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W. Krzyzanski · SciRah

Researcher profile · Semantic Scholar

W. Krzyzanski

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W. Krzyzanski — researcher profile on SciRah

h-index: 31
Works: 124
Citations: 2,589

Most-cited papers

Quasi-Equilibrium Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition
D. Mager, W. Krzyzanski
2005Pharmaceutical Research220 citations
Semantic Scholar
Selection between Michaelis–Menten and target-mediated drug disposition pharmacokinetic models
Xiao-Yu Yan, D. Mager, W. Krzyzanski
2009Journal of Pharmacokinetics and Pharmacodynamics93 citations Open access
Semantic Scholar
Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects.
W. Krzyzanski, W. Jusko, M. Wacholtz, N. Minton +1 more
2005European Journal of Pharmaceutical Sciences89 citations
Semantic Scholar
Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys
Jim J. Xiao, W. Krzyzanski, Yow-Ming C. Wang, Hong-Yan Li +5 more
2010AAPS Journal84 citations Open access
Semantic Scholar
Pharmacodynamics-Mediated Drug Disposition (PDMDD) and Precursor Pool Lifespan Model for Single Dose of Romiplostim in Healthy Subjects
Yow-Ming C. Wang, W. Krzyzanski, S. Doshi, Jim J. Xiao +2 more
2010AAPS Journal80 citations Open access
Semantic Scholar
Target-mediated pharmacokinetic and pharmacodynamic model of recombinant human erythropoietin (rHuEPO)
S. Woo, W. Krzyzanski, W. Jusko
2007Journal of Pharmacokinetics and Pharmacodynamics72 citations
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietin after Intravenous and Subcutaneous Administration in Rats
S. Woo, W. Krzyzanski, W. Jusko
2006Journal of Pharmacology and Experimental Therapeutics67 citations
Semantic Scholar
Interpretation of transit compartments pharmacodynamic models as lifespan based indirect response models
W. Krzyzanski
2010Journal of Pharmacokinetics and Pharmacodynamics52 citations Open access
Semantic Scholar
Population Modeling of Filgrastim PK‐PD in Healthy Adults Following Intravenous and Subcutaneous Administrations
W. Krzyzanski, P. Wiczling, P. Lowe, E. Pigeolet +3 more
2010Journal of clinical pharmacology52 citations
Semantic Scholar
Quantitative Prediction of Human Pharmacokinetics for mAbs Exhibiting Target-Mediated Disposition
Aman P. Singh, W. Krzyzanski, S. Martin, Gregory L. Weber +6 more
2014AAPS Journal49 citations Open access
Semantic Scholar
Pharmacodynamic Analysis of Recombinant Human Erythropoietin Effect on Reticulocyte Production Rate and Age Distribution in Healthy Subjects
J. Pérez-Ruixo, W. Krzyzanski, J. Hing
2008Clinical Pharmacokinetics47 citations Open access
Semantic Scholar
Modeling of delays in PKPD: classical approaches and a tutorial for delay differential equations
Gilbert Koch, W. Krzyzanski, J. Pérez-Ruixo, J. Schropp
2014Journal of Pharmacokinetics and Pharmacodynamics44 citations
Semantic Scholar
Pharmacodynamic model for chemotherapy-induced anemia in rats
S. Woo, W. Krzyzanski, W. Jusko
2008Cancer Chemotherapy and Pharmacology42 citations Open access
Semantic Scholar
Pharmacokinetics and pharmacodynamics of erythropoietin receptor in healthy volunteers
W. Krzyzanski, E. Wyska
2008Naunyn-Schmiedeberg's Archives of Pharmacology40 citations
Semantic Scholar
Pharmacodynamic Models for Agents that Alter Production of Natural Cells with Various Distributions of Lifespans
W. Krzyzanski, S. Woo, W. Jusko
2006Journal of Pharmacokinetics and Pharmacodynamics39 citations
Semantic Scholar
Partial derivative—Based sensitivity analysis of models describing target-mediated drug disposition
A. K. Abraham, W. Krzyzanski, D. Mager
2007AAPS Journal38 citations Open access
Semantic Scholar
Population Cell Life Span Models for Effects of Drugs Following Indirect Mechanisms of Action
J. Pérez-Ruixo, H. Kimko, A. Chow, V. Piotrovsky +2 more
2005Journal of Pharmacokinetics and Pharmacodynamics38 citations
Semantic Scholar
Methods of solving rapid binding target-mediated drug disposition model for two drugs competing for the same receptor
Xiao-Yu Yan, Yang Chen, W. Krzyzanski
2012Journal of Pharmacokinetics and Pharmacodynamics36 citations Open access
Semantic Scholar
Population Pharmacokinetic and Pharmacodynamic Model-Based Comparability Assessment of a Recombinant Human Epoetin Alfa and the Biosimilar HX575
Xiao-Yu Yan, P. Lowe, M. Fink, A. Berghout +2 more
2011Journal of clinical pharmacology36 citations Open access
Semantic Scholar
Pharmacokinetics and Pharmacodynamics of the Erythropoietin Mimetibody™ Construct CNTO 528 in Healthy Subjects
J. Pérez-Ruixo, W. Krzyzanski, E. Bouman‐Thio, B. Miller +8 more
2009Clinical Pharmacokinetics36 citations
Semantic Scholar
An Assessment of Recombinant Human Erythropoietin Effect on Reticulocyte Production Rate and Lifespan Distribution in Healthy Subjects
W. Krzyzanski, J. Pérez-Ruixo
2007Pharmaceutical Research33 citations
Semantic Scholar
Basic pharmacodynamic models for agents that alter the lifespan distribution of natural cells
W. Krzyzanski, J. Pérez-Ruixo, A. Vermeulen
2008Journal of Pharmacokinetics and Pharmacodynamics31 citations Open access
Semantic Scholar
Population Pharmacokinetics and Pharmacodynamics of Peptidic Erythropoiesis Receptor Agonist (ERA) in Healthy Volunteers
S. Woo, W. Krzyzanski, A. Duliege, R. Stead +1 more
2008Journal of clinical pharmacology30 citations
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Modeling of Romiplostim in Animals
W. Krzyzanski, Liviawati Sutjandra, J. Pérez-Ruixo, Bethlyn Sloey +2 more
2012Pharmaceutical Research29 citations
Semantic Scholar
FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition
M. Brenner, W. Krzyzanski, James Z. Chou, Pierre E. Signore +9 more
2016Pharmaceutical Research28 citations Open access
Semantic Scholar
Numerical validation and properties of a rapid binding approximation of a target-mediated drug disposition pharmacokinetic model
Anshu Marathe, W. Krzyzanski, D. Mager
2009Journal of Pharmacokinetics and Pharmacodynamics28 citations
Semantic Scholar
Population Pharmacokinetic Modelling of Filgrastim in Healthy Adults following Intravenous and Subcutaneous Administrations
P. Wiczling, P. Lowe, E. Pigeolet, F. Lüdicke +2 more
2009Clinical Pharmacokinetics28 citations
Semantic Scholar
Assessment of Basic Indirect Pharmacodynamic Response Models with Physiological Limits
Z. Yao, W. Krzyzanski, W. Jusko
2006Journal of Pharmacokinetics and Pharmacodynamics26 citations
Semantic Scholar
Flow cytometric assessment of homeostatic aging of reticulocytes in rats.
P. Wiczling, W. Krzyzanski
2008Experimental Hematology24 citations Open access
Semantic Scholar
Clinical Pharmacokinetics and Pharmacodynamics of Erythropoiesis-Stimulating Agents
S. Doshi, W. Krzyzanski, S. Yue, S. Elliott +2 more
2013Clinical Pharmacokinetics21 citations
Semantic Scholar
Simultaneous Pharmacokinetics/Pharmacodynamics Modeling of Recombinant Human Erythropoietin upon Multiple Intravenous Dosing in Rats
S. Ait-Oudhia, J. Scherrmann, W. Krzyzanski
2010Journal of Pharmacology and Experimental Therapeutics20 citations Open access
Semantic Scholar
Solving delay differential equations in S-ADAPT by method of steps
R. Bauer, Gary Mo, W. Krzyzanski
2013Comput. Methods Programs Biomed.18 citations
Semantic Scholar
Lifespan based indirect response models
W. Krzyzanski, J. P. Ruixo
2012Journal of Pharmacokinetics and Pharmacodynamics18 citations Open access
Semantic Scholar
Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women
W. Krzyzanski, M. Milad, A. Jobe, Thomas E. Peppard +2 more
2021Journal of Pharmacokinetics and Pharmacodynamics17 citations Open access
Semantic Scholar
Flow cytometric analysis of reticulocyte maturation after erythropoietin administration in rats
P. Wiczling, S. Ait-Oudhia, W. Krzyzanski
2009Cytometry Part A17 citations Open access
Semantic Scholar
Ordinary differential equation approximation of gamma distributed delay model
W. Krzyzanski
2019Journal of Pharmacokinetics and Pharmacodynamics16 citations
Semantic Scholar
Quantitative assessment of minimal effective concentration of erythropoiesis-stimulating agents
Xiao-Yu Yan, W. Krzyzanski
2013CPT: Pharmacometrics & Systems Pharmacology15 citations Open access
Semantic Scholar
Population Model of Serum Creatinine as Time-Dependent Covariate in Neonates
W. Krzyzanski, A. Smits, J. V. van den Anker, K. Allegaert
2021AAPS Journal14 citations Open access
Semantic Scholar
Method of determination of the reticulocyte age distribution from flow cytometry count by a structured‐population model
P. Wiczling, W. Krzyzanski
2007Cytometry Part A14 citations
Semantic Scholar
Mathematical Assessment of Properties of Precursor-Dependent Indirect Pharmacodynamic Response Models
A. Hazra, W. Krzyzanski, W. Jusko
2006Journal of Pharmacokinetics and Pharmacodynamics14 citations
Semantic Scholar
Minimal physiologically‐based hybrid model of pharmacokinetics in pregnant women: Application to antenatal corticosteroids
W. Krzyzanski, M. Milad, A. Jobe, W. Jusko
2023CPT: Pharmacometrics & Systems Pharmacology13 citations Open access
Semantic Scholar
Pharmacodynamic model of slow reversible binding and its applications in pharmacokinetic/pharmacodynamic modeling: review and tutorial
Tianjing Ren, Xu Zhu, Natalie M. Jusko, W. Krzyzanski +1 more
2022Journal of Pharmacokinetics and Pharmacodynamics13 citations Open access
Semantic Scholar
Indirect Pharmacodynamic Models for Responses with Circadian Removal
Vivaswath S. Ayyar, W. Krzyzanski, W. Jusko
2019Journal of Pharmacokinetics and Pharmacodynamics12 citations Open access
Semantic Scholar
Reticulocyte-Based Estimation of Red Blood Cell Lifespan
W. Krzyzanski, M. Brier, T. M. Creed, A. Gaweda
2013Experimental Hematology12 citations Open access
Semantic Scholar
Erythropoietin induced erythroid precursor pool depletion causes erythropoietin hyporesponsiveness
Xiao-Yu Yan, S. Ait-Oudhia, W. Krzyzanski
2012Pharmaceutical Research12 citations Open access
Semantic Scholar
Dose correction for the Michaelis–Menten approximation of the target-mediated drug disposition model
Xiao-Yu Yan, W. Krzyzanski
2012Journal of Pharmacokinetics and Pharmacodynamics11 citations Open access
Semantic Scholar
Use of a Local Sensitivity Analysis to Inform Study Design Based on a Mechanistic Toxicokinetic Model for γ-Hydroxybutyric Acid
M. Felmlee, W. Krzyzanski, Bridget L. Morse, M. Morris
2011AAPS Journal11 citations Open access
Semantic Scholar
Mechanism of ethanol enhancement of apoptosis and caspase activation in serum-deprived PC12 cells.
W. Krzyzanski, Jan Oberdoester, R. Rabin
2007Life Science11 citations
Semantic Scholar
Assessment of Dosing Impact on Intra-Individual Variability in Estimation of Parameters for Basic Indirect Response Models
W. Krzyzanski, J. Dmochowski, Nobuko Matsushima, W. Jusko
2006Journal of Pharmacokinetics and Pharmacodynamics11 citations
Semantic Scholar
Simplification of Complex Physiologically Based Pharmacokinetic Models of Monoclonal Antibodies
M. Elmeliegy, P. Lowe, W. Krzyzanski
2014AAPS Journal10 citations Open access
Semantic Scholar

Frequent co-authors

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W. Jusko×13
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W. Jusko — researcher profile on SciRah
J. Pérez-Ruixo×10
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J. Pérez-Ruixo — researcher profile on SciRah
Xiao-Yu Yan×6
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Xiao-Yu Yan — researcher profile on SciRah
S. Woo×5
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S. Woo — researcher profile on SciRah

×5

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P. Wiczling — researcher profile on SciRah

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D. Mager — researcher profile on SciRah

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A. Chow — researcher profile on SciRah

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P. Lowe — researcher profile on SciRah

Yow-Ming C. Wang×3

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Yow-Ming C. Wang — researcher profile on SciRah

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S. Balser — researcher profile on SciRah

S. Ait-Oudhia×3

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S. Ait-Oudhia — researcher profile on SciRah

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Jim J. Xiao — researcher profile on SciRah