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F. Lai · SciRah

Researcher profile · Semantic Scholar

F. Lai

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F. Lai — researcher profile on SciRah

h-index: 25
Works: 113
Citations: 2,437

Most-cited papers

The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodology
B. Handen, I. Lott, B. Christian, N. Schupf +18 more
2020Alzheimer's & Dementia118 citations Open access
Semantic Scholar
Further understanding the connection between Alzheimer’s disease and Down syndrome
H. Snyder, Lisa J. Bain, A. Brickman, M. Carrillo +20 more
2020Alzheimer's & Dementia90 citations Open access
Semantic Scholar
Alzheimer-Related Cerebrovascular Disease in Down Syndrome
P. Lao, J. Gutierrez, D. Keator, Batool Rizvi +16 more
2020Annals of Neurology64 citations Open access
Semantic Scholar
Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers
S. Janelidze, Bradley T. Christian, Julie C. Price, C. Laymon +11 more
2022JAMA Neurology53 citations Open access
Semantic Scholar
Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study
Anna H. Boerwinkle, B. Gordon, Julie K. Wisch, S. Flores +46 more
2023Lancet Neurology47 citations Open access
Semantic Scholar
Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer disease: a cross-sectional study
A. Fagan, Rachel L. Henson, Yan Li, Anna H. Boerwinkle +30 more
2021Lancet Neurology47 citations Open access
Semantic Scholar
Plasma total-tau and Neurofilament light chain (Nf-L) as diagnostic biomarkers of Alzheimer’s disease dementia and mild cognitive impairment in adults with Down syndrome
M. Petersen, M. Rafii, Fan Zhang, J. Hall +21 more
2020Journal of Alzheimer's Disease38 citations Open access
Semantic Scholar
Evaluation of the National Task Group-Early Detection Screen for Dementia: Sensitivity to ‘mild cognitive impairment’ in adults with Down syndrome
W. Silverman, S. Krinsky-McHale, F. Lai, H. Rosas +5 more
2020Journal of Applied Research in Intellectual Disabilities35 citations Open access
Semantic Scholar
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study
Julie K. Wisch, Nicole S. Mckay, Anna H. Boerwinkle, James T. Kennedy +46 more
2024Lancet Neurology34 citations Open access
Semantic Scholar
Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome
Rachel L. Henson, E. Doran, B. Christian, B. Handen +8 more
2020Alzheimer's & Dementia34 citations Open access
Semantic Scholar
The AT(N) framework for Alzheimer's disease in adults with Down syndrome.
M. Rafii, B. Ances, N. Schupf, S. Krinsky-McHale +14 more
2020Alzheimer's & Dementia33 citations Open access
Semantic Scholar
Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase
David Mengel, Wen Liu, R. Glynn, D. Selkoe +7 more
2019Alzheimer's Research & Therapy32 citations Open access
Semantic Scholar
Sex differences in risk of Alzheimer's disease in adults with Down syndrome
F. Lai, Pooja G. Mhatre, Yuchen Yang, Mei-Cheng Wang +2 more
2020Alzheimer's & Dementia29 citations Open access
Semantic Scholar
The Alzheimer's Biomarker Consortium–Down Syndrome (ABC‐DS): A 10‐year report
B. Handen, M. Mapstone, S. Hartley, Howard F. Andrews +21 more
2025Alzheimer's & Dementia27 citations Open access
Semantic Scholar
Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer’s Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study
James A. Hendrix, D. Airey, A. Britton, Anna D. Burke +42 more
2021Journal of Clinical Medicine27 citations Open access
Semantic Scholar
Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome
J. Wegiel, M. Flory, I. Kuchna, K. Nowicki +8 more
2022Acta Neuropathologica Communications26 citations Open access
Semantic Scholar
Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study
M. Petersen, Fan Zhang, N. Schupf, S. Krinsky-McHale +19 more
2020Alzheimer's & Dementia25 citations Open access
Semantic Scholar
Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?
H. Rosas, E. Hsu, N. Mercaldo, F. Lai +10 more
2020Alzheimer's & Dementia22 citations Open access
Semantic Scholar
Language skills as a predictor of cognitive decline in adults with Down syndrome
Margaret B. Pulsifer, C. Evans, C. Hom, S. Krinsky-McHale +6 more
2020Alzheimer's & Dementia22 citations Open access
Semantic Scholar
Cerebrovascular disease is associated with Alzheimer’s plasma biomarker concentrations in adults with Down syndrome
Natalie C. Edwards, P. Lao, M. Alshikho, Olivia M. Ericsson +21 more
2024Brain Communications21 citations Open access
Semantic Scholar
Down syndrome: Distribution of brain amyloid in mild cognitive impairment
D. Keator, Michael J. Phelan, Lisa Taylor, E. Doran +14 more
2020Alzheimer's & Dementia19 citations Open access
Semantic Scholar
Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer’s continuum
P. Lao, M. E. Zimmerman, S. Hartley, J. Gutierrez +17 more
2022SLEEP Advances18 citations Open access
Semantic Scholar
Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome
H. Hillerstrom, Richard A Fisher, M. Janicki, B. Chicoine +18 more
2024Alzheimer's & Dementia17 citations Open access
Semantic Scholar
Cognitive Function during the Prodromal Stage of Alzheimer’s Disease in Down Syndrome: Comparing Models
C. Hom, K. Kirby, J. Ricks-Oddie, D. Keator +7 more
2021Brain Science17 citations Open access
Semantic Scholar
Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome
Emily K. Schworer, B. Handen, M. Petersen, S. O'Bryant +18 more
2024Alzheimer's & Dementia16 citations Open access
Semantic Scholar
Timing of Alzheimer’s Disease by Intellectual Disability Level in Down Syndrome
S. Hartley, Victoria Fleming, E. Schworer, Jamie Peven +17 more
2023Journal of Alzheimer's Disease14 citations Open access
Semantic Scholar
Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study
S. Janelidze, L. Collij, N. Mattsson-Carlgren, Alex Antill +17 more
2025Lancet Neurology12 citations Open access
Semantic Scholar
The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome
Anna H. Boerwinkle, Julie K. Wisch, B. Handen, E. Head +13 more
2024Alzheimer's & Dementia12 citations Open access
Semantic Scholar
Weight Loss and Alzheimer’s Disease in Down Syndrome
Victoria Fleming, B. Helsel, Lauren T. Ptomey, H. Rosas +11 more
2022Journal of Alzheimer's Disease12 citations Open access
Semantic Scholar
Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: “Accelerated aging” or a prelude to Alzheimer's disease?
H. Rosas, Lydia Lewis, N. Mercaldo, S. Nasr +8 more
2021Alzheimer's & Dementia10 citations Open access
Semantic Scholar
Association between Inflammatory Conditions and Alzheimer’s Disease Age of Onset in Down Syndrome
F. Lai, N. Mercaldo, Cassandra M. Wang, Giovi G. Hersch +1 more
2021Journal of Clinical Medicine10 citations Open access
Semantic Scholar
Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome
J. Wegiel, M. Flory, I. Kuchna, K. Nowicki +8 more
2022Acta Neuropathologica Communications9 citations Open access
Semantic Scholar
Regional differences in astrocytic Aquaporin-4 protein levels and distribution in aging and Alzheimer’s disease in down syndrome
Cherie A. Stringer, Haley Miyasato, Kevin Camey, Krina A Ghadia +18 more
2025Neurobiology of Disease8 citations Open access
Semantic Scholar
Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome
Natalie C. Edwards, P. Lao, M. Alshikho, Olivia M. Ericsson +21 more
2023medRxiv8 citations Open access
Semantic Scholar
Probing the proteome to explore potential correlates of increased Alzheimer’s-related cerebrovascular disease in adults with Down syndrome
F. Moni, M. Petersen, Fan Zhang, P. Lao +20 more
2022Alzheimer's & Dementia8 citations Open access
Semantic Scholar
Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome
Natalie D. DiProspero, Mithra T. Sathishkumar, John T. Janecek, Anna P. Smith +18 more
2024Alzheimer's & Dementia7 citations Open access
Semantic Scholar
Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome
Melissa R. Jenkins, Jamie Peven, Lauren Kubic, B. Handen +20 more
2025Journal of Neurodevelopmental Disorders6 citations Open access
Semantic Scholar
Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI
Jr-Jiun Liou, Jing-Hang Li, J. Berardinelli, He-Cheng Jin +70 more
2025Journal of Neuropathology and Experimental Neurology6 citations Open access
Semantic Scholar
The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome
L. Xicota, Lam N. T. Dang, Alice Lee, S. Krinsky-McHale +20 more
2024EBioMedicine6 citations Open access
Semantic Scholar
Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome
F. Lai, N. Mercaldo, Cassandra M. Wang, Micaela S Hersch +2 more
2021Brain Science6 citations Open access
Semantic Scholar
Imaging and Plasma Biomarkers for Pathological Accumulation in Down Syndrome
Julie K. Wisch, Z. Jiao, James T. Kennedy, Ann D. Cohen +22 more
2025Brain : a journal of neurology5 citations
Semantic Scholar
Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome
H. Rosas, N. Mercaldo, Yasemin Hasimoglu, M. Petersen +9 more
2024Alzheimer's & Dementia5 citations Open access
Semantic Scholar
Blood‐brain barrier neuropathology in individuals with Down syndrome and Alzheimer’s disease
Lisi Flores Aguilar, Annie Du, J. Kofler, M. Ikonomovic +3 more
2023Alzheimer's & Dementia5 citations Open access
Semantic Scholar
Development of a symptom menu to facilitate Goal Attainment Scaling in adults with Down syndrome-associated Alzheimer’s disease: a qualitative study to identify meaningful symptoms
K. Knox, J. Stanley, James A. Hendrix, H. Hillerstrom +8 more
2021Journal of Patient-Reported Outcomes5 citations Open access
Semantic Scholar
Joint‐label fusion brain atlases for dementia research in Down syndrome
Nazek Queder, Michael J. Phelan, Lisa Taylor, N. Tustison +17 more
2020medRxiv5 citations Open access
Semantic Scholar
Age and sex are associated with Alzheimer's disease neuropathology in Down syndrome
Elizabeth J. Andrews, P. Ngo, Jesse R. Pascual, Freddy Gonzalez +10 more
2025Alzheimer's & Dementia4 citations Open access
Semantic Scholar
Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome
Natalie C. Edwards, P. Lao, M. Alshikho, Olivia M. Ericsson +21 more
2025Alzheimer's & Dementia4 citations Open access
Semantic Scholar
Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross‐sectional associations with early cognitive impairments
J. Fu, Arun Garimella, A. Lapointe, William W. T. Aye +18 more
2025Alzheimer's & Dementia3 citations Open access
Semantic Scholar
A pathway linking pulse pressure to dementia in adults with Down syndrome
Batool Rizvi, P. Lao, Mithra T. Sathishkumar, Lisa Taylor +18 more
2024Brain Communications3 citations Open access
Semantic Scholar
P2‐148: ALZHEIMER'S‐RELATED CEREBROVASCULAR DISEASE IN DOWN SYNDROME
P. Lao, J. Gutierrez, F. Lai, H. Rosas +11 more
2019Alzheimer's & Dementia3 citations
Semantic Scholar

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