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Samuel C. C. Chiang · SciRah

Researcher profile · Semantic Scholar

Samuel C. C. Chiang

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Samuel C. C. Chiang — researcher profile on SciRah

h-index: 30
Works: 66
Citations: 4,496

Most-cited papers

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
H. Schlums, Frank Cichocki, B. Tesi, J. Theorell +12 more
2015Immunity722 citations Open access
Semantic Scholar
CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin
S. Cheuk, H. Schlums, Irène Gallais Sérézal, E. Martini +16 more
2017Immunity631 citations Open access
Semantic Scholar
A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes.
Y. Bryceson, D. Pende, A. Maul‐Pavicic, K. Gilmour +16 more
2012Blood295 citations Open access
Semantic Scholar
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.
E. Haapaniemi, Meri Kaustio, H. Rajala, A. V. van Adrichem +23 more
2015Blood262 citations Open access
Semantic Scholar
Molecular Mechanisms of Natural Killer Cell Activation
Y. Bryceson, Samuel C. C. Chiang, S. Darmanin, C. Fauriat +3 more
2011Journal of Innate Immunity231 citations Open access
Semantic Scholar
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis
A. Maul‐Pavicic, Samuel C. C. Chiang, A. Rensing-Ehl, Birthe Jessen +15 more
2011Proceedings of the National Academy of Sciences of the United States of America221 citations Open access
Semantic Scholar
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.
B. Tesi, J. Davidsson, M. Voss, Elisa J. Rahikkala +21 more
2017Blood193 citations Open access
Semantic Scholar
Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production.
Samuel C. C. Chiang, J. Theorell, Miriam Entesarian, Marie Meeths +18 more
2013Blood148 citations
Semantic Scholar
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.
A. Cohnen, Samuel C. C. Chiang, A. Stojanovic, Hendrik Schmidt +6 more
2013Blood141 citations Open access
Semantic Scholar
A novel intellectual disability syndrome caused by GPI anchor deficiency due to homozygous mutations in PIGT
M. Kvarnung, D. Nilsson, A. Lindstrand, G. Korenke +9 more
2013Journal of Medical Genetics130 citations
Semantic Scholar
Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2.
Marie Meeths, Miriam Entesarian, W. Al-Herz, Samuel C. C. Chiang +13 more
2010Blood129 citations
Semantic Scholar
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.
Marie Meeths, Samuel C. C. Chiang, Stephanie Wood, Miriam Entesarian +20 more
2011Blood124 citations
Semantic Scholar
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity.
Stephanie Wood, Marie Meeths, Samuel C. C. Chiang, A. Bechensteen +11 more
2009Blood111 citations
Semantic Scholar
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation
T. D. Holmes, R. Pandey, Eric Y. Helm, H. Schlums +19 more
2021Science immunology80 citations Open access
Semantic Scholar
Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency.
B. Tesi, E. Sieni, C. Neves, F. Romano +15 more
2015Journal of Allergy and Clinical Immunology74 citations Open access
Semantic Scholar
Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.
H. Schlums, Moonjung Jung, Hongya Han, J. Theorell +17 more
2017Blood67 citations Open access
Semantic Scholar
Chediak-Higashi syndrome: LYST domains regulate exocytosis of lytic granules, but not cytokine secretion by NK cells
A. Gil-Krzewska, Stephanie Wood, Y. Murakami, Victoria V. Nguyen +8 more
2015Journal of Allergy and Clinical Immunology57 citations Open access
Semantic Scholar
Targeted high-throughput sequencing for genetic diagnostics of hemophagocytic lymphohistiocytosis
B. Tesi, K. Lagerstedt-Robinson, Samuel C. C. Chiang, Eya Ben Bdira +22 more
2015Genome Medicine46 citations Open access
Semantic Scholar
A case of XMEN syndrome presented with severe auto-immune disorders mimicking autoimmune lymphoproliferative disease.
T. Patiroglu, H. Akar, K. Gilmour, E. Unal +7 more
2015Clinical Immunology45 citations
Semantic Scholar
Successful Hematopoietic Stem Cell Transplantation in a Patient with LPS-Responsive Beige-Like Anchor (LRBA) Gene Mutation
B. Tesi, P. Priftakis, F. Lindgren, Samuel C. C. Chiang +7 more
2016Journal of Clinical Immunology44 citations
Semantic Scholar
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency
Frank Cichocki, H. Schlums, Hong-Chuan Li, V. Stache +7 more
2014Journal of Experimental Medicine44 citations Open access
Semantic Scholar
Efficacy of Moderately Dosed Etoposide in Macrophage Activation Syndrome–Hemophagocytic Lymphohistiocytosis
A. Horne, Tatiana von Bahr Greenwood, Samuel C. C. Chiang, Marie Meeths +8 more
2021Journal of Rheumatology43 citations
Semantic Scholar
RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis.
A. Kalinichenko, Giovanna Perinetti Casoni, Loïc Dupré, L. Trotta +20 more
2021Blood39 citations Open access
Semantic Scholar
Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity.
Marie Meeths, Samuel C. C. Chiang, A. Löfstedt, Martha-Lena Müller +3 more
2014Experimental Cell Research39 citations
Semantic Scholar
Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations
M. Machaczka, Monika Klimkowska, Samuel C. C. Chiang, Marie Meeths +4 more
2013Haematologica39 citations Open access
Semantic Scholar
Novel deep intronic and missense UNC13D mutations in familial haemophagocytic lymphohistiocytosis type 3
Miriam Entesarian, Samuel C. C. Chiang, H. Schlums, Marie Meeths +6 more
2013British Journal of Haematology39 citations Open access
Semantic Scholar
Spectrum of Atypical Clinical Presentations in Patients with Biallelic PRF1 Missense Mutations
B. Tesi, Samuel C. C. Chiang, D. El-Ghoneimy, A. Hussein +10 more
2015Pediatric Blood & Cancer37 citations
Semantic Scholar
Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak–Higashi Syndrome Patients
Samuel C. C. Chiang, Stephanie Wood, B. Tesi, H. Akar +17 more
2017Frontiers in Immunology33 citations Open access
Semantic Scholar
Cancer risk in relatives of patients with a primary disorder of lymphocyte cytotoxicity: a retrospective cohort study.
A. Löfstedt, Samuel C. C. Chiang, E. Onelöv, Y. Bryceson +2 more
2015The Lancet Haematology32 citations
Semantic Scholar
Quercetin Ameliorates XIAP Deficiency Associated Hyperinflammation.
Samuel C. C. Chiang, E. Owsley, N. Panchal, Vijaya Chaturvedi +7 more
2022Blood31 citations Open access
Semantic Scholar
Screening for Wiskott-Aldrich syndrome by flow cytometry.
Samuel C. C. Chiang, Sue Vergamini, Ammar Husami, Lisa Neumeier +18 more
2018Journal of Allergy and Clinical Immunology30 citations
Semantic Scholar
Hemophagocytic syndrome in a 4‐month‐old infant with biotinidase deficiency
F. Kardaş, T. Patiroglu, E. Unal, Samuel C. C. Chiang +2 more
2012Pediatric Blood & Cancer27 citations
Semantic Scholar
An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2
Martha-Lena Müller, Samuel C. C. Chiang, Marie Meeths, B. Tesi +7 more
2013Frontiers in Immunology26 citations Open access
Semantic Scholar
Alemtuzumab treatment for hemophagocytic lymphohistiocytosis
M. Machaczka, Johan Vaktnäs, Samuel C. C. Chiang, Y. Bryceson
2010Nature Reviews Clinical Oncology26 citations
Semantic Scholar
A RAB27A 5′ untranslated region structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation
B. Tesi, J. Rascon, Samuel C. C. Chiang, B. Burnytė +21 more
2018Journal of Allergy and Clinical Immunology25 citations Open access
Semantic Scholar
Novel PIGT Variant in Two Brothers: Expansion of the Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 Phenotype
Nadia Skauli, S. Wallace, Samuel C. C. Chiang, Tuva Barøy +6 more
2016Genes25 citations Open access
Semantic Scholar
Current Flow Cytometric Assays for the Screening and Diagnosis of Primary HLH
Samuel C. C. Chiang, J. Bleesing, R. Marsh
2019Frontiers in Immunology22 citations Open access
Semantic Scholar
Sensitive and viable quantification of inside-out signals for LFA-1 activation in human cytotoxic lymphocytes by flow cytometry.
J. Theorell, H. Schlums, Samuel C. C. Chiang, T. Huang +3 more
2011JIM - Journal of Immunological Methods22 citations
Semantic Scholar
Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease
S. Keskitalo, E. Haapaniemi, V. Glumoff, Xiao-Nan Liu +12 more
2019npj Genomic Medicine20 citations Open access
Semantic Scholar
Site-Specific Photolabeling of the IgG Fab Fragment Using a Small Protein G Derived Domain.
Sara Kanje, Emma von Witting, Samuel C. C. Chiang, Y. Bryceson +1 more
2016Bioconjugate chemistry19 citations
Semantic Scholar
Elevated ferritin and soluble CD25 in critically ill are associated with parameters of (hyper)inflammation and lymphocyte cytotoxicity.
Tatiana von Bahr Greenwood, Kajsa Palmkvist-Kaijser, Samuel C. C. Chiang, B. Tesi +3 more
2019Minerva Anestesiologica18 citations
Semantic Scholar
A Rare Case of Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS) Presenting With Hemophagocytosis Complicated With Hodgkin Lymphoma.
M. Cansever, Natalia Ziȩtara, Samuel C. C. Chiang, A. Ozcan +10 more
2020Journal of pediatric hematology/oncology16 citations
Semantic Scholar
A Toolkit and Framework for Optimal Laboratory Evaluation of Individuals with Suspected Primary Immunodeficiency.
Vijaya Knight, J. Heimall, H. Chong, Sarada L. Nandiwada +14 more
2021Journal of Allergy and Clinical Immunology: In Practice12 citations
Semantic Scholar
Novel STAT3 Mutation Causing Hyper-IgE Syndrome: Studies of the Clinical Course and Immunopathology
M. Sundin, B. Tesi, Maria Sund Böhme, Y. Bryceson +5 more
2014Journal of Clinical Immunology11 citations
Semantic Scholar
Hematopoietic stem cell transplantation of an adolescent with neurological manifestations of homozygous missense PRF1 mutation
A. Hussein, T. Hamadah, M. Qandeel, M. Sughayer +6 more
2014Pediatric Blood & Cancer9 citations
Semantic Scholar
Different Clinical Presentation of 3 Children With Familial Hemophagocytic Lymphohistiocytosis With 2 Novel Mutations.
Şefika Akyol, A. Ozcan, T. Sekine, Samuel C. C. Chiang +5 more
2020Journal of pediatric hematology/oncology8 citations
Semantic Scholar
Fatal Central Nervous System Lymphocytic Vasculitis after Treatment for Burkitt Lymphoma in a Patient with a SH2D1A Mutation
J. Neves, Lamberto Torralba Raga, Samuel C. C. Chiang, B. Tesi +4 more
2019The Pediatric Infectious Disease Journal8 citations Open access
Semantic Scholar
A Newborn With Familial Hemophagocytic Lymphohistiocytosis Complicated With Transfusion Associated Graft Versus Host Disease.
A. Ozdemir, T. Gunes, Samuel C. C. Chiang, E. Unal
2017Journal of pediatric hematology/oncology8 citations
Semantic Scholar
Microdeletion of 7p12.1p13, including IKZF1, causes intellectual impairment, overgrowth, and susceptibility to leukaemia
Tekla Järviaho, V. Zachariadis, B. Tesi, Samuel C. C. Chiang +9 more
2018British Journal of Haematology6 citations Open access
Semantic Scholar
Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis
Samuel C. C. Chiang, L. Covill, B. Tesi, T. Campbell +27 more
2024Blood5 citations Open access
Semantic Scholar

Frequent co-authors

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Y. Bryceson×45
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Y. Bryceson — researcher profile on SciRah
J. Henter×20
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J. Henter — researcher profile on SciRah
Marie Meeths×18
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Marie Meeths — researcher profile on SciRah
B. Tesi×15
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B. Tesi — researcher profile on SciRah

M. Nordenskjöld

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M. Nordenskjöld — researcher profile on SciRah

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H. Schlums — researcher profile on SciRah

Stephanie Wood×10

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Stephanie Wood — researcher profile on SciRah

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E. Unal — researcher profile on SciRah

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J. Theorell — researcher profile on SciRah

H. Ljunggren×6

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H. Ljunggren — researcher profile on SciRah

T. Patiroglu×6

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T. Patiroglu — researcher profile on SciRah

Miriam Entesarian×5

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Miriam Entesarian — researcher profile on SciRah