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M. Mckinlay · SciRah

Researcher profile · Semantic Scholar

M. Mckinlay

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M. Mckinlay — researcher profile on SciRah

h-index: 32
Works: 97
Citations: 5,469

Most-cited papers

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
J. Vince, W. Wong, Nufail R. Khan, R. Feltham +14 more
2007Cell1,153 citations Open access
Semantic Scholar
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating.
T. Smith, M. Kremer, M. Luo, G. Vriend +6 more
1986Science445 citations
Semantic Scholar
Efficacy and Safety of Oral Pleconaril for Treatment of Colds Due to Picornaviruses in Adults: Results of 2 Double-Blind, Randomized, Placebo-Controlled Trials
F. Hayden, D. Herrington, Teresa L Coats, Kenneth Kim +7 more
2003Clinical Infectious Diseases269 citations Open access
Semantic Scholar
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
J. Vince, Diep Chau, B. Callus, W. Wong +10 more
2008Journal of Cell Biology255 citations Open access
Semantic Scholar
Crystal structure of human rhinovirus serotype 1A (HRV1A).
Sangsoo Kim, T. J. Smith, M. Chapman, M. Rossmann +5 more
1989Journal of Molecular Biology186 citations
Semantic Scholar
Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors
D. Pevear, M. Fancher, Peter J. Felock, Michael G. Rossmann +5 more
1989Journal of Virology184 citations Open access
Semantic Scholar
Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models
C. Benetatos, Y. Mitsuuchi, J. Burns, E. Neiman +17 more
2014Molecular Cancer Therapeutics168 citations Open access
Semantic Scholar
Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization*
R. Feltham, Bodhi I. Bettjeman, Rhesa Budhidarmo, P. Mace +7 more
2011Journal of Biological Chemistry162 citations Open access
Semantic Scholar
The structure of human rhinovirus 16.
Marcos A. Oliveira, Rui Zhao, Wai-Ming Lee, M. Kremer +7 more
1993Structure162 citations Open access
Semantic Scholar
Structural analysis of a series of antiviral agents complexed with human rhinovirus 14.
John Badger, I. Minor, M. Kremer, Marcos A. Oliveira +12 more
1988Proceedings of the National Academy of Sciences of the United States of America161 citations Open access
Semantic Scholar
Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug
M. P. Fox, Michael J. Otto, M. Mckinlay
1986Antimicrobial Agents and Chemotherapy159 citations Open access
Semantic Scholar
Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.
S. Condon, Y. Mitsuuchi, Yi-Jun Deng, M. Laporte +25 more
2014Journal of Medicinal Chemistry154 citations
Semantic Scholar
Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound
Beverly A. Heinz, R. Rueckert, D. Shepard, F. Dutko +5 more
1989Journal of Virology121 citations Open access
Semantic Scholar
In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug
Michael J. Otto, M. P. Fox, M. Fancher, M. Kuhrt +2 more
1985Antimicrobial Agents and Chemotherapy119 citations Open access
Semantic Scholar
Relationship of Pleconaril Susceptibility and Clinical Outcomes in Treatment of Common Colds Caused by Rhinoviruses
D. Pevear, F. Hayden, Tina M Demenczuk, L. Barone +2 more
2005Antimicrobial Agents and Chemotherapy105 citations Open access
Semantic Scholar
Treatment of the picornavirus common cold by inhibitors of viral uncoating and attachment.
M. Mckinlay, D. Pevear, Michael G. Rossmann
1992Annual Review of Microbiology104 citations
Semantic Scholar
The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells
C. Krepler, S. Chunduru, Molly B. Halloran, Xu He +11 more
2013Clinical Cancer Research96 citations Open access
Semantic Scholar
A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
K. H. Kim, Peter Willingmann, Z. Gong, M. Kremer +9 more
1994Journal of Molecular Biology84 citations
Semantic Scholar
Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo-Controlled Human Oral Poliovirus Vaccine Challenge Model
M. Collett, J. Hincks, Kimberley S. M. Benschop, E. Duizer +6 more
2016Journal of Infectious Diseases74 citations Open access
Semantic Scholar
In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug
M. Woods, G. Diana, M. Rogge, M. Otto +2 more
1989Antimicrobial Agents and Chemotherapy68 citations Open access
Semantic Scholar
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
Guy D. Diana, M. Mckinlay, Michael J. Otto, Vahan Akullian +1 more
1985Journal of Medicinal Chemistry68 citations
Semantic Scholar
Progress in the development of poliovirus antiviral agents and their essential role in reducing risks that threaten eradication.
M. Mckinlay, M. Collett, J. Hincks, M. Oberste +5 more
2014Journal of Infectious Diseases67 citations
Semantic Scholar
Inhibition of poliovirus uncoating by disoxaril (WIN 51711).
Heinz Zeichhardt, M. Otto, M. Mckinlay, P. Willingmann +1 more
1987Virology66 citations
Semantic Scholar
Treatment of human enterovirus infections.
H. Rotbart, J. O'Connell, M. Mckinlay
1998Antiviral Research57 citations
Semantic Scholar
Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways
M. Tanzer, Nufail R. Khan, J. Rickard, N. Etemadi +14 more
2017Cell Death and Differentiation54 citations Open access
Semantic Scholar
Isoxazoles with antipicornavirus activity.
Guy D. Diana, M. Mckinlay, C. Brisson, Ethel S. Zalay +2 more
1985Journal of Medicinal Chemistry53 citations
Semantic Scholar
Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
A. Aghamohammadi, Hassan Abolhassani, N. Kutukculer, S. Wassilak +24 more
2017Frontiers in Immunology51 citations Open access
Semantic Scholar
Oral efficacy of WIN 51711 in mice infected with human poliovirus
M. Mckinlay, B. A. Steinberg
1986Antimicrobial Agents and Chemotherapy49 citations Open access
Semantic Scholar
New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data.
M. Shaghaghi, Saeed Soleyman-jahi, Hassan Abolhassani, R. Yazdani +5 more
2018Vaccine45 citations
Semantic Scholar
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
Guy D. Diana, D. Cutcliffe, R. C. Oglesby, Michael J. Otto +3 more
1989Journal of Medicinal Chemistry39 citations
Semantic Scholar
Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells
A. Metwalli, Sanaz Khanbolooki, G. Jinesh, D. Sundi +8 more
2010Cancer Biology & Therapy38 citations Open access
Semantic Scholar
The partnership for influenza vaccine introduction (PIVI): Supporting influenza vaccine program development in low and middle-income countries through public-private partnerships
J. Bresee, K. Lafond, M. McCarron, E. Azziz-Baumgartner +44 more
2019Vaccine35 citations Open access
Semantic Scholar
Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
Thomas S. Griffith, T. Kucaba, M. O'Donnell, J. Burns +4 more
2010Apoptosis31 citations
Semantic Scholar
Recent advances in the treatment of rhinovirus infections.
M. Mckinlay
2001Current opinion in pharmacology (Print)31 citations
Semantic Scholar
Three-dimensional structures of drug-resistant mutants of human rhinovirus 14.
John Badger, Sankaran Krishnaswamy, M. Kremer, Marcos A. Oliveira +5 more
1990Journal of Molecular Biology31 citations
Semantic Scholar
Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice.
M. Mckinlay, J. Frank, D. Benziger, B. A. Steinberg
1986Journal of Infectious Diseases31 citations
Semantic Scholar
WIN 51711, a new systematically active broad-spectrum antipicornavirus agent.
M. Mckinlay
1985Journal of Antimicrobial Chemotherapy30 citations
Semantic Scholar
Prevention of human poliovirus-induced paralysis and death in mice by the novel antiviral agent arildone
M. Mckinlay, J. V. Miralles, C. Brisson, F. Pancic
1982Antimicrobial Agents and Chemotherapy29 citations Open access
Semantic Scholar
Inhibitors of viral uncoating.
G. Diana, D. Pevear, M. Otto, M. Mckinlay +3 more
1989Pharmacology and Therapeutics27 citations
Semantic Scholar
Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14
M. P. Fox, M. Mckinlay, Guy D. Diana, F. Dutko
1991Antimicrobial Agents and Chemotherapy25 citations Open access
Semantic Scholar
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
Guy D. Diana, R. C. Oglesby, Vahan Akullian, P. Carabateas +6 more
1987Journal of Medicinal Chemistry25 citations
Semantic Scholar
Pleconaril. A broad spectrum antipicornaviral agent.
J. Rogers, G. Diana, M. Mckinlay
1999Advances in Experimental Medicine and Biology23 citations
Semantic Scholar
Inhibitors of picornavirus uncoating as antiviral agents.
Guy D. Diana, Michael J. Otto, M. Mckinlay
1985Pharmacology and Therapeutics23 citations
Semantic Scholar
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
B. Jubelt, A. K. Wilson, S. L. Ropka, P. Guidinger +1 more
1989Journal of Infectious Diseases22 citations
Semantic Scholar
"The Herpesvirus hypothesis"--are Koch's postulates satisfied?
Laure Aurelian, M. Manak, M. Mckinlay, C. Smith +2 more
1981Gynecologic Oncology22 citations
Semantic Scholar
Rational design of antiviral agents.
M. Mckinlay, Michael G. Rossmann
1989Annual Review of Pharmacology and Toxicology21 citations
Semantic Scholar
Abstract LB-406: Phase 1 study of the Smac mimetic TL32711 in adult subjects with advanced solid tumors and lymphoma to evaluate safety, pharmacokinetics, pharmacodynamics, and antitumor activity
R. Amaravadi, R. Schilder, G. Dy, Wen W. Ma +8 more
201120 citations
Semantic Scholar
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14.
Guy D. Diana, Michael J. Otto, Adi M. Treasurywala, M. Mckinlay +4 more
1988Journal of Medicinal Chemistry20 citations
Semantic Scholar
Human rhinovirus 14 complexed with fragments of active antiviral compounds.
Jodi K. Bibler-Muckelbauer, M. Kremer, Michael G. Rossmann, Guy D. Diana +3 more
1994Virology19 citations
Semantic Scholar
Intestinal antibody responses to a live oral poliovirus vaccine challenge among adults previously immunized with inactivated polio vaccine in Sweden
E. Brickley, R. Connor, W. Wieland-Alter, M. Collett +10 more
2019BMJ Global Health18 citations Open access
Semantic Scholar

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Guy D. Diana×13
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Guy D. Diana — researcher profile on SciRah
S. Chunduru×10
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F. Dutko×10
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D. Pevear×9
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C. Benetatos — researcher profile on SciRah

Michael G. Rossmann×7

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S. Condon — researcher profile on SciRah

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M. Kremer — researcher profile on SciRah

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J. Silke — researcher profile on SciRah

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G. Diana — researcher profile on SciRah

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M. Collett — researcher profile on SciRah

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J. Vince — researcher profile on SciRah