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B. Maryanoff · SciRah

Researcher profile · Semantic Scholar

B. Maryanoff

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B. Maryanoff — researcher profile on SciRah

h-index: 53
Works: 399
Citations: 12K

Most-cited papers

Molecular Pharmacodynamics, Clinical Therapeutics, and Pharmacokinetics of Topiramate
R. P. Shank, B. Maryanoff
2008CNS Neuroscience & Therapeutics154 citations Open access
Semantic Scholar
Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions
M. A. Cejas, W. A. Kinney, Cai-Lin Chen, J. G. Vinter +8 more
2008Proceedings of the National Academy of Sciences of the United States of America149 citations Open access
Semantic Scholar
Synthesis of macrocycles via cobalt-mediated [2 + 2 + 2] cycloadditions.
L. Bonaga, Han-Cheng Zhang, A. Moretto, Hong Ye +4 more
2005Journal of the American Chemical Society128 citations Open access
Semantic Scholar
Deuterated Drug Molecules: Focus on FDA-Approved DeutetrabenazinePublished as part of the Biochemistry series "Biochemistry to Bedside".
S. Dewitt, B. Maryanoff
2017Biochemistry121 citations
Semantic Scholar
Collagen-related peptides: self-assembly of short, single strands into a functional biomaterial of micrometer scale.
M. A. Cejas, W. A. Kinney, Cai-Lin Chen, G. Leo +4 more
2007Journal of the American Chemical Society120 citations
Semantic Scholar
Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis
Po-Shen B. Chen, Audrey S. Black, Adam L Sobel, Yan-Nan Zhao +13 more
2020Nature Biotechnology104 citations Open access
Semantic Scholar
Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.
Han-Cheng Zhang, L. Bonaga, Hong Ye, C. Derian +2 more
2007Bioorganic & Medicinal Chemistry Letters89 citations Open access
Semantic Scholar
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase
L. de Garavilla, M. Greco, N. Sukumar, Zhi-Wei Chen +13 more
2005Journal of Biological Chemistry86 citations Open access
Semantic Scholar
Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.
E. Lawson, D. Luci, Shyamali Ghosh, W. A. Kinney +9 more
2009Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
Mimicry of High-Density Lipoprotein: Functional Peptide–Lipid Nanoparticles Based on Multivalent Peptide Constructs
Yan-Nan Zhao, T. Imura, L. Leman, L. Curtiss +2 more
2013Journal of the American Chemical Society71 citations Open access
Semantic Scholar
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
B. Maryanoff, M. J. Costanzo
2008Bioorganic & Medicinal Chemistry68 citations Open access
Semantic Scholar
Molecules that Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis
L. Leman, B. Maryanoff, M. Ghadiri
2013Journal of Medicinal Chemistry67 citations Open access
Semantic Scholar
Pharmacokinetic and Metabolic Investigation of Topiramate Disposition in Healthy Subjects in the Absence and in the Presence of Enzyme Induction by Carbamazepine
M. Britzi, E. Perucca, S. Soback, R. Levy +6 more
2005Epilepsia67 citations Open access
Semantic Scholar
Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats
Rosemary J. Santulli, W. A. Kinney, Shyamali Ghosh, B. Decorte +13 more
2008Journal of Pharmacology and Experimental Therapeutics62 citations
Semantic Scholar
Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.
Han-Cheng Zhang, C. Derian, D. McComsey, K. White +15 more
2005Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
M. J. Costanzo, H. Almond, L. R. Hecker, Mary R. Schott +10 more
2005Journal of Medicinal Chemistry60 citations Open access
Semantic Scholar
Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation.
B. Maryanoff, L. de Garavilla, M. Greco, B. Haertlein +3 more
2010American Journal of Respiratory and Critical Care Medicine59 citations
Semantic Scholar
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
M. Greco, M. Hawkins, E. Powell, H. Almond +10 more
2007Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
RWJ-58259: a selective antagonist of protease activated receptor-1.
B. Damiano, C. Derian, B. Maryanoff, Han-Cheng Zhang +1 more
2006Cardiovascular Drug Reviews52 citations
Semantic Scholar
Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.
B. Maryanoff, D. McComsey, M. J. Costanzo, Coralie Hochman +2 more
2005Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
7-fluoroindazoles as potent and selective inhibitors of factor Xa.
Yu-Kai Lee, D. Parks, Tian-Bao Lu, Tho V. Thieu +11 more
2008Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Urotensin-II receptor modulators as potential drugs.
B. Maryanoff, W. A. Kinney
2010Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
M. J. Costanzo, S. C. Yabut, Han-Cheng Zhang, Kimberley B. White +12 more
2008Bioorganic & Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
L. Aluisio, Brian Lord, A. Barbier, I. Fraser +8 more
2008European Journal of Pharmacology40 citations
Semantic Scholar
Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site.
B. Maryanoff, John C. O'Neill, D. McComsey, S. C. Yabut +7 more
2011ACS Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I[S]
Yan-Nan Zhao, Audrey S. Black, D. J. Bonnet, B. Maryanoff +3 more
2014Journal of Lipid Research35 citations Open access
Semantic Scholar
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.
Yong Gong, J. Barbay, Alexey B. Dyatkin, Tamara A. Miskowski +15 more
2006Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
M. H. Parker, Virginia L. Smith-Swintosky, David F. McComsey, Yifang Huang +15 more
2009Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.
A. Klinger, D. McComsey, V. Smith-Swintosky, R. P. Shank +1 more
2006Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.
Tian-Bao Lu, Thomas P. Markotan, Shelley K. Ballentine, E. Giardino +11 more
2010Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
2009 Edward E Smissman Award. Pharmaceutical "gold" from neurostabilizing agents: topiramate and successor molecules.
B. Maryanoff
2009Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Novel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Pharmacological Properties of (S)-N-[(6-Chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)
D. McComsey, V. Smith-Swintosky, M. H. Parker, D. Brenneman +12 more
2013Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR
Darren M. Hutt, C. A. Olsen, C. Vickers, David M. Herman +7 more
2011ACS Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
K. Kreutter, Tian-Bao Lu, L. Lee, E. Giardino +16 more
2008Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
A Comparative Study of the Effect of Carbamazepine and Valproic Acid on the Pharmacokinetics and Metabolic Profile of Topiramate at Steady State in Patients with Epilepsy
Dorit Mimrod, Luigi M. Specchio, M. Britzi, E. Perucca +8 more
2005Epilepsia26 citations
Semantic Scholar
Self-Assembling Cyclic d,l-α-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents
Yan-Nan Zhao, L. Leman, D. Search, Ricardo A. García +3 more
2017ACS Central Science25 citations Open access
Semantic Scholar
Generation of novel, potent urotensin-II receptor antagonists by alkylation-cyclization of isoindolinone C3-carbanions
D. Luci, E. Lawson, Shyamali Ghosh, W. A. Kinney +5 more
200924 citations
Semantic Scholar
Exploration of Potential Prodrugs of RWJ‐445167, an Oxyguanidine‐based Dual Inhibitor of Thrombin and Factor Xa
B. Maryanoff, David F. McComsey, M. J. Costanzo, Stephen C. Yabut +4 more
2006Chemical Biology and Drug Design24 citations Open access
Semantic Scholar
Potency variation of small-molecule chymase inhibitors across species.
J. Kervinen, C. Crysler, S. Bayoumy, M. Abad +5 more
2010Biochemical Pharmacology23 citations
Semantic Scholar
Sugar sulfamates for seizure control: discovery and development of topiramate, a structurally unique antiepileptic drug.
B. Maryanoff
2009Current Topics in Medicinal Chemistry23 citations
Semantic Scholar
Phenotypic Assessment and the Discovery of Topiramate
B. Maryanoff
2016ACS Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Pyridine-Containing Macrocycles via Cobalt-Mediated [2 + 2 + 2] Cycloadditions of α,ω-Bisalkynes
B. Maryanoff, Han-Cheng Zhang
200720 citations Open access
Semantic Scholar
Metabolism and excretion of the antiepileptic/antimigraine drug, topiramate in animals and humans
G. Caldwell, Wu-Nan Wu, J. Masucci, L. A. Mckown +4 more
2005European journal of drug metabolism and pharmacokinetics20 citations
Semantic Scholar
Nanoparticles that display short collagen-related peptides. Potent stimulation of human platelet aggregation by triple helical motifs.
M. A. Cejas, Cai-Lin Chen, W. A. Kinney, B. Maryanoff
2007Bioconjugate chemistry19 citations
Semantic Scholar
Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies.
W. A. Kinney, C. Teleha, A. Thompson, Maria Newport +13 more
2008Journal of Organic Chemistry18 citations
Semantic Scholar
Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket.
B. Maryanoff, John C. O'Neill, D. McComsey, S. C. Yabut +3 more
2012Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
M. Xiang, P. Rybczynski, Mona Patel, Robert H. K. Chen +11 more
2007Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.
D. Luci, Shyamali Ghosh, Charles E. Smith, Jenson Qi +10 more
2007Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Synthesis of an αvβ3 integrin antagonist intermediate via asymmetric hydrogenation of an α,β-unsaturated ester with BoPhoz-iridium and BoPhoz-rhodium catalysts
A. Zanotti-gerosa, W. A. Kinney, G. Grasa, Jonathan A. Medlock +4 more
200815 citations
Semantic Scholar
Examination of Two Independent Kinetic Assays for Determining the Inhibition of Carbonic Anhydrases I and II: Structure–Activity Comparison of Sulfamates and Sulfamides
R. P. Shank, David F. McComsey, Virginia L. Smith-Swintosky, B. Maryanoff
2006Chemical Biology and Drug Design15 citations
Semantic Scholar

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W. A. Kinney×10
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Han-Cheng Zhang×8
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