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Xue-Ru Wu · SciRah

Researcher profile · Semantic Scholar

Xue-Ru Wu

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Xue-Ru Wu — researcher profile on SciRah

h-index: 57
Works: 237
Citations: 11K

Most-cited papers

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells
Hyun-Wook Lee, Sung-Hyun Park, Mao-Wen Weng, Hsiang-Tsui Wang +5 more
2018Proceedings of the National Academy of Sciences of the United States of America334 citations Open access
Semantic Scholar
Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice
M. Tang, Xue-Ru Wu, Hyun-Wook Lee, Yong Xia +5 more
2019Proceedings of the National Academy of Sciences of the United States of America214 citations Open access
Semantic Scholar
Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis
Mao-Wen Weng, Hyun-Wook Lee, Sung-Hyun Park, Yu Hu +8 more
2018Proceedings of the National Academy of Sciences of the United States of America129 citations Open access
Semantic Scholar
Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis.
R. Micanovic, Kaice A. LaFavers, P. Garimella, Xue-Ru Wu +1 more
2019Nephrology, Dialysis and Transplantation94 citations Open access
Semantic Scholar
Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin
Xing Wang, Feng-Lin Zhang, Xue-Ru Wu
2017Scientific Reports87 citations Open access
Semantic Scholar
Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
R. Micanovic, Shehnaz Khan, Danielle Janosevic, Maya E. Lee +9 more
2017Journal of the American Society of Nephrology76 citations Open access
Semantic Scholar
ATDC/TRIM29 drives invasive bladder cancer formation through microRNA-mediated and epigenetic mechanisms
P. Palmbos, Li-Dong Wang, Huibin Yang, Yin Wang +13 more
2015Cancer Research71 citations Open access
Semantic Scholar
ATG7 Promotes Bladder Cancer Invasion via Autophagy‐Mediated Increased ARHGDIB mRNA Stability
Junlan Zhu, Zhongxian Tian, Yang Li, Xiaohui Hua +10 more
2019Advancement of science70 citations Open access
Semantic Scholar
Circulating Uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel
Kaice A. LaFavers, E. Macedo, P. Garimella, C. Lima +11 more
2019Science Translational Medicine68 citations Open access
Semantic Scholar
Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
Yong Xia, Yan Liu, Chao Yang, D. Simeone +5 more
2021Nature Communications65 citations Open access
Semantic Scholar
Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer.
Opal L. Reddy, Justin M. M. Cates, L. Gellert, Henry Crist +16 more
2015American Journal of Pathology65 citations Open access
Semantic Scholar
PKM2 is essential for bladder cancer growth and maintenance
Yong Xia, Xing Wang, Yan Liu, E. Shapiro +4 more
2021Cancer Research59 citations Open access
Semantic Scholar
Episodic Aspiration with Oral Commensals Induces a MyD88-dependent, Pulmonary Th17 Response that Mitigates Susceptibility to Streptococcus pneumoniae.
Benjamin G. Wu, I. Sulaiman, Jun-Chieh J. Tsay, Luisanny Perez +23 more
2020American Journal of Respiratory and Critical Care Medicine54 citations Open access
Semantic Scholar
XIAP Overexpression Promotes Bladder Cancer Invasion in Vitro and Lung Metastasis in Vivo via Enhancing Nucleolin-Mediated Rho-GDIβ mRNA Stability
Yonghui Yu, Honglei Jin, Ji-Heng Xu, Jiayan Gu +10 more
2017International Journal of Cancer53 citations Open access
Semantic Scholar
Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6)
Mingzhu Nie, M. Bal, Jie Liu, Zhu-Feng Yang +6 more
2018Journal of Biological Chemistry52 citations Open access
Semantic Scholar
MEG3, as a Competing Endogenous RNA, Binds with miR-27a to Promote PHLPP2 Protein Translation and Impairs Bladder Cancer Invasion
Chao Huang, Xin Liao, Honglei Jin, Fei Xie +6 more
2019Molecular Therapy: Nucleic Acids51 citations Open access
Semantic Scholar
Tamm-Horsfall protein/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia.
Yan Liu, D. Goldfarb, Tarek M. El-Achkar, J. Lieske +1 more
2018AJP - Renal Physiology41 citations Open access
Semantic Scholar
XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell
Chao Huang, Xing-Ruo Zeng, Guo-Song Jiang, Xin Liao +7 more
2017Journal of Hematology & Oncology41 citations Open access
Semantic Scholar
Uromodulin–SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells
S. Yanagihara, T. Kanaya, S. Fukuda, G. Nakato +4 more
2017International Immunology39 citations
Semantic Scholar
Role of STAT3 and FOXO1 in the divergent therapeutic responses of non-metastatic and metastatic bladder cancer cells to miR-145
Guo-Song Jiang, Chao Huang, Jingxia Li, Hai-Shan Huang +4 more
2017Molecular Cancer Therapeutics37 citations Open access
Semantic Scholar
On a FOX hunt: functions of FOX transcriptional regulators in bladder cancer
H. Yamashita, Vasty Osei Amponsa, J. Warrick, Zong-Yu Zheng +5 more
2017Nature reviews. Urology35 citations
Semantic Scholar
PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein
Minggang Peng, Jingjing Wang, Dongyun Zhang, Honglei Jin +3 more
2018Oncogene32 citations Open access
Semantic Scholar
RhoGDIβ promotes Sp1/MMP‐2 expression and bladder cancer invasion through perturbing miR‐200c‐targeted JNK2 protein translation
Hai-Shan Huang, Honglei Jin, HuiRong Zhao, Jingjing Wang +12 more
2017Molecular Oncology32 citations Open access
Semantic Scholar
XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63α protein translation and promoting transformation of bladder epithelial cells
Honglei Jin, Ji-Heng Xu, Xirui Guo, Hai-Shan Huang +7 more
2016OncoTarget31 citations Open access
Semantic Scholar
Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells
B. Wankel, Jiang-Yong Ouyang, Xue-Mei Guo, K. Hadjiolova +19 more
2016Molecular Biology of the Cell29 citations Open access
Semantic Scholar
Oncogenic HRAS activates epithelial-mesenchyme transition and confers stemness to p53-deficient urothelial cells to drive muscle invasion of basal subtype carcinomas
F. He, J. Melamed, M. Tang, Chuan-Shu Huang +1 more
2015Cancer Research27 citations Open access
Semantic Scholar
Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
Haiping Zhou, Xing Wang, L. Mo, Yan Liu +4 more
2016OncoTarget25 citations Open access
Semantic Scholar
p63α protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion
Honglei Jin, Q. Xie, Xirui Guo, Ji-Heng Xu +6 more
2017Journal of Biological Chemistry24 citations Open access
Semantic Scholar
The kidney protects against sepsis by producing systemic uromodulin
Kaice A. LaFavers, C. Hage, V. Gaur, R. Micanovic +10 more
2021bioRxiv20 citations Open access
Semantic Scholar
Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes
Yi Liao, D. Tham, Feng-Xia Liang, Jennifer C. Chang +16 more
2019Molecular Biology of the Cell20 citations Open access
Semantic Scholar
Characterization of Histone Deacetylase Expression Within In Vitro and In Vivo Bladder Cancer Model Systems
Jenna M. Buckwalter, W. Chan, Lauren Shuman, Thomas Wildermuth +7 more
2019International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
High sensitivity of an Ha-RAS transgenic model of superficial bladder cancer to metformin is associated with ~ 240-fold higher drug concentration in urine than serum
Zhongbo Liu, N. Yokoyama, C. Blair, Xuesen Li +7 more
2016Molecular Cancer Therapeutics19 citations Open access
Semantic Scholar
Targeting mTOR and p53 signaling inhibits muscle invasive bladder cancer in vivo
Venkateshwar Madka, A. Mohammed, Q. Li, Yuting Zhang +8 more
2015Cancer Prevention Research19 citations Open access
Semantic Scholar
Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer
Honglei Jin, Lei Xue, L. Mo, Dongyun Zhang +10 more
2019Cell Adhesion & Migration18 citations Open access
Semantic Scholar
Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100)
Jia-Wei Xu, Yulei Wang, Xiaohui Hua, Ji-Heng Xu +5 more
2016OncoTarget18 citations Open access
Semantic Scholar
Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli
Yan Liu, S. Mémet, R. Saban, Xiangpeng Kong +4 more
2015Scientific Reports17 citations Open access
Semantic Scholar
Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia
Lijie Ma, Yan Liu, Nichole K Landry, Tarek M. El-Achkar +2 more
2017PLoS ONE15 citations Open access
Semantic Scholar
FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma
Haiping Zhou, F. He, C. Mendelsohn, M. Tang +2 more
2016Scientific Reports14 citations Open access
Semantic Scholar
The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells
Guo-Song Jiang, Chao Huang, Xin Liao, Jingxia Li +3 more
2019Journal of Biological Chemistry13 citations Open access
Semantic Scholar
Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence
Yi Liao, Hung-Chi Chang, Feng-Xia Liang, Pei-Jung Chung +17 more
2018Molecular Biology of the Cell12 citations Open access
Semantic Scholar
Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy
Olena Maydan, Paul McDade, Yan Liu, Xue-Ru Wu +2 more
2018Physiological Reports12 citations Open access
Semantic Scholar
Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS
Christopher H. Yee, Zong-Yu Zheng, Lauren Shuman, H. Yamashita +4 more
2019Scientific Reports10 citations Open access
Semantic Scholar
Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation
Xia Xu, Xuejiao Tian, Lian-Kun Song, Jun Xie +7 more
2023Biomolecules9 citations Open access
Semantic Scholar
Urothelium-specific expression of mutationally activated Pik3ca initiates early lesions of non-invasive bladder cancer
Lauren Shuman, Jonathan T. Pham, Thomas Wildermuth, Xue-Ru Wu +3 more
2023bioRxiv9 citations Open access
Semantic Scholar
Structural or functional defects of PTEN in urothelial cells lacking P53 drive basal/squamous-subtype muscle-invasive bladder cancer
F. He, Feng-Lin Zhang, Yi Liao, M. Tang +1 more
2022Cancer Letters9 citations Open access
Semantic Scholar
DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells
Ji-Heng Xu, Rui Yang, Jingxia Li, Li-Dong Wang +4 more
2022Cancers7 citations Open access
Semantic Scholar
Tumorigenicity of RTK/RAS in urothelium
Xue-Ru Wu, C. Mendelsohn, D. DeGraff
2015Oncoscience7 citations Open access
Semantic Scholar
Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism
Zhongbo Liu, Lian-Kun Song, Jun Xie, Xue-Ru Wu +4 more
2023Molecules6 citations Open access
Semantic Scholar
The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ras Model
Zhongbo Liu, N. Yokoyama, Lian-Kun Song, Jun Xie +7 more
2023Cancers3 citations Open access
Semantic Scholar
The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells
Hsiang-Tsui Wang, Hyun-Wook Lee, Mao-Wen Weng, Yang Liu +4 more
2021eLife2 citations Open access
Semantic Scholar

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