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G. Gibson · SciRah

Researcher profile · Semantic Scholar

G. Gibson

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G. Gibson — researcher profile on SciRah

h-index: 59
Works: 207
Citations: 15K

Most-cited papers

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, M. Abdellatif +496 more
2021Autophagy4,016 citations Open access
Semantic Scholar
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.
E. Area‐Gomez, A. de Groof, I. Boldogh, T. Bird +7 more
2009American Journal of Pathology393 citations Open access
Semantic Scholar
Dopaminergic cell death induced by MPP+, oxidant and specific neurotoxicants shares the common molecular mechanism
Hong S. Chun, G. Gibson, L. DeGiorgio, Hui Zhang +2 more
2001Journal of Neurochemistry268 citations Open access
Semantic Scholar
Cause and Consequence: Mitochondrial Dysfunction Initiates and Propagates Neuronal Dysfunction, Neuronal Death and Behavioral Abnormalities in Age Associated Neurodegenerative Diseases
G. Gibson, A. Starkov, J. Blass, R. Ratan +1 more
2009Biochimica et Biophysica Acta240 citations Open access
Semantic Scholar
Succinylation links metabolism to protein functions.
Yun Yang, G. Gibson
2019Neurochemical Research195 citations Open access
Semantic Scholar
The α-ketoglutarate dehydrogenase complex in neurodegeneration
G. Gibson, L. Park, K. R. Sheu, J. Blass +1 more
2000193 citations
Semantic Scholar
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype
G. Gibson, V. Haroutunian, Hui Zhang, L. Park +5 more
2000Annals of Neurology189 citations
Semantic Scholar
Oxidative Stress and Transcriptional Regulation in Alzheimer Disease
Qing-Li Shi, G. Gibson
2007Alzheimer Disease and Associated Disorders171 citations Open access
Semantic Scholar
Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration.
G. Gibson, Hui Zhang
2002Neurochemistry International147 citations
Semantic Scholar
A Mitocentric View of Alzheimer’s Disease Suggests Multi-Faceted Treatments
G. Gibson, Qing-Li Shi
2010Journal of Alzheimer's Disease117 citations Open access
Semantic Scholar
Frontal Lobe Dysfunction in Progressive Supranuclear Palsy
D. S. Albers, S. Augood, L. Park, Susan E. Browne +7 more
2000Journal of Neurochemistry108 citations
Semantic Scholar
The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response
Manuel D. Díaz-Muñoz, Sarah E. Bell, K. Fairfax, Elisa Monzón-Casanova +12 more
2015Nature Immunology103 citations Open access
Semantic Scholar
Reversal of Thiamine Deficiency‐Induced Neurodegeneration
Zun-Ji Ke, L. DeGiorgio, B. Volpe, G. Gibson
2003Journal of Neuropathology and Experimental Neurology97 citations
Semantic Scholar
The role of the metabolic lesion in Alzheimer's disease
J. Blass, G. Gibson, S. Hoyer
2002Journal of Alzheimer's Disease97 citations
Semantic Scholar
Benfotiamine and Cognitive Decline in Alzheimer’s Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial
G. Gibson, J. Luchsinger, Rosanna Cirio, Huan-Lian Chen +13 more
2020Journal of Alzheimer's Disease87 citations Open access
Semantic Scholar
Tricarboxylic acid cycle enzymes following thiamine deficiency.
P. Bubber, Zun-Ji Ke, G. Gibson
2004Neurochemistry International86 citations
Semantic Scholar
The alpha-ketoglutarate dehydrogenase complex in neurodegeneration.
G. Gibson, L. Park, K. Sheu, J. Blass +1 more
2000Neurochemistry International86 citations
Semantic Scholar
Abnormal Thiamine-Dependent Processes in Alzheimer’s Disease. Lessons from Diabetes
G. Gibson, Joseph A. Hirsch, Rosanna Cirio, B. Jordan +2 more
2012Molecular and cellular neurosciences84 citations Open access
Semantic Scholar
Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism.
Zun-Ji Ke, G. Gibson
2004Neurochemistry International83 citations
Semantic Scholar
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
Victor Tapias, Shari Jainuddin, M. Ahuja, Cliona Stack +17 more
2018Human Molecular Genetics79 citations Open access
Semantic Scholar
Phosphonate Analogues of α-Ketoglutarate Inhibit the Activity of the α-Ketoglutarate Dehydrogenase Complex Isolated from Brain and in Cultured Cells†
V. Bunik, Travis T. Denton, Hui Xu, C. Thompson +2 more
200576 citations
Semantic Scholar
Oxidative stress in Alzheimer's disease.
G. Gibson, Hsueh-Meei Huang
2005Neurobiology of Aging72 citations
Semantic Scholar
Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease.
G. Gibson, Hsueh-Meei Huang
2002Frontiers in Bioscience72 citations
Semantic Scholar
Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease.
G. Gibson
2002Free Radical Biology & Medicine72 citations
Semantic Scholar
Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition
M. Dumont, Daniel J. Ho, N. Calingasan, Hui Xu +2 more
2009Free Radical Biology & Medicine71 citations Open access
Semantic Scholar
The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration
Grace E Hansen, G. Gibson
2022International Journal of Molecular Sciences70 citations Open access
Semantic Scholar
Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex*
Qing-Li Shi, Hui Xu, Haiqiang Yu, Na-Wei Zhang +4 more
2011Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Brain energetics, integration of molecular and cellular processes
A. Lajtha, G. Gibson, G. Dienel
200770 citations
Semantic Scholar
Mitochondrial Enzymes and Endoplasmic Reticulum Calcium Stores as Targets of Oxidative Stress in Neurodegenerative Diseases
G. Gibson, Hsueh-Meei Huang
2004Journal of Bioenergetics and Biomembranes69 citations
Semantic Scholar
Deficits in the Mitochondrial Enzyme α-Ketoglutarate Dehydrogenase Lead to Alzheimer’s Disease-like Calcium Dysregulation
G. Gibson, Huan-Lian Chen, Hui Xu, Linghua Qiu +3 more
2011Neurobiology of Aging65 citations Open access
Semantic Scholar
Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation.
Hsueh-Meei Huang, Hui Zhang, Hui Xu, G. Gibson
2003Biochimica et Biophysica Acta62 citations Open access
Semantic Scholar
Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death
Hsueh-Meei Huang, H. Ou, Hui Xu, Huan-Lian Chen +2 more
2003Journal of Neuroscience Research61 citations
Semantic Scholar
Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease.
Qing-Li Shi, Hui Xu, W. Kleinman, G. Gibson
2008Biochimica et Biophysica Acta58 citations Open access
Semantic Scholar
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.
B. Krasnikov, Soo-Youl Kim, Stephen J. McConoughey, H. Ryu +8 more
2005Biochemistry58 citations Open access
Semantic Scholar
Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism.
Saravanan S. Karuppagounder, Qing-Li Shi, Hui Xu, G. Gibson
2007Neurobiology of Disease56 citations Open access
Semantic Scholar
Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme.
G. Gibson, Hui Zhang, Hui Xu, L. Park +1 more
2002Biochimica et Biophysica Acta56 citations Open access
Semantic Scholar
Vascular Factors Are Critical in Selective Neuronal Loss in an Animal Model of Impaired Oxidative Metabolism
N. Y. Calingasan, Paul L. Huang, Hong S. Chun, A. Fabian +1 more
2000Journal of Neuropathology and Experimental Neurology52 citations
Semantic Scholar
Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism.
N. Y. Calingasan, G. Gibson
2000Brain Research52 citations Open access
Semantic Scholar
Mitochondrial impairment in cerebellum from patients with progressive supranuclear palsy
L. Park, D. S. Albers, M. Beal, G. Gibson
200052 citations
Semantic Scholar
Co-culture with astrocytes or microglia protects metabolically impaired neurons.
L. Park, Hui Zhang, G. Gibson
2001Mechanisms of Ageing and Development51 citations
Semantic Scholar
University of Birmingham The RNA-binding protein HuR is essential for the B cell antibody response
Manuel D. Díaz-Muñoz, Sarah E. Bell, K. Fairfax, Elisa Monzón-Casanova +14 more
201649 citations
Semantic Scholar
Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability.
Qing-Li Shi, Saravanan S. Karuppagounder, Hui Xu, David B. Pechman +2 more
2007Neurochemistry International49 citations Open access
Semantic Scholar
Inhibitors of the α‐ketoglutarate dehydrogenase complex alter [1‐13C]glucose and [U‐13C]glutamate metabolism in cerebellar granule neurons
Sónia Sá Santos, G. Gibson, Arthur James Cooper, Travis T. Denton +4 more
200649 citations
Semantic Scholar
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.
Lei Zhang, Arthur J. L. Cooper, B. Krasnikov, Hui Xu +4 more
2006Biochemistry48 citations Open access
Semantic Scholar
Mitochondrial enzymes in schizophrenia
P. Bubber, Ji-Cheng Tang, V. Haroutunian, Hui Xu +3 more
2007Journal of Molecular Neuroscience47 citations
Semantic Scholar
Mitochondrial Aconitase is a Transglutaminase 2 Substrate: Transglutamination is a Probable Mechanism Contributing to High-Molecular-Weight Aggregates of Aconitase and Loss of Aconitase Activity in Huntington Disease Brain
Soo-Youl Kim, L. Marekov, P. Bubber, S. Browne +7 more
2005Neurochemical Research47 citations
Semantic Scholar
Abnormalities in the Tricarboxylic Acid Cycle in Huntington Disease and in a Huntington Disease Mouse Model
Nima N. Naseri, Hui Xu, Joseph Bonica, J. Vonsattel +4 more
2015Journal of Neuropathology and Experimental Neurology46 citations Open access
Semantic Scholar
Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α‐ketoglutarate dehydrogenase
H. Waagepetersen, G. H. Hansen, K. Fenger, J. Lindsay +2 more
2006Glia46 citations
Semantic Scholar
Mild metabolic perturbations alter succinylation of mitochondrial proteins
Huan-Lian Chen, Hui Xu, Samuel Potash, Anatoly Starkov +4 more
2017Journal of Neuroscience Research44 citations Open access
Semantic Scholar
Enzyme-Catalyzed Side Reactions with Molecular Oxygen may Contribute to Cell Signaling and Neurodegenerative Diseases
V. Bunik, J. Schloss, J. Pinto, G. Gibson +1 more
2007Neurochemical Research43 citations
Semantic Scholar

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