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O. Abián · SciRah

Researcher profile · Semantic Scholar

O. Abián

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O. Abián — researcher profile on SciRah

h-index: 34
Works: 161
Citations: 4,770

Most-cited papers

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening
O. Abián, David Ortega-Alarcón, A. Jiménez-Alesanco, Laura Ceballos-Laita +4 more
2020International Journal of Biological Macromolecules222 citations Open access
Semantic Scholar
Isothermal titration calorimetry
Margarida Bastos, O. Abián, Christopher M. Johnson, F. Ferreira-da-Silva +4 more
2023Nature Reviews Methods Primers153 citations Open access
Semantic Scholar
Targeting intrinsically disordered proteins involved in cancer
P. Santofimia-Castaño, B. Rizzuti, Yi Xia, O. Abián +4 more
2019Cellular and Molecular Life Sciences97 citations Open access
Semantic Scholar
Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.
P. Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou +8 more
2019Journal of Clinical Investigation93 citations Open access
Semantic Scholar
Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs
B. Rizzuti, F. Grande, F. Conforti, A. Jiménez-Alesanco +6 more
2021Biomedicines75 citations Open access
Semantic Scholar
MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2
Alexia Martínez de Paz, Leila Khajavi, H. Martin, Rafael Claveria-Gimeno +19 more
2018Epigenetics & Chromatin58 citations Open access
Semantic Scholar
Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma
P. Santofimia-Castaño, Yi Xia, Ling Peng, A. Velázquez-Campoy +8 more
2019Cells56 citations Open access
Semantic Scholar
Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of Mpro and Its Antiviral Activity in Cells against SARS-CoV-2
Francesca Mangiavacchi, Paweł Botwina, E. Menichetti, Luana Bagnoli +18 more
2021International Journal of Molecular Sciences55 citations Open access
Semantic Scholar
ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents
Wenjun Lan, P. Santofimia-Castaño, M. Swayden, Yi Xia +15 more
2020JCI Insight49 citations Open access
Semantic Scholar
Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
J. Felix, Katharina Weinhäupl, Christophe Chipot, François Dehez +8 more
2019Science Advances49 citations Open access
Semantic Scholar
Uncertainty in protein–ligand binding constants: asymmetric confidence intervals versus standard errors
V. Paketurytė, V. Petrauskas, A. Zubrienė, O. Abián +9 more
2021European Biophysics Journal38 citations Open access
Semantic Scholar
Enzyme/Nanocopper Hybrid Nanozymes: Modulating Enzyme-like Activity by the Protein Structure for Biosensing and Tumor Catalytic Therapy
Noelia Losada-García, A. Jiménez-Alesanco, A. Velázquez-Campoy, O. Abián +1 more
2021ACS Applied Materials and Interfaces35 citations Open access
Semantic Scholar
The PANcreatic Disease ReseArch (PANDoRA) consortium: ten years' experience of association studies to understand the genetic architecture of pancreatic cancer.
D. Campa, M. Gentiluomo, Angelika Stein, M. Aoki +90 more
2023Critical reviews in oncology/hematology31 citations Open access
Semantic Scholar
Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).
P. Santofimia-Castaño, B. Rizzuti, O. Abián, A. Velázquez-Campoy +2 more
2018Biochimica et Biophysica Acta - General Subjects31 citations Open access
Semantic Scholar
Thermal Liquid Biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study
A. Velázquez-Campoy, S. Vega, O. Sanchez-Gracia, Á. Lanas +8 more
2018Biochimica et Biophysica Acta - General Subjects31 citations Open access
Semantic Scholar
A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin
J. Neira, B. Rizzuti, A. Jiménez-Alesanco, Martina Palomino-Schätzlein +3 more
2020Biomolecules28 citations Open access
Semantic Scholar
Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function
B. Rizzuti, Wenjun Lan, P. Santofimia-Castaño, Zhengwei Zhou +6 more
2021Biomolecules27 citations Open access
Semantic Scholar
Biochemical and biophysical characterization of PADI4 supports its involvement in cancer.
J. Neira, Salomé Araujo-Abad, A. Cámara-Artigas, B. Rizzuti +4 more
2022Archives of Biochemistry and Biophysics23 citations Open access
Semantic Scholar
Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study
B. López-Méndez, B. Baron, C. Brautigam, T. Jowitt +43 more
2021European Biophysics Journal23 citations Open access
Semantic Scholar
Discovery of Diverse Natural Products as Inhibitors of SARS-CoV-2 Mpro Protease through Virtual Screening
J. Rubio-Martínez, A. Jiménez-Alesanco, Laura Ceballos-Laita, David Ortega-Alarcón +9 more
2021Journal of Chemical Information and Modeling21 citations Open access
Semantic Scholar
Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds
B. Rizzuti, Laura Ceballos-Laita, David Ortega-Alarcón, A. Jiménez-Alesanco +5 more
2021Pharmaceuticals20 citations Open access
Semantic Scholar
Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2
David Ortega-Alarcón, Rafael Claveria-Gimeno, S. Vega, Ladan Kalani +5 more
2024Nucleic Acids Research19 citations Open access
Semantic Scholar
Human Enzyme PADI4 Binds to the Nuclear Carrier Importin α3
J. Neira, B. Rizzuti, O. Abián, Salomé Araujo-Abad +2 more
2022Cells19 citations Open access
Semantic Scholar
Thermal Liquid Biopsy (TLB): A Predictive Score Derived from Serum Thermograms as a Clinical Tool for Screening Lung Cancer Patients
A. Rodrigo, Jorge L Ojeda, S. Vega, O. Sanchez-Gracia +4 more
2019Cancers19 citations Open access
Semantic Scholar
Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
P. Santofimia-Castaño, B. Rizzuti, Yi Xia, O. Abián +4 more
2019Molecular & Cellular Oncology18 citations Open access
Semantic Scholar
Thermal Liquid Biopsy (TLB) of Blood Plasma as a Potential Tool to Help in the Early Diagnosis of Multiple Sclerosis
F. Annesi, S. Hermoso-Durán, B. Rizzuti, R. Bruno +9 more
2021Journal of Personalized Medicine17 citations Open access
Semantic Scholar
A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca2+ and Mg2+ binding to EDTA
A. Velázquez-Campoy, Bárbara Claro, O. Abián, Jonas Höring +13 more
2021European Biophysics Journal16 citations
Semantic Scholar
Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2
David Ortega-Alarcón, Rafael Claveria-Gimeno, S. Vega, Olga C. Jorge-Torres +3 more
2021Biomolecules15 citations Open access
Semantic Scholar
Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction.
David Ortega-Alarcón, Rafael Claveria-Gimeno, S. Vega, Olga C. Jorge-Torres +3 more
2021International Journal of Biological Macromolecules15 citations Open access
Semantic Scholar
Repositioning small molecule drugs as allosteric inhibitors of the BFT‐3 toxin from enterotoxigenic Bacteroides fragilis
A. Jiménez-Alesanco, U. Eckhard, Marta Asencio Del Rio, S. Vega +4 more
2022Protein Science14 citations Open access
Semantic Scholar
The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3
J. Neira, B. Rizzuti, A. Jiménez-Alesanco, O. Abián +2 more
2020International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Dendrimers as competitors of protein-protein interactions of the intrinsically disordered nuclear chromatin protein NUPR1.
J. Neira, Juan Correa, B. Rizzuti, P. Santofimia-Castaño +4 more
2019Biomacromolecules14 citations
Semantic Scholar
Enzyme structure and function protection from gastrointestinal degradation using enteric coatings.
Rubén Gracia, C. Yus, O. Abián, G. Mendoza +4 more
2018International Journal of Biological Macromolecules13 citations
Semantic Scholar
Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C-H activation in aqueous media.
Carlos Perez-Rizquez, O. Abián, J. M. Palomo
2019Chemical Communications12 citations Open access
Semantic Scholar
Cationic poly(ester amide) dendrimers: alluring materials for biomedical applications.
Alexandre Lancelot, Rebeca González-Pastor, Rafael Claveria-Gimeno, P. Romero +4 more
2018Journal of materials chemistry. B12 citations Open access
Semantic Scholar
l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells
L. Sancineto, C. Ostacolo, David Ortega-Alarcón, A. Jiménez-Alesanco +12 more
2021Molecules11 citations Open access
Semantic Scholar
Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis
S. Hermoso-Durán, G. García-Rayado, Laura Ceballos-Laita, Carlos Sostres +7 more
2020Journal of Personalized Medicine11 citations Open access
Semantic Scholar
Multi-Point Covalent Immobilization of Enzymes on Supports Activated with Epoxy Groups: Stabilization of Industrial Enzymes.
C. Mateo, O. Abián, G. Fernandez-Lorente, B. Pessela +3 more
2020Methods in molecular biology11 citations
Semantic Scholar
The intrinsically disordered, epigenetic factor RYBP binds to the citrullinating enzyme PADI4 in cancer cells.
Salomé Araujo-Abad, M. Fuentes-Baile, B. Rizzuti, J. Bazan +8 more
2023International Journal of Biological Macromolecules10 citations Open access
Semantic Scholar
The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4.
J. Neira, B. Rizzuti, Salomé Araujo-Abad, O. Abián +3 more
2022Biochimica et Biophysica Acta - Proteins and Proteomics10 citations Open access
Semantic Scholar
Biosourced All-Acrylic ABA Block Copolymers with Lactic Acid-Based Soft Phase
Nabil Bensabeh, A. Jiménez-Alesanco, I. Liblikas, J. C. Ronda +5 more
2020Molecules10 citations Open access
Semantic Scholar
Handling complexity in biological interactions
S. Vega, O. Abián, A. Velázquez-Campoy
2019Journal of Thermal Analysis and Calorimetry10 citations
Semantic Scholar
Development of an efficient NUPR1 inhibitor with anticancer activity
Xi Liu, A. Jiménez-Alesanco, Ze-Xian Li, Bruno Rizzuti +11 more
2024Scientific Reports9 citations Open access
Semantic Scholar
Development of a Machine‐Learning Model for Diagnosis of Pancreatic Cancer from Serum Samples Analyzed by Thermal Liquid Biopsy
S. Hermoso-Durán, N. Fraunhoffer, Judith Millastre Bocos, O. Sanchez-Gracia +6 more
2024Advanced Intelligent Systems9 citations Open access
Semantic Scholar
Autochthonous Peruvian Natural Plants as Potential SARS-CoV-2 Mpro Main Protease Inhibitors
M. N. Peralta-Moreno, Vanessa Anton-Muñoz, David Ortega-Alarcón, A. Jiménez-Alesanco +7 more
2023Pharmaceuticals9 citations Open access
Semantic Scholar
Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2
David Ortega-Alarcón, Rafael Claveria-Gimeno, S. Vega, Olga C. Jorge-Torres +3 more
2020Biomolecules9 citations Open access
Semantic Scholar
Dual Biochemically Breakable Drug Carriers from Programmed Telechelic Homopolymers.
Adrián Moreno, A. Jiménez-Alesanco, J. C. Ronda, V. Cádiz +4 more
2020Biomacromolecules9 citations Open access
Semantic Scholar
Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells.
Salomé Araujo-Abad, B. Rizzuti, Lourdes Soto-Conde, Miguel Vidal +4 more
2024International Journal of Biological Macromolecules8 citations Open access
Semantic Scholar
New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4
Salomé Araujo-Abad, B. Rizzuti, A. Villamarin-Ortiz, D. Pantoja-Uceda +5 more
2023Protein Science8 citations Open access
Semantic Scholar
In Vitro Antiviral Activity of Tyrosinase from Mushroom Agaricus bisporus against Hepatitis C Virus
David Lopez-Tejedor, Rafael Claveria-Gimeno, A. Velázquez-Campoy, O. Abián +1 more
2021Pharmaceuticals8 citations Open access
Semantic Scholar

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