholar
The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors
G. Manfroni, Rolando Cannalire, M. L. Barreca, Neerja Kaushik-Basu +12 more
2013Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli
D. Machado, L. Fernandes, S. S. Costa, Rolando Cannalire +5 more
2017PeerJ40 citations Open access
Semantic Scholar
New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors
G. Manfroni, Dinesh Manvar, M. L. Barreca, Neerja Kaushik-Basu +12 more
2014Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.
Rolando Cannalire, K. Chan, Maria Sole Burali, C. P. Gwee +10 more
2020ACS Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.
Rolando Cannalire, D. Tarantino, Andrea Astolfi, M. L. Barreca +8 more
2018European journal of medicinal chemistry35 citations Open access
Semantic Scholar
Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View
Tommaso Felicetti, G. Manfroni, V. Cecchetti, Rolando Cannalire
2020ChemMedChem32 citations
Semantic Scholar
Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium.
Rolando Cannalire, D. Machado, Tommaso Felicetti, Sofia Santos Costa +8 more
2017European journal of medicinal chemistry31 citations
Semantic Scholar
Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3‐Phenyl‐1,4‐benzothiazine Analogues
Tommaso Felicetti, Rolando Cannalire, Maria Sole Burali, S. Massari +7 more
2017ChemMedChem30 citations Open access
Semantic Scholar
Computer‐Aided Design, Synthesis and Validation of 2‐Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti‐HIV‐1 Tat‐Mediated Transcription Activity
L. Sancineto, N. Iraci, S. Massari, Vanessa Attanasio +9 more
2013ChemMedChem30 citations
Semantic Scholar
Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6‐Naphthyridone Derivative with Potent and Selective Anti‐HIV Activity
O. Tabarrini, S. Massari, L. Sancineto, D. Daelemans +4 more
2011ChemMedChem30 citations
Semantic Scholar
Boosting Effect of 2-Phenylquinoline Efflux Inhibitors in Combination with Macrolides against Mycobacterium smegmatis and Mycobacterium avium.
D. Machado, Rolando Cannalire, Sofia Santos Costa, G. Manfroni +5 more
2015ACS Infectious Diseases29 citations
Semantic Scholar
Small Molecule Drugs Targeting Viral Polymerases
Deborah Palazzotti, Martina Sguilla, G. Manfroni, V. Cecchetti +2 more
2024Pharmaceuticals28 citations Open access
Semantic Scholar
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase
S. Massari, Chiara Bertagnin, M. C. Pismataro, A. Donnadio +13 more
2020European journal of medicinal chemistry28 citations Open access
Semantic Scholar
Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold
I. Andreev, Dinesh Manvar, M. L. Barreca, Dmitry S. Belov +10 more
2015European journal of medicinal chemistry28 citations Open access
Semantic Scholar
Studies of Anti‐HIV Transcription Inhibitor Quinolones: Identification of Potent N1‐Vinyl Derivatives
O. Tabarrini, S. Massari, D. Daelemans, Francesco Meschini +6 more
2010ChemMedChem28 citations
Semantic Scholar
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity
Maria Giulia Nizi, L. Persoons, A. Corona, Tommaso Felicetti +15 more
2022ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions.
Rolando Cannalire, D. Tarantino, G. Piorkowski, Tea Carletti +11 more
2019Antiviral Research25 citations
Semantic Scholar
A Comprehensive Structural Overview of p38α Mitogen‐Activated Protein Kinase in Complex with ATP‐Site and Non‐ATP‐Site Binders
Andrea Astolfi, G. Manfroni, V. Cecchetti, M. L. Barreca
2018ChemMedChem25 citations
Semantic Scholar
Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs
Tommaso Felicetti, V. Cecchetti, G. Manfroni
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Comprehensive response to Usutu virus following first isolation in blood donors in the Friuli Venezia Giulia region of Italy: Development of recombinant NS1-based serology and sensitivity to antiviral drugs
I. Caracciolo, Erick Mora-Cardenas, Chiara Aloise, Tea Carletti +9 more
2020PLoS Neglected Tropical Diseases23 citations Open access
Semantic Scholar
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.
Maria Giulia Nizi, J. Desantis, Y. Nakatani, S. Massari +17 more
2020European journal of medicinal chemistry23 citations Open access
Semantic Scholar
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
J. Desantis, S. Massari, A. Corona, Andrea Astolfi +7 more
2020Molecules22 citations Open access
Semantic Scholar
Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.
Tommaso Felicetti, Rolando Cannalire, Maria Giulia Nizi, O. Tabarrini +7 more
2018European journal of medicinal chemistry21 citations Open access
Semantic Scholar
A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors
Andrea Astolfi, N. Iraci, G. Manfroni, M. L. Barreca +1 more
2015ChemMedChem21 citations
Semantic Scholar
Accounting for Target Flexibility and Water Molecules by Docking to Ensembles of Target Structures: The HCV NS5B Palm Site I Inhibitors Case Study
M. L. Barreca, N. Iraci, G. Manfroni, Rosy Gaetani +4 more
2014Journal of Chemical Information and Modeling21 citations
Semantic Scholar
Recent Progress toward the Discovery of Small Molecules as Novel Anti-Respiratory Syncytial Virus Agents.
Tommaso Felicetti, Chiara Sarnari, Roberta Gaito, O. Tabarrini +1 more
2024Journal of Medicinal Chemistry20 citations
Semantic Scholar
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.
Andrea Astolfi, Mark Kudolo, J. Bréa, Giorgia Manni +13 more
2019European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.
L. Sancineto, N. Iraci, M. L. Barreca, S. Massari +7 more
2014Bioorganic & Medicinal Chemistry20 citations Open access
Semantic Scholar
Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener.
R. Sardella, A. Carotti, G. Manfroni, D. Tedesco +4 more
2014Journal of Chromatography A19 citations Open access
Semantic Scholar
1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions.
A. Martelli, G. Manfroni, Paola Sabbatini, M. L. Barreca +8 more
2013Journal of Medicinal Chemistry19 citations
Semantic Scholar
A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation.
Chiara Acchioni, Marta Acchioni, F. Mancini, Antonello Amendola +15 more
2023Virology18 citations Open access
Semantic Scholar
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
S. Massari, A. Corona, S. Distinto, J. Desantis +9 more
2018Journal of Enzyme Inhibition and Medicinal Chemistry18 citations Open access
Semantic Scholar
Studies on Cycloheptathiophene-3-Carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H inhibitors
A. Corona, J. Desantis, S. Massari, S. Distinto +10 more
2016ChemMedChem17 citations Open access
Semantic Scholar
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors
Tommaso Felicetti, G. Mangiaterra, Rolando Cannalire, Nicholas Cedraro +9 more
2020Journal of Enzyme Inhibition and Medicinal Chemistry16 citations Open access
Semantic Scholar

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V. Cecchetti×44
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V. Cecchetti — researcher profile on SciRah
O. Tabarrini×34
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O. Tabarrini — researcher profile on SciRah
S. Sabatini×33
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S. Sabatini — researcher profile on SciRah
M. L. Barreca×30
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M. L. Barreca — researcher profile on SciRah

×26

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S. Massari — researcher profile on SciRah

Rolando Cannalire×16

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Rolando Cannalire — researcher profile on SciRah

Tommaso Felicetti×16

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Tommaso Felicetti — researcher profile on SciRah

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N. Iraci — researcher profile on SciRah

Andrea Astolfi×9

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Andrea Astolfi — researcher profile on SciRah

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G. Kaatz — researcher profile on SciRah

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C. Pannecouque — researcher profile on SciRah

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J. Desantis — researcher profile on SciRah