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N. Hirayama · SciRah

Researcher profile · Semantic Scholar

N. Hirayama

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N. Hirayama — researcher profile on SciRah

h-index: 29
Works: 256
Citations: 2,947

Most-cited papers

Use of Amino Acid Composition to Predict Ligand-Binding Sites
Shinji Soga, H. Shirai, M. Kobori, N. Hirayama
2007Journal of Chemical Information and Modeling193 citations
Semantic Scholar
Free Radical Biology and Medicine
T. Kanno, Kazunori Tanaka, Yoshiko Yanagisawa, K. Yasutake +4 more
2012169 citations
Semantic Scholar
ASEDock-Docking Based on Alpha Spheres and Excluded Volumes
Junichi Goto, R. Kataoka, H. Muta, N. Hirayama
2008Journal of Chemical Information and Modeling146 citations
Semantic Scholar
Inhibition of Plasminogen Activator Inhibitor-1: Its Mechanism and Effectiveness on Coagulation and Fibrosis
Y. Izuhara, Satoru Takahashi, M. Nangaku, S. Takizawa +5 more
2008Arteriosclerosis, Thrombosis and Vascular Biology135 citations Open access
Semantic Scholar
A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia
M. Nangaku, Y. Izuhara, S. Takizawa, T. Yamashita +6 more
2007Arteriosclerosis, Thrombosis and Vascular Biology117 citations Open access
Semantic Scholar
A Novel Inhibitor of Plasminogen Activator Inhibitor-1 Provides Antithrombotic Benefits Devoid of Bleeding Effect in Nonhuman Primates
Y. Izuhara, Nagahisa Yamaoka, Hidehiko Kodama, Takashi Dan +5 more
2010Journal of Cerebral Blood Flow and Metabolism109 citations Open access
Semantic Scholar
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.
T. Kanno, Kazunori Tanaka, Yoshiko Yanagisawa, K. Yasutake +4 more
2012Free Radical Biology & Medicine56 citations
Semantic Scholar
Use of amino acid composition to predict epitope residues of individual antibodies.
Shinji Soga, Daisuke Kuroda, H. Shirai, M. Kobori +1 more
2010Protein engineering, design & selection : PEDS49 citations
Semantic Scholar
TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche.
T. Yahata, A. Ibrahim, Y. Muguruma, M. Eren +9 more
2017Blood47 citations Open access
Semantic Scholar
Binding Affinity and Interaction of LL-37 with HLA-C*06:02 in Psoriasis.
Tomotaka Mabuchi, N. Hirayama
2016Journal of Investigative Dermatology32 citations Open access
Semantic Scholar
A Novel Acylaminoimidazole Derivative, WN1316, Alleviates Disease Progression via Suppression of Glial Inflammation in ALS Mouse Model
Kazunori Tanaka, T. Kanno, Yoshiko Yanagisawa, K. Yasutake +3 more
2014PLoS ONE31 citations Open access
Semantic Scholar
Na+/H+ Exchanger 1 Is Regulated via Its Lipid-Interacting Domain, Which Functions as a Molecular Switch: A Pharmacological Approach Using Indolocarbazole Compounds
Naoko Shimada-Shimizu, T. Hisamitsu, Tomoe Y. Nakamura, N. Hirayama +1 more
2014Molecular Pharmacology29 citations
Semantic Scholar
Association of HLA-A*11:01 with sulfonamide-related severe cutaneous adverse reactions in Japanese patients.
R. Nakamura, T. Ozeki, N. Hirayama, A. Sekine +17 more
2020Journal of Investigative Dermatology28 citations Open access
Semantic Scholar
Prediction of solubility of drugs by conductor-like screening model for real solvents.
Hirotaka Ikeda, K. Chiba, Atsushi Kanou, N. Hirayama
2005Chemical and pharmaceutical bulletin26 citations Open access
Semantic Scholar
Dielectrically Controlled Enantiomeric Resolution (DCR) of (R)- and (S)-2-Methylpyrrolidine by (R,R)-Tartaric Acid
R. Sakurai, A. Yuzawa, K. Sakai, N. Hirayama
200621 citations
Semantic Scholar
Effects of interleukin‐17A in nucleus pulposus cells and its small‐molecule inhibitors for intervertebral disc disease
Kaori Suyama, D. Sakai, N. Hirayama, Yoshihiko Nakamura +6 more
2018Journal of Cellular and Molecular Medicine20 citations Open access
Semantic Scholar
Docking simulations between drugs and HLA molecules associated with idiosyncratic drug toxicity.
N. Hirayama
2017Drug Metabolism and Pharmacokinetics19 citations
Semantic Scholar
A simple method to improve the odds in finding 'lead-like' compounds from chemical libraries.
K. Horio, H. Muta, Junichi Goto, N. Hirayama
2007Chemical and pharmaceutical bulletin19 citations Open access
Semantic Scholar
Identification of the Druggable Concavity in Homology Models Using the PLB Index
Shinji Soga, H. Shirai, M. Kobori, N. Hirayama
2007Journal of Chemical Information and Modeling19 citations
Semantic Scholar
Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells
Nobuo Watanabe, M. Kidokoro, Makiko Tanaka, S. Inoue +11 more
2020Cancer Cell International18 citations Open access
Semantic Scholar
In Silico Risk Assessment of HLA-A∗02:06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients
Hideto Isogai, HirokoMiyadera, M. Ueta, C. Sotozono +3 more
201317 citations
Semantic Scholar
Resolution of 1-cyclohexylethylamine via diastereomeric salt formation with enantiopure 2-phenylacetic acids
K. Sakai, Masami Yokoyama, R. Sakurai, N. Hirayama
200617 citations
Semantic Scholar
Molecular mechanism of DCR phenomenon observed in ( RS )-1-cyclohexylethylamine–mandelic acid resolution system
K. Sakai, R. Sakurai, N. Hirayama
200616 citations
Semantic Scholar
Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma.
Ken-ichi Aoyama, Y. Ota, K. Kajiwara, N. Hirayama +1 more
2014Biochemical and Biophysical Research Communications - BBRC14 citations
Semantic Scholar
Molecular Mechanisms of Dielectrically Controlled Resolution (DCR).
K. Sakai, R. Sakurai, N. Hirayama
2007Topics in current chemistry14 citations
Semantic Scholar
AutoGPA: An Automated 3D-QSAR Method Based on Pharmacophore Alignment and Grid Potential Analysis
N. Asakawa, S. Kobayashi, Junichi Goto, N. Hirayama
2012International Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Human PZP and common marmoset A2ML1 as pregnancy related proteins
H. Kashiwagi, H. Ishimoto, Sun-ichiro Izumi, Toshiro Seki +10 more
2020Scientific Reports12 citations Open access
Semantic Scholar
In Silico Prediction of Interactions between Site II on Human Serum Albumin and Profen Drugs
Hideto Isogai, N. Hirayama
2013ISRN Pharmaceutics12 citations Open access
Semantic Scholar
Interaction of Nevirapine with the Peptide Binding Groove of HLA-DRB1*01:01 and Its Effect on the Conformation of HLA-Peptide Complex
M. Hirasawa, Katsunobu Hagihara, K. Abe, O. Ando +1 more
2018International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01
M. Hirasawa, Katsunobu Hagihara, K. Abe, O. Ando +1 more
2017International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
HLA-Modeler: Automated Homology Modeling of Human Leukocyte Antigens
Shinji Amari, R. Kataoka, T. Ikegami, N. Hirayama
2013International Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Crystal Structure of Ganciclovir
T. Kawamura, N. Hirayama
20099 citations Open access
Semantic Scholar
A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule
Nobuo Watanabe, Yusuke Suzuki, Takahisa Yonezu, Yuki Nakagawa +4 more
2017Scientific Reports8 citations Open access
Semantic Scholar
Practical resolution of racemic trans-2-benzylaminocyclohexanol with di-p-toluoyl-l-tartaric acid via diastereomeric salt formation based on the Pope and Peachey method
Ryuji Ogawa, T. Fujino, N. Hirayama, K. Sakai
20088 citations
Semantic Scholar
G-CSF receptor-binding cyclic peptides designed with artificial amino-acid linkers.
Kenji Shibata, Kumiko Maruyama-Takahashi, M. Yamasaki, N. Hirayama
2006Biochemical and Biophysical Research Communications - BBRC8 citations
Semantic Scholar
A Possible Molecular Mechanism of Immunomodulatory Activity of Bilirubin
Hideto Isogai, N. Hirayama
2013International Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
Structure and conformation of a novel inhibitor of angiotensin I converting enzyme--a tripeptide containing phosphonic acid.
N. Hirayama, M. Kasai, K. Shirahata
2009International journal of peptide & protein research7 citations
Semantic Scholar
Prediction of solvents suitable for crystallization of small organic molecules.
K. Hosokawa, Junichi Goto, N. Hirayama
2005Chemical and pharmaceutical bulletin7 citations Open access
Semantic Scholar
In silico Analysis of Interactions between HLA-B*58:01 and Allopurinol-related Compounds
M. Osabe, M. Tohkin, N. Hirayama
20166 citations Open access
Semantic Scholar
Crystal Structure of Linezolid
R. Tanaka, N. Hirayama
20086 citations Open access
Semantic Scholar
In silico Analysis of Interactions between Nevirapine-related Compounds, HLA-B*14:02 and T-cell Receptor
Hideto Isogai, N. Hirayama
20165 citations Open access
Semantic Scholar
Chemocavity: Specific Concavity in Protein Reserved for the Binding of Biologically Functional Small Molecules
Shinji Soga, H. Shirai, M. Kobori, N. Hirayama
2008Journal of Chemical Information and Modeling5 citations
Semantic Scholar
Structure of Trimetazidine
R. Tanaka, M. Haramura, A. Tanaka, N. Hirayama
20055 citations Open access
Semantic Scholar
Diphenyl-tetrazol-propanamide Derivatives Act as Dual-Specific Antagonists of Platelet CLEC-2 and Glycoprotein VI
Nobuo Watanabe, Yoshiko Shinozaki, Sanae Ogiwara, Riko Miyagasako +17 more
2023Thrombosis and Haemostasis4 citations
Semantic Scholar
A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction
Nobuo Watanabe, M. Kidokoro, Yusuke Suzuki, Makiko Tanaka +7 more
2019PLoS ONE4 citations Open access
Semantic Scholar
Production of a Locus- and Allele-Specific Monoclonal Antibody for the Characterization of SLA-1*0401 mRNA and Protein Expression Levels in MHC-Defined Microminipigs
Y. Kametani, S. Ohshima, A. Miyamoto, Atsuko Shigenari +12 more
2016PLoS ONE4 citations Open access
Semantic Scholar
Structure of Etoposide
R. Tanaka, N. Hirayama
20074 citations Open access
Semantic Scholar
[Docking method for drug discovery].
N. Hirayama
2007Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan4 citations Open access
Semantic Scholar
Structure of Tolperisone Monohydrochloride
R. Tanaka, N. Hirayama
20073 citations Open access
Semantic Scholar
Megsin gene: its genomic analysis, pathobiological functions, and therapeutic perspectives.
T. Miyata, Ming Li, Xue-Qing Yu, N. Hirayama
2007Current Genomics3 citations Open access
Semantic Scholar

Frequent co-authors

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T. Miyata×5
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T. Miyata — researcher profile on SciRah
K. Sakai×5
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K. Sakai — researcher profile on SciRah
Shinji Soga×4
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Shinji Soga — researcher profile on SciRah
H. Shirai×4
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H. Shirai — researcher profile on SciRah

×4

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M. Kobori — researcher profile on SciRah

Junichi Goto×4

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Junichi Goto — researcher profile on SciRah

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R. Sakurai — researcher profile on SciRah

Nobuo Watanabe×4

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Nobuo Watanabe — researcher profile on SciRah

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S. Inokuchi — researcher profile on SciRah

Hideto Isogai×4

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Hideto Isogai — researcher profile on SciRah

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R. Tanaka — researcher profile on SciRah

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T. Kanno — researcher profile on SciRah