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T. McDonald · SciRah

Researcher profile · Semantic Scholar

T. McDonald

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T. McDonald — researcher profile on SciRah

h-index: 36
Works: 101
Citations: 4,478

Most-cited papers

Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome.
Sean M. Mcbride, Catherine H. Choi, Yan Wang, D. Liebelt +8 more
2005Neuron495 citations Open access
Semantic Scholar
A minK–HERG complex regulates the cardiac potassium current IKr
T. McDonald, Zhi-Hui Yu, Ming Zhen, Eugen C. Palma +4 more
1997Nature405 citations Open access
Semantic Scholar
Cyclic AMP regulates the HERG K(+) channel by dual pathways.
J. Cui, Y. Melman, Eugen C. Palma, G. Fishman +1 more
2000Current Biology173 citations Open access
Semantic Scholar
14‐3‐3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity
A. Kagan, Y. Melman, A. Krumerman, T. McDonald
2002EMBO Journal150 citations Open access
Semantic Scholar
KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity.
Y. Melman, S. Um, A. Krumerman, A. Kagan +1 more
2004Neuron149 citations Open access
Semantic Scholar
HERG K+ Channel Activity Is Regulated by Changes in Phosphatidyl Inositol 4,5-Bisphosphate
Jinsong Bian, J. Cui, T. McDonald
2001Circulation Research141 citations Open access
Semantic Scholar
Activation of Ca2+ current in Jurkat T cells following the depletion of Ca2+ stores by microsomal Ca(2+)-ATPase inhibitors.
B. Premack, T. McDonald, P. Gardner
1994Journal of Immunology132 citations Open access
Semantic Scholar
Structural Determinants of KvLQT1 Control by the KCNE Family of Proteins*
Y. Melman, A. Doménech, S. de la Luna, T. McDonald
2001Journal of Biological Chemistry125 citations Open access
Semantic Scholar
Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment
Catherine H. Choi, Brian P. Schoenfeld, Aaron J. Bell, Paul Hinchey +9 more
2010Brain Research117 citations Open access
Semantic Scholar
The Dominant Negative LQT2 Mutation A561V Reduces Wild-type HERG Expression*
A. Kagan, Zhi-Hui Yu, G. Fishman, T. McDonald
2000Journal of Biological Chemistry113 citations Open access
Semantic Scholar
Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells.
T. McDonald, B. Premack, P. Gardner
1993Journal of Biological Chemistry106 citations Open access
Semantic Scholar
Analysis of the Cyclic Nucleotide Binding Domain of the HERG Potassium Channel and Interactions with KCNE2*
J. Cui, A. Kagan, Danmei Qin, Jehu S. Mathew +2 more
2001Journal of Biological Chemistry101 citations Open access
Semantic Scholar
A Single Transmembrane Site in the KCNE-encoded Proteins Controls the Specificity of KvLQT1 Channel Gating*
Y. Melman, A. Krumerman, T. McDonald
2002Journal of Biological Chemistry98 citations Open access
Semantic Scholar
Voltage-Gated Potassium Channels: Regulation by Accessory Subunits
Yan Li, S. Um, T. McDonald
2006The Neuroscientist95 citations
Semantic Scholar
Insulin Signaling Misregulation underlies Circadian and Cognitive Deficits in a Drosophila Fragile X Model
Rachel E Monyak, Danielle Emerson, Brian P. Schoenfeld, Xiangzhong Zheng +10 more
2016Molecular Psychiatry92 citations Open access
Semantic Scholar
CaT1 Contributes to the Stores-operated Calcium Current in Jurkat T-lymphocytes*
J. Cui, J. Bian, A. Kagan, T. McDonald
2002Journal of Biological Chemistry88 citations Open access
Semantic Scholar
KATP Channels Regulate Mitogenically Induced Proliferation in Primary Rat Hepatocytes and Human Liver Cell Lines
H. Malhi, A. Irani, P. Rajvanshi, S. Suadicani +3 more
2000Journal of Biological Chemistry86 citations Open access
Semantic Scholar
Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths.
Dawei Wang, Krunal Shah, S. Um, Lucy Eng +8 more
2014Forensic Science International83 citations
Semantic Scholar
An LQT mutant minK alters KvLQT1 trafficking.
A. Krumerman, Xiao-Hong Gao, J. Bian, Y. Melman +2 more
2004American Journal of Physiology - Cell Physiology81 citations
Semantic Scholar
Molecular analysis of PIP2 regulation of HERG and IKr.
J. Bian, A. Kagan, T. McDonald
2004American Journal of Physiology. Heart and Circulatory Physiology79 citations
Semantic Scholar
Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current.
T. McDonald, P. Nghiem, P. Gardner, C. Martens
1992Journal of Biological Chemistry75 citations Open access
Semantic Scholar
Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue
Catherine H. Choi, Sean M. Mcbride, Brian P. Schoenfeld, D. Liebelt +13 more
2009Biogerontology (Dordrecht)67 citations Open access
Semantic Scholar
KCNE regulation of KvLQT1 channels: structure-function correlates.
Y. Melman, Andrew Krummerman, T. McDonald
2002Trends in cardiovascular medicine66 citations
Semantic Scholar
Characterization of a novel intracellular sphingolipid-gated Ca(2+)-permeable channel from rat basophilic leukemia cells.
L. Kindman, Sung-Hou Kim, T. McDonald, Phyllis Gardner
1994Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Microarray analysis of global changes in gene expression during cardiac myocyte differentiation.
Chang-Fu Peng, Yi Wei, J. Levsky, T. McDonald +2 more
2002Physiological Genomics62 citations
Semantic Scholar
Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents.
J. Wagner, T. McDonald, P. Nghiem, A. Lowe +4 more
1992Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel.
Jing-Song Fan, Min Jiang, Dun Wen, T. McDonald +1 more
1999Biophysical Journal56 citations Open access
Semantic Scholar
PDE-4 Inhibition Rescues Aberrant Synaptic Plasticity in Drosophila and Mouse Models of Fragile X Syndrome
Catherine H. Choi, Brian P. Schoenfeld, Eliana D. Weisz, Aaron J. Bell +21 more
2015Journal of Neuroscience53 citations Open access
Semantic Scholar
Identification of a hemolysin from Actinobacillus pleuropneumoniae and characterization of its channel properties in planar phospholipid bilayers.
G. Lalonde, T. McDonald, Phyllis Gardner, P. O'Hanley
1989Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Functional Interactions between KCNE1 C-Terminus and the KCNQ1 Channel
Jerri Chen, R. Zheng, Y. Melman, T. McDonald
2009PLoS ONE50 citations Open access
Semantic Scholar
Differential Association between HERG and KCNE1 or KCNE2
S. Um, T. McDonald
2007PLoS ONE47 citations Open access
Semantic Scholar
Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models
Catherine H. Choi, Brian P. Schoenfeld, Aaron J. Bell, J. Hinchey +26 more
2016Frontiers in Behavioral Neuroscience46 citations Open access
Semantic Scholar
Phosphatidylinositol 4,5-bisphosphate interactions with the HERG K+ channel
J. Bian, T. McDonald
2007Pflügers Archiv: European Journal of Physiology43 citations
Semantic Scholar
PKA phosphorylation of HERG protein regulates the rate of channel synthesis.
Jian Chen, Jakub Sroubek, Y. Krishnan, Yan Li +2 more
2009American Journal of Physiology. Heart and Circulatory Physiology42 citations Open access
Semantic Scholar
A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation
Nikhil deSouza, J. Cui, M. Důra, T. McDonald +1 more
2007Journal of Cell Biology42 citations Open access
Semantic Scholar
Pharmacological and genetic reversal of age dependent cognitive deficits due to decreased presenilin function
Sean M. Mcbride, Catherine H. Choi, Brian P. Schoenfeld, Aaron J. Bell +16 more
2010Journal of Neuroscience36 citations Open access
Semantic Scholar
Applying High-Resolution Variant Classification to Cardiac Arrhythmogenic Gene Testing in a Demographically Diverse Cohort of Sudden Unexplained Deaths
Ying Lin, Nori Williams, Dawei Wang, W. Coetzee +8 more
2017Circulation: Cardiovascular Genetics35 citations Open access
Semantic Scholar
Functional characterization of a putative aquaporin from Encephalitozoon cuniculi, a microsporidia pathogenic to humans.
K. Ghosh, C. Cappiello, Sean M. Mcbride, J. Occi +4 more
2006International Journal of Parasitology35 citations Open access
Semantic Scholar
Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits
R. Zheng, Keith Thompson, Edmond Obeng-Gyimah, D. Alessi +3 more
2010Biochemical Journal33 citations Open access
Semantic Scholar
Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes.
T. McDonald, K. Courtney, W. Clusin
1989Biophysical Journal33 citations Open access
Semantic Scholar
KATP channels regulate mitogenically-induced proliferation in primary hepatocytes and human liver cell lines: implications for liver growth control and potential therapeutic targeting
H. Malhi, A. Irani, P. Rajvanshi, S. Suadicani +3 more
31 citations
Semantic Scholar
A Homolog of FHM2 Is Involved in Modulation of Excitatory Neurotransmission by Serotonin in C. elegans
E. Govorunova, Mustapha Moussaif, A. Kullyev, Ken C. Q. Nguyen +3 more
2010PLoS ONE29 citations Open access
Semantic Scholar
Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines.
Xiao-Qin Ren, Gong-Xin Liu, L. E. Organ-Darling, R. Zheng +5 more
2010American Journal of Physiology. Heart and Circulatory Physiology29 citations Open access
Semantic Scholar
Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-á-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2.
Zhiyuan Wu, Kun Chen, B. Haendler, T. McDonald +1 more
2008Endocrinology27 citations Open access
Semantic Scholar
Motivation to Pursue Genetic Testing in Individuals with a Personal or Family History of Cardiac Events or Sudden Cardiac Death
Kathleen E. Erskine, Nadia Z. Hidayatallah, Christine A. Walsh, T. McDonald +3 more
2014Journal of Genetic Counseling25 citations Open access
Semantic Scholar
Infant sudden death: Mutations responsible for impaired Nav1.5 channel trafficking and function
Ivan Gando, Jace G. Morganstein, Kundan R. Jana, T. McDonald +2 more
2017Pacing and clinical electrophysiology : PACE23 citations Open access
Semantic Scholar
An interdisciplinary approach to personalized medicine: case studies from a cardiogenetics clinic
Kathleen E. Erskine, Eleanor Griffith, Nicole DeGroat, Marina Stolerman +9 more
2013Personalized Medicine23 citations Open access
Semantic Scholar
Protein Kinase A Activity at the Endoplasmic Reticulum Surface Is Responsible for Augmentation of Human ether-a-go-go-related Gene Product (HERG)*
Jakub Sroubek, T. McDonald
2011Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Post-Transcriptional Control of Human Ether-a-go-go-Related Gene Potassium Channel Protein by α-Adrenergic Receptor Stimulation
Jian Chen, Kun Chen, Jakub Sroubek, Zhiyuan Wu +3 more
2010Molecular Pharmacology23 citations Open access
Semantic Scholar
Dynamic control of hERG/I(Kr) by PKA-mediated interactions with 14-3-3.
A. Kagan, T. McDonald
2005Novartis Foundation symposium21 citations
Semantic Scholar

Frequent co-authors

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Y. Melman×9
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Y. Melman — researcher profile on SciRah
Sean M. Mcbride×8
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Sean M. Mcbride — researcher profile on SciRah
A. Kagan×8
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A. Kagan — researcher profile on SciRah
Catherine H. Choi×7
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Catherine H. Choi — researcher profile on SciRah

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T. Jongens — researcher profile on SciRah

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J. Bian — researcher profile on SciRah

Brian P. Schoenfeld×6

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Brian P. Schoenfeld — researcher profile on SciRah

Paul Hinchey×6

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Paul Hinchey — researcher profile on SciRah

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D. Liebelt — researcher profile on SciRah

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J. Cui — researcher profile on SciRah

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S. Um — researcher profile on SciRah

Aaron J. Bell×5

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Aaron J. Bell — researcher profile on SciRah