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A. Larner · SciRah

Researcher profile · Semantic Scholar

A. Larner

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A. Larner — researcher profile on SciRah

h-index: 52
Works: 112
Citations: 12K

Most-cited papers

Function of Mitochondrial Stat3 in Cellular Respiration
J. Węgrzyn, Ramesh Potla, Y. Chwae, N. B. Sepuri +22 more
2009Science1,033 citations Open access
Semantic Scholar
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.
Chao-Lan Yu, D. Meyer, G. S. Campbell, A. Larner +3 more
1995Science990 citations
Semantic Scholar
Mitochondrial Stat3 Supports Ras-Dependent Oncogenic Transformation
Daniel J. Gough, Alicia T. Corlett, K. Schlessinger, J. Węgrzyn +2 more
2009Science740 citations Open access
Semantic Scholar
Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins.
M. David, E. Petricoin, C. Benjamin, R. Pine +2 more
1995Science577 citations
Semantic Scholar
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
C. Bacon, E. Petricoin, J. Ortaldo, R. Rees +3 more
1995Proceedings of the National Academy of Sciences of the United States of America497 citations Open access
Semantic Scholar
Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane Signaling (*)
Oscar R. Colamonici, P. Domanski, S. Sweitzer, A. Larner +1 more
1995Journal of Biological Chemistry409 citations Open access
Semantic Scholar
Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
M. David, Haiyan Chen, S. Goelz, A. Larner +1 more
1995Molecular and Cellular Biology376 citations Open access
Semantic Scholar
Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1
S. Ito, P. Ansari, M. Sakatsume, H. Dickensheets +4 more
1999371 citations
Semantic Scholar
Tyrosine phosphorylation of DNA binding proteins by multiple cytokines.
A. Larner, M. David, G. Feldman, K. Igarashi +5 more
1993Science339 citations
Semantic Scholar
Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species*
Karol Szczepanek, Qun Chen, Marta Derecka, Fadi N. Salloum +7 more
2011Journal of Biological Chemistry226 citations Open access
Semantic Scholar
Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.
K. Igarashi, G. Garotta, L. Ozmen, A. Ziemiecki +4 more
1994Journal of Biological Chemistry211 citations Open access
Semantic Scholar
The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain
Prasad Tammineni, Chandrashekhar Anugula, Fareed Mohammed, Murari Anjaneyulu +2 more
2012Journal of Biological Chemistry200 citations Open access
Semantic Scholar
Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.
S. Ito, P. Ansari, M. Sakatsume, H. Dickensheets +4 more
1999Blood200 citations
Semantic Scholar
Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine Stimulation (*)
L. Stancato, M. David, C. Carter-Su, A. Larner +1 more
1996Journal of Biological Chemistry191 citations Open access
Semantic Scholar
Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580.
L. DaSilva, H. Rui, Rebecca A. Erwin, O. M. Zack Howard +5 more
1996Molecular and Cellular Endocrinology189 citations
Semantic Scholar
Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA*
R. Sharf, David Meraro, A. Azriel, A. Thornton +6 more
1997Journal of Biological Chemistry188 citations Open access
Semantic Scholar
Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727*
Qi-Fang Zhang, V. Raje, V. Yakovlev, A. Yacoub +11 more
2013Journal of Biological Chemistry181 citations Open access
Semantic Scholar
STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin
M. David, Lily Wong, R. Flavell, S. A. Thompson +3 more
1996Journal of Biological Chemistry179 citations Open access
Semantic Scholar
Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2
Sheng Wei, A. Gamero, Jin-Hong Liu, Angela A. Daulton +5 more
1998Journal of Experimental Medicine175 citations Open access
Semantic Scholar
Toward a new STATe: The role of STATs in mitochondrial function
Jeremy A. Meier, A. Larner
2014Seminars in Immunology170 citations Open access
Semantic Scholar
Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the Janus kinases.
F. Dong, A. Larner
2000Blood151 citations
Semantic Scholar
Antiproliferative action of interferon-α requires components of T-cell-receptor signalling
E. Petricoin, S. Ito, B. L. Williams, S. Audet +10 more
1997Nature137 citations
Semantic Scholar
Craf-1 protein kinase is essential for mouse development.
L. Wojnowski, L. Stancato, Anne M. Zimmer, H. Hahn +4 more
1998Mechanisms of Development133 citations Open access
Semantic Scholar
Histone Deacetylase Activity Is Required to Recruit RNA Polymerase II to the Promoters of Selected Interferon-stimulated Early Response Genes*
S. Sakamoto, Ramesh Potla, A. Larner
2004Journal of Biological Chemistry132 citations Open access
Semantic Scholar
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
Paul K. Ziegler, J. Bollrath, Charles Pallangyo, T. Matsutani +24 more
2018Cell127 citations Open access
Semantic Scholar
Cytoprotection by the Modulation of Mitochondrial Electron Transport Chain: The Emerging Role of Mitochondrial STAT3
Karol Szczepanek, Qun Chen, A. Larner, E. Lesnefsky
2011Mitochondrion (Amsterdam. Print)121 citations Open access
Semantic Scholar
The Jak Kinases Differentially Associate with the and (Accessory Factor) Chains of the Interferon Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors (*)
M. Sakatsume, K. Igarashi, K. Winestock, G. Garotta +2 more
1995Journal of Biological Chemistry119 citations Open access
Semantic Scholar
A nuclear tyrosine phosphatase downregulates interferon-induced gene expression
M. David, P. Grimley, D. Finbloom, A. Larner
1993Molecular and Cellular Biology119 citations Open access
Semantic Scholar
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway
L. Stancato, M. Sakatsume, M. David, P. Dent +10 more
1997Molecular and Cellular Biology114 citations Open access
Semantic Scholar
Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production
Jeremy A. Meier, Moonjung Hyun, Marc T. Cantwell, A. Raza +11 more
2017Science Signaling112 citations Open access
Semantic Scholar
Multi-Tasking: Nuclear Transcription Factors with Novel Roles in the Mitochondria
Karol Szczepanek, E. Lesnefsky, A. Larner
2012Trends in Cell Biology111 citations Open access
Semantic Scholar
The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression*
M. David, Gao-Chao Zhou, R. Pine, J. Dixon +1 more
1996Journal of Biological Chemistry106 citations Open access
Semantic Scholar
Stimulation of Stat5 by granulocyte colony-stimulating factor (G-CSF) is modulated by two distinct cytoplasmic regions of the G-CSF receptor.
Fan Dong, Xiu-Wen Liu, J. D. de Koning, I. Touw +3 more
1998Journal of Immunology104 citations
Semantic Scholar
Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity
Marta Derecka, A. Górnicka, Sergei B Koralov, Karol Szczepanek +20 more
2012Cell Metabolism98 citations Open access
Semantic Scholar
Prolactin Stimulates Serine/Tyrosine Phosphorylation and Formation of Heterocomplexes of Multiple Stat5 Isoforms in Nb2 Lymphocytes*
R. Kirken, M. Grazia Malabarba, Jun Xu, Xiu-Wen Liu +5 more
1997Journal of Biological Chemistry96 citations Open access
Semantic Scholar
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca2+ - de novo ceramide - PP2A - ROS dependent signaling pathway
Margaret A. Park, Clint Mitchell, Guo Zhang, A. Yacoub +10 more
2010Cancer Research93 citations Open access
Semantic Scholar
Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor That Regulates Rates of Inactivation of Jak2 and Stat Proteins*
R. Hackett, Yi-Ding Wang, S. Sweitzer, G. Feldman +2 more
1997Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.
Massimo Gadina, Louis M. Stancato, C. Bacon, A. Larner +1 more
1998Journal of Immunology88 citations Open access
Semantic Scholar
In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate
K. Igarashi, M. David, A. Larner, D. Finbloom
1993Molecular and Cellular Biology86 citations Open access
Semantic Scholar
In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase.
M. David, G. Romero, Zhong-Ying Zhang, J. Dixon +1 more
1993Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Activation of Protein Kinase A Inhibits Interferon Induction of the Jak/Stat Pathway in U266 Cells (*)
M. David, E. Petricoin, A. Larner
1996Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Prolactin activates the interferon-regulated p91 transcription factor and the Jak2 kinase by tyrosine phosphorylation.
M. David, E. F. Petricoin, K. Igarashi, Gerald M. Feldman +2 more
1994Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Interferonγ Activation of Raf-1 Is Jak1-dependent and p21ras-independent*
M. Sakatsume, L. Stancato, M. David, O. Silvennoinen +4 more
1998Journal of Biological Chemistry72 citations Open access
Semantic Scholar
A PI‐3 kinase‐dependent, Stat1‐independent signaling pathway regulates interferon‐stimulated monocyte adhesion
A. Navarro, B. Anand-Apte, Y. Tanabe, G. Feldman +1 more
2003Journal of Leukocyte Biology70 citations Open access
Semantic Scholar
The Carboxyl Terminus of the Granulocyte Colony- Stimulating Factor Receptor, Truncated in Patients with Severe Congenital Neutropenia/Acute Myeloid Leukemia, Is Required for SH2-Containing Phosphatase-1 Suppression of Stat Activation1
F. Dong, Yaling Qiu, T. Yi, I. Touw +1 more
2001Journal of Immunology66 citations Open access
Semantic Scholar
In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade
K. Igarashi, M. David, D. Finbloom, A. Larner
1993Molecular and Cellular Biology62 citations Open access
Semantic Scholar
IL-4 attenuates the transcriptional activation of both IFN-alpha and IFN-gamma-induced cellular gene expression in monocytes and monocytic cell lines.
A. Larner, E. Petricoin, Y. Nakagawa, D. Finbloom
1993Journal of Immunology57 citations
Semantic Scholar
Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes.
A. Larner, D. Finbloom
1995Biochimica et Biophysica Acta56 citations Open access
Semantic Scholar
The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors.
M. Sakatsume, K. Igarashi, K. Winestock, G. Garotta +2 more
1995Journal of Biological Chemistry55 citations
Semantic Scholar
Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C
F. Dong, J. Gutkind, A. Larner
2001Journal of Biological Chemistry54 citations Open access
Semantic Scholar

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