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J. L. Vaught · SciRah

Researcher profile · Semantic Scholar

J. L. Vaught

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J. L. Vaught — researcher profile on SciRah

h-index: 32
Works: 75
Citations: 4,892

Most-cited papers

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.
R. Raffa, E. Friderichs, W. Reimann, R. P. Shank +2 more
1992Journal of Pharmacology and Experimental Therapeutics1,214 citations
Semantic Scholar
Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.
R. Raffa, E. Friderichs, W. Reimann, R. P. Shank +4 more
1993Journal of Pharmacology and Experimental Therapeutics456 citations
Semantic Scholar
Mu and delta receptors: their role in analgesia in the differential effects of opioid peptides on analgesia.
J. L. Vaught, R. Rothman, T. Westfall
1982Life Science215 citations
Semantic Scholar
CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family*
A. Maroney, J. P. Finn, T. Connors, J. T. Durkin +8 more
2001Journal of Biological Chemistry207 citations Open access
Semantic Scholar
Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.
J. L. Vaught, A. Takemori
1979Journal of Pharmacology and Experimental Therapeutics199 citations
Semantic Scholar
Insulin-like growth factor-I: potential for treatment of motor neuronal disorders.
M. Lewis, N. Neff, P. Contreras, D. Stong +3 more
1993Experimental Neurology185 citations
Semantic Scholar
Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse.
F. Porreca, J. S. Heyman, H. Mosberg, J. Omnaas +1 more
1987Journal of Pharmacology and Experimental Therapeutics161 citations
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CEP‐1347/KT‐7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ‐induced cortical neuron apoptosis
D. Bozyczko‐Coyne, T. O'Kane, Zhi-Liang Wu, P. Dobrzanski +3 more
2001Journal of Neurochemistry158 citations Open access
Semantic Scholar
A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen.
J. L. Vaught, K. Pelley, L. Costa, P. Setler +1 more
1985Neuropharmacology157 citations
Semantic Scholar
Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.
A. Kammesheidt, F. Boyce, A. Spanoyannis, Brian J Cummings +4 more
1992Proceedings of the National Academy of Sciences of the United States of America145 citations Open access
Semantic Scholar
Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease.
Edward S. Kimball, F. Persico, J. L. Vaught
1988Journal of Immunology122 citations Open access
Semantic Scholar
Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587).
C. Dionne, A. M. Camoratto, J. Jani, Erling O. Emerson +8 more
1998Clinical Cancer Research119 citations
Semantic Scholar
Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives.
B. Maryanoff, M. J. Costanzo, S. Nortey, M. Greco +4 more
1998Journal of Medicinal Chemistry109 citations
Semantic Scholar
Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases.
P. Waldmeier, D. Bozyczko‐Coyne, Michael Williams, J. L. Vaught
2006Biochemical Pharmacology102 citations
Semantic Scholar
Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease.
D. Hantai, M. Akaaboune, C. Lagord, M. Murawsky +5 more
1995Journal of Neurological Sciences91 citations
Semantic Scholar
Aurintricarboxylic Acid Protects Hippocampal Neurons from NMDA‐and Ischemia‐Induced Toxicity In Vivo
Jill M. Roberts-Lewis, Val R. Marcy, Yonghua Zhao, J. L. Vaught +2 more
1993Journal of Neurochemistry91 citations
Semantic Scholar
Chronic 1,25-dihydroxyvitamin D3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain.
M. Saporito, E. R. Brown, K. C. Hartpence, H. M. Wilcox +2 more
1994Brain Research86 citations
Semantic Scholar
CEP‐751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti‐tumor activity
Anna Marie Camoratto, Jitesh Jani, T. Angeles, A. Maroney +6 more
1997International Journal of Cancer80 citations Open access
Semantic Scholar
Pharmacological induction of nerve growth factor mRNA in adult rat brain.
M. Saporito, H. M. Wilcox, K. C. Hartpence, M. Lewis +2 more
1993Experimental Neurology74 citations
Semantic Scholar
A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clini
D. Gingrich, D. R. Reddy, M. Iqbal, Jasbir Singh +12 more
2003Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.
B. Maryanoff, J. L. Vaught, R. P. Shank, D. McComsey +2 more
1990Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Can supraspinal δ-opioid receptors mediate antinociception?
J. S. Heyman, J. L. Vaught, R. Raffa, F. Porreca
198860 citations
Semantic Scholar
Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice.
P. Contreras, J. L. Vaught, J. A. Gruner, C. Brosnan +5 more
1997Brain Research59 citations
Semantic Scholar
Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.
J. L. Vaught, J. R. Mathiasen, R. B. Raffa
1988Journal of Pharmacology and Experimental Therapeutics59 citations
Semantic Scholar
A further characterization of the differential effects of leucine enkephalin, methionine enkephalin and their analogs on morphine-induced analgesia.
J. L. Vaught, A. Takemori
1979Journal of Pharmacology and Experimental Therapeutics45 citations
Semantic Scholar
Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis.
M. Saporito, E. R. Brown, S. Carswell, A. M. DiCamillo +5 more
1998Neuroscience43 citations
Semantic Scholar
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.
Allen B. Reitz, D. Bennett, Paul S. Blum, E. Codd +6 more
1994Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Systemic dexamethasone administration increases septal Trk autophosphorylation in adult rats via an induction of nerve growth factor.
M. Saporito, E. R. Brown, K. C. Hartpence, H. M. Wilcox +3 more
1994Molecular Pharmacology38 citations
Semantic Scholar
Pyrrole mannich bases as potential antipsychotic agents.
M. K. Scott, G. E. Martin, D. L. DiStefano, C. Fedde +8 more
1992Journal of Medicinal Chemistry34 citations
Semantic Scholar
Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.
Allen B. Reitz, E. W. Baxter, E. Codd, C. B. Davis +10 more
1998Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Differentiation of multiple neurokinin receptors in the guinea pig ileum.
H. Jacoby, I. Lopez, David Wright, J. L. Vaught
1986Life Science32 citations
Semantic Scholar
Tachykinin-like central activity of neuromedin K in mice.
J. L. Vaught, L. J. Post, H. Jacoby, David Wright
1984European Journal of Pharmacology32 citations
Semantic Scholar
The Potential of Insulin‐like Growth Factor‐I as a Therapeutic for the Treatment of Neuromuscular Disorders
Michael E. Lewis, J. L. Vaught, N. Neff, Peter E. Grebow +4 more
1993Annals of the New York Academy of Sciences30 citations
Semantic Scholar
Intrathecal bombesin in rats: effects on behaviour and gastrointestinal transit.
Debra E. Gmerek, Alan Cowan, J. L. Vaught
1983European Journal of Pharmacology24 citations
Semantic Scholar
Interactions of substance P antagonists with serotonin in the mouse spinal cord.
J. L. Vaught, R. Scott
1988Peptides23 citations
Semantic Scholar
A species difference in the slowing effect of intrathecal morphine on gastrointestinal transit.
J. L. Vaught, Alan Cowan, Debra E. Gmerek
1983European Journal of Pharmacology22 citations
Semantic Scholar
Piperazinylalkyl heterocycles as potential antipsychotic agents.
M. K. Scott, E. W. Baxter, D. Bennett, Robert E. Boyd +16 more
1995Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis.
C. Murray, A. Cowan, D. Wright, J. L. Vaught +1 more
1987Journal of Pharmacology and Experimental Therapeutics18 citations
Semantic Scholar
Multidimensional analysis of ligand binding data: application to opioid receptors.
R. Rothman, R. Barrett, J. L. Vaught
1983Neuropeptides18 citations
Semantic Scholar
Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease.
J. L. Vaught, P. Contreras, M. Glicksman, N. Neff
2007Ciba Foundation symposium15 citations
Semantic Scholar
Intrathecal morphine slows gastrointestinal transit in rats.
Randy J. Koslo, J. L. Vaught, Alan Cowan, Debra E. Gmerek +1 more
1985European Journal of Pharmacology15 citations
Semantic Scholar
μ and δ, but not κ, opioid agonists induce contractions of the canine small intestine in vivo
J. L. Vaught, A. Cowan, H. Jacoby
198515 citations
Semantic Scholar
Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity
R. Raffa, R. P. Shank, J. L. Vaught
2005Psychopharmacology13 citations
Semantic Scholar
CEP‐1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria‐fornix lesion
S. Harper, M. Saporito, L. Hewson, L. Young +8 more
2000NeuroReport10 citations
Semantic Scholar
Can supraspinal delta-opioid receptors mediate antinociception?
J. S. Heyman, J. L. Vaught, R. Raffa, F. Porreca
1988TIPS - Trends in Pharmacological Sciences10 citations
Semantic Scholar
rhIGF‐I Enhances Functional Recovery from Sciatic Crush Time‐Course and Dose‐Response Study
P. Contreras, Cathy Steffler, J. L. Vaught
1993Annals of the New York Academy of Sciences9 citations
Semantic Scholar
Anticonvulsant sugar sulfamates. Potent cyclic sulfate and cyclic sulfite analogues of topiramate
B. Maryanoff, M. J. Costanzo, R. P. Shank, J. Schupsky +2 more
19939 citations
Semantic Scholar
A differentiation between peripheral and central neurokinin receptors using phenoxybenzamine.
J. L. Vaught, R. Scott, H. Jacoby
1986European Journal of Pharmacology9 citations
Semantic Scholar
Mu and delta, but not kappa, opioid agonists induce contractions of the canine small intestine in vivo.
J. L. Vaught, A. Cowan, H. Jacoby
1985European Journal of Pharmacology9 citations
Semantic Scholar
Modulation of Morphine Analgesia by Opioid Peptides
J. L. Vaught, R. Barrett
19876 citations
Semantic Scholar

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