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T. Kakkar · SciRah

Researcher profile · Semantic Scholar

T. Kakkar

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T. Kakkar — researcher profile on SciRah

h-index: 11
Works: 22
Citations: 674

Most-cited papers

Approximations of the target-mediated drug disposition model and identifiability of model parameters
L. Gibiansky, E. Gibiansky, T. Kakkar, Pei-Ming Ma
2008Journal of Pharmacokinetics and Pharmacodynamics279 citations
Semantic Scholar
Estimation of Ki in a competitive enzyme-inhibition model: comparisons among three methods of data analysis.
T. Kakkar, H. Boxenbaum, M. Mayersohn
1999Drug Metabolism And Disposition117 citations
Semantic Scholar
Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor
T. Kakkar, C. Sung, L. Gibiansky, T. Vu +8 more
2011Pharmaceutical Research48 citations
Semantic Scholar
Evaluation of a minimal experimental design for determination of enzyme kinetic parameters and inhibition mechanism.
T. Kakkar, Yvonne Pak, M. Mayersohn
2000Journal of Pharmacology and Experimental Therapeutics35 citations
Semantic Scholar
Pharmacokinetics and Safety of a Fully Human Hepatocyte Growth Factor Antibody, AMG 102, in Cynomolgus Monkeys
T. Kakkar, M. Ma, Y. Zhuang, A. Patton +2 more
2007Pharmaceutical Research33 citations
Semantic Scholar
A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis
M. Cardiel, P. Tak, W. Bensen, F. Burch +8 more
2010Arthritis Research & Therapy29 citations Open access
Semantic Scholar
An Open-Label Crossover Study of the Pharmacokinetics of the 60-mg Edoxaban Tablet Crushed and Administered Either by a Nasogastric Tube or in Apple Puree in Healthy Adults
K. Duchin, A. Duggal, G. Atiee, M. Kidokoro +5 more
2017Clinical Pharmacokinetics24 citations Open access
Semantic Scholar
Interim results from a first-in-human study with AMG102, a fully human monoclonal antibody that neutralizes hepatocyte growth factor (HGF), the ligand to c-Met receptor, in patients (pts) with advanced solid tumors
M. Gordon, D. Mendelson, C. Sweeney, N. Erbeck +5 more
200724 citations
Semantic Scholar
Simultaneous quantitative analysis of methyl salicylate, ethyl salicylate and salicylic acid from biological fluids using gas chromatography-mass spectrometry.
T. Kakkar, M. Mayersohn
1998Journal of Chromatography B: Biomedical Sciences and Applications19 citations
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Modeling of a Monoclonal Antibody Antagonist of Glucagon Receptor in Male ob/ob Mice
Yvonne Y. Lau, Pei-Ming Ma, L. Gibiansky, R. Komorowski +5 more
2009AAPS Journal14 citations Open access
Semantic Scholar
Administration of an Antagonist of Neurokinin Receptors 1, 2, and 3 Results in Reproductive Tract Changes in Beagle Dogs, but Not Rats
P. Losco, M. Leach, D. Sinha, Preston P. Davis +5 more
2007Toxicologic pathology (Print)13 citations Open access
Semantic Scholar
Effect of Renal Function on the Pharmacokinetics of Palifermin
B. Gillespie, P. Zia‐Amirhosseini, M. Salfi, T. Kakkar +5 more
2006Journal of clinical pharmacology9 citations
Semantic Scholar
Physiologically‐based pharmacokinetic modeling of immunoglobulin and antibody coadministration in patients with primary human immunodeficiency
S. Salerno, R. Deng, T. Kakkar
2022CPT: Pharmacometrics & Systems Pharmacology8 citations Open access
Semantic Scholar
Highlights From a Recent BIO Survey on Therapeutic Protein‐Drug Interactions
P. Lloyd, Hong-Hui Zhou, F. Theil, T. Kakkar +2 more
2012Journal of clinical pharmacology6 citations
Semantic Scholar
Dosing Recommendation Based on the Effects of Different Meal Types on Pexidartinib Pharmacokinetics in Healthy Subjects: Implementation of Model‐informed Drug Development Strategy
H. Zahir, O. Yin, Ching Hsu, A. Wagner +6 more
2023Clinical pharmacology in drug development5 citations Open access
Semantic Scholar
Edoxaban Exposure in Patients With Atrial Fibrillation and Estimated Creatinine Clearance Exceeding 100 mL/min
O. Yin, T. Kakkar, A. Duggal, Masakatsu Kotsuma +3 more
2021Clinical pharmacology in drug development5 citations Open access
Semantic Scholar
Multiple-Dose Study of AMG 317 in Adults with Asthma: Pharmacokinetics and Safety
C. Banfield, M. Vincent, T. Kakkar, M. Chia +4 more
20084 citations
Semantic Scholar
Single-Dose, First-in-Human Study of AMG 317: Pharmacokinetics and Safety in Healthy and Asthmatic Adults
M. Vincent, C. Banfield, T. Kakkar, S. Shakib +3 more
20082 citations Open access
Semantic Scholar
First‐In‐Human Evaluation of the Pharmacokinetics, Pharmacodynamics, and Safety of Tilpisertib Fosmecarbil (GS‐5290), an Oral Prodrug of a Tumor Progression Locus 2 Inhibitor in Healthy Participants
P. Madia, Emily Wendt, A. R. Qin, Xin Qi +7 more
2026Journal of clinical pharmacology0 citations Open access
Semantic Scholar
UvA-DARE ( Digital Academic Repository ) A phase 2 randomized , double-blind study of AMG 108 , a fully human monoclonal antibody to IL-1 R , in patients with rheumatoid arthritis
M. Cardiel, P. Tak, W. Bensen, F. Burch +8 more
20170 citations
Semantic Scholar
Drug Interactions for Growth Factors and Hormones
Yow-Ming C. Wang, T. Kakkar
20130 citations
Semantic Scholar
Theoretical studies on enzyme inhibition kinetics
T. Kakkar
19990 citations
Semantic Scholar

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