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E. Zhang · SciRah

Researcher profile · Semantic Scholar

E. Zhang

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E. Zhang — researcher profile on SciRah

h-index: 15
Works: 45
Citations: 862

Most-cited papers

Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling
Gina Lee, Yuxiang Zheng, Sungyun Cho, Cholsoon Jang +16 more
2017Cell206 citations Open access
Semantic Scholar
Single Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.
M. Guo, Jane J. Yu, Anne-Karina T. Perl, K. Wikenheiser-Brokamp +14 more
2020American Journal of Respiratory and Critical Care Medicine78 citations Open access
Semantic Scholar
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells
Cheng-Gang Li, Po-Shun Lee, Yang Sun, Xiaoxiao Gu +18 more
2014Journal of Experimental Medicine70 citations Open access
Semantic Scholar
Folliculin regulates cell–cell adhesion, AMPK, and mTORC1 in a cell‐type‐specific manner in lung‐derived cells
D. Khabibullin, Doug A. Medvetz, M. Pinilla, V. Hariharan +10 more
2014Physiological Reports65 citations Open access
Semantic Scholar
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells
Jing Li, A. Csibi, Sun Yang, G. Hoffman +4 more
2014Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells
Yang Sun, Xiaoxiao Gu, E. Zhang, Mi-Ae Park +8 more
2014Cell Death and Disease53 citations Open access
Semantic Scholar
Small‐molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase‐associated malignant glioma growth
J. Qiu, Qianqian Li, Katherine A Bell, Xue Yao +6 more
2019British Journal of Pharmacology47 citations Open access
Semantic Scholar
Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis.
Cheng-Gang Li, Xiao-Bo Zhou, Yang Sun, E. Zhang +6 more
2013American Journal of Respiratory Cell and Molecular Biology35 citations Open access
Semantic Scholar
Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis
Yang Sun, E. Zhang, T. Lao, A. M. Pereira +6 more
2014Hormones & cancer27 citations Open access
Semantic Scholar
Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex
Sharon L. Barone, K. Zahedi, Marybeth Brooks, E. Henske +5 more
2021Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas
Wang Ma, Shuangyuan Wang, Tengfei Zhang, E. Zhang +4 more
2018Journal of Pharmaceutical and Biomedical Analysis22 citations
Semantic Scholar
Rapamycin-Insensitive Up-Regulation of Adipocyte Phospholipase A2 in Tuberous Sclerosis and Lymphangioleiomyomatosis
Cheng-Gang Li, E. Zhang, Yang Sun, Po-Shun Lee +7 more
2014PLoS ONE22 citations Open access
Semantic Scholar
Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis
Y. Uehara, Yusuke Tanaka, Shu-Yang Zhao, Nikolaos M. Nikolaidis +20 more
2023Nature Communications18 citations Open access
Semantic Scholar
Financial support: J. Li is a Tuberous Sclerosis Alliance Postdoctoral Fellow
Jing Li, Sejeong Shin, Yang Sun, Sang-Oh Yoon +5 more
201618 citations
Semantic Scholar
Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells
Yi-Yang Lu, Xiao-Lei Liu, E. Zhang, E. Kopras +6 more
2020PLoS ONE17 citations Open access
Semantic Scholar
Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells
Matthildi Valianou, Natalia Filippidou, Daniel L. Johnson, P. Vogel +6 more
2019Scientific Reports15 citations Open access
Semantic Scholar
Tuberin Regulates Prostaglandin Receptor–Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells
Cheng-Gang Li, Xiao-Lei Liu, Yang Liu, E. Zhang +19 more
2017Molecular Cancer Research14 citations Open access
Semantic Scholar
Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.
Yang Sun, Dana A. Gallacchi, E. Zhang, S. Reynolds +8 more
2014American Journal of Respiratory Cell and Molecular Biology13 citations Open access
Semantic Scholar
Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.
Cheng-Gang Li, Na Li, Xiao-Lei Liu, E. Zhang +14 more
2016JCI Insight12 citations Open access
Semantic Scholar
Connectivity Map Analysis of a Single-Cell RNA-Sequencing -Derived Transcriptional Signature of mTOR Signaling
N. al Mahi, E. Zhang, S. Sherman, Jane J. Yu +1 more
2021International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells
Tasnim Olatoke, A. Wagner, A. Astrinidis, E. Zhang +13 more
2023Science Advances9 citations Open access
Semantic Scholar
Inhibition of the mechanistic target of rapamycin induces cell survival via MAPK in tuberous sclerosis complex
Yi-Yang Lu, E. Zhang, Jie Liu, Jane J. Yu
2020Orphanet Journal of Rare Diseases8 citations Open access
Semantic Scholar
Identification of the lymphangioleiomyomatosis cell and its uterine origin
M. Guo, Jane J. Yu, Anne-Karina T. Perl, K. Wikenheiser-Brokamp +14 more
2019bioRxiv7 citations Open access
Semantic Scholar
Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis
Xiang-Ke Li, Xiao-Lei Liu, Linda Zhang, Cheng-Gang Li +4 more
2017OncoTarget7 citations Open access
Semantic Scholar
Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex
A. Astrinidis, Cheng-Gang Li, E. Zhang, Xueheng Zhao +20 more
2023JCI Insight6 citations Open access
Semantic Scholar
mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Jing Li, Sejeong Shin, Yang Sun, S. Yoon +5 more
2016Cancer Research6 citations Open access
Semantic Scholar
STAT1 Promotes PD-L1 Activation and Tumor Growth in Lymphangioleiomyomatosis
Tasnim Olatoke, E. Zhang, Andrew Wagner, Q. He +5 more
2024bioRxiv2 citations Open access
Semantic Scholar
Abstract 5398: Inhibition of PHGDH suppresses mTOR signaling and metabolic reprogramming in TSC2-deficient lymphangioleiomyomatosis cells
E. K. Abor, E. Zhang, Jane J. Yu
2025Cancer Research1 citations
Semantic Scholar
Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.
Ken Chen, Shuyang Zhao, Min-Zhe Guo, H. Reza +12 more
2026European Respiratory Journal0 citations Open access
Semantic Scholar
HOX/PBX Inhibition Attenuates Tsc2-Null Cell Viability and Lung Metastasis in Lymphangioleiomyomatosis
Tasnim Olatoke, A. Astrinidis, M. Guo, E. Zhang +5 more
2023Physiology0 citations
Semantic Scholar
Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells
Tasnim Olatoke, A. Wagner, A. Astrinidis, M. Guo +14 more
2022bioRxiv0 citations Open access
Semantic Scholar
Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis Complex
A. Astrinidis, Cheng-Gang Li, E. Zhang, Xueheng Zhao +14 more
2022bioRxiv0 citations Open access
Semantic Scholar
Combination of Volasertib and Rapamycin Inhibits the Regrowth of TSC2-Deficient Tumors
Matthildi Valianou, E. Zhang, Daniel L. Johnson, Rhett Meyers +6 more
2022bioRxiv0 citations Open access
Semantic Scholar
Tumor Suppressor Tuberin (TSC2) Negatively Regulates the Expression of Sphingolipid Metabolism Genes and Functions
J.-J. Yu, E. Zhang
2022A60. PULMONARY FIBROSIS: ANIMAL AND CELL CULTURE MODELS0 citations
Semantic Scholar
Novel insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis
Y. Uehara, Nikolaos M. Nikolaidis, L. Pitstick, Huixing Wu +20 more
2021bioRxiv0 citations Open access
Semantic Scholar
Single Cell RNA Sequencing Identifies Aberrant Sphingolipid Metabolism and Actions in Pulmonary Lymphangioleiomyomatosis
Y. Lu, E. Zhang, M. Guo, X. Zhao +13 more
20200 citations Open access
Semantic Scholar
Connectivity analysis of single cell RNA-sequencing derived transcriptional signature of lymphangioleiomyomatosis
N. al Mahi, E. Zhang, S. Sherman, Jane J. Yu +1 more
2020bioRxiv0 citations Open access
Semantic Scholar
Osteogenesis and Osteolysis in Pulmonary Alveolar Microlithiasis
Y. Uehara, Nikolaos M. Nikolaidis, L. Pitstick, J. Woods +9 more
2019C18. RARE LUNG DISEASES0 citations
Semantic Scholar
Abstract A35: Regulation of the tumor microenvironment by oncogenic p62 in mTORC1-hyperactive diseases: Tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM)
Hilaire C. Lam, A. Parkhitko, Alicia Llorente Lope, N. Alesi +8 more
20160 citations
Semantic Scholar
Abstract B10: Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in tuberous sclerosis complex
Cheng-Gang Li, Po-Shun Lee, Yang Sun, E. Zhang +9 more
20150 citations
Semantic Scholar
Abstract B09: Aspirin inhibits cyclooxygenase 2-mediated prostaglandin production and tumorigenesisin a preclinical model of tuberous sclerosis complex
Cheng-Gang Li, Po-Shun Lee, Yang Sun, Xiaoxiao Gu +11 more
20140 citations
Semantic Scholar
Abstract C59: Estradiol and mTORC2 orchestrate to enhance prostaglandin biosynthesis andtumorigenesis in tuberous sclerosis complex
Cheng-Gang Li, Po-Shun Lee, Xiaoxiao Gu, Yang Sun +12 more
20130 citations
Semantic Scholar
Abstract LB-129: Evidence from expression profiling, proteomics, metabolomics and FDG-PET of an estrogen-dependent metabolic switch in tuberin-null cells.
Yang Sun, Cheng-Gang Li, K. Marks, E. Zhang +10 more
20130 citations
Semantic Scholar
MTORC1-Dependent Dysregulated Expression Of MicroRNA Contributes To The Pathogenesis Of Lymphangioleiomyomatosis (LAM)
A. Trindade, Doug A. Medvetz, Nicole Neuman, Faina Myachina +3 more
2012Asian Test Symposium0 citations
Semantic Scholar
Estradiol-Induced Alterations Of The Extracellular Matrix And Activation Of Matrix Metalloproteinase 2 Are Associated With The Lung Metastasis Of Tuberin-Null Cells In A Xenograft Model Of Lymphangioleiomyomatosis (LAM)
Jane J. Yu, Tasha A. Morrison, Faina Myachina, E. Zhang +1 more
2011Asian Test Symposium0 citations
Semantic Scholar

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