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Hsi-Hsien Lin · SciRah

Researcher profile · Semantic Scholar

Hsi-Hsien Lin

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Hsi-Hsien Lin — researcher profile on SciRah

h-index: 42
Works: 130
Citations: 5,407

Most-cited papers

Adhesion-GPCRs: emerging roles for novel receptors.
S. Yona, Hsi-Hsien Lin, Willie O. Siu, S. Gordon +1 more
2008TIBS -Trends in Biochemical Sciences. Regular ed235 citations
Semantic Scholar
F4/80 and the related adhesion‐GPCRs
S. Gordon, J. Hamann, Hsi-Hsien Lin, M. Stacey
2011European Journal of Immunology161 citations Open access
Semantic Scholar
Risk Factors of Cage Subsidence in Patients Received Minimally Invasive Transforaminal Lumbar Interbody Fusion.
Yu-Cheng Yao, Po-Hsin Chou, Hsi-Hsien Lin, Shih-Tien Wang +2 more
2020Spine125 citations
Semantic Scholar
Specific expression of GPR56 by human cytotoxic lymphocytes
Yen-Ming Peng, M. V. D. van de Garde, Kai Cheng, P. Baars +5 more
2011Journal of Leukocyte Biology124 citations
Semantic Scholar
The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells.
G. Chang, Cheng-Chih Hsiao, Yen-Ming Peng, F. A. Vieira Braga +12 more
2016Cell Reports121 citations Open access
Semantic Scholar
Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms*
N. Chiang, Cheng-Chih Hsiao, Yi-Shu Huang, Hsin-Yi Chen +3 more
2011Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
S. Z. Manrique, Maria Adelaida Duque Correa, D. Hoelzinger, A. Dominguez +5 more
2011Journal of Experimental Medicine74 citations Open access
Semantic Scholar
Activation of Myeloid Cell-Specific Adhesion Class G Protein-Coupled Receptor EMR2 via Ligation-Induced Translocation and Interaction of Receptor Subunits in Lipid Raft Microdomains
Yi-Shu Huang, N. Chiang, Ching-Hsun Hu, Cheng-Chih Hsiao +7 more
2012Molecular and Cellular Biology67 citations Open access
Semantic Scholar
Adhesion GPCRs in Regulating Immune Responses and Inflammation.
Hsi-Hsien Lin, Cheng-Chih Hsiao, C. Pabst, J. Hébert +2 more
2017Advances in Immunology66 citations
Semantic Scholar
Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival.
J. Davies, Hsi-Hsien Lin, M. Stacey, S. Yona +7 more
2011Oncology Report59 citations Open access
Semantic Scholar
TNFR signalling and its clinical implications
W. Tseng, Yi-Shu Huang, Hsi-Hsien Lin, Shue-Fen Luo +4 more
2018Cytokine53 citations
Semantic Scholar
Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility
N. Chiang, G. Chang, Yi-Shu Huang, Yen-Ming Peng +3 more
2016Journal of Cell Science53 citations Open access
Semantic Scholar
The role of GPR56/ADGRG1 in health and disease
A. Singh, Hsi-Hsien Lin
2021Biomedical Journal51 citations Open access
Semantic Scholar
Ligands and Beyond: Mechanosensitive Adhesion GPCRs
Hsi-Hsien Lin, K. Ng, Tse-Ching Chen, W. Tseng
2022Pharmaceuticals50 citations Open access
Semantic Scholar
F4/80: the macrophage-specific adhesion-GPCR and its role in immunoregulation.
Hsi-Hsien Lin, M. Stacey, J. Stein-Streilein, S. Gordon
2010Advances in Experimental Medicine and Biology50 citations
Semantic Scholar
GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα12/13/RhoA Signaling.
N. Chiang, Yen-Ming Peng, H. Juang, Tse-Ching Chen +3 more
2017Journal of Investigative Dermatology47 citations Open access
Semantic Scholar
Control of Adhesion GPCR Function Through Proteolytic Processing.
M. Nieberler, Robert J. Kittel, A. Petrenko, Hsi-Hsien Lin +1 more
2016Handbook of Experimental Pharmacology47 citations
Semantic Scholar
Adhesion GPCRs as Modulators of Immune Cell Function.
J. Hamann, Cheng-Chih Hsiao, Chang Sup Lee, K. Ravichandran +1 more
2016Handbook of Experimental Pharmacology47 citations
Semantic Scholar
Site‐specific N‐glycosylation regulates the GPS auto‐proteolysis of CD97
Cheng-Chih Hsiao, Kai Cheng, Hsin-Yi Chen, Y. Chou +3 more
2009FEBS Letters47 citations
Semantic Scholar
The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions
Cheng-Chih Hsiao, Tai-Ying Chu, Chia-Jung Wu, M. van den Biggelaar +9 more
2018Frontiers in Immunology45 citations Open access
Semantic Scholar
Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways
Kuan-Yu I, Yi-Shu Huang, Ching-Hsun Hu, W. Tseng +5 more
2017Frontiers in Immunology45 citations Open access
Semantic Scholar
GPS proteolytic cleavage of adhesion-GPCRs.
Hsi-Hsien Lin, M. Stacey, S. Yona, G. Chang
2010Advances in Experimental Medicine and Biology42 citations
Semantic Scholar
GPS autoproteolysis is required for CD97 to up‐regulate the expression of N‐cadherin that promotes homotypic cell–cell aggregation
Cheng-Chih Hsiao, Hsin-Yi Chen, G. Chang, Hsi-Hsien Lin
2011FEBS Letters40 citations Open access
Semantic Scholar
Is a drain tube necessary for minimally invasive lumbar spine fusion surgery?
Pei-I Hung, M. Chang, Po-Hsin Chou, Hsi-Hsien Lin +2 more
2017European spine journal37 citations
Semantic Scholar
G-protein-Coupled Receptors and Their (Bio) Chemical Significance Win 2012 Nobel Prize in Chemistry
Hsi-Hsien Lin
2013Biomedical Journal35 citations Open access
Semantic Scholar
Classification and citation analysis of the 100 top-cited articles on adult spinal deformity since 2011: A bibliometric analysis
Po-Chun Liu, Yi Lu, Hsi-Hsien Lin, Yu-Cheng Yao +4 more
2021Journal of the Chinese Medical Association34 citations Open access
Semantic Scholar
GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation
Tai-Ying Chu, Céline Zheng-Gérard, Kuan-Yeh Huang, Yu-Chu Chang +20 more
2022Nature Communications33 citations Open access
Semantic Scholar
Could the Topping-Off Technique Be the Preventive Strategy against Adjacent Segment Disease after Pedicle Screw-Based Fusion in Lumbar Degenerative Diseases? A Systematic Review
Po-Hsin Chou, Hsi-Hsien Lin, H. An, Kang-Ying Liu +2 more
2017BioMed Research International31 citations Open access
Semantic Scholar
Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis
Yi-Shu Huang, W. Tseng, F. Clanchy, L. Topping +13 more
2021Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
Role of ADGRG1/GPR56 in Tumor Progression
K. Ng, Tse-Ching Chen, M. Stacey, Hsi-Hsien Lin
2021Cells30 citations Open access
Semantic Scholar
The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells
W. Tjong, Hsi-Hsien Lin
2019Scientific Reports30 citations Open access
Semantic Scholar
The Adhesion GPCR CD97/ADGRE5 inhibits apoptosis.
Cheng-Chih Hsiao, K. Keysselt, Hsin-Yi Chen, D. Sittig +3 more
2015International Journal of Biochemistry and Cell Biology27 citations
Semantic Scholar
EMR2 receptor ligation modulates cytokine secretion profiles and cell survival of lipopolysaccharide-treated neutrophils.
Tzu-Ying Chen, T. Hwang, Chun-Yen Lin, Tsung-Nan Lin +3 more
2011Chang Gung medical journal27 citations
Semantic Scholar
The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
Kuan-Yeh Huang, Hsi-Hsien Lin
2018Frontiers in Oncology26 citations Open access
Semantic Scholar
The fates of pedicle screws and functional outcomes in a geriatric population following polymethylmethacrylate augmentation fixation for the osteoporotic thoracolumbar and lumbar burst fractures with mean ninety five month follow-up
Hsi-Hsien Lin, M. Chang, Shih-Tien Wang, Chien-Lin Liu +1 more
2018International Orthopaedics26 citations
Semantic Scholar
Surgical treatment for septic arthritis of the knee joint in elderly patients: a 10-year retrospective clinical study.
Chao-Ming Chen, Hsi-Hsien Lin, Shih-Chieh Hung, Tung-Fu Huang +3 more
2013Orthopedics26 citations
Semantic Scholar
Outcome of Ti/PEEK Versus PEEK Cages in Minimally Invasive Transforaminal Lumbar Interbody Fusion
Yu-Cheng Yao, Po-Hsin Chou, Hsi-Hsien Lin, Shih-Tien Wang +1 more
2021Global Spine Journal25 citations Open access
Semantic Scholar
Adhesion family of G protein-coupled receptors and cancer.
Hsi-Hsien Lin
2012Chang Gung medical journal25 citations Open access
Semantic Scholar
Ground truth generalizability affects performance of the artificial intelligence model in automated vertebral fracture detection on plain lateral radiographs of the spine.
Po-Hsin Chou, Tony Hong-Ting Jou, H. Wu, Yu-Cheng Yao +5 more
2021The spine journal24 citations Open access
Semantic Scholar
Determination of the painful level in osteoporotic vertebral fractures—Retrospective comparison between plain film, bone scan, and magnetic resonance imaging
Hsi-Hsien Lin, Po-Hsin Chou, Shih-Tien Wang, Jung-Kuang Yu +2 more
2015Journal of the Chinese Medical Association23 citations Open access
Semantic Scholar
CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP‐2/MT1‐ MMP/MMP‐2 activity – role of GPS autoproteolysis and functional cooperation between the N‐ and C‐terminal fragments
Cheng-Chih Hsiao, Wenchang Wang, Wan-Lin Kuo, Hsin-Yi Chen +3 more
2014The FEBS Journal23 citations
Semantic Scholar
Anterior release may not be necessary for idiopathic scoliosis with a large curve of more than 75° and a flexibility of less than 25.
Ming Cheng, Hsiao-Li Ma, Hsi-Hsien Lin, Po-Hsin Chou +3 more
2017The spine journal22 citations
Semantic Scholar
Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients
Chien-Hao Huang, W. Jeng, Y. Ho, W. Teng +6 more
2016Scientific Reports22 citations Open access
Semantic Scholar
Bracing Following Transforaminal Lumbar Interbody Fusion is not Necessary for Patients With Degenerative Lumbar Spine Disease: A Prospective, Randomized Trial
Yu-Cheng Yao, Hsi-Hsien Lin, M. Chang
2018Clinical Spine Surgery20 citations
Semantic Scholar
Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions
Kuo-An Wu, Chih-Ching Wu, Chi-De Chen, Chi-Ming Chu +5 more
2017Scientific Reports20 citations Open access
Semantic Scholar
Increased Soluble CD4 in Serum of Rheumatoid Arthritis Patients Is Generated by Matrix Metalloproteinase (MMP)-Like Proteinases
W. Tseng, Yi-Shu Huang, N. Chiang, Y. Chou +5 more
2013PLoS ONE20 citations Open access
Semantic Scholar
Cerclage wiring in displaced associated anterior column and posterior hemi-transverse acetabular fractures.
Hsi-Hsien Lin, Shih-Hsin Hung, Yu-Ping Su, Fang-Yao Chiu +1 more
2012Injury20 citations
Semantic Scholar
High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis.
W. Tseng, Yeong-Jian Jan Wu, Tai-Yun Yang, N. Chiang +6 more
2017Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi19 citations Open access
Semantic Scholar
Differences in the interbody bone graft area and fusion rate between minimally invasive and traditional open transforaminal lumbar interbody fusion: a retrospective short-term image analysis
Yu-Cheng Yao, Hsi-Hsien Lin, Po-Hsin Chou, Shih-Tien Wang +1 more
2019European spine journal18 citations
Semantic Scholar
Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes
Kuan-Yu I, W. Tseng, Wenchang Wang, S. Gordon +2 more
2021Frontiers in Immunology17 citations Open access
Semantic Scholar

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