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B. Tounge · SciRah

Researcher profile · Semantic Scholar

B. Tounge

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B. Tounge — researcher profile on SciRah

h-index: 18
Works: 42
Citations: 1,888

Most-cited papers

Ligand binding efficiency: trends, physical basis, and implications.
C. Reynolds, B. Tounge, S. Bembenek
2008Journal of Medicinal Chemistry302 citations
Semantic Scholar
Frequency selective heteronuclear dipolar recoupling in rotating solids: accurate (13)C-(15)N distance measurements in uniformly (13)C,(15)N-labeled peptides.
C. Jaroniec, B. Tounge, J. Herzfeld, R. Griffin
2001Journal of the American Chemical Society238 citations
Semantic Scholar
Ligand efficiency and fragment-based drug discovery.
S. Bembenek, B. Tounge, C. Reynolds
2009Drug Discovery Today180 citations
Semantic Scholar
The role of molecular size in ligand efficiency.
C. Reynolds, S. Bembenek, B. Tounge
2007Bioorganic & Medicinal Chemistry Letters165 citations
Semantic Scholar
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
E. W. Baxter, K. Conway, L. Kennis, F. Bischoff +19 more
2007Journal of Medicinal Chemistry139 citations Open access
Semantic Scholar
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation
R. Scannevin, R. Alexander, Tara Mezzasalma Haarlander, Sharon L. Burke +20 more
2017Journal of Biological Chemistry126 citations Open access
Semantic Scholar
Collagen-related peptides: self-assembly of short, single strands into a functional biomaterial of micrometer scale.
M. A. Cejas, W. A. Kinney, Cai-Lin Chen, G. Leo +4 more
2007Journal of the American Chemical Society120 citations
Semantic Scholar
A two-state homology model of the hERG K+ channel: application to ligand binding.
R. Rajamani, B. Tounge, J. Li, C. Reynolds
2005Bioorganic & Medicinal Chemistry Letters75 citations Open access
Semantic Scholar
Measurement of 13C−15N Distances in Uniformly 13C Labeled Biomolecules: J-Decoupled REDOR
C. Jaroniec, B. Tounge, C. M. Rienstra, J. Herzfeld +1 more
199975 citations
Semantic Scholar
The 2 1Ag state of trans,trans‐1,3,5,7‐octatetraene in free jet expansions
H. Petek, A. Bell, Young S. Choi, K. Yoshihara +2 more
199362 citations
Semantic Scholar
Calculation of the binding affinity of beta-secretase inhibitors using the linear interaction energy method.
B. Tounge, C. Reynolds
2003Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
M. J. Costanzo, S. C. Yabut, Han-Cheng Zhang, Kimberley B. White +12 more
2008Bioorganic & Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Inhibitor Bound Dengue NS2B-NS3pro Reveals Multiple Dynamic Binding Modes.
A. Gibbs, R. Steele, Gao-Hua Liu, B. Tounge +1 more
2018Biochemistry36 citations
Semantic Scholar
Electron density guided fragment-based lead discovery of ketohexokinase inhibitors.
A. Gibbs, M. Abad, Xu-Qing Zhang, B. Tounge +5 more
2010Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Linear interaction energy models for beta-secretase (BACE) inhibitors: Role of van der Waals, electrostatic, and continuum-solvation terms.
B. Tounge, R. Rajamani, E. W. Baxter, A. Reitz +1 more
2006Journal of Molecular Graphics and Modelling26 citations
Semantic Scholar
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.
Yifang Huang, E. Strobel, Chih Y. Ho, C. Reynolds +13 more
2010Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Noncovalent self-assembly of bicyclo[4.2.2]diketopiperazines: influence of saturation in the bridging carbacyclic ring.
Yanming Du, Christopher J. Creighton, B. Tounge, A. Reitz
2004Organic Letters24 citations
Semantic Scholar
One‐ and two‐photon fluorescence excitation spectra of the 2 1Ag states of linear tetraenes in free jet expansions
H. Petek, A. Bell, Young S. Choi, K. Yoshihara +2 more
199523 citations
Semantic Scholar
Discovery of piperidine carboxamide TRPV1 antagonists.
Wing S. Cheung, R. Calvo, B. Tounge, Sui-Po Zhang +5 more
2008Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Designing a diverse high-quality library for crystallography-based FBDD screening.
B. Tounge, M. H. Parker
2011Methods in Enzymology17 citations
Semantic Scholar
Hit triage using efficiency indices after screening of compound libraries in drug discovery.
A. Reitz, Garry R. Smith, B. Tounge, C. Reynolds
2009Current Topics in Medicinal Chemistry14 citations
Semantic Scholar
Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins
B. D. De Corte, W. A. Kinney, Li Liu, Shyamali Ghosh +12 more
200412 citations Open access
Semantic Scholar
Chemical Information Based Scaling of Molecular Descriptors: A Universal Chemical Scale for Library Design and Analysis
B. Tounge, Lori B. Pfahler, C. Reynolds
2002Journal of chemical information and computer sciences12 citations
Semantic Scholar
Synthesis and biological evaluation of type VI beta-turn templated RGD peptidomimetics.
Christopher J. Creighton, Yanming Du, Rosemary J. Santulli, B. Tounge +1 more
2006Bioorganic & Medicinal Chemistry Letters11 citations
Semantic Scholar
Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions
E. Lawson, W. A. Kinney, M. J. Costanzo, W. Hoekstra +6 more
200410 citations
Semantic Scholar
Defining Privileged Reagents Using Subsimilarity Comparison
B. Tounge, C. Reynolds
2004Journal of Chemical Information and Modeling9 citations
Semantic Scholar
Rotationally Resolved Electronic Spectra of trans,trans-Octatetraene and Its Derivatives
J. Pfanstiel, D. Pratt, B. Tounge, R. L. Christensen
19999 citations
Semantic Scholar
An unusual intramolecular transfer of the fluorobenzyl cation between two remote amidic nitrogen atoms induced by collision in the gas phase.
Zheng-Yin Yan, B. Tounge, G. Caldwell
2012Rapid Communications in Mass Spectrometry8 citations
Semantic Scholar
Accurate 13C-15N Distance Measurements in Uniformly 13C,15N-Labeled Peptides
C. Jaroniec, B. Tounge, J. Herzfeld, R. Griffin
20018 citations
Semantic Scholar
A Concise Synthesis of an Indenopyrrolidine-based Dual avb3/avb5 Integrin Antagonist
W. A. Kinney, D. Luci, Rosemary J. Santulli, D. Gauthier +10 more
20047 citations Open access
Semantic Scholar
A Web-based chemoinformatics system for drug discovery.
S. Bembenek, B. Tounge, S. Coats, C. Reynolds
2004Methods in molecular biology3 citations
Semantic Scholar
Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase. 2. Investigation of the Carboxamide Portion of Spirocyclic Piperidine Amides
M. J. Costanzo, S. C. Yabut, Han-Cheng Zhang, Kimberley B. White +8 more
20082 citations
Semantic Scholar
Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.
B. D. De Corte, W. A. Kinney, Li Liu, Shyamali Ghosh +12 more
2004Bioorganic & Medicinal Chemistry Letters2 citations
Semantic Scholar
Labeled Biomolecules: J-Decoupled REDOR
C. Jaroniec, B. Tounge, C. M. Rienstra, J. Herzfeld +1 more
19992 citations
Semantic Scholar
Chemical Information Based Scaling of Molecular Descriptors: A Universal Chemical Scale for Library Design and Analysis.
B. Tounge, Lori B. Pfahler, C. Reynolds
20021 citations
Semantic Scholar
Novel, highly biased mu opioid receptor compounds minus side effects for the treatment of pain
B. Tounge, S. Bayoumy, R. Besthof, S. Dax +2 more
20180 citations Open access
Semantic Scholar
Alkynyl derivatives useful as inhibitors of DPP-1
M. H. Parker, D. Hlasta, Yifang Huang, A. Reitz +7 more
20100 citations
Semantic Scholar
inhibitors as beta-secretase (BACE) useful 2-amino-quinazoline derivatives
E. W. Baxter, F. Bischoff, R. E. Boyd, M. Braeken +12 more
20050 citations
Semantic Scholar
Derivatives of 2-amino-quinazoline used as inhibitors of beta-secretase (BACE).
E. W. Baxter, F. Bischoff, R. E. Boyd, M. Braeken +12 more
20050 citations
Semantic Scholar
2-amino-puinazolin derivatives useful as inhibitors of beta-secretase (BACE)
E. W. Baxter, F. Bischoff, R. E. Boyd, M. Braeken +12 more
20050 citations
Semantic Scholar
Defining Privileged Reagents Using Subsimilarity Comparison.
B. Tounge, C. Reynolds
20040 citations
Semantic Scholar
POLYENE ELECTRONIC SPECTROSCOPY AT ROTATIONAL $RESOLUTION,^{1}$
R. L. Christensen, J. Pfanstiel, D. Pratt, B. Tounge
19930 citations
Semantic Scholar

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